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自然科学进展 2005年第5期15卷 534-538页

作者：李保华 kemal Topac Ertan Christoph Hemleben 中国科学院南京地质古生物研究所 Institute of Geology university of Tubingen D-72076Germany

传统的微体古生物学研究中,有孔虫是生活于海洋环境中以具有膜状、胶结质或钙质壳为特征的丝网状肉足虫类原生动物.最近对底栖有孔虫rDNA序列的分析研究,揭示了有孔虫还有无壳(裸露)种类以及生活于陆地淡水环境的类型. 同时分子系统学... 详细信息

传统的微体古生物学研究中,有孔虫是生活于海洋环境中以具有膜状、胶结质或钙质壳为特征的丝网状肉足虫类原生动物.最近对底栖有孔虫rDNA序列的分析研究,揭示了有孔虫还有无壳(裸露)种类以及生活于陆地淡水环境的类型. 同时分子系统学研究表明有孔虫位于真核生物系统树的基部,在双滴虫类与绿眼虫类之间.对浮游有孔虫大量基因型及其与环境关系的研究, 揭示了传统研究低估了有孔虫的多样性.有孔虫基因型与生物地理分布、海洋环境有关研究表明利用rDNA序列分析识别出的同一物种的不同基因型可以为古环境研究提供更加精确的替代性指标.

关键词：分子生物学研究进展分子系统学研究 DNA序列分析古生物学研究 rDNA序列海洋环境底栖有孔虫浮游有孔虫替代性指标基因型原生动物淡水环境真核生物环境关系地理分布环境研究肉足虫系统树绿眼虫多样性传统

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Early Repair of Sternal Instability Prevents Mediastinitis

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World Journal of Cardiovascular Surgery 2014年第2期4卷 13-16页

作者： koray Aykut Gokhan Albayrak Aycan kavala Mehmet Guzeloglu kemal karaarslan Eyup Hazan Department of Cardiovascular Surgery Bakirkoy Dr. Sadi Konuk Research Hospital Istanbul Turkey Department of Cardiovascular Surgery Izmir University Izmir Turkey Department of Cardiovascular Surgery Tepecik Research Hospital Izmir Turkey

Background: Discharge due to superficial wound infection and sternal dehiscence are the common complications of median sternotomy. This condition leads to mediastinitis. Mediastinitis is a serious condition which increases morbidity, mortality and hospital costs. The correct time for surgical treatment is contraversial in cases who have sternal dehiscence and discharge due to superficial infection. In this study, patients received sternal stabilization as soon as a diagnosis was made and monitored for the development of mediastinitis. Methods: Among the 1440 patients who had undergone elective CABG, a total of 85 patients who developed sternal dehiscence and superficial wound discharge were included in this study. These patients were re-operated on as soon as diagnosed and early sternal stabilization was provided. Results: The ratio of overall dehiscence was 5.9%. Mediastinitis developed in only 2 of the 85 patients. These patients were treated with VAC (Vacuum Assisted Closure) therapy. The ratio of overall mediastinitis was 0.13. Mediastinitis-related mortality was not detected. Conclusion: The ratio of mediastinitis decreases when patients who have discharge due to sternal dehiscence and superficial wound infection are immediately reviewed without waiting for the results of conventional methods such as antibiotic treatment and chest binder support.

关键词： Coronary Artery Bypass Grafting Sternal Dehiscence Mediastinitis

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The Importance of Prolactin Levels in Patients Treated with Cabergoline for the Prevention of OHSS:Is Cabergoline Really Effective in Patients with High Risk of OHSS?

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Open Journal of Obstetrics and Gynecology 2015年第6期5卷 344-349页

作者： Serkan Oral Yasam kemal Akpak Nilay karaca kadir Savan Department of Assisted Reproduction LIV HospitalIstanbulTurkey Department of Obstetrics and Gynecology Ankara Mevki Military HospitalAnkaraTurkey Department of Obstetrics and Gynecology Bezmi Alem Vakif University HospitalIstanbulTurkey Department of Assisted Reproduction Bahcelievler Medicalpark HospitalIstanbulTurkey

Background: OHSS is a dangerous and potentially life-threatening condition for which many researchers look for new ways to treat. Aim: To determine the effectiveness of prophylactic cabergoline administration on prolactine levels in patients with high risk for ovarian hyperstimulation syndrome (OHSS). Material and Methods: 163 in vitro fertilisation (IVF) patients with high risk for OHSS were enrolled in the study. The criteria for inclusion were more than 15 oocytes retrieved at oocyte pick up. A standard antagonist protocol was used for ovulation induction. Cabergoline treatments (0.5 mg/day) were started on the day of oocyte retrieval and continued for eight days. Prolactine levels were measured at the day of oocyte retrieval and the 9th day after the oocyte retrieval. Results: Of the 163 patients, 26 (15.9%) had OHSS. Prolactine levels on the day of oocyte retrieval were 44.22 ± 24.78 ng/mL and 37.6 ± 22.5 ng/mL in patients with OHSS and without OHSS, respectively (P > 0.05). In contrary prolactine levels were significantly higher in patients with OHSS patients (3.9 ± 5.07 ng/mL) than in patients without OHSS (2.1 ± 2.92 ng/mL) at the 9th day after oocyte retrieval (P < 0.05). Conclusion: Prolactine levels were higher in patients with OHSS than without OHSS who were treated with cabergoline for the prevention of OHSS.

