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Snail-borne parasitic diseases:an update on global epidemiological distribution,transmission interruption and control methods

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Infectious Diseases of Poverty 2018年第1期7卷 285-300页

作者： Xiao-Ting Lu Qiu-Yun Gu Yanin Limpanont Lan-Gui Song Zhong-Dao Wu Kamolnetr Okanurak Zhi-Yue Lv School of Public Health Sun Yat-sen UniversityGuangzhou 510080China Faculty of Tropical Medicine Mahidol UniversityBangkok 10400Thailand Fifth Affiliated Hospital Zhongshan School of MedicineSun Yat-sen UniversityGuangdongChina Key Laboratory of Tropical Disease Control(Sun Yat-sen University) Ministry of EducationGuangzhou 510080China Provincial Engineering Technology research Center for Biological Vector Control Guangzhou 510080China

Background:Snail-borne parasitic diseases,such as angiostrongyliasis,clonorchiasis,fascioliasis,fasciolopsiasis,opisthorchiasis,paragonimiasis and schistosomiasis,pose risks to human health and cause major socioeconomic problems in many tropical and sub-tropical *** this review we summarize the core roles of snails in the life cycles of the parasites they host,their clinical manifestations and disease distributions,as well as snail control *** body:Snails have four roles in the life cycles of the parasites they host:as an intermediate host infected by the first-stage larvae,as the only intermediate host infected by miracidia,as the first intermediate host that ingests the parasite eggs are ingested,and as the first intermediate host penetrated by miracidia with or without the second intermediate host being an aquatic ***-borne parasitic diseases target many organs,such as the lungs,liver,biliary tract,intestines,brain and kidneys,leading to overactive immune responses,cancers,organ failure,infertility and even *** countries in Africa,Asia and Latin America have the highest incidences of these diseases,while some endemic parasites have developed into worldwide epidemics through the global spread of ***,chemical and biological methods have been introduced to control the host snail populations to prevent ***:In this review,we summarize the roles of snails in the life cycles of the parasites they host,the worldwide distribution of parasite-transmitting snails,the epidemiology and pathogenesis of snail-transmitted parasitic diseases,and the existing snail control measures,which will contribute to further understanding the snail-parasite relationship and new strategies for controlling snail-borne parasitic diseases.

关键词： Snail-borne parasitic diseases epidemiology Pathogenesis Snail control

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High Sensitivity C-Reactive Protein Associated with Different Health Predictors in Middle-Aged and oldest old Chinese

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Biomedical and Environmental Sciences 2012年第3期25卷 257-266页

作者： ZHAI Yi SHI Xiao Ming FITZGERALD Simon Michael QIAN Han Zhu KRAUS Virginia B SERENY Melanie HU Perry YIN Zhao Xue XU Jian Wei ZENG Yi Chinese Center for Disease Control and Prevention Beijing 102206 China SUNY Downstate College of Medicine NY 11218 USA Division of epidemiology Vanderbilt University School of Medicine TN 37203-1738 USA Department of Sociology Duke University Durham NC 27708 USA Department ofSociology Duke University Durham NC 27708 USA Ronald Reagan UCLA Medical Center Los Angeles CA90095USA Center for the Study of Aging and Human Development and Geriatric Division of Medical SchoolDuke University Box 3003 Room 1506 BUSSE Building Durham NC27710 USA China Center for Economicresearch National School of Development at Peking University Beij'ing 100087 China

Objective To describe the distribution of plasma high sensitivity C-reactive protein （hsCRP） and explore the relationship between hsCRP and metabolic risk factors among residents living in longevity areas of China. Methods 268 individuals aged between 40 and 59 years and 506 individuals aged over 90 years were selected from 5 longevity areas of China to participate in a cross section longitudinal cohort study. The participants were interviewed with general health related questionnaire to collect their demographic, behavioral and lifestyle data, as well as their chronic conditions, and meanwhile their physical and biomedical parameters including waist circumference （WC）, blood pressure （BP）, hsCRP, plasma lipids, and fasting blood glucose （FBG） were measured. Results The median of hsCRP was 0.99 mg/L in the middle-aged group and 2.76 mg/L in the oldest old group. No significant gender difference was observed between the above two groups. Among the oldest old individuals, 36.56% had an hsCRP level 〉3.0 mg/L. The prevalence of high hsCRP was 26.79% in the middle-aged group. The results of stepwise multiple linear regression analyses showed that HDL-C was independently associated with In （hsCRP） concentration in the middle-aged group, whereas In （TG）, HDL-C and FBG were correlated after adjustment for gender, study site, smoking, drinking, education and BMI in the oldest old group. Conclusion HDL-C is a stronger predictor of elevated hsCRP than other metabolic factors in the middle-aged population. For the oldest old persons, high TG, low HDL-C, and FBG predict elevated plasma hsCRP.

