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Isoimperatorin alleviates acetic acid-induced colitis in rats

Asian Pacific Journal of Tropical Biomedicine 2024年第4期14卷 147-153页

作者： Saied Goodarzi Amir Hossein Abdolghaffari Behnaz Najafi Mostafa Pirali Hamedani Saeed Tavakoli Mahshad Marvi Maryam Baeeri Narguess Yassa Abbas Hadjiakhoondi Mohammad Abdollahi Zahra Tofighi Medicinal Plants Research Center Faculty of PharmacyTehran University of Medical SciencesTehranIran Department of Toxicology and Pharmacology Faculty of PharmacyTehran Medical SciencesIslamic Azad UniversityTehranIran Department of Pharmacognosy Faculty of PharmacyTehran University of Medical SciencesTehranIran Medicinal Plants Research Center Institute of Medicinal PlantsACECRKarajIran International Campus School of Pharmacy Tehran University of Medical SciencesTehranIran Toxicology and Diseases group The Pharmaceutical Sciences Research CenterTehran University of Medical SciencesTehranIran Department of Toxicology and Pharmacology Faculty of PharmacyTehran University of Medical SciencesTehranIran

Objective:To investigate the effect of isoimperatorin on histopathological and biochemical changes in acetic acid-induced colitis ***:Colitis was induced by intracolonic administration of acetic acid solution(4%v/v)in *** were divided into six groups including the sham group,the negative control group,the dexamethasone-treated group,and the groups treated with isoimperatorin(0.1,1,and 10 mg/kg/d by gavage).The treatments were administered for three days and then colonic status was assessed by macroscopic,histopathological,and biochemical ***:Isoimperatorin significantly alleviated colonic damage in a dose-dependent manner and improved histological changes in rats with acetic acid-induced *** also significantly reduced myeloperoxidase,TNF-α,IL-1β,and malodialdehyde ***:Isoimperatorin alleviates acetic acid-induced colitis in rats and may be a potential therapeutic agent for the treatment of colitis.

关键词： Isoimperatorin Inflammatory bowel disease Acetic acid Colitis TNF-α IL-1β

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The Relationship between Consumption of Fast Food with Level of Serum Folat among Nursing Students of Islamic Azad university, tehran medical Sciences Branch in 2016

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International Journal of Clinical Medicine 2017年第5期8卷 338-343页

作者： Naghibeiranvand Mehran Moshtagheshgh Zahra Islamic Azad university tehran medical Sciences Branch Tehran Iran

In recent decades, substantial increase in average weight of individuals has been seen in rich countries. Such changes are the result of significant changes in pattern of people’s lives. One of these issues is increasing levels in consumption of fast foods or processed foods. According to experts, the consumption of processed foods, because of having high-calories and trans-fatty acids, is fattening and harmful. In this study, the researchers after obtaining permission from the ethics committee and head of the School of Nursing, introduced themselves to nursing students then, samples were randomly selected among those who are eligible for the study. Before performing to complete the questionnaire and relevant experiments, testimonial were asked from the subjects. At the end of the study, results were suggested that, levels of Serum folate between males and females and also among married and single people were equivalent. Level of Serum folate among those students who usually have anemia in their families is significantly lower than those ones who have not anemia in their families (P = 0.003). There was a significant relationship between age and semester with levels of folate (P i.e. by increasing age and educational terms, levels of serum folate would be reduced. The level of serum folate among students who smoke is lesser than those do not (P = 0.001).

