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Movement analysis in the diagnosis and management of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 485-486页

作者： Johannes Burtscher Nicolas Bourdillon Jules MJanssen Daalen Aurélien Patoz Julien FBally Martin Kopp Davide Malatesta Bastiaan RBloem Institute of Sport Sciences University of LausanneLausanneSwitzerland Radboud University Medical center Department of NeurologyDonders Institute for BrainCognition and BehaviorCenter of Expertise for Parkinson and Movement DisordersNijmegenThe Netherlands Radboud University Medical center Department of Medical BioSciencesNijmegenThe Netherlands Research and Development Department Volodalen Swiss Sport LabAigleSwitzerland service of Neurology Department of Clinical NeurosciencesLausanne University Hospital(CHUV)and University of Lausanne(UNIL)LausanneSwitzerland Department of Sport Science University of InnsbruckInnsbruckAustria

Challenges in the diagnosis and treatment of Parkinson’s disease:Parkinson’s disease(PD)is an increasingly prevalent neurodegenerative disease,at first sight primarily characterized by motor symptoms,although non-motor symptoms also constitute a major part of the overall ***,this disease cannot be diagnosed reliably until a large part of the vulnerable dopaminergic neurons has been irretrievably lost,and the disease progresses *** biological criteria for PD have been proposed recently and might eventually improve early diagnosis,but they require further validation,and their use will initially be restricted to a research environment(Darweesh et al.,2024).

关键词： diagnosis Clinical eventually

Discrete Numerical Study on Type II Fracture of Partially Detached Concrete Panels in Cold Region

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Structural Durability & Health Monitoring 2025年第1期19卷 167-191页

作者： Huayi Zhang Maobin Song Lei Shen Nizar Faisal Alkayem Maosen Cao College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing210024China Haihe River Huaihe River and Xiaoqinghe River Basin Water Conservancy Management and Service Center of Shandong ProvinceJinan250100China College of Mechanics and Engineering Science Hohai UniversityNanjing211100China

When the upper chord beam of the beam-string structure(BSS)is made of concrete-ﬁlled steel tube(CFST),its overall stiffness will change greatly with the construction of concrete placement,which will have an impact on the design of the tensioning plans and selection of control measures for the *** order to accurately obtain the bending stiffness of CFST beam and clarify its impact on the mechanical properties of composite BSS during con-struction,the inﬂuence of some factors such as height-width ratio,wall thickness of steel tube,elasticity modulus of concrete,and friction coefﬁcient on the bending stiffness are analyzed parametrically by the numerical simula-tion technology based on an actual *** calculation formula of the equivalent bending stiffness of CFST is also established through mathematical statistical ***,the equivalent bending stiffness is introduced into the construction and use stages of the composite BSS,respectively,and the mechanical properties such as prestress-tensioning control value,structural deformation,and internal force of key members are comparatively analyzed when adopting two different construction ***,the optimal construction plan of concrete placementﬁrst and then prestress-tensioning is proposed.

关键词： Beam-string structure(BSS) concrete-ﬁlled steel tube(CFST) bending stiffness timing of concrete placement prestress-tensioning

Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu Na Li Zhengxiang Zhou Ru Ye Liyan Zhong Yashuang Xu Junhui Ren Yi Liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health service center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

Macrophysical properties of specific cloud types from radiosonde and surface active remote sensing measurements over the ARM Southern Great Plains site

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Atmospheric and Oceanic Science Letters 2017年第1期10卷 29-35页

作者： ZHANG Jin-Qiang CHEN Hong-Bin Key Laboratory of Middle Atmosphere and Global Environment Observation center of technical Support and service IAPCA

Accurate observation of clouds is challenging because of the high variability and complexity of cloud types and *** using the long-term cloud data collected during the ARM program at the Southern Great Plains central facility during 2001-2010,the consistencies and differences in the macrophysical properties of clouds between radiosonde and ground-based active remote sensing are quantitatively evaluated according to six cloud types：low;mid-low（ML）;high-midlow;mid;high-mid（HM）;and high.A similar variability trend is exhibited by the radiosonde and surface observations for the cloud fractions of the six cloud ***,the magnitudes of the differences between the two methods are different among the six cloud types,with the largest difference seen in the high *** distribution of the cloud-base height of the ML,mid,and HM clouds agrees in both methods,whereas large differences are seen in the cloud-top height for the ML and high *** cloud thickness variations generally agree between the two datasets for the six cloud types.

