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Perioperative cardiac risks in myasthenia gravis

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World Journal of Clinical Cases 2024年第13期12卷 2147-2150页

作者： Deb Sanjay Nag Abhishek Chatterjee Pratap Rudra Mahanty Merina Sam Murari Kumar Bharadwaj Department of Anaesthesiology Tata Main HospitalJamshedpur 831001India Department of Anaesthesiology Manipal Tata Medical CollegeJamshedpur 831017India

Myasthenia gravis(MG)is an autoimmune disorder that affects the neuromuscular *** primary pathology in MG involves the presence of autoantibodies to acetylcholine receptors(AChRs),which results in qualitative and quantitative reductions in the availability of functional *** muscles are also affected,resulting in various perioperative cardiac *** antibodies are commonly reported in MG cases with cardiac *** the presence of thymoma,the prevalence of cardiac manifestations in patients with MG increases to approximately 10%-15%.Cardiac involvement in MG may range from asymptomatic electrocardiogram changes to ventricular tachycardia,myocarditis,conduction disorders,heart failure,and sudden *** incidence of atrial fibrillation,ventricular and supraventricular extra systoles,and prolonged QTc have also been reported in patients with *** should consider the evaluation of autonomic dysfunction and risk of cardiovascular disease in patients with MG.

关键词： Myasthenia Gravis Perioperative period Receptors Cholinergic Anesthesia

Pain management in chronic pancreatitis

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World Journal of Clinical Cases 2024年第12期12卷 2016-2022页

作者： Deb Sanjay Nag Bhanu Pratap Swain Rishi Anand Tapas Kumar Barman Vatsala Department of Anaesthesiology Tata Main HospitalJamshedpur 831001India

Pain in chronic pancreatitis(CP)is difficult to *** patients suffer from inadequate pain relief,completely incapacitating them in their daily ***,despite their well-known adverse effects,opioids have been the pillar of treatment regimens in painful *** management is now gradually evolving with a better understanding of the underlying pathophysiology of CP-related *** should follow a holistic approach to the management of CPassociated pain,which must involve lifestyle changes that are coupled with analgesic medications and other pain-relieving ***,there is no easy cure for vanquishing CP-associated *** patient must be evaluated on a case-by-case basis by a multidisciplinary team to decide which treatment option is best suited for that individual.

关键词： Pancreatitis Abdominal pain Palliative care Analgesics Life style Psychology

Pitfalls in internal jugular vein cannulation

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World Journal of Clinical Cases 2024年第10期12卷 1714-1717页

作者： Deb Sanjay Nag Amlan Swain Seelora Sahu Bhanu Pratap Swain Merina Sam Department of Anaesthesiology Tata Main HospitalJamshedpur 831001JharkhandIndia

Central venous catheter insertion in the internal jugular vein(IJV)is frequently performed in acute care settings,facilitated by its easy availability and increased use of ultrasound in healthcare *** the increased safety profile and insertion convenience,it has ***,we aim to inform readers about the existing literature on the plethora of complications with potentially disastrous consequences for patients undergoing IJV cannulation.

关键词： Catheterization Central venous Complications Thoracic duct Arteriovenous fistula Vocal cord paralysis Pneumothorax Cardiac tamponade

Relevance of sleep for wellness:New trends in using artificial intelligence and machine learning

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World Journal of Clinical Cases 2024年第7期12卷 1196-1199页

作者： Deb Sanjay Nag Amlan Swain Seelora Sahu Abhishek Chatterjee Bhanu Pratap Swain Department of Anaesthesiology Tata Main HospitalJamshedpur 831001JharkhandIndia

Sleep and well-being have been intricately linked,and sleep hygiene is paramount for developing mental well-being and *** widespread,sleep disorders require elaborate polysomnography laboratory and patient-stay with sleep in unfamiliar *** technologies have allowed various devices to diagnose sleep disorders at ***,these devices are in various validation stages,with many already receiving approvals from competent *** has captured vast patient-related physiologic data for advanced analytics using artificial intelligence through machine and deep learning *** is expected to be integrated with patients’Electronic Health Records and provide individualized prescriptive therapy for sleep disorders in the future.

