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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Coinfection with Malaria in Selected States in Nigeria

Advances in Infectious Diseases 2024年第2期14卷 442-455页

作者： Oluwagbemiga Olanrewaju Aina Olufemi Samuel Amoo Kazeem Adewale Osuolale Adewale Kayode Ojogbede Azuka Patrick Okwuraiwe David Ayoola Oladele Adesola Zaidat Musa Tajudeen Akanji Bamidele Celestina Onyinye Okoyenta Abideen Olurotimi Salako Toyosi Yekeen Raheem Ifeoma Eugenia Idigbe Fehintola Anthonia Ige Joseph Ojonugwa Shaibu Gregory Aigbe Ohihoin Kikelomo Wright Bisola Adebayo Hussein Abdu-Razzaq Abdulrahman Ahmad Mustapha Imam Bashir Bello Tambuwal Muhammad Shuaibu Gobir Richard Ikwuogu Christian Tetsola Gloria Patrick-Ferife Nathaniel Enamuotor Mildred Okowa William Nwachukwu Cornelius Ohonsi Magdalene Egede Chinwe Ochu Ehimario Igumbor Oliver Chukwujekwu Ezechi Babatunde Lawal Salako Rosemary Ajuma Audu Biochemistry and nutrition Department Nigerian Institute of Medical Research Lagos Nigeria Centre for Human Virology and Genomics Microbiology Department Nigerian Institute of Medical Research Lagos Nigeria Monitoring and Evaluation Unit Nigerian Institute of Medical Research Lagos Nigeria Public Health and Epidemiology Department Nigerian Institute of Medical Research Lagos Nigeria Clinical Sciences Department Nigerian Institute of Medical Research Lagos Nigeria Molecular Biology and Biotechnology Department Nigerian Institute of Medical Research Lagos Nigeria Department of Community Health & Primary Health Care Lagos State University College of Medicine Lagos State University Teaching Hospital Lagos Nigeria research Unit Lagos State Ministry of Health Lagos Nigeria Sokoto State Ministry of Health Sokoto Nigeria Department of Medical Biochemistry Usmanu Danfodiyo University Sokoto Nigeria Centre for Advanced Medical research and Training Usmanu Danfodiyo University Sokoto Nigeria Delta State Ministry of Health Asaba Nigeria Nigeria Centre for Disease Control Abuja Nigeria Center for Infectious Disease research Nigerian Institute of Medical Research Lagos Nigeria

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Plasmodium species are the causative agents of coronavirus disease 2019 (COVID-19) and malaria respectively with similar clinical presentations. The objective of this study is to determine the burden of co-infection of SARS-CoV-2 and malaria in the general population. Five (5 mLs) of blood samples were collected for SARS-CoV-2 and malaria parasite test. The malaria test was performed using a commercially available one-step malaria antigen Plasmodium falciparum histidine-rich protein 2 (Pf HRP-II) rapid test kit. The results of the study showed that the participants that were coinfected with SARS-CoV-2 IgG and malaria were 13 (2.5%) in Lagos, 1114 (39.1%) in Delta and 49 (2.3%) in Sokoto States. The prevalence of coinfection of SARS-CoV-2 and malaria in urban areas in Lagos, Delta and Sokoto States were 7 (2.2%), 1373 (48.1%), and 5 (0.2%) respectively. In rural areas, the prevalence of coinfection of SARS-CoV-2 and malaria in Lagos, Delta and Sokoto States were 6 (0.3%), 365 (12.8%), and 44 (2.1%) respectively in this study. This suggests that participants in the urban areas were more prone to co-infections than the rural areas in Lagos and Delta states, while it was otherwise in Sokoto State. In conclusion, the co-infection of SARS-CoV-2 and malaria was very high in Delta State compared to the other States. It is important for clinics to screen for both diseases when patients present with symptoms of malaria. This is because the infections have similar symptoms and the public is quick to assume malaria infection without diagnosing for COVID-19 and vice versa.

关键词： SARS-CoV-2 Malaria Coinfection

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A nearly deterministic scheme for generation of multiphoton GHZ states with weak cross-Kerr nonlinearity

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Chinese Physics B 2011年第10期20卷 91-95页

作者：王奕叶柳方保龙 School of Physics and Material Science Anhui University teaching and research section of Physics School of Life Sciences Anhui Medical University

We propose a scheme to generate polarization-entangled multiphoton Greenberger-Horne^Zeilinger （GHZ） states based on weak cross-Kerr nonlinearity and subsequent homodyne measurement. It can also be generalized to pr... 详细信息

关键词： GHZ state cross-Kerr nonlinearity quantum entanglement

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Investigation of the Acceptability of Cultured Meat in University Students

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Food and nutrition Sciences 2024年第2期15卷 151-169页

