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Journal of Energy Chemistry 2025年第1期100卷 621-627页

作者： Fei Lv Longjie Liu Jiazhe Wu Pengfei Wang Lixia Pan Dengwei Jing Yubin Chen international Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong University

Combining water electrolysis and rechargeable battery technologies into a single system holds great promise for the co-production of hydrogen （H2） and ***,the design and development of such systems is still in its ***,an integrated hydrogen-oxygen （O2）-electricity co-production system featuring a bipolar membrane-assisted decoupled electrolyzer and a Na-Zn ion battery was established with sodium nickelhexacyanoferrate （NaNiHCF） and Zn2+/Zn as dual redox *** decoupled electrolyzer enables to produce H2and O2in different time and space with almost 100%Faradaic efficiency at 100 mA ***,the charged NaNiHCF and Zn electrodes after the electrolysis processes formed a Na-Zn ion battery,which can generate electricity with an average cell voltage of 1.75 V at 10 m A *** connecting Si photovoltaics with the modular electrochemical device,a well-matched solar driven system was built to convert the intermittent solar energy into hydrogen and electric energy with a solar to hydrogen-electricity efficiency of 16.7%,demonstrating the flexible storage and conversion of renewables.

关键词： Hydrogen Electricity Decoupled water electrolyzer Na-Zn ion battery Solar energy

Protein arginine methyltransferase-6 regulates heterogeneous nuclear ribonucleoprotein-F expression and is a potential target for the treatment of neuropathic pain

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Neural Regeneration Research 2025年第9期20卷 2682-2696页

作者： Xiaoyu Zhang Yuqi Liu Fangxia Xu Chengcheng Zhou Kaimei Lu Bin Fang Lijuan Wang Lina Huang Zifeng Xu Department of Anesthesiology International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Anesthesiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Embryo Original Diseases ShanghaiChina

Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal ***,it remains unclear whether protein arginine methyl transferase-6 modifies neuropathic pain and,if so,what the mechanisms of this *** this study,protein arginine methyltransferase-6 expression levels and its effect on neuropathic pain were investigated in the spared nerve injury model,chronic constriction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-free proteomic *** results showed that protein arginine methyltransferase-6 mostly co-localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased following spared nerve injury,chronic constriction injury and bone cancer *** addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain ***,the development of spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransferase-6 ***,when protein arginine methyltransferase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was ***,protein arginine methyltransferase-6 appeared to contribute to spared nerve injury-induced neuropathic pain by regulating the expression of heterogeneous nuclear ***,protein arginine methyltransfe rase-6-mediated modulation of hete rogeneous nuclear ribonucleoprotein-F expression required amino atids 319 to 388,but not classical H3R2 *** findings indicated that protein arginine methyltransferase-6 is a potential therapeutic target fo r the treatment of peripheral neuro pathic pain.

关键词： dorsal root ganglion heterogeneous nuclear ribonucleoprotein F neuropathic pain protein arginine methyltransferase-6 sensory neurons

Recent development in electrode design for wide-temperature supercapacitors

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Science China Chemistry 2025年第1期 96-117页

作者： Jianhong Liu Qiang Zhou Yuxiao Lin Xinsheng Zhao Guangmin Zhou Xiaoxiao Li School of Physics and Electronic Engineering Jiangsu Normal University Tsinghua-Berkeley Shenzhen Institute & Tsinghua Shenzhen international Graduate School Tsinghua University

An ever-increasing market demand has stimulated the soaring enthusiasm of researchers to develop wide-temperature supercapacitors(SCs). The active electrode is one of the most important parts of SC, which is directly related to the energy density,power transmission and long-term cyclability of the device in the wide-temperature environment. Compared with the SC electrodes aimed for room-temperature application, the SC electrodes for operating at wide-temperature scene often face greater challenges. In this review, the main challenges of SC electrodes under various temperature conditions, including low, high and cross-fade temperatures, are summarized. The relevant performance decay and failure mechanisms of wide-temperature SC electrodes are analyzed. In addition, this review deals with the recent studies and developments in robust wide-temperature SC electrodes with respect to the rational design of electrode structures and the exploitation of advanced active materials. Finally, the future directions for exploring reliable wide-temperature SCs are also proposed.

