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A perspective review on the biosynthesis of plant-based secondary metabolites and their application as potent drugs

bioCELL 2024年第4期48卷 541-557页

作者： JHILAM PRAMANIK AKASH KUMAR SARVESH RUSTAGI MEHAK KATYAL SHEETAL THAKUR JUTISHNA BORA SUMIRA MALIK ANCHAL TREHAN NAYAN TALUKDAR PETR SLAMA Department of Food Technology ITM UniversityGwaliorIndia Department of Food Technology SRM UniversitySonipatIndia Department of Food Technology Uttaranchal UniversityDehradunIndia Department of Nutrition and Dietetics Manav Rachna International Institute of Research&Studies(MRIIRS)FaridabadIndia University Centre for research and Development UIBTChandigarh UniversityMohaliIndia Amity institute of biotechnology Amity UniversityJharkhandRanchiIndia Department of biotechnology University Center for Research&Development(UCRD)Chandigarh UniversityMohaliPunjabIndia Department of Science Guru Nanak College of Pharmaceutical SciencesDehradunIndia Program of biotechnology Faculty of ScienceAssam down town UniversityGuwahatiIndia Department of Animal Morphology Physiology and GeneticsMendel University in BrnoBrnoCzech Republic

Many phytochemicals and their derived metabolites produced by plants are extensively employed in commercial goods,pharmaceutical products as well as in the environmental and medicalﬁ***,these secondary metabolites obtained from plants are in low amounts,and it is difﬁcult to synthesize them at the industrial *** these challenges,they may be utilized for a variety of medicinal products that are either available in the market or are being researched and *** metabolites are complex compounds that exhibit ***,under controlled conditions with elicitors,desired secondary metabolites may be produced from plant cell *** review emphasizes the various aspects of secondary metabolites including their types,synthesis,and applications as medicinal *** article aims to promote the use of plant secondary metabolites in the management and treatment of various diseases.

关键词： Secondary metabolites Medicinal plant Synthesis Health benefits

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Reversal of complete atrioventricular block in dialysis patients following parathyroidectomy:A case report

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World Journal of Clinical Cases 2024年第7期12卷 1313-1319页

作者： Shan-Shan Xu Li-Hai Hao Yan-Meng Guan Hemodialysis center Weifang People’s HospitalWeifang 261041Shandong ProvinceChina

BACKGROUND Refractory secondary hyperparathyroidism(SHPT)is a common complication observed in patients with end-stage renal disease and can result in ectopic *** calcification involving the heart valves and the conduction system can easily lead to arrhythmias,including atrioventricular *** case report describes a maintenance hemodialysis patient with refractory SHPT resulting in a complete atrioventricular block(CAVB),which was eventually reversed to a first-degree atrioventricular *** SUMMARY We present the case of a 31-year-old Asian female who was receiving maintenance hemodialysis because of lupus *** developed SHPT,and an electrocardiogram revealed a first-degree atrioventricular ***,she underwent parathyroidectomy(PTX)with ***,a few years later,she developed SHPT again,and an electrocardiogram revealed a CAVB.A few years after the second PTX surgery,the calcification of the left atrium and left ventricle improved,and her CAVB was *** This case revealed that metastatic cardiac calcification can result in complete atrioventricular *** parathyroid surgery,calcification of the cardiac conduction system improved,leading to reversal of the atrioventricular *** is important for dialysis patients to optimize intact parathyroid hormone therapy and pay attention to calcification metastasis.

关键词： Secondary hyperparathyroidism Ectopic calcification Atrioventricular block Reversal Case report

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Impact of gonadotropin-releasing hormone agonist and hormone replacement therapy on pregnancy outcomes in single euploid frozen-thawed embryo transfer for patients with endometrial polyps

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Reproductive and Developmental Medicine 2024年第1期8卷 1-7页

作者： Qing Zhao Jie Li Wei-Lin Wang Ying-Bo Liu Jing Li Tian-Xiang Ni Wei Zhou Qian Zhang Jun-Hao Yan center for Reproductive Medicine Shandong UniversityJinan 250012China State Key Laboratory of Reproductive Medicine and Offspring Health Shandong UniversityJinan 250012China Key Laboratory of Reproductive Endocrinology of Ministry of Education Shandong UniversityJinan 250012China Shandong Key Laboratory of Reproductive Medicine Jinan 250012China Shandong Provincial Clinical research center for Reproductive Health Jinan 250012China Shandong Technology Innovation center for Reproductive Health Jinan 250012China National research center for Assisted Reproductive Technology and Reproductive Genetics Shandong UniversityJinan 250012China