作者： Merve Kumru Hulya Demir nutrition and Dietetic Department Health Science Faculty Yeditepe University Istanbul Türkiye

Background: Over the past 20 years, cultured meat has drawn a lot of public attention as a potential solution to issues with animal husbandry, including inadequate use of natural sources, improper animal welfare practices, and possible risks to public health and safety. The novel method of producing meat through culture reduces the need for animals to produce muscle fiber, thereby obviating the necessity for animal slaughter. Apart from its ethical advantages, cultured meat presents a possible way to fulfill the expanding need for food among growing populations. The purpose of this research was to find out whether Turkish students would be willing to pay for and accept cultured meat. Technique: Method: 371 university students who willingly consented to fill out a questionnaire and provide demographic data make up the research sample. Questions from previous studies on the acceptability of cultured meat were compiled to create the survey. The research’s data collection took place in March and April of 2022. The research was completed in June 2022 after the data had been processed and analyzed. Results: The results showed that the majority of participants were female and had omnivorous eating habits. Based on the results of the Bonferroni correction test, students with a higher intention to purchase and consume cultured meat were those who received economics and business education. Students with two years of university education had a higher overall survey score than those with four years of education (p section points (r = -109, p = 0.036) (r = -0.121, p = 0.019). In conclusion, university students generally have a negative outlook on health-related issues, such as eating cultured meat as an alternative.

关键词： Cultured Meat University Students

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Terminal Angular Constraint Integrated Guidance and Control for Flexible Hypersonic Vehicle with Dead-Zone Input Nonlinearity

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Journal of Beijing Institute of Technology 2020年第4期29卷 489-503页

作者： Hewei Zhao Detection Guidance and Control teaching research section Naval Aviation UniversityYantai 264001ShandongChina

This paper presents an integrated guidance and control model for a flexible hypersonic vehicle with terminal angular *** integrated guidance and control model is bounded and the dead-zone input nonlinearity is considered in the system *** line of sight angle,line of sight angle rate,attack angle and pitch rate are involved in the integrated guidance and control *** controller is designed with a backstepping method,in which a first order filter is employed to avoid the differential *** full tuned radial basis function(RBF)neural network(NN)is used to approximate the system dynamics with robust item coping with the reconstruction errors,the exactitude model requirement is reduced in the controller *** the last step of backstepping method design,the adaptive control with Nussbaum function is used for the unknown dynamics with a time-varying control gain *** uniform ultimate boundedness stability of the control system is *** simulation results validate the effectiveness of the controller design.

关键词： hypersonic vehicle terminal angular constraint dead-zone input nonlinearity full tuned radial basis function(RBF)neural network(NN) integrated guidance and control

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Nerve protective effect of rhTPO and G-CSF on hypoxic ischemic brain damage in rats

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Asian Pacific Journal of Tropical Medicine 2014年第9期7卷 725-729页

作者： Hong-Xia Zhou Chun-Lai Zhang Yue-Hong Li Yu-Xin Zhang Zi-Feng Wei Xi Wang Meng Ling-Li Anatomy teaching and research section Hebei Union University Worker Hospital Affiliated to Hebei Medical University

Objective:To observe the protection effect of rhTPO and granulocyte colony stimulating factor(G-CSFi on brain nerve after hypoxic ischemic brain damage(HIBD)in neonatal rats,exploring new ways for the laboratory basis of treatment for hypoxic ischemic encephalopathy,and provide for ***:A total of 120 newborn SD rats aging 7 d were randomly divided into control group,model group,TPO group and G-CSF group,using the method of blockingleft carotid artery to establish HIBD *** left carotid artery was only seperated rather than blocked in the control group;after modeling,saline injection,rhTPO treatment and G-CSF treatment were adopted in the model group,TPO group and C-CSF group *** 10rats of 4 groups were executed at Day 3,7,14 after modeling,brain tissue was extracted to observe the brain damage:Immunohistochemical method was used to observe the histopathological changes of brain tissue and changes of nest protein(nestin)***:Injured brain mass of model group,TPO group and G-CSF group were significantly higher than that of control group at corresponding time point(P<0.05).Injured brain mass of TPO group and G-CSF group were significantly lower than that of model group(P<0.05),and with the increase of age,more significant increasing *** Day 3 after modeling,the expression of nestin positive cells in cerebral cortex of model group,TPO group and G-CSF gnmp increased significantly than that of control group{P<0.05);nestin positive cells of G-CSF group outnumbered TPO group significantly(P<0.05).Conclusions:The early TPO,G-CSF treatment of HIBD rats can improve brain function after hypoxia ischemia by neural protection.G-CSF can promote the differentiation of neural cells proliferation,and reduee degeneration and necrosis of nerve cells.