关键词： Fast Food Serum Folate Nursing Students

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Prevalence of Anemia in Patients with Diabetes Mellitus:A Systematic Review and Meta-Analysis

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Biomedical and Environmental Sciences 2024年第1期37卷 96-107页

作者： Monireh Faghir-Ganji Narjes Abdolmohammadi Maryam Nikbina Alireza Amanollahi Alireza Ansari-Moghaddam Rozhan Khezri Hamidreza Baradaran Student Research Committee Iran University of Medical SciencesTehranIran Department of Epidemiology School of Public HealthIran University of Medical SciencesTehranIran Department of Epidemiology School of Public HealthTehran University of Medical SciencesTehranIran Department of Midwifery Shoushtar Faculty of Medical SciencesShoushtarIran Department of Epidemiology School of Public Health and SafetyShahid Beheshti University of Medical SciencesTehranIran Trauma and Injury Research Center Iran University of Medical SciencesTehranIran Health Promotion Research Center Zahedan University of Medical SciencesZahedanIran Endocrine Research Center Institute of Endocrinology and MetabolismIran University of Medical SciencesTehranIran

Objective Anemia is a common public health concern in patients with type 2 diabetes *** study aimed to identify the prevalence of anemia among patients with *** Electronic databases,including PubMed,Scopus,Web of Sciences,and Google Scholar,were searched systematically for studies published between 2010 and *** removing duplicates and inappropriate reports,the remaining manuscripts were reviewed and appraised using theNewcastleOttawa Scale(NOS)tool.A random-effects model was used to calculate the pooled estimates of the extracted data using Stata version *** of the studies was assessed using the Q *** A total of 51 articles containing information on 26,485 patients with diabetes were included in this *** articles were mainly from Asia(58.82%)and Africa(35.29%).The overall prevalence of anemia was 35.45%(95%CI:30.30–40.76),with no evidence of heterogeneity by *** the two continents with the highest number of studies,the prevalence of anemia in patients with diabetes was significantly higher in Asia[40.02;95%CI:32.72–47.54]compared to Africa[28.46;95%CI:21.90–35.50](P for heterogeneity=0.029).Moreover,there has been an increasing trend in the prevalence of anemia in patients with diabetes over time,from[15.28;95%CI:9.83–22.21]in 2012 to[40.70;95%CI:10.21–75.93]in *** Globally,approximately 4 in 10 patients with diabetes suffer from ***,routine anemia screening and control programs every 3 months might be useful in improving the quality of life of these patients.

关键词： Prevalence Diabetic foot Anemia Diabetes mellitus

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Enhanced axonal regeneration and functional recovery of the injured sciatic nerve in a rat model by lithium-loaded electrospun nanofibrous scaffolds

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Bio-Design and Manufacturing 2024年第5期7卷 701-720页

作者： Banafsheh Dolatyar Bahman Zeynali Iman Shabani Azita Parvaneh Tafreshi Reza Karimi-Soflou Developmental Biology Laboratory School of BiologyCollege of ScienceUniversity of TehranTehran ***Iran Department of Biomedical Engineering Amirkabir University of Technology(Tehran Polytechnic)Tehran ***Iran Department of Molecular Medicine Faculty of Medical BiotechnologyNational Institute of Genetic Engineering and BiotechnologyTehran ***Iran 123

Increasing evidence indicates that engineered nerve grafts have great potential for the regeneration of peripheral nerve injuries(PNIs).While most studies have focused only on the topographical features of the grafts,we have considered both the biophysical and biochemical manipulations in our applied *** achieve this,we fabricated an electrospun nanofibrous scaffold(ENS)containing polylactide nanofibers loaded with lithium(Li)ions,a Wnt/β-catenin signaling *** addition,we seeded human adipose-derived mesenchymal stem cells(hADMSCs)onto this engineered scaffold to examine if their differentiation toward Schwann-like cells was *** further examined the efficacy of the scaffolds for nerve regeneration in vivo via grafting in a PNI rat *** results showed that Li-loaded ENSs gradually released Li within 11 d,at concentrations ranging from 0.02 to(3.64±0.10)mmol/L,and upregulated the expression of Wnt/β-catenin target genes(cyclinD1 and c-Myc)as well as those of Schwann cell markers(growth-associated protein 43(GAP43),S100 calcium binding protein B(S100B),glial fibrillary acidic protein(GFAP),and SRY-box transcription factor 10(SOX10))in differentiated *** the PNI rat model,implantation of Li-loaded ENSs with/without cells improved behavioral features such as sensory and motor functions as well as the electrophysiological characteristics of the injured *** improved function was further validated by histological analysis of sciatic nerves grafted with Li-loaded ENSs,which showed no fibrous connective tissue but enhanced organized myelinated *** potential of Li-loaded ENSs in promoting Schwann cell differentiation of hADMSCs and axonal regeneration of injured sciatic nerves suggests their potential for application in peripheral nerve tissue engineering.

