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Role of copper chelating agents: between old applications and new perspectives in neuroscience

Neural Regeneration Research 2025年第3期20卷 751-762页

作者： Rosalba Leuci Leonardo Brunetti Vincenzo Tufarelli Marco Cerini Marco Paparella Nikola Puvača Luca Piemontese Department of pharmacy-Pharmaceutical Science University of Bari Aldo MoroBariItaly Department of Precision and Regenerative medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly Department of Engineering Management in Biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target

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Olfactory receptors in neural regeneration in the central nervous system

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Neural Regeneration Research 2025年第9期20卷 2480-2494页

作者： Rafael Franco Claudia Garrigós Toni Capó Joan Serrano-Marín Rafael Rivas-Santisteban Jaume Lillo Molecular Neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain CiberNed Network Center for Biomedical Research in Neurodegenerative Diseases Spanish National Health Institute Carlos ⅢMadridSpain School of Chemistry Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Physiology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Laboratory of Computational medicine Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors are crucial for detecting odors and play a vital role in our sense of smell,influencing behaviors from food choices to emotional *** receptors also contribute to our perception of flavor and have potential applications in medical diagnostics and environmental *** ability of the olfactory system to regenerate its sensory neurons provides a unique model to study neural regeneration,a phenomenon largely absent in the central nervous *** gained from how olfactory neurons continuously replace themselves and reestablish functional connections can provide strategies to promote similar regenerative processes in the central nervous system,where damage often results in permanent *** the molecular and cellular mechanisms underpinning olfactory neuron regeneration could pave the way for developing therapeutic approaches to treat spinal co rd injuries and neurodegenerative diseases like Alzheimer's *** ctory receptors are found in almost any cell of eve ry orga n/tissue of the mammalian *** ectopic expression provides insights into the chemical structures that can activate olfactory *** addition to odors,olfactory receptors in ectopic expression may respond to endogenous compounds and molecules produced by mucosal colonizing *** analysis of the function of olfactory receptors in ectopic expression provides valuable information on the signaling pathway engaged upon receptor activation and the receptor's role in proliferation and cell differentiation *** review explo res the ectopic expression of olfa ctory receptors and the role they may play in neural regeneration within the central nervous system,with particular attention to compounds that can activate these receptors to initiate regenerative *** suggests that olfactory receptors could serve as potential therapeutic targets for enhancing neural repair and recovery following central nervous syste

关键词： adenosine receptors adrenergic receptors ectopic expression G proteincoupled receptors glia neurons

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Male genital damage in COVID-19 patients:Are available data relevant?

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Asian Journal of Urology 2021年第3期8卷 324-326页

作者： Youssef Kharbach Abdelhak Khallouk Urology Department Tangier University HospitalFaculty of MedicineAbdelmalek Essaadi University90000TangierMorocco

Over the past few weeks,we have observed increasing concern about the possible impact of coronavirus disease 2019(COVID-19)which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2 virus)on male *** mechanisms of male reproductive damages are still unclear,but it seems that high temperature resulting from persistent fever and triggering a secondary autoimmune response leading to an autoimmune orchitis are the most likely involved ***,angiotensin conversion enzyme 2(ACE2)plays a highly important role in cellular entry for SARS-CoV-2 and male genital system presents high ACE2 *** these preliminary findings suggest that COVID-19 could impact men's reproductive ***,we examined available data including published and unpublished articles to assess the potential risk of COVID-19 in particular on the male reproductive system.

关键词： Coronavirus disease 2019 Severe acute respiratory syndrome coronavirus 2 Male genital system Testis Male infertility

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Effects of Nigella sativa on outcome of hepatitis C in Egypt

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World Journal of Gastroenterology 2013年第16期19卷 2529-2536页

作者： Eman Mahmoud Fathy Barakat Lamia Mohamed El Wakeel Radwa Samir Hagag Department of Tropical medicine Faculty of Medicine Ain Shams University Department of Clinical pharmacy Faculty of Pharmacy Ain Shams University Department of Clinical pharmacy Faculty of Pharmacy Egyptian Russian University

AIM: To evaluate the safety, efficacy and tolerability of Nigella sativa (N. sativa ) in patients with hepatitis C not eligible for interferon (IFN)-α. METHODS: Thirty patients with hepatitis C virus (HCV) infection, who were not eligible for IFN/ribavirin therapy, were included in the present study. Inclusion criteria included: patients with HCV with or without cirrhosis, who had a contraindication to IFN-α therapy, or had refused or had a financial constraint to IFN-α therapy. Exclusion criteria included: patients on IFN-α therapy, infection with hepatitis B or hepatitis Ⅰ virus, hepatocellular carcinoma, other malignancies, major severe illness, or treatment non-compliance. Various parameters, including clinical parameters, complete blood count, liver function, renal function, plasma glucose, total antioxidant capacity (TAC), and polymerase chain reaction, were all assessed at baseline and at the end of the study. Clinical assessment included: hepato and/ or splenomegaly, jaundice, palmar erythema, flapping tremors, spider naevi, lower-limb edema, and ascites. N. sativa was administered for three successive months at a dose of (450 mg three times daily). Clinical response and incidence of adverse drug reactions were assessed initially, periodically, and at the end of the study. RESULTS: N. sativa administration significantly improved HCV viral load (380808.7 ± 610937 vs 147028.2 ± 475225.6, P = 0.001) and TAC (1.35 ± 0.5 vs 1.612 ± 0.56, P = 0.001). After N. sativa administration, the following laboratory parameters improved: total protein (7.1 ± 0.7 vs 7.5 ± 0.8, P = 0.001), albumin (3.5 ± 0.87 vs 3.69 ± 0.91, P = 0.008), red blood cell count (4.13 ± 0.9 vs 4.3 ± 0.9, P = 0.001), and platelet count (167.7 ± 91.2 vs 198.5 ± 103, P = 0.004). Fasting blood glucose (104.03 ± 43.42 vs 92.1 ± 31.34, P = 0.001) and postprandial blood glucose (143.67 ± 72.56 vs 112.1 ± 42.9, P = 0.001) were significantly decreased in both diabetic and non-diabetic HCV patients. Patients

关键词： Hepatitis C virus Nigella sativa Oxidative stress Viral load

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Psychological Effects Caused by COVID-19 on Moroccan Children

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Open Journal of Medical Psychology 2022年第4期11卷 235-242页

作者： Yousra El Boussaadni Fadila Bousgheiri Adil El Ammouri Adil Najdi Abdallah Oulmaati Pediatrics Department Chu Tanger Faculty of Medicine and Pharmacy of Tangier Abdelmalek Essaadi University Tangier Morocco Laboratory of Epidemiology and Public Health Faculty of Medicine and Pharmacy of Tangier Abdelmalek Essaadi University Tangier Morocco Department of Psychiatry CHU Tanger Faculty of Medicine and Pharmacy of Tangier Abdelmalek Essaadi University Tangier Morocco

Coronavirus disease 2019 is declared as a Public Health Emergency of International Concern by the World Health Organization. On March 22, 2020, the Moroccan government declared a health emergency and also confinement. This study aimed to clarify the adverse effects of confinement on children and to analyze the factors influencing these effects. Our study concerns 495 families with 973 children specifying their activities during confinement, we find that 35% of children spend more than 3 hours on the TV, 29% engaged with their smartphones and 14% playing video games. 76% also had the opportunity to be involved in distance learning. Among consequences of home confinement, there is an increase in behavioral problems from 14% to 31% at the end of the 2nd week of confinement. Overall 77% experienced difficulties such as emotional disturbance, behavioral problems as well as sleep and eating disturbance. The under 6 aged children appeared to be more vulnerable to confinement. 75% of parents, however, noted that confinement also afforded the opportunity to improve relationship with their children. This is an important study that contributes to discussion and further studies on adverse effects of home confinement for children during epidemics. This should lead to further identification of activities that may lead to minimizing the adverse consequences of the experience. Examples might be family outings into places that do not involve meeting other people with close contacts. Distance learning might also be enriched with virtual meetings and discussions of schoolmates that may also involve teachers and parents.

关键词： COVID-19 Children Confinement

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Recognition and quality mapping of traditional herbal drugs:way forward towards artificial intelligence

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Traditional medicine Research 2025年第1期10卷 12-26页

作者： Sanyam Sharma Subh Naman Ashish Baldi faculty of pharmacy Pacific Academy of Higher Education and Research UniversityUdaipur 313024India Pharma Innovation Lab Department of Pharmaceutical Sciences and TechnologyMaharaja Ranjit Singh Punjab Technical UniversityBathinda 151001India faculty of Pharmaceutical Sciences The ICFAI UniversityBaddi 174103India.

The use of traditional herbal drugs derived from natural sources is on the rise due to their minimal side effects and numerous health ***,a major limitation is the lack of standardized knowledge for identifying and mapping the quality of these herbal *** article aims to provide practical insights into the application of artificial intelligence for quality-based commercialization of raw herbal *** focuses on feature extraction methods,image processing techniques,and the preparation of herbal images for compatibility with machine learning *** article discusses commonly used image processing tools such as normalization,slicing,cropping,and augmentation to prepare images for artificial intelligence-based *** also provides an overview of global herbal image databases and the models employed for herbal plant/drug *** will gain a comprehensive understanding of the potential application of various machine learning models,including artificial neural networks and convolutional neural *** article delves into suitable validation parameters like true positive rates,accuracy,precision,and more for the development of artificial intelligence-based identification and authentication techniques for herbal *** article offers valuable insights and a conclusive platform for the further exploration of artificial intelligence in the field of herbal drugs,paving the way for smarter identification and authentication methods.

关键词： artificial intelligence Ayurveda machine learning models herbal drugs image pre-processing medicinal plants

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Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery

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Neural Regeneration Research 2025年第8期20卷 2181-2198页

作者： Jiali Chen Yiyang Li Xingping Quan Jinfen Chen Yan Han Li Yang Manfei Zhou Greta Seng Peng Mok Ruibing Wang Yonghua Zhao Institute of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of pharmacy Hunan Provincial People’s Hospitalthe First Affiliated Hospital of Hunan Normal UniversityChangshaHunan ProvinceChina Department of Electrical and Computer Engineering University of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina

Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on *** vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic ***,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery *** utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly ***,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic *** extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke *** this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification *** the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment ***,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.

关键词： delivery engineering extracellular vesicles identification ischemic stroke isolation mitochondria targeting strategy therapeutic effects

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A Practical Guide to Statistical Tests in the Biomedical Field: From Parametric to Nonparametric, Where and How?

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Journal of Biosciences and medicines 2024年第11期12卷 1-14页

作者： Adil Gourinda Hicham El Bouri Faïza Charif Zaynab Mahdi Fadila Bousgheiri Karima Sammoud Saloua Lemrabett Adil Najdi Laboratory of Epidemiology and Public Health Faculty of Medicine and Pharmacy of Tangier Abdelmalek Essadi University CHU of Tangier Tangier Morocco

Healthcare decisions are based on scientific evidence obtained from medical studies by gathering data and analyzing it to obtain the best results. When analyzing data, biostatistics is a powerful tool, but healthcare professionals lack knowledge in this field. This lack of knowledge can manifest itself in situations such as choosing the wrong statistical test for the right situation or applying a statistical test without checking its assumptions, leading to inaccurate results and misleading conclusions. With the help of this “narrative review”, the aim is to bring biostatistics closer to healthcare professionals by answering certain questions: how to describe the distribution of data? how to assess the normality of data? how to transform data? and how to choose between nonparametric and parametric tests? Through this work, our hope is that the reader will be able to choose the right test for the right situation, in order to obtain the most accurate results.

关键词： Teaching Statistics Distribution Normality Transformation Nonparametric Test Parametric Test

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Cross-talks among GBA mutations,glucocerebrosidase,and a-synuclein in 66/4-associated Parkinson's disease and their targeted therapeutic approaches:a comprehensive review

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Translational Neurodegeneration 2021年第1期10卷 27-39页

作者： Tapan Behl Gagandeep Kaur Ovidiu Fratila Camelia Buhas Claudia Teodora Judea-Pusta Nicoleta Negrut Cristiana Bustea Simona Bungau Chitkara College of pharmacy Chitkara UniversityRajpuraPunjabIndia Departm ent of Medical Disciplines Faculty of Medicine and PharmacyUniversity of OradeaOradeaRomania Department of Morphological Disciplines Faculty of Medicine and PharmacyUniversity of OradeaOradeaBihor CountyRomania Departm ent of Psycho-Neuroscience and Recovery Faculty of Medicine and PharmacyUniversity of OradeaOradeaRomania Department of Preclinical Disciplines Faculty of Medicine and PharmacyUniversity of OradeaOradeaRomania Department of pharmacy Faculty of Medicine and PharmacyUniversity of OradeaOradeaRomania

Current therapies for Parkinson's disease(PD)are palliative,of which the levodopa/carbidopa therapy remains the primary choice but is unable to modulate the progression of *** to the complication of such a multifactorial disorder and significant limitations of the therapy,numerous genetic approaches have been proved effective in finding out genes and mechanisms implicated in this *** the observation of a higher frequency of PD in Gaucher's disease(GD),a lysosomal storage condition,mutations of glycosylceramidase beta(GBA)encoding glucocerebrosidase(GCase)have been shown to be involved and have been explored in the context of *** mutations are the most common genetic risk factor of *** studies have revealed the relationships between PD and GM gene mutations,facilitating a better understanding of this *** hypotheses delineate that the pathological mutations of GBA minimize the enzymatic activity of GCase,which affects the proliferation and clearance of α-synuclein;this affects the lysosomal homeostasis,exacerbating the endoplasmic reticulum stress or encouraging the mitochondrial *** of the pathological mechanisms underlying the GM-associated parkinsonism(GBA+PD)advances our understanding of *** review based on current literature aims to elucidate various genetic and clinical characteristics correlated with GBA mutations and to identify the numerous pathological processes underlying GBA+*** also delineate the therapeutic strategies to interfere with the mutant GCase function for further improvement of the related asynuclein-GCase ***,the various therapeutic approaches such as gene therapy,chaperone proteins,and histone deacetylase inhibitors for the treatment of GBA+PD are discussed.

关键词： Parkinson's disease Glycosylceramidase Glucocerebrosidase Gaucher's disease Mutations α-Synuclein

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Influenza vaccination in acute coronary syndromes patients in Thailand： the cost-effectiveness analysis of the prevention for cardiovascular events and pneumonia

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Journal of Geriatric Cardiology 2018年第6期15卷 413-421页

作者： Apirak Sribhutom Arintaya Phrommintikul Wanwarang Wongcharoen Usa Chaikledkaew Suntara Eakanunkul Apichard Sukonthasam Program in Clinical Epidemiology Faculty of Medicine Chiang Mai University Thailand Department of pharmacy Practice School of Pharmaceutical Sciences University of Phayao Thailand Cardiology Division Department of Internal Medicine Faculty of Medicine Chiang Mai University Thailand Social and Administrative pharmacy Excellence Research Unit (SAPER) Department of Pharmacy Faculty of Pharmacy Mahidol University Thailand Department of Pharmaceutical Sciences Faculty of Pharmacy Chiang Mai University Thailand

Background Influenza vaccination has been clinically shown to reduce adverse cardiovascular outcomes in acute coronary syndrome （ACS） patients, but the economic perspectives can provide important data to make informed decisions. This study aimed to perform the economic evaluation of lifelong annual influenza vaccination for cardiovascular events and well-established pneumonia prevention. Methods Lifetime costs, life-expectancy, and quality-adjusted live years （QALYs） were estimated beyond one-year cycle length of a six-health states Markov model condition on whether a hospitalization for ACS, stroke, heart failure, pneumonia, no hospitalizations occurred, or death. The comparison of three age-groups of 40-49, 50-65, and 〉 65 years scenario was performed. Incremental cost-effectiveness ratio （ICER） and net monetary benefit （NMB） were presented as a societal perspective in 2016. The model robustness was determined by one-way and prob- abilistic sensitivity analyses. Results The influenza vaccination was cost-effective in all age-groups, by dominant ICERs （lower cost with higher effectiveness） which was completely lower than acceptable willingness-to-pay threshold of Thailand [160,000 THB （4,466.8 USD） per QALYs], with a great incremental value of NMB. Especially, the 50-year-old-and- above scenario was shown as the most benefit at 129,092 THB （3,603.9 USD） for each patient. Conclusions The annually additional influenza vaccination to standard treatment in ACS was cost-effective in all age-groups, which should be considered in clinical practice and health-policy making process.

关键词： Acute coronary syndrome Cost-effectiveness Heart failure Influenza vaccine Pneumonia Stroke

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