关键词： TPO G-CSF HIBD Nerve protection

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Dose-response effect of pre-exercise carbohydrates under muscle glycogen unavailability:Insights from McArdle disease

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Journal of Sport and Health Science 2024年第3期13卷 398-408页

作者： Pedro L.Valenzuela Alfredo Santalla Lidia B.Alejo Andrea Merlo Asuncion Bustos Laura Castellote-Belles Roser Ferrer-Costa Nicola A.Maffiuletti David Barranco-Gil Tomas Pinos Alejandro Lucia Physical Activity and Health research Group(“PaHerg”) Research Institute of Hospital“12 de Octubre”(“imas12”)Madrid 28041Spain Department of Systems Biology University of AlcalaMadrid 28871Spain Department of Sport and Computer Science Section of Physical Education and SportsFaculty of SportUniversidad Pablo de OlavideSevilla 41013Spain EVOPRED research Group Universidad Europea de CanariasTenerife 38300Spain Faculty of Sport Sciences Universidad Europea de MadridMadrid 28670Spain Gait&Motion Analysis Laboratory Sol et Salus HospitalTorre Pedrera di Rimini(RN)47922Italy Department of Clinical Biochemistry Laboratoris ClınicsHospital Universitari Vall d’HebronBarcelona 08035Spain Human Performance Lab Schulthess ClinicZurich 8008Switzerland Biomedical research Networking Center on Rare Disorders(CIBERER) Barcelona 08035Spain Mitochondrial and Neuromuscular Disorders Unit Vall d’Hebron Institut de RecercaUniversitat Autonoma de BarcelonaBarcelona 08035Spain

Background:This study aimed to determine the effect of different carbohydrate(CHO)doses on exercise capacity in patients with McArdle disease—the paradigm of“exercise intolerance”,characterized by complete muscle glycogen unavailability—and to determine whether higher exogenous glucose levels affect metabolic responses at the McArdle muscle cell(in vitro)***:Patients with McArdle disease(n=8)and healthy controls(n=9)underwent a 12-min submaximal cycling constant-load bout followed by a maximal ramp test 15 min after ingesting a non-caloric *** a randomized,double-blinded,cross-over design,patients repeated the tests after consuming either 75 g or 150 g of CHO(glucose:fructose=2:1).Cardiorespiratory,biochemical,perceptual,and electromyographic(EMG)variables were ***,glucose uptake and lactate appearance were studied in vitro in wild-type and McArdle mouse myotubes cultured with increasing glucose concentrations(0.35,1.00,4.50,and 10.00 g/L).Results:Compared with controls,patients showed the“classical”second-wind phenomenon(after prior disproportionate tachycardia,myalgia,and excess electromyographic activity during submaximal exercise,all p<0.05)and an impaired endurance exercise capacity(-51%ventilatory threshold and55%peak power output,both p<0.001).Regardless of the CHO dose(p<0.05 for both doses compared with the placebo),CHO intake increased blood glucose and lactate levels,decreased fat oxidation rates,and attenuated the second wind in the ***,only the higher dose increased ventilatory threshold(+27%,p=0.010)and peak power output(+18%,p=0.007).In vitro analyses revealed no differences in lactate levels across glucose concentrations in wild-type myotubes,whereas a doseresponse effect was observed in McArdle ***:CHO intake exerts beneficial effects on exercise capacity in McArdle disease,a condition associated with total muscle glycogen *** of these benefits are dose dependent.

关键词： Endurance Glycogen storage disease Glycogenosis nutrition Supplement

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Second Order Linear Differential Equations with Almost Periodic Solutions

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Acta Mathematica Sinica,English Series 1991年第4期7卷 354-359页

作者：肖体俊梁进 teaching and research section of Mathematics Kunming Institute of Technology Department of Mathematics Yunnan Teachers’ University

In this paper, a charactenzation of almost periodic strongly continuous Sine operatorfonction is given. and in a Hilbert space, it is shown that the almost periodicity of a Sine operator functionimplies that of the co... 详细信息

关键词： Second Order Linear Differential Equations with Almost Periodic Solutions

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Impact of Pitx3 gene knockdown on glial cell line-derived neurotrophic factor transcriptional activity in dopaminergic neurons

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Neural Regeneration research 2017年第8期12卷 1347-1351页

作者： Jing Chen Xiao-yu Kang Chuan-xi Tang Dian-shuai Gao Experiment teaching Center of Morphology Xuzhou Medical University Xuzhou Jiangsu Province China teaching and research section of Neurobiology and Anatomy Xuzhou Medical University Xuzhou Jiangsu Province China