关键词： Stem cell Schwann cell differentiation Electrospun nanofibrous scaffold Lithium ion Nerve regeneration

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Late infection after peri-orbital autologous micro-fat graft:a case presentation and literature review

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 603-606页

作者： Farzad Pakdel Hassan Asadigandomani Melika Arab Bafrani Zohreh Nozarian Zohre Abedinifar Niloofar Pirmarzdashti Behzad Jafari Zaynab Siami Department of Oculofacial Plastic Surgery Farabi HospitalSchool of MedicineTehran University of Medical SciencesTehran ***Iran Craniomaxillofacial Research Center Tehran University of Medical SciencesTehran ***Iran Department of Ophthalmology School of MedicineTehran University of Medical SciencesTehran ***Iran Department of Pathology Farabi HospitalSchool of MedicineTehran University of Medical SciencesTehran ***Iran Department of Microbiology Farabi HospitalSchool of MedicineTehran University of Medical SciencesTehran ***Iran Pediatric Cell and Gene Therapy Research Center Children’s Medical CenterSchool of MedicineTehran University of Medical SciencesTehran ***Iran

Citation:Pakdel F,Asadigandomani H,Arab Bafrani M,Nozarian Z,Abedinifar Z,Pirmarzdashti N,Jafari B,Siami *** infection after peri-orbital autologous micro-fat graft:a case presentation and literature *** J Ophthalmol ... 详细信息

关键词： graft orbital after

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Self Evaluation in Department of Communicable Diseases, Faculty of Medicine, tehran university of medical Sciences

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Health 2014年第16期6卷 2197-2203页

作者： Fereshteh Farzianpour Mahbobeh Hajabdolbaghi Siross Jafary Hamid Emady Kochak Department of Health Management and Economic School of Public Health Tehran University of Medical Sci-ences Tehran Iran Members of Educational Evaluation Committee of Communicable Diseases Faculty of Medicine Tehran University of Medical Sciences Tehran Iran

Introduction: Self evaluation is a process that defines and collects required data to judge about decision making issues at educational system on whether the educational department is fit to educate students? The objective of this study was determining the quality of the structural elements of the department of Communicable Diseases & determining the strengths, weaknesses, opportunities and threats to improve the quality of activities in the department under research. Materials and Methods: The employed method was Mixed methods (qualitative & quantitative research), on the basis of 10 procedural steps and within 8 sections dealing with evaluated factors;such as 1) organizational and management structure 2) scientific board members 3) students 4) Manpower 5) Space of educational research and health care 6) Equipment 7) curriculum 8) satisfaction of graduates, which were studied using 61 criteria and 172 indicators. Five-point Likert Scale was used for the responses in the questionnaire (1 - 1.75 = undesirable, to 4.2 - 5 completely desirable). Finally the data were analyzed using descriptive statistics indices and the assessment software of the Educational Development Center of TUMS. The instruments used in this method included assessment software, interview, observation and self-prepared questionnaire which consisted of 7 questionnaires and 2 check lists. Finding: The results of the research showed that general average of 8 investigating sections was 56.9% as a rather desirable research work. Conclusions: Therefore, it was concluded that function of the educational management in that group was directly in line with evaluation process, but continuing the process of evaluation seems necessary.

