检索结果-南通市图书馆

CRISPR,CAR-T,and NK:Current applications and future perspectives

Genes & Diseases 2024年第4期11卷 246-257页

作者： Mohadeseh Khoshandam Hossein Soltaninejad Amir Ali Hamidieh Saman Hosseinkhani Department of Reproductive Biology Academic Center for EducationCultureand Research(ACECR)Qom branch***Iran National Institute of Genetic Engineering and Biotechnology(NIGEB) Tehran 14965/161Iran Department of stem cells technology and Tissue Regeneration Faculty of Interdisciplinary Science and TechnologiesTarbiat Modares UniversityTehran 15614Iran Pediatric Cell Therapy and Gene Therapy Research Center GeneCell&Tissue Research InstituteTehran University of Medical SciencesTehran ***Iran Department of Biochemistry Faculty of Biological SciencesTarbiat Modares UniversityTehran 15614Iran

Chimeric antigen receptor T(CAR-T)cell therapy represents a breakthrough in personalized cancer *** this regard,synthetic receptors comprised of antigen recognition domains,signaling,and stimulatory domains are used to reprogram T-cells to target tum or cells and destroy *** the success of this approach in refractory B-cell malignancies,the optimal potency of CAR T-cell therapy for many other cancers,particularly solid tumors,has not been *** killer cells are powerful cytotoxic lymphocytes specialized in recognizing and dispensing the tumor cells in coordination with other anti-tumor immunity *** on these studies,many investigations are focused on the accurate designing of CAR T-cells with clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)system or other novel gene editing tools that can induce hereditary changes with or without the presence of a double-stranded break into the *** methodologies can be specifically focused on negative controllers of T-cells,induce modifications to a particular gene,and produce reproducible,safe,and powerful allogeneic CAR T-cells for on-demand cancer *** improvement of the CRISPR/Cas9 innovation offers an adaptable and proficient gene-editing capability in activating different pathways to help natural killer cells interact with novel CARs to particularly target tumor *** achievements and future challenges of combining next-generation CRISPR-Cas9 gene editing tools to optimize CAR T-cell and natural killer cell treatment for future clinical trials toward the foundation of modern cancer treatments have been assessed inthis review.

关键词： Cancer CAR T-cell CRISPR Gene editing Immunotherapy NK cell

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Platform Evolution in an Oligo-Miocene Back-arc Basin:An Example from the Central Iran Basin

引用

Acta Geologica Sinica(English Edition) 2024年第1期98卷 185-206页

作者： Masoud SHARIFI-YAZDI Amirhossein ENAYATI Jamal SALEHI AGHDAM Mohammad BAHREHVAR Seyed Mustafa REZAEI Department of Geology Faculty of Earth SciencesGeography and AstronomyUniversity of Vienna1090 Vienna.Austria Geology and Geophysics Department Tehran Energy Consultants(TEC Co.)TehranIran School of Geology College of ScienceUniversity of TehranTehranIran Department of Geology Tarbiat Modares UniversityTehranIran

The Qom Formation is the most important hydrocarbon reservoir target in Central *** Qom platform developed in a back-arc basin during the Oligo-Miocene due to the closing of the Tethyan *** formation consists of a variety of carbonate and non-carbonate facies deposited on a platform ranging from supratidal to basin.A combination of tectonic and eustatic events led to some lateral and vertical facies variations in the study *** third-order depositional sequences and related surfaces were identified regarding vertical facies changes in the studied sections of this Oligo-Miocene *** to all results and data,this succession was initially deposited during the Chattian upon a distally steepened ramp of siliciclastic-carbonate composition,including the Bouma ***,from the late Chattian to the Aquitanian,the platform changed into a homoclinal carbonate ramp with a gentle *** respect to tectonic activity,this phase was a calm period during the deposition of the Qom ***,a drowned carbonate platform and a rimmed shelf emerged during the Burdigalian,terminated by the continental deposits of the Upper Red *** all geological characteristics,three main tectono-eustatic evolutionary phases have been recognized in the Qom back-arcbasin.