Pitx3 is strongly associated with the phenotype, differentiation, and survival of dopaminergic neurons. The relationship between Pitx3 and glial cell line-derived neurotrophic factor（GDNF） in dopaminergic neurons remains poorly understood. The present investigation sought to construct and screen a lentivirus expression plasmid carrying a rat Pitx3 short hairpin（sh）RNA and to assess the impact of Pitx3 gene knockdown on GDNF transcriptional activity in MES23.5 dopaminergic neurons. Three pairs of interference sequences were designed and separately ligated into GV102 expression vectors. These recombinant plasmids were transfected into MES23.5 cells and western blot assays were performed to detect Pitx3 protein expression. Finally, the most effective Pitx3 sh RNA and a dual-luciferase reporter gene plasmid carrying the GDNF promoter region（GDNF-luciferase） were cotransfected into MES23.5 cells. Sequencing showed that the synthesized sequences were identical to the three Pitx3 interference sequences. Inverted fluorescence microscopy revealed that the lentivirus expression plasmids carrying Pitx3-sh RNA had 40-50% transfection efficiency. Western blot assay confirmed that the corresponding Pitx3 of the third knockdown sequence had the lowest expression level. Dual-luciferase reporter gene results showed that the GDNF transcriptional activity in dopaminergic cells cotransfected with both plasmids was decreased compared with those transfected with GDNF-luciferase alone. Together, the results showed that the designed Pitx3-sh RNA interference sequence decreased Pitx3 protein expression, which decreased GDNF transcriptional activity.

关键词： nerve regeneration neurodegeneration Parkinson's disease glial cell line-derived neurotrophic .factor Pitx3 MES23.5 cells shorthairpin RNA gene knockdown plasmid dual-luciferase reporter gene neural regeneration

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Protective effects of Ginseng mixture on myocardial fibrosis in rats

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Asian Pacific Journal of Tropical Medicine 2014年第9期7卷 730-734页

作者： Chun-Lai Zhang Yue-Hong Li Hong-Xia Zhou Yu-Xin Zhang Yong-Sheng Wang Zhi-Yong Zhang Ling-Li Meng Xiao-Ming Shang Tangshan Workers Hospital affiliated to Hebei Medical University Anatomy teaching and research section of Hebei Union University

Objective:To explore the protective effects of ginseng mixture on myocardial fibrosis(MF)in ***:A total of 60 Wistar rats were randomly divided into control group without modeling operation,and another 4 groups using subcutaneous injections of isopropyl adrenaline for 10 d to set up the MF model:model group with saline lavage treatment after modeling,captopril group with captopril lavage,ginseng mixture group A and group B with low and high dose mixture treatment *** treatment for 14 d,abdominal aorta and myocardial tissue were extracted to observe the pathological morphological changes and heart weight index in each ***:The left ventricular weight and heart heavy index of captopril group and group B were significantly lower than that of model group and group A(P<0.05);Model group and group A showed a higher hydroxyproline(Hyp)content in myocardial tissue than the control group and lower catalase(CAT)activity than Gontrol group(P<0.05);captopril group and group B showed a lower Hyp content and higher CAT activity compared with group A and model group(P<0.05),a significantly lower level of serum glutathione peroxidase(GSH-PX)and CAT and a higher level of serum creatine kinase,lactate dehydrogenase and H_2O_2 in model group and group A were observed compared with the control group(P<0.05).A higher level of GSH-PX and CAT and a lower level of creatine kinase,lactate dehydrogenase and H_2O_2 in captopril group and group B were observed compared with group A and model group(P<0.05);and histopathological examination showed that in captopril group and group B,secretion of collagen fiber was significantly inhibited and myocardial injury was significantly lighter than that of model ***:Ginseng mixture plays a protective effect on myocardium by inhibiting antioxidant process of MF.

关键词： Ginseng mixture Captopril Myocardial fibrosis Protection

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BIFURCATIONS OF LIMIT CYCLES FORMING COMPOUND EYES IN THE CUBIC SYSTEM

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数学年刊(英文版) 1987年第4期8卷 391-403页

作者：李继彬黄其明 teaching and research section of Mathematics Kunming Institute of Technology Kunming China. Department of Mathematics Yunnan University

Let H（n）be the maximal number of limit cycle of planar real polynomial differentialsystem with the degree n and Cmk denote the nest of k limit cycles enclosing m singular *** computing detection functions,tne authors study bifurcation and phase diagrams in theclass of a planar cubic disturbed Hamiltonian *** particular,the following conclusionis reached:The planar cubic system（Eε）has 11 limit cycles,which form the pattern ofcompound eyes of C91（?）2[C’ε（?）（2C12）and have the symmetrical structure;so the Hilbertnumber H（3）≥11.

关键词： symmetrical planar bifurcation Hamiltonian maximal cubic singular polynomial cycle disturbed

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