Objective:Although consensus on the optimal endometrial preparation protocol for frozen-thawed embryo transfer(FET)is lacking,this is particularly true for patients with infertility and a history of endometrial polyps(EPs).In this study,we aimed to investigate whether a gonadotropin-releasing hormone agonist combined with hormone replacement therapy(GnRHa-HRT)could improve pregnancy outcomes in single euploid FET for patients with a history of ***:In this retrospective cohort study,395 women who underwent their first single euploid FET cycle were divided into groups according to endometrial preparation protocols as follows:natural cycle(NC)(n=220),hormone replacement therapy(HRT)(n=122),and GnRHa-HRT groups(n=53).Subsequently,the FET cycles in the three groups were subdivided according to maternal *** patients underwent hysteroscopic polypectomy before FET,and their EPs were confirmed by ***:No statistically significant differences were observed in live birth rates among the three groups(58.64%vs.58.20%vs.56.60%,P=0.964).Furthermore,the rates of miscarriage,ectopic pregnancy,premature live birth,and pregnancy complications were comparable among the three groups(P>0.05).After adjusting for potential confounding factors,no significant differences in pregnancy outcomes were reported between the groups(adjusted odds ratios[OR]and 95%credible intervals[CI]for live birth rate,***:1.119,0.660–1.896,P=0.677;***:1.165,0.610–2.226,P=0.643).Additionally,the pregnancy outcomes of the FET cycle were not influenced by the endometrial preparation protocols in the subgroups when stratified by maternal age(P>0.05).Conclusion:GnRHa-HRT did not improve the pregnancy outcomes of the single euploid FET in patients with a history of EPs.

关键词： Endometrial polyps Frozen-thawed embryo transfer GnRHa Hormone replacement therapy Preimplantation genetic testing

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Guidelines for application of high-content screening in traditional Chinese medicine:concept,equipment,and troubleshooting

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Acupuncture and Herbal Medicine 2024年第1期4卷 1-15页

作者： Xuechun Chen Lu Li Mingxu Zhang Jian Yang ChunMing Lyu Yizhou Xu Yang Yang Yi Wang Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhouChina Department of Cardiology Hangzhou First People’s HospitalHangzhouChina National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxingChina Molecular Devices Shanghai Corporation ShanghaiChina National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Science and Technology Experiment center Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering research center of Innovative Anticancer Drugs Ministry of Educationhangzhou China

High-content screening(HCS)technology combines automated high-speed imaging hardware and single-cell quantitative *** can greatly accelerate data acquisition in cellular fluorescence imaging and is a powerful research technique in traditional Chinese medicine(TCM).An increasing number of laboratories and platforms,including TCM laboratories,have begun utilizing HCS ***,this technology is still in its infancy in TCM research and there is a lack of sufficient experience with the associated concepts,instrument configurations,and analysis *** improve the understanding of HCS among researchers in the field of TCM,this paper summarizes the concept of HCS,software and hardware configuration,the overall research process,as well as common problems and related solutions of HCS in TCM research based on our team’s previous research experience,providing several research examples and an outlook on future perspectives,aiming to provide a technical guide for HCS in TCM research.

关键词： High-content imaging High-content screening Traditional Chinese medicine

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V0405 Dra:A New Deep and Low Mass Ratio Contact Binary with Extremely Fast Decrease in the Orbital Period

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research in Astronomy and Astrophysics 2024年第6期24卷 287-293页

作者： Chao-Yue Li Lin-Qiao Jiang Jie Zheng Yi-Man Liu Xiao-Yu Long Min Sun Han-Lu Zhang Xiao-Man Tian School of Science Leshan Normal UniversityLeshan 614000China center for Applied Optics research Leshan Normal UniversityLeshan 614000China Key Laboratory of Detection and Application of Space Effect in Southwest Sichuan Leshan 614000China CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Aeronautics Shandong Jiaotong UniversityJinan 250000China

V0405 Dra is a W UMa-type binary *** on the TESS data,we have conducted an orbital period study and performed a light curve analysis for the *** orbital period study reveals that the O-C curve for V0405 Dra exhibits secular decrease at an extremely high rate of d P/dt=-2.71×10^(-6)day year^(-1),along with periodic variations characterized by an amplitude of A_(3)=0.0032 day and a period of P_(3)=1.413 *** orbital periodic change is possibly due to the light-travel time effect resulting from an additional third body in the system,for which we estimate a minimum mass of M_(3)=0.77M_(⊙).By employing the 2013 version of the Wilson-Devinney(W-D)method to synthesize a light curve,we derived photometric solutions indicating that V0405 Dra is a new deep(f=68.7%)and low-mass ratio(q=0.175)contact *** fast decrease in its orbital period is likely caused by mass transfer from the more massive primary star to the less massive secondary star,or due to angular momentum *** further mass transfer and loss of angular momentum,the binary will gradually evolve into a tighter contact configuration,eventually leading to a merger into a single star,following the evolutionary paths suggested for such deep and low mass ratio contact binaries.