关键词： carbonate ramp depositional facies submarine fan eustasy basement faults back-arc basin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Geometric investigation of entrance proportions of houses from the Qajar to the beginning of the early Pahlavi in Dezful City(1789—1979)

引用

Frontiers of Architectural Research 2024年第1期13卷 57-78页

作者： Raziyeh Rezadoost Dezfuli Mohammad Mehrakizadeh Behnaz Safar Ali Najar Hassan Bazazzadeh Mohammadjavad Mahdavinejad Department of Architecture Poznan University of Technology61-131 PoznanPoland Department of Architecture and Urban Planning Jundi Shapur University of TechnologyDezfulIran College of Engineering and Architecture University of Nizwa616 Birkat Al MawzOman Department of Architecture Faculty of Art and ArchitectureTarbiat Modares UniversityTehranIran

Due to the importance of the historical context of Dezful City,investigating historic buildings is *** unfortunately,a large part of it is being *** this reason,it is essential to discover the guidelines and logic behind the architectural design of these buildings to help their reconstruction or ***,there is no logical information about the components of this context and the reconstructions are usually done according to taste and based on architecture tested or personal ***,it is necessary to find a logic behind these critical components that support the whole plan or parts of it in a particular *** purpose of this research is to discover and find the logic behind the design of this building in the historical context of *** geometrical proportions can significantly help to reconstruct buildings better and more *** this purpose,30 historical houses of Dezful were randomly selected,and their input information was drawn in 2D form in ***,the length,width,and height proportions were measured,and the obtained ratios were compared with the golden proportions and dynamic *** paper studies entrance based on ratios of√2,√3,√4,√4,√1.25 andφ(the golden section).The results show that golden proportions and proportions derived from dynamic rectangles are present in the wording of all ***,the range of ratios in the plan is from 1.34 to 2,and the content of changes in the section is from 1.22 to *** results can help architects,and particularly building owners,to reconstruct based on existing logic by discovering the proportions of the entrances of the *** is possible to administer a part of the damaged tissue and estimate its dimensions and sizes because the proportions’completeness can help revive half-destroyed historical buildings.

关键词： Proportions Historical houses House entrance Dezful city Qajar period to early Pahlavi

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optimal site selection for geothermal heated greenhouses in cold climates: a fuzzy logic and geographic information system approach

引用

CLEAN ENERGY 2024年第2期8卷 8-26页

作者： Mirabadi, Amirhossein Minaei, Saeid Noorollahi, Younes Almasi, Morteza Islamic Azad Univ Dept Agr Syst Sci & Res Branch Tehran Iran tarbiat modares Univ Fac Agr Biosyst Engn Dept Tehran Iran Univ Tehran Fac New Sci & Technol Energy Modelling & Sustainable Energy Syst METSAP Tehran Iran

This paper presents a comprehensive model for selecting optimal sites for geothermal heated greenhouses in the agricultural industry. The research involves two main componentsf: assessing the geothermal energy resource using geological, geochemical and geophysical indicators; and developing a siting model based on fuzzy logic that considers technical, environmental and socio-economic factors. The study focuses on East Azerbaijan province in Iran-a cold region. The results indicate that similar to 3.24% of the total area of the province is suitable for constructing geothermal greenhouses, resulting in potential savings of similar to 148 000 and 745 978 m(3) of natural gas in areas with high and very high suitability, respectively. [GRAPHICS] .