关键词： High-sensitivity C-reactive protein Blood lipids Fasting blood glucose Middle-aged Oldestold individuals Longevity China

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Genetic mechanisms of critical illness in Covid-19

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四川生理科学杂志 2020年第4期42卷 455-455页

作者： Erola Pairo-Castineira Roslin Institute University of Edinburgh Edinburgh UK MRC Human Genetics Unit Institute of Genetics and Molecular Medicine University of Edinburgh Western General Hospital Edinburgh UK Genomics England London UK Centre for Inflammation research The Queen’s Medical Research Institute University of Edinburgh Edinburgh UK Centre for Genomic and Experimental Medicine Institute of Genetics and Molecular Medicine University of Edinburgh Western General Hospital Edinburgh UK Edinburgh clinical research Facility Western General Hospital University of Edinburgh Edinburgh UK Intensive Care National Audit & research Centre London UK Institute for Molecular Bioscience The University of Queensland Brisbane Queensland Australia Biostatistics Group School of Life Sciences Sun Yat-sen University Guangzhou China The Crick Institute London UK Intensive Care Unit Royal Infirmary of Edinburgh Edinburgh UK School of Life Sciences Westlake University Hangzhou China Westlake Laboratory of Life Sciences and Biomedicine Hangzhou China Wellcome Centre for Human Genetics University of Oxford Oxford UK Department of Medicine University of Cambridge Cambridge UK Department of Intensive Care Medicine Guy’s and St Thomas’ NHS Foundation Trust London UK School of Immunology and Microbial Sciences King’s College London London UK NIHR Health Protection research Unit for Emerging and Zoonotic Infections Institute of Infection Veterinary and Ecological Sciences University of Liverpool Liverpool UK MRC-University of Glasgow Centre for Virus research Institute of Infection Immunity and Inflammation College of Medical Veterinary and Life Sciences University of Glasgow Glasgow UK William Harvey research Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK Centre for Tropical Medicine and Global Health Nuffield Department of Medicine University of Oxford Oxford UK clinical research Centre at St Vincent’s University Hospital Un

Host-mediated lung inflammation is present,1 and drives mortality,2 in critical illness caused by *** genetic variants associated with critical illness may identify mechanistic targets for therapeutic development.3 Here we report the results of the GenOMICC(Genetics Of Mortality In Critical Care)genome-wide association study(GWAS)in 2244 critically ill Covid-19 patients from 208 UK intensive care units(ICUs).We identify and replicate novel genome-wide significant associations,on chr12q24.13(rs10735079,p=1.65[Formula:see text]10-8)in a gene cluster encoding antiviral restriction enzyme activators(OAS1,OAS2,OAS3),on chr19p13.2(rs2109069,p=2.3[Formula:see text]10-12)near the gene encoding tyrosine kinase 2(TYK2),on chr19p13.3(rs2109069,p=3.98[Formula:see text]10-12)within the gene encoding dipeptidyl peptidase 9(DPP9),and on chr21q22.1(rs2236757,p=4.99[Formula:see text]10-8)in the interferon receptor gene *** identify potential targets for repurposing of licensed medications:using Mendelian randomisation we found evidence in support of a causal link from low expression of IFNAR2,and high expression of TYK2,to life-threatening disease;transcriptome-wide association in lung tissue revealed that high expression of the monocyte/macrophage chemotactic receptor CCR2 is associated with severe *** results identify robust genetic signals relating to key host antiviral defence mechanisms,and mediators of inflammatory organ damage in *** mechanisms may be amenable to targeted treatment with existing ***-scale randomised clinical trials will be essential before any change to clinical practice.

关键词： lung drugs critical

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