关键词： Self Evaluation Department of Communicable Diseases Faculty of Medicine tehran university of medical Sciences Educational Management

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Prevalence of retinal pathologies in people over 60 years:the tehran Geriatrics Eye Study

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 721-728页

作者： Abolghasem Mortazavi Alireza Hashemi Alirerza Jamali Hassan Hashemi Mohammadreza Aghamirsalim Mehdi Khabazkhoob Department of Neurosurgery Sina HospitalTehran University of Medical SciencesTehran ***Iran Noor Ophthalmology Research Center Noor Eye HospitalTehran ***Iran Rehabilitation Research Center Department of OptometrySchool of Rehabilitation SciencesIran University of Medical SciencesTehran ***Iran Noor Research Center for Ophthalmic Epidemiology Noor Eye HospitalTehran ***Iran Translational Ophthalmology Research Center Tehran University of Medical SciencesTehran ***Iran Department of Basic Sciences School of Nursing and MidwiferyShahid Beheshti University of Medical SciencesTehran ***Iran

AIM:To determine the prevalence of some retinal pathologies in people over 60y and their association with demographic and ocular ***:A cross-sectional study was conducted in tehran using multistage cluster *** selecting subjects aged 60 and over,optometric,and ophthalmic examinations were *** retinal examination,a 90 D lens was used and indirect ophthalmoscopy was performed after instilling tropicamide *** was done using the IOL Master for all ***:Of 3791 people that were invited through cluster sampling,3310 participated in the study(response rate=82%).The prevalence of retinal pigmented epithelium(RPE)change,drusen,geographic atrophy(GA),hypertensive retinopathy(HTR),nonproliferative diabetic retinopathy(NPDR),proliferative diabetic retinopathy(PDR),choroidal neovascularization(CNV),central retinal artery occlusion(CRAO),myopic retinopathy(MR),branch retinal vein occlusion(BRVO),and central retinal vein occlusion(CRVO)was 27.42%,11.08%,4.52%,3.03%,4.05%,0.54%,0.82%,0.39%,0.20%,0.49%,and 0.19%,*** removing the effect of age,the odds of NPDR were 1.68 times higher in women compared to men(P=0.014).After removing the effect of sex,the odds of drusen,RPE change,GA,CNV,BRVO,and CRVO increased with ***:There is a higher prevalence of RPE change,drusen,GA,CNV and a lower prevalence of MR and CRAO in the elderly population of tehran aged over 60y compared to global average *** the correlation of most of the diseases with age and their effects on vision,attention should be paid to these diseases and the related screening programs to prevent vision impairment.

关键词： retinal pathologies cross-sectional study vision impairment

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Effect of prisms on visual acuity,contrast sensitivity and nystagmus in patients with albinism

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1864-1868页

作者： Maryam Dashti Abbas Riazi Majid Ashrafi Saeed Rahmani Seyyed Mehdi Tabatabaei Department of Optometry School of RehabilitationShahid Beheshti University of Medical SciencesTehran ***Iran Department of Optometry School of RehabilitationIran University of Medical SciencesTehran ***Iran Department of Audiology School of RehabilitationShahid Beheshti University of Medical SciencesTehran ***Iran School of Rehabilitation Shahid Beheshti University of Medical SciencesTehran ***Iran

AIM:To investigate the effect of using base-out prisms on nystagmus,visual acuity and contrast sensitivity in patients with ***:In this interventional study,patients with albinism who had nystagmus were enrolled.A comprehensive eye exam was conducted,which included refraction,assessment of far and near vision acuity,and contrast sensitivity *** check for the nystagmus,a videonystagmography was *** tests were carried out in three modes:without any correction,with optical correction,and with correction using base-out prisms in three different powers,including 4,6,and 8 prism ***:Totally 23 patients with average age of 28.65±12.13 were *** was found that the use of optical correction and optical correction with prisms resulted in a statistically significant improvement in both far(at least:P<0.006)and near visual acuity(at least:P<0.001 except for prism 8;P<0.02).In addition,contrast sensitivity significantly improved at all low and medium frequencies except for correction with prism 8 in frequency 1.5(at least:P<0.01 except for prism 4,frequency 6;P=0.04).no significant improvement was observed in the evaluation of nystagmus ***:Optical correction with a prism can improve visual acuity and some spatial frequencies,but failed to improve nystagmus parameters.