关键词： (stars:)binaries(including multiple):close (stars:)binaries:eclipsing stars:individual(V0405 Dra)

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Contribution of SAR Radar Imagery in the Detection of Suspicious Vessels in the Ivorian EEZ

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World Journal of Engineering and Technology 2024年第1期12卷 200-212页

作者： Koffi Cyprien Yoboue Jean-Baptiste Kassi Eric Valère Djagoua Tiemelé Jacque-André Laboratory of Remote Sensing and GIS University Center for Research and Application in Remote Sensing (CURAT) Félix Houphouet-Boigny University of Abidjan Cocody Ivory Coast

The present work proposed a method for match SAR and AIS data to detect vessels carrying out suspicious activity in the Ivorian EEZ. Two superposition methods, detected AIS and SAR data, based on point-to-point association on the one hand and point-to-line on the other hand, were used to detect suspicious vessels in Ivorian marine waters. The results showed that most vessels detected in the Ivorian EEZ do not declare their positions to avoid being spotted. These funds are likely to practice illegal, undeclared and unregulated fishing (INN fishing). This clandestine activity is very recurrent in Ivorian waters. This is illustrated by the number of suspicious vessels detected by SAR radar imagery which is greater compared to declared or authorized vessels.

关键词： INN Fishing CFAR Algorithm AIS Sentinel-1A Ivory Coast

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Fifteen acute retrobulbar optic neuritis associated with COVID-19:A case report and review of literature

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World Journal of Clinical Cases 2024年第21期12卷 4827-4835页

作者： Rong-Rong Li Bao-Ming Zhang Su-Ran Rong Huan Li Peng-Fei Shi Yun-Chang Wang Hebei Provincial Key Laboratory of Ophthalmology Hebei Provincial Clinical Research Center for Eye DiseasesHebei Eye HospitalXingtai 054001Hebei ProvinceChina

BACKGROUND A subtype of the Omicron variant of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is suggested to be responsible for the outbreak in Northern China since the quarantine was lifted in December *** coronavirus disease 2019 virus is primarily responsible for the development of respiratory illnesses,however,it can present a plethora of symptoms affecting a myriad of body *** virus has been theorized to be linked to demyelinating lesions of the peripheral and central nervous system including transverse myelitis and acute retrobulbar optic neuritis(ARON).For example,magnetic resonance imaging(MRI)of the orbit and brain showed enlargement of the retrobulbar intraorbital segments of the optic nerve with high T2 signal,and no abnormalities were seen in the brain *** this case series,we analyzed the connection between SARSCoV-2 infection and the onset of *** SUMMARY Fifteen patients,and a teenage boy who did not have any pre-existing ocular or demyelinating diseases suddenly experienced a loss of vision after SARS-CoV-2 *** patients expressed a central scotoma and a fever as the primary *** results of the fundus photography were found to be ***,the automated perimetry and MRI scans showed evidence of some typical *** of the 15 patients diagnosed with ARON after SARS-CoV-2 infection,only one individual tested positive for the aquaporin-4 *** Direct viral invasion of the central nervous system and an immune-related process are the two primary causes of SARS-CoV-2-related ARON.

关键词： SARS-CoV-2 COVID-19 Acute retrobulbar optic neuritis Central scotoma Li RR et al.ARON associated with COVID-19

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Factors Associated with HIV/Tuberculosis Coinfection among People Living with HIV after Initiation of Antiretroviral Treatment in Lingwala Health Zone from 2021 to 2023

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Advances in Infectious Diseases 2024年第1期14卷 176-195页

作者： Jean Claude Mikobi Maleshila Espérant Ntambue Malu Fabrice Sewolo Tacite Kpanya Mazoba Jean Nyandwe Kyloka Kinshasa School of Public Health University of Kinshasa Kinshasa Democratic Republic of the Congo Interdisciplinary center for research in Medical Imaging (CIRIMED) Kinshasa Democratic Republic of the Congo