关键词： Cloud macrophysical properties cloud types radiosonde remote sensing

Multisensory mechanisms of gait and balance in Parkinson’s disease:an integrative review

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Neural Regeneration Research 2025年第1期20卷 82-92页

作者： Stiven Roytman Rebecca Paalanen Giulia Carli Uros Marusic Prabesh Kanel Teus van Laar Nico I.Bohnen Department of Radiology University of MichiganAnn ArborMIUSA Department of Neurology University of MichiganAnn ArborMIUSA Morris K.Udall center of Excellence for Parkinson’s Disease Research University of MichiganAnn ArborMIUSA Institute for Kinesiology Research Science and Research Centre KoperKoperSlovenia Department of Health Sciences Alma Mater Europaea–ECMMariborSlovenia Parkinson’s Foundation Research center of Excellence University of MichiganAnn ArborMIUSA Department of Neurology University of GroningenUniversity Medical Center GroningenGroningenThe Netherlands Neurology service and GRECC VA Ann Arbor Healthcare SystemAnn ArborMIUSA

Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging *** and gait control does not happen automatically,as previously believed,but rather requires continuous involvement of central nervous *** effectively exert control over the body,the brain must integrate multiple streams of sensory information,including visual,vestibular,and somatosensory *** mechanisms which underpin the integration of these multisensory signals are the principal topic of the present *** multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older *** emphasis,however,has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and *** the present work,we review the contributions of somatosensory,visual,and vestibular modalities,along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s *** also review evidence of vestibular contributions to multisensory temporal binding windows,previously shown to be highly pertinent to fall risk in older ***,we relate multisensory vestibular mechanisms to potential neural substrates,both at the level of neurobiology(concerning positron emission tomography imaging)and at the level of electrophysiology(concerning electroencephalography).We hope that this integrative review,drawing influence across multiple subdisciplines of neuroscience,paves the way for novel research directions and therapeutic neuromodulatory approaches,to improve the lives of older adults and patients with neurodegenerative diseases.

关键词： aging balance encephalography functional magnetic resonance imaging gait multisensory integration Parkinson’s disease positron emission tomography somatosensory vestibular visual

Modelling of meander migration in an incised channel

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International Journal of Sediment Research 2014年第4期29卷 441-453页

作者： Jianchun HUANG Blair P.GREIMANN Timothy J.RANDLE Hydraulic Engineers Sedimentation and River Hydraulics GroupTechnical Service CenterBureau of Reclamation

An updated linear computer model for meandering rivers with incision has been *** model simulates the bed topography,flow field,and bank erosion rate in an incised meandering *** a scenario where the upstream sediment load decreases(e.g.,after dam closure or soil conservation),alluvial river experiences cross section deepening and slope *** channel migration rate might be affected in two ways:decreased channel slope and steeped bank *** proposed numerical model combines the traditional one-dimensional(1D) sediment transport model in simulating the channel erosion and the linear model for channel meandering.A non-equilibrium sediment transport model is used to update the channel bed elevation and gradations.A linear meandering model was used to calculate the channel alignment and bank erosion/accretion,which in turn was used by the 1D sediment transport *** the 1D sediment transport model,the channel bed elevation and gradations are representedin each channel cross *** the meandering model,the bed elevation and gradations are stored in two dimensional(2D) cells to represent the channel and terrain properties(elevation and gradation).A new method is proposed to exchange information regarding bed elevations and bed material fractions between 1D river geometry and 2D channel and *** ability of the model is demonstrated using the simulation of the laboratory channel migration of Friedkin in which channel incision occurs at the upstream end.

关键词： Numerical model River channel migration Meandering river Linearization analysis Sediment transport

Bioinspired Ultrasensitive Flexible Strain Sensors for Real‑Time Wireless Detection of Liquid Leakage

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Nano-Micro Letters 2025年第3期17卷 310-327页

作者： Weilong Zhou Yu Du Yingying Chen Congyuan Zhang Xiaowei Ning Heng Xie Ting Wu Jinlian Hu Jinping Qu Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of EducationHubei Key Laboratory of Material Chemistry and Service Failure and Hubei Engineering Research Center for Biomaterials and Medical Protective MaterialsSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China School of Materials Science and Engineering Wuhan Institute of TechnologyWuhan 430205People’s Republic of China Department of Biomedical Engineering City University of Hong KongHong KongSAR 999077People’s Republic of China