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Chemical Safety as a Major Challenge for Developing Countries: Role of the international program on Chemical Safety^1

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Biomedical and Environmental Sciences 1990年第2期3卷 211-216页

作者： M.MERCIER international program on Chemical Safety Division of Environmental HealthWorld Health Organization. Geneva. Switzerland

Developing countries face a number of unique problems related to the hazards of chemicals. The WHO international program on Chemical Safety may play a useful role by working jointly with Member Nations and such intern... 详细信息

关键词： Pro Chemical Safety as a Major Challenge for Developing Countries Role of the international program on Chemical Safety~1

Two paths, one goal: mechanism of calcium homeostasis to balance plant growth and immunity

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Science China Life Sciences 2025年第1期 306-308页

作者： Aziz Ul Ikram Yanping Jing Huan Chen Jian Chen international Genome Center Jiangsu University Joint Center for Single Cell Biology School of Agriculture and BiologyShanghai Jiao Tong University

Calcium(Ca2+) is an essential nutrient and a cellular signal in plants. The level of free Ca2+in the apoplast is ～10,000-fold higher than that in the cytoplasm at the resting state. This large Ca2+level gradient across the membrane between the interior and exterior can cause Ca2+overload and toxicity. Plants have evolved mechanisms to export Ca2+out of the cytoplasm or store it in intracellular organelles, such as endoplasmic reticulum（ER）, mitochondria, and vacuole.

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Maximizing Sampling Efficiency

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Applied Mathematics 2013年第11期4卷 1547-1557页

作者： Harmon S. Jordan health Care Quality program RTI International Waltham Massachusetts USA

Background and Goals: Although health care quality improvement has traditionally involved extensive work with paper records, the adoption of health information technology has increased the use of electronic record and administrative systems. Despite these advances, quality improvement practitioners now and for the foreseeable future need guidance in defining populations of individuals for study and in selecting and analyzing sample data from such populations. Statistical data analysis in health care research often involves using samples to make inferences about populations. The investigator needs to consider the goals of the study, whether sampling is to be used, and the type of population being studied. While there are numerous sampling strategies designed to conserve resources and yield accurate results, one of these techniques—use of the finite population correction (FPC)—has received relatively little attention in health care sampling contexts. It is important for health care quality practitioners to be aware of sampling options that may increase accuracy and conserve resources. This article describes common sampling situations in which the issue of the finite population correction decision often arises. Methods: This article describes 3 relevant sampling situations that influence the design and analysis phases of a study and offers guidance for choosing the most effective and efficient design. Situation 1: The study or activity involves taking a sample from a large finite target population for which enumerative inferences are needed. Situation 2: The population is finite and the study is enumerative. A complete enumerative count of “defects” in the process is needed so that remediation can occur. Here, statistical inference is unnecessary. Situation 3: The target population is viewed as infinite;such populations are “conceptual populations” [1] or “processes”. Results: The article shows how savings in resources can be achieved by choosing the correct analytic f

关键词： Sampling Finite Population Correction FPC Finite Population Infinite Population

THE GREENING OF THE PARKING INDUSTRY–BEST PRACTICES,AND A NEW CERTIFICATION program FOR PARKING STRUCTURES

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Journal of Green Building 2014年第4期9卷 61-77页

作者： Rachel Yoka program Development International Parking Institute

Sustainable building design is now *** United States Green Building Council(USGBC)and the LEED Ratings Systems have moved the market,proving that“a rising tide lifts all boats.”Consumers now factor environmental effect into their buying decisions,a trend that looks to continue and intensify with the millennial *** and homeowners are willing to pay more for high-performing and better quality housing based on environmental *** recognize that indoor air quality and daylighting improve employee performance and boost retention *** even bottom-line businesses are investing in benchmarking and efficiency projects that have the right return on investment *** Urban Land Institute’s Greenprint Center for Building Performance serves as a prime example of the ways developers implement benchmarking,energy