关键词： geothermal energy site selection GIS fuzzy logic resource assessment ENERGY PROVINCE

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Color and Gloss Changes of a Lignin-Based Polyurethane Coating under Accelerated Weathering

引用

Journal of Renewable Materials 2024年第2期12卷 305-323页

作者： Fatemeh Hassani Khorshidi Saeed Kazemi Najafi Farhood Najafi Antonio Pizzi Dick Sandberg Rabi Behrooz Department of Wood Science and Technology Faculty of Natural ResourcesTarbiat Modares UniversityTehranIran Department of Resin and Additives Institute for Color Science and TechnologyP.O.Box 16765-654TehranIran LERMAB University of LorraineBlvd des AiguillettesNancy54000France Wood Science and Engineering LuleåUniversity of TechnologySkellefteåSweden

The purpose of this research study was to investigate the properties of polyurethane coatings based on lignin *** this purpose,the prepared coatings were applied to pine wood surfaces and weathered ***,color and gloss of the coatings were measured before and after the weathering *** emission scanning electron microscopy(FE-SEM)micrographs prepared from the coatings showed that the average size of nano-particles in the polyurethane substrate was approximately 500 *** magnetic resonance(13C-NMR)spectroscopy showed that strong urethane bonds were formed in the nano-lignin-based *** calorimetric analysis(DSC)test revealed that the glass-transition temperature(Tg)of lignin nanoparticles modified with diethylenetriamine(DETA)was 112.8℃ and Tg of lignin nano-particles modified with ethylenediamine(EDA)was 102.5℃,which is lower than the Tg of un-modified lignin(114.6℃)and lignin modified with DETA(126.8℃)and lignin modified with EDA(131.3℃).The coatings modified with lignin nano-particles had a greater change in *** lignin nano-particles in the modified coating are trapping hydroxyl radicals which reduces photoactivity and yellowing of the polyurethane by about 3 times compared to unmodified polyurethane *** weathering test,the nano-lignin-based coating had a rougher surface with a lower contact angle(0.78°)compared to the unmodified polyurethane coating(0.85°).

关键词： Amination propylene carbonate lignin biopolymer polyurethane coating polyol UN SDG 13

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An intrinsically self-healing and anti-freezing molecular chains induced polyacrylamide-based hydrogel electrolytes for zinc manganese dioxide batteries

引用

Journal of Energy Chemistry 2024年第2期89卷 565-578,I0013页

作者： Haiyang Liao Wenzhao Zhong Chen Li Jieling Han Xiao Sun Xinhui Xia Ting Li Abolhassan Noori Mir F.Mousavi Xin Liu Yongqi Zhang Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina School of Mechanical Engineering Hunan University of TechnologyZhuzhou 412007HunanChina School of Materials Science and Engineering Zhejiang University of TechnologyHangzhou 310014ZhejiangChina Department of Chemistry Faculty of Basic SciencesTarbiat Modares UniversityTehran 14117-13116Iran State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200HubeiChina

The anti-freezing strategy of hydrogels and their self-healing structure are often contradictory,it is vital to break through the molecular structure to design and construct hydrogels with intrinsic anti-freezing/self-healing for meeting the rapid development of flexible and wearable devices in diverse service ***,we design a new hydrogel electrolyte(AF/SH-Hydrogel)with intrinsic anti-freezing/self-healing capabilities by introducing ethylene glycol molecules,dynamic chemical bonding(disulfide bond),and supramolecular interaction(multi-hydrogen bond)into the polyacrylamide molecular *** to the exceptional freeze resistance(84%capacity retention at-20℃)and intrinsic self-healing capabilities(95%capacity retention after 5 cutting/self-healing cycles),the obtained AF/SH-Hydrogel makes the zinc||manganese dioxide cell an economically feasible battery for the state-of-the-art *** Zn||AF/SH-Hydrogel||MnO_(2)device offers a near-theoretical specific capacity of 285 m A h g^(-1)at 0.1 A g^(-1)(Coulombic efficiency≈100%),as well as good self-healing capability and mechanical flexibility in an ice *** work provides insight that can be utilized to develop multifunctional hydrogel electrolytes for application in next generation of self-healable and freeze-resistance smart aqueous energy storage devices.