Liquid leakage of pipeline networks not only results in considerableresource wastage but also leads to environmental pollution and ecological *** response to this global issue, a bioinspired superhydrophobic thermoplastic polyurethane/carbon nanotubes/graphene nanosheets flexible strain sensor (TCGS) hasbeen developed using a combination of micro-extrusion compression molding andsurface modification for real-time wireless detection of liquid leakage. The TCGSutilizes the synergistic effects of Archimedean spiral crack arrays and micropores,which are inspired by the remarkable sensory capabilities of scorpions. This designachieves a sensitivity of 218.13 at a strain of 2%, which is an increase of 4300%. Additionally, it demonstrates exceptional durability bywithstanding over 5000 usage cycles. The robust superhydrophobicity of the TCGS significantly enhances sensitivity and stability indetecting small-scale liquid leakage, enabling precise monitoring of liquid leakage across a wide range of sizes, velocities, and compositionswhile issuing prompt alerts. This provides critical early warnings for both industrial pipelines and potential liquid leakage scenariosin everyday life. The development and utilization of bioinspired ultrasensitive flexible strain sensors offer an innovative and effectivesolution for the early wireless detection of liquid leakage.

关键词： Thermoplastic polyurethane Bioinspired Cracks Liquid leakage Flexible strain sensor

Climate Change Facts in Central China during 1961-2010

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Advances in Climate Change Research 2013年第2期4卷 103-109页

作者： WAN Su-Qin GAO Yuan ZHOU Bo WANG Hai-Jun LIU Min SHI Rui-Qin WANG Kai Wuhan Regional Climate center Hubei Meteorological Service Yichang Meteorological service Hubei Provincial Meteorological Information and technical Support center

Based on the observations from 239 meteorological stations located in Central China （Henan, Hubei and Hunan provinces）, this paper focuses on the climate change facts during 1961- 2010. There was a significant increasing trend in annual mean temperature for Central China during 1961 -2010. The increasing rate was 0.15℃ per decade, which was lower than the national trend. Since the mid-1980s, temperature increasing was obvious. Large increasing rate was observed in the mid-eastern part of Central China. For the four seasons, the increasing rate in winter was the largest （0.27℃ per decade）. The increasing rate in the annual mean minimum temperature was larger than that in the annual mean maximum temperature from 1961 to 2010. As a result, the diurnal range of temperature decreased at the rate of -0.10℃ per decade. The extreme high temperature events were increasing while the extreme low temperature events were significantly decreasing. There was no obvious trend in annual precipitation for Central China during 1961-2010. Precipitation in summer and winter significantly increased; change of precipitation in spring was not obvious; precipitation in autumn was decreasing. The decreasing rate of annual rainy days was -3.4 d per decade. The precipitation intensity increased at the rate of 0.25 mm d-1 per decade. Heavy-rain days significantly increased. Spring and summer started earlier while autumn and winter started later. As a result, spring and summer duration was expanding whereas autumn and winter duration shortened.

关键词： Central China climate change temperature precipitation

Surface modulation of MoS_(2)/O-ZnIn_(2)S_(4) to boost photocatalytic H_(2)evolution

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Journal of Energy Chemistry 2022年第12期75卷 276-284,I0007页

作者： Yanhua Peng Xinlei Guo Shufei Xu Ya'nan Guo Dongsheng Zhang Meijiao Wang Guosong Wei Xiaolong Yang Zhuo Li Yan Zhang Fenghui Tian College of Chemistry and Chemical Engineering Qingdao UniversityQingdao 266071ShandongChina Comprehensive technical service center of Penglai Customs Yantai 265600ShandongChina

To realize the continuous production of hydrogen energy,the efficient photocatalysts are required in the heterogeneous reaction for water ***,we reported a surface modulation strategy,via doping oxygen atoms to tune the surface state of ZnIn_(2)S_(4)nanosheets with cocatalyst MoS_(2)modification,to enhance water adsorption and surface catalytic reaction for boosting the photocatalytic ***,MoS_(2)/O-ZnIn_(2)S_(4)photocatalysts showed a remarkably superior photocatalytic H_(2)production performance of 4.002 mmol g^(-1)h^(-1)and an apparent quantum yield(AQY)of~2.53%,5.4 folds higher than ZnIn_(2)S_(4).Using operando infrared spectroscopy and DFT calculation,we revealed the dynamic structural evolution,as well as the active sites for water adsorption and the catalytic reaction at the MoS_(2)/O ZnIn_(2)S_(4)*** work reveals the effect of surface modulation on the photocatalytic activity for MoS_(2)/O-ZnIn_(2)S_(4)and offers a feasible method to devise excellent nanomaterial photocatalysts for H_(2)production.

关键词： Photocatalytic hydrogen evolution Surface modulation Oxygen doping MoS_(2) Operando DRIFT DFT calculation