关键词： Cabergoline Ovarian Hyperstimulation Syndrome(OHSS) Prolactine Levels In Vitro Fertilization(IVF) Vascular Endothelial Growth Factor(VEGF)

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Causal Variants of the GJB6 Gene are Associated with Hearing Loss and Skin Manifestations:A Case Report from Turkey

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International Journal of Dermatology and Venereology 2022年第3期5卷 166-168页

作者： Neslihan Duzkale Gamze Tas Aygar kemal keseroglu Murad Mutlu Mehmet Birol Ugur Department of Medical Genetic Diskapi Yildirim Beyazit Training and Research HospitalAltindagAnkara 06110Turkey Department of Dermatology Diskapi Yildirim Beyazit Training and Research HospitalAnkaraTurkey Department of Otorhinolaryngology Diskapi Yildirim Beyazit Training and Research HospitalAnkaraTurkey Department of Otorhinolaryngology Gazi UniversitySchool of MedicineBestepeAnkaraTurkey

Introduction:The gap junction beta 6(GJB6)gene encodes connexin *** protein plays critical role in tissues and is responsible for the formation of gap junctions,which have a wide variety of physiological ***-associated variants of GJB6 cause non-syndromic hearing loss(HL)and skin *** herein describe a Turkish girl who was diagnosed with HL and in whom genetic analysis revealed a causal variant of *** presentation:The 1-year-old girl patient was diagnosed with bilateral HL when she was 1 month *** from this,the patient’s motor/mental development and physical examination were *** a result of the analysis with the multi-gene panel,the causative genomic change,c.175G>A(***59Arg)in the GJB6 gene was determined as *** analysis proved the same genotype in the patient’s mother and *** patient’s mother and grandfather had bilateral HL and palmoplantar hyperkeratosis *** patient was diagnosed with Clouston syndrome,and genetic counseling was provided to her ***:Causal variants of GJB6 cause skin manifestations and signs of *** diagnosis of these patients is a valuable tool for clinicians in reaching their optimal treatment and clinical ***:In syndromic cases in which many organs are affected,the determination of the causative gene is important in directing the patients to appropriate observation,screening,and treatment strategies.

关键词： hearing loss GJB6 palmoplantar keratoderma Clouston syndrome

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Umbilical Cord Blood CD33 and Erythropoietin Levels of Pregnants with Abnormal Doppler Waveforms and to Compare with Normal Pregnancies

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Open Journal of Obstetrics and Gynecology 2015年第4期5卷 234-238页

作者： Nilay karaca Gokhan Bolluk Yasam kemal Akpak Aslihan Erken Serkan Oral Department of Obstetrics and Gynecology Bezmi Alem Vakif UniversityMedical FacultyIstanbulTurkey Department of Obstetrics and Gynecology Lütfiye Nuri Burat State HospitalIstanbulTurkey Department of Obstetrics and Gynecology Ankara Mevki Military HospitalAnkaraTurkey Department of Obstetrics and Gynecology Bayrampasa State HospitalIstanbulTurkey Department of Assisted Reproduction LIV HospitalIstanbulTurkey

Objective: In this study, we aimed to investigate umbilical cord blood CD33 and erythropoietin (EPO) levels of pregnants with abnormal umbilical and uterine artery doppler waveforms and to compare with normal pregnancies. Materials and Methods: Total 40 pregnant women were included in this study. Of these 40 women, while 20 patients had abnormal umbilical and uterine artery doppler waveforms, the other 20 patients had normal umbilical and uterine artery doppler waveforms. After the delivery, blood samples were taken from umbilical artery of double clemped umbilical cord for blood gas parameters, EPO and CD33 levels. Sociodemographic findings, antepartum, intrapartum test results, labor and delivery characteristics and newborn examination results were recorded. Blood gas parameters, EPO and CD33 levels between groups were analyzed. Mann-Whitney U test and t-test were used as statistical methods. Results: There were no differences between parity, gestational ages and newborn weights of the groups. Cord blood CD33 and EPO levels of group with abnormal umbilical and uterine artery doppler waveforms were significantly higher than group with normal umbilical and uterine artery doppler waveforms (p < 0.01). Conclusion: Pathology on doppler screen shows to us a connection between chronic hypoxemia and abnormal on doppler screen. Preference of high blood CD33 levels for cord blood transplantation especially during last years can also be used with preference of cord blood with abnormal doppler findings.

关键词： Antenatal Care CD33 Doppler Ultrasonography Erythropoietin Perinatology Umbilical Cord Blood

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