关键词： Flexible aqueous battery Hydrogel electrolyte Anti-freezing Self-healing Dual-dynamic reversible bond

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Experimental and Finite Element Analysis of Corroded High-Pressure Pipeline Repaired by Laminated Composite

引用

Computer Modeling in Engineering & Sciences 2024年第8期140卷 1783-1806页

作者： Seyed Mohammad Reza Abtahi Saeid Ansari Sadrabadi Gholam Hosein Rahimi Gaurav Singh Hamid Abyar Daniele Amato Luigi Federico Faculty of Mechanical Engineering Tarbiat Modares UniversityTehran***Iran A.Leon Linton Department of Mechanical Robotics and Industrial EngineeringLawrence Technological UniversitySouthfieldMI48075USA Department of Mechanical Engineering Faculty of EngineeringMeybod UniversityYazd***Iran Department of Industrial Engineering University of SalernoVia Giovanni PaoloⅡFiscianoItaly Italian Aerospace Research Center(C.I.R.A.) Via MaioriseCapuaCE81043Italy

Repairs of corroded high-pressure pipelines are essential for fluids transportation under high *** of the methods used in their repairs is the use of layered *** composite used must have the necessary ***,the experiments and analytical solutions presented in this paper are performed according to the relevant standards and codes,including ASME PCC-2,ASME B31.8S,ASME B31.4,ISO 24817 and ASME *** addition,the experimental tests are replicated numerically using the finite element *** the strain gauges at different distances from the defect location,can reduce the nonlinear effects,deformation,and fluctuations due to the high *** direct relationship between the depth of an axial defect and the stress concentration is observed at the inner side edges of the *** reparation reduces the non-linearities related to the sharp variation of the geometry and a more reliable numerical simulation could be performed.

关键词： High-pressure pipeline composite repair ASME PCC-2 ISO 24817

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A contrasting analysis of CO_(2) and N_(2) foam flood for enhanced oil recovery and geological storage of CO_(2)

引用

Petroleum Research 2024年第1期9卷 55-60页

作者： Alireza Roozbahani Farshad Soofivan Ali Sagban Hassoon Al-Tameemi Hadi Abdollahi Sogand Saatchi Abdolhamid Ansari Petroleum Engineering Department Faculty of Chemical EngineeringTarbiat Modares UniversityTehranIran School of Chemical and Petroleum Engineering Shiraz UniversityShirazIran School of Chemical and Petroleum Engineering Shiraz BranchIslamic Azad UniversityShirazIran Department of Petroleum Engineering Science and Research BranchAzad UniversityTehranIran Department of Chemistry and Chemical Engineering Rasht BranchIslamic Azad UniversityRashtIran Department of Petroleum Engineering Lamerd BranchIslamic Azad UniversityLamerdIran

Foam flooding using CO_(2)has emerged as a promising method for both enhanced oil recovery(EOR)and the storage of CO_(2)in geological *** study conducts a thorough analysis of the behavior of CO_(2)and N_(2)foams in bulk and porous media,utilizing bubble-scale analyses and foam flooding *** study compares the foamability and longevity of CO_(2)and N_(2)foams,with findings indicating that N_(2)foam bubbles tend to be smaller and less varied in size than CO_(2)foam bubbles,leading to increased foam ***,the study compares the half-lives of CO_(2)and N_(2)foams generated through sparging and winding methods,showing that N_(2)foam has half-lives 22 and 10 times greater than CO_(2)foam when produced using the sparging and winding methods,***,CO_(2)foam generated through the sparging method had a lower foaming volume than N_(2)foam due to CO_(2)'s *** the foam flooding experiments,N_(2)foam proved more effective in recovering oil from porous media than CO_(2)foam,thus demonstrating the effectiveness of the foam injection *** results offer valuable insights into the differing performance of N_(2)and CO_(2)foam floods for EOR and CO_(2)geological storage.