关键词： nystagmus albinism prism

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Role of Fibrinogen-like Protein 1 in Tumor Recurrence Following Hepatectomy

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Journal of Clinical and Translational Hepatology 2024年第4期12卷 406-415页

作者： Zahra Shafieizadeh Zohreh Shafieizadeh Maryam Davoudi Reza Afrisham Xiaolei Miao Department of medical Laboratory Sciences School of Allied Medical SciencesTehran University of Medical SciencesTehranIran School of Pharmacy Xianning Medical CollegeHubei University of Science and TechnologyXianningHubeiChina

Partial hepatectomy is a first-line treatment for hepatocellular *** 2 weeks following partial hepatectomy,specific molecular pathways are activated to promote liver ***,residual microtumors may also exploit these pathways to reappear and *** targeting molecules that are differentially regulated between normal cells and malignancies,such as fibrinogen-like protein 1(FGL1),appears to be an effective *** potential functions of FGL1 in both regenerative and malignant cells are discussed within the ambit of this *** FGL1 is normally elevated in regenerative hepatocytes,it is normally downregulated in malignant *** does indeed upregulate FGL1 by increasing the release of transcription factors that promote FGL1,including HNF-1α and STAT3,and inflammatory effectors,such as TGF-β and ***,in turn,stimulates certain proliferative pathways,including EGFR/Src/*** alters the phase transition of highly differentiated hepatocytes from G0 to G1,thereby transforming susceptible cells into cancerous *** of the PI3K/Akt/mTOR pathway by FGL1 allele loss on chromosome 8,a tumor suppressor area,may also cause hepatocellular ***,FGL1 is specifically expressed in the liver via HNF-1α histone acetylase activity,which triggers lipid metabolic reprogramming in ***1 might also be involved in other carcinogenesis processes such as hypoxia,epithelial-mesenchymal transition,immunosuppression,and sorafenib-mediated drug *** study highlights a research gap in these disciplines and the necessity for additional research on FGL1 function in the described processes.

关键词： Fibrinogen-like protein 1 FGL1 Hepatocellular carcinoma Liver regeneration Hepatectomy Lipogenesis Recurrence

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Non-medical factors on choice of delivery (CS/NVD) in hospitals of tehran university of medical Sciences

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Open Journal of Obstetrics and Gynecology 2013年第1期3卷 67-73页

作者： Rahim Ostovar Batool Hossein Rashidi Fedeyh Haghallahi Mohammad Fararoei Mahin Rasouli Ebrahim Naeimi Department of Public Health School of Health Yasuj University of Medical Sciences Yasuj Iran Department of Statistics and Epidemiology School of Health Tehran University of Medical Sciences Tehran Iran Public Health Department School of Health Yasuj University of Medical Sciences Yasuj Iran Social Determinants of Health Research Center School of Health Yasuj University of Medical Sciences Yasuj Iran Vali-e-Asr Reproductive Health Research Center Tehran University of Medical Sciences Tehran Iran

Background: Kind of delivery affect many aspects of individuals, families and health systems situations. The aim of this study was to identify the Role of non-medical factors on choice of delivery (CS/NVD) in hospitals affiliated to tehran university of medical Sciences. Materials and Method: This cross-sectional study was performed to identify the factors involved in the choice of delivery (CS/NVD) among women attending hospitals affiliated to tehran university of medical Sciences. Data was derived from the medical records of women who gave birth in the hospitals. Results: A significant statistical relationship was found between factors such as age of mother, level of education, occupational status, type of previous delivery, person supervising the pregnancy and dissatisfaction about delivery were more frequent in women who underwent CS than those who gave birth by NVD. Conclusion: The highly increasing rise in the rate of unnecessary CS during throughout the world, and its adverse effect on maternal and child health, the financial burden imposed on families and health systems, has highlighted the importance of studies to identify the non-medical factors that affect decision-making concerning type of delivery as well as to determine the appropriate medical indications of CS.

关键词： Cesarean Section Normal Vaginal Delivery Inappropriate Health Care Health System

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