Context and objective: Around 8% of incident cases of tuberculosis (TB) were reported among people living with HIV worldwide in 2022. Tuberculosis is the leading cause of death among people living with HIV. Africa accounts for the majority of co-infection episodes, with over 50% of cases in some parts of southern Africa. In the Democratic Republic of Congo (DRC), around 9% of persons living with HIV (PLHIV) develop TB and 11% of TB patients are infected with HIV. The DRC is one of the 30 countries in the world bearing the brunt of co-infection. Despite the efforts made by countries to improve access to antiretroviral traitement (ART), TB remains a major problem among people living with HIV. The Lingwala Health Zone in the provincial city of Kinshasa recorded a large number of cases of HIV/TB co-infection during the study period. The aim of this study was to determine the factors associated with HIV/TB co-infection among PLHIV on ART in the Lingwala health zone (HZ) in Kinshasa. Methods: This was a case-control study conducted in the state-run HIV care facilities in the Lingwala health district among PLHIV who had visited the health facilities during the period 2021-2023. Cases were coinfected patients and controls were PLHIV who had not developed tuberculosis during the study period. Results: A total of 281 PLHIV were enrolled in the study, with 70 cases and 211 controls. Factors associated with HIV/TB co-infection after multivariate analysis were viral load (OR = 5.34;95% CI;1.8-15.8, p = 0.005). History of tuberculosis (OR = 20.84;95% CI;8.6-50.3, p -85.0, p = 0.005) and BMI Conclusion: The results of this study indicate that the detection of these enumerated factors should prompt providers to actively search for tuberculosis with a view to organising early management.

关键词： PLHIV on ART HIV/TB Co-Infection Viral Load Antiretroviral (ARV) Adherence

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Suppression of nanosecond prepulses from regenerative amplifier and multipass amplifiers in the SULF-1PW laser

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Chinese Optics Letters 2024年第5期22卷 75-79页

作者：白培乐张宗昕王新亮钱佳毅朱佳诚吴分翔胡家兵杨晓骏归佳彦陆效明刘彦祺许毅梁晓燕冷雨欣李儒新 State Key Laboratory of High Field Laser Physics and CAS center for Excellence in Ultra-intense Laser Science Shanghai Institute of Optics and Fine Mechanics(SIOM)Chinese Academy of Sciences(CAS)Shanghai 201800China center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

In this research,we report the latest progress in the suppression of nanosecond prepulses from regenerative amplifier and multipass amplifiers in the SULF-1PW *** prepulse generated from the Pockels cell(PC)in a regenerative amplifier is delay-shifted by enlarging the distance between the PC and the nearby cavity mirror,and then removed by the extra pulse pickers outside the regenerative *** prepulses arising from multipass amplifiers are also further suppressed by adopting a novel amplifier configuration and properly rotating the Ti:sapphire *** the optimizations,the temporal contrast on a nanosecond time scale is promoted to be better than a contrast level of 10^(-9).This research can provide beneficial guidance for the suppression of nanosecond prepulses in the high-peak-power femtosecond laser systems.

关键词： high-peak-power femtosecond laser nanosecond prepulses temporal contrast

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Edible prodelphinidins that improve postprandial hyperglycemia were first discovered in Chinese bayberry(Myrica rubra Sieb. et Zucc.) fruits

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Food Science and Human Wellness 2024年

作者： Yi Wang Laiming Zhang Jiaxiong Wu Chengxiao Yu Xingqian Ye Haibo Pan Shiguo Chen Ningbo research Institute， Zhejiang University College of biosystems Engineering and Food Science，Zhejiang Key Laboratory for Agro-Food Processing， Integrated research Base of Southern Fruit and Vegetable Preservation Technology， Zhejiang International Scientific and Technological Cooperation Base of Health Food Manufacturing and Quality Control， Zhejiang University Zhejiang University Zhongyuan Institute Innovation center of Yangtze River Delta， Zhejiang University

Plant polyphenols are potential substitutes for clinical α-glucosidase inhibitors. Our previous studies indicated that prodelphinidins from Chinese bayberry leaves (BLPs) have stronger α-glucosidase inhibitory activity than other common polyphenols， but they have no safe history of consumption. There is a reasonable prospect that prodelphinidins from Chinese bayberry fruits (BFPs) can improve postprandial hyperglycemia， though known active components are only myricetin and cyanidin-3-O-glucoside. Hence， the aim of this study was to analyze structure and hypoglycemic effect of BFPs of “Biqi” (BQPs) and “Dongkui” (DKPs) cultivars， and compare their difference with BLPs. The contents of BQPs and DKPs were (221.73±0.60) and (136.82±4.33) mg EC equivalents/g dry weight， respectively. The most subunits were EGCG along with a small amount of EGC， ECG and EC connected by B-type linkages and a small portion of A-type linkages with mean polymerization degree of 4.25 and 4.08， respectively. Importantly， BQPs and DKPs were α-glucosidase inhibitors with IC50of 11.91 and 9.47 μg/mL respectively， which were significantly stronger than BLPs. DKPs could also improve postprandial hyperglycemia of normal mice and high fat diet-induced type Ⅱ diabetic mice. Therefore， edible prodelphinidins， which have stronger hypoglycemic effect than BLPs， were first found in Chinese bayberry fruits.

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