关键词： CO_(2) storage Foam flood Enhanced oil recovery N_(2) foam CO_(2) foam

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Erratum to:Cadmium nanoclusters in a protein matrix:Synthesis,characterization,and application in targeted drug delivery and cellular imaging

引用

Nano Research 2024年第6期17卷 5755-5755页

作者： Morteza Sarparast Abolhassan Noori Hoda Ilkhani S.Zahra Bathaie Maher F.El-Kady Lisa J.Wang Huong Pham Kristofer L.Marsh Richard B.Kaner Mir F.Mousavi Department of Chemistry Tarbiat Modares UniversityTehran 14115-175Iran Department of Clinical Biochemistry Faculty of Medical SciencesTarbiat Modares UniversityTehran 14115-111Iran Department of Chemistry and Biochemistry University of CaliforniaLos AngelesLos AngelesCA 90095USA Department of Chemistry Faculty of ScienceCairo UniversityGiza 12613Egypt California NanoSystems Institute University of CaliforniaLos AngelesLos AngelesCA 90095USA

The Electronic Supplementary Material available online erroneously only contains the first six pages of the entire supplementary material *** will find the entire supplementary material file online linked to this publisher’s *** publisher apologizes to the authors and readers for this *** Supplementary Material:Supplementary material(detailed description on procedures,and further characterizations,including synthesis,optimization,and characterization of CdNCs,HA-CdNCs,and DOX-HA-CdNCs;calculating quantum yield;a Jellium model for assigning the most valid number of the atoms in the NCs;drug loading and release;cellular uptake and cytotoxicity)is available in the online version of this article at https://***/10.1007/s12274-016-1201-z.

关键词： characterization matrix calculating

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geyser Inspired Algorithm:A New Geological-inspired Meta-heuristic for Real-parameter and Constrained Engineering Optimization

引用

Journal of Bionic Engineering 2024年第1期21卷 374-408页

作者： Mojtaba Ghasemi Mohsen Zare Amir Zahedi Mohammad-Amin Akbari Seyedali Mirjalili Laith Abualigah Department of Electronics and Electrical Engineering Shiraz University of TechnologyShirazIran Department of Electrical Engineering Faculty of EngineeringJahrom UniversityJahromFrasIran Department of Electrical and Computer Engineering Tarbiat Modares UniversityTehranIran Department of Electrical and Computer Engineering University ofCyprusNicosiaCyprus Centre for Artificial Intelligence Research and Optimisation Torrens University AustraliaBrisbaneQLD 4006Australia university Research and Innovation Center Obuda University1034 BudapestHungary Department of Electrical and Computer Engineering Lebanese American UniversityByblos 13-5053Lebanon Hourani Center for Applied Scientific Research Al-Ahliyya Amman UniversityAmman 19328Jordan MEU Research Unit Middle East UniversityAmman 11831Jordan Applied Science Research Center Applied Science Private UniversityAmman 11931Jordan

Over the past years,many efforts have been accomplished to achieve fast and accurate meta-heuristic algorithms to optimize a variety of real-world *** study presents a new optimization method based on an unusual geological phenomenon in nature,named Geyser inspired Algorithm(GEA).The mathematical modeling of this geological phenomenon is carried out to have a better understanding of the optimization *** efficiency and accuracy of GEA are verified using statistical examination and convergence rate comparison on numerous CEC 2005,CEC 2014,CEC 2017,and real-parameter benchmark ***,GEA has been applied to several real-parameter engineering optimization problems to evaluate its *** addition,to demonstrate the applicability and robustness of GEA,a comprehensive investigation is performed for a fair comparison with other standard optimization *** results demonstrate that GEA is noticeably prosperous in reaching the optimal solutions with a high convergence rate in comparison with other well-known nature-inspired algorithms,including ABC,BBO,PSO,and *** that the source code of the GEA is publicly available at https://***/projects/gea.

关键词： Nature-inspired algorithms Real-world and engineering optimization Mathematical modeling Geyser algorithm(GEA)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：