关键词： Sleep initiation and maintenance disorders Sleep apnea Obstructive Machine learning Artificial intelligence Algorithms

Stroke:Evolution of newer treatment modalities for acute ischemic stroke

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World Journal of Clinical Cases 2024年第28期12卷 6137-6147页

作者： Deb Sanjay Nag Amlan Swain Seelora Sahu Biswajit Sen Vatsala Sadiya Parween Department of Anaesthesiology Tata Main HospitalJamshedpur 831001India Department of Anaesthesiology Manipal Tata Medical CollegeJamshedpur 831017India

Acute ischemic stroke is one of the leading causes of morbidity and mortality *** of cerebral blood flow to affected ischemic areas has been the cornerstone of therapy for patients for eligible patients as early diagnosis and treatment have shown improved ***,there has been a paradigm shift in the management approach over the last decade,and with the emphasis currently directed toward including newer modalities such as neuroprotection,stem cell treatment,magnetic stimulation,anti-apoptotic drugs,delayed recanali-zation,and utilization of artificial intelligence for early diagnosis and suggesting algorithm-based management protocols.

关键词： Acute ischemic stroke Neuroprotection Treatment Neurocritical care Thrombolytic therapy Reperfusion injury Oxidative stress

On the Geometry of the Anti-canonical Bundle of the Bott–Samelson–Demazure–Hansen Varieties

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Acta Mathematica Sinica,English Series 2024年第8期40卷 1920-1940页

作者： Indranil BISWAS S.Senthamarai KANNAN Pinakinath SAHA School of Mathematics Tata Institute of Fundamental Research1 Homi Bhabha RoadMumbai 400005India Chennai Mathematical Institute Plot H1SIPCOT IT ParkSiruseriKelambakkam603103India

Let G be a semi-simple simply connected algebraic group over the field C of complex *** T be a maximal torus of G,and let W be the Weyl group of G with respect to *** Z(w,i)be the Bott–Samelson–Demazure–Hansen variety corresponding to a tuple i associated to a reduced expression of an element w∈*** prove that for the tuple i associated to any reduced expression of a minuscule Weyl group element w,the anti-canonical line bundle on Z(w,i)is globally *** consequence,we prove that Z(w,i)is weak *** that G is a simple algebraic group whose type is different from *** S={α1,...,αn}be the set of simple *** w be such that support of w is equal to *** prove that Z(w,i)is Fano for the tuple i associated to any reduced expression of w if and only if w is a Coxeter element and w^(−1)(Σ_(t=1)^(n)αt)∈−S.

关键词： Bott-Samelson-Demazure-Hansen variety Coxeter element anti-canonical line bundle Fano weak Fano

Recent advances in managing obstructive sleep apnea

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World Journal of Clinical Cases 2024年第24期12卷 5456-5461页

作者： Deb Sanjay Nag Abhishek Chatterjee Roushan Patel Biswajit Sen Bappa Ditya Pal Gunjan Wadhwa Department of Anaesthesiology Tata Main HospitalJamshedpur 831001JharkhandIndia Department of Anaesthesiology Manipal Tata Medical CollegeJamshedpur 831017India

Obstructive sleep apnea(OSA)is a rapidly increasing global *** it remains untreated,it can lead to cardiovascular,metabolic,and psychiatric complications and may result in premature *** efficient and effective management of OSA can have a beneficial effect and help reduce the financial burden on the health *** has been constant development in OSA management,and numerous options are *** mainstay of therapy is still the conventional measures and behavioral ***,in cases of failure of these modalities,surgical therapy is the only *** studies have shown that proper management of OSA has beneficial effects with good long-term outcomes.

关键词： Sleep apnea Obstructive Continuous positive airway pressure Concepts Pharmacological

Epidemiology of EGFR Mutation in Adenocarcinoma NSCLC Patients in India: A Systematic Review and Meta-Analysis

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Advances in Lung Cancer 2024年第1期13卷 1-21页

作者： Ankita Jain Kumar Prabhash Venkatraman Radhakrishnan Shashank Srinivasan Pfizer Products India Private Limited Mumbai India tata Memorial Hospital Mumbai India Cancer Institute (W.I.A.) Chennai India

Studies reporting the Indian prevalence of Epidermal Growth Factor Receptor (EGFR) mutation are mostly single centers with small sample sizes. This systematic review and meta-analysis summarized the available evidence of EGFR mutation epidemiology in Indian patients with adenocarcinoma (ADC) Non-Small Cell Lung Cancer (NSCLC). We conducted a structured literature search in PubMed, and EMBASE databases from January 2004 through October 2019. The primary outcome of interest was prevalence of EGFR mutation by gender, smoking status, and mutation subtype. The review included 34 studies. EGFR mutation prevalence was 39.5% in patients with ADC, and significantly higher in females, non-smokers, and patients with exon 19 deletions. The EGFR mutation frequency in Indian patients with ADC was higher than reported in Caucasians but at a lower range of that reported in East Asians. These findings support the use of EGFR mutation testing to guide choice of treatment.

关键词： Epidemiology Epidermal Growth Factor Receptor Adenocarcinoma Non-Small Cell Lung Cancer India

Melting of hydrous pyroxenites with alkali amphiboles in the continental mantle:*** relations and major element compositions of melts

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Geoscience Frontiers 2022年第4期13卷 48-74页

作者： Stephen F.Foley Isra S.Ezad Sieger R.van der Laan Maik Pertermann School of Natural Sciences Macquarie UniversityNorth RydeNew South Wales 2109Australia Research School of Earth Sciences Australian National UniversityCanberraACT 2601Australia tata steel europe Research and DevelopmentIjmuidenThe Netherlands Coos Bay OregonUSA

Melting experiments on ultramafic rocks rich in the hydrous minerals phlogopite or phlogopite+K-rich terite,some including 5%of accessory phases,have been conducted at 15 and 50 *** assemblages represent probable source components that contribute to melts in cratonic regions,but whose melt compositions are poorly known.A main series of starting compositions based on MARID xenoliths consisted of a third each of clinopyroxene(CPX),phlogopite(PHL)and K-richterite(KR)with or without 5%ilmenite,rutile or *** experiments were run without KR and with higher proportions of accessory *** traps were used at near-solidus temperatures to facilitate accurate analysis of wellquenched melts,for which reversal experiments demonstrate *** show that KR melts rapidly and completely within 50°C of the solidus,so that melts reflect the composition of the amphibole and its melting *** have high SiO_(2) and especially K_(2)O but low CaO and Al_(2)O_(3) relative to basaltic melts produced from peridotites at similar *** have no counterparts amongst natural rocks,but most closely resemble leucite lamproites at 15 *** and PHL melt incongruently to form olivine(OL)and CPX at 15 kbar,promoting SiO2 contents of the melt,whereas orthopyroxene OPX is increasingly stable at lower lithosphere pressures,leading to an increase in Mg O and decrease in SiO_(2) in melts,which resemble olivine *** of mica pyroxenites without KR are richer in CaO and Al_(2)O_(3) and do not resemble *** experiments show that low CaO and Al_(2)O_(3) in igneous rocks is not necessarily a sign of a depleted peridotite *** phases produce melts exceptionally rich in P_(2)O_(5) or TiO_(2) depending on the phases present and are unlike any melts seen at the Earth’s surface,but may be important agents of metasomatism seen in *** addition of the 5%accessory phases ilmenite,rutile or apatite result in melting temper

关键词： Hydrous pyroxenite Experimental petrology Mantle melts Phlogopite Lamproite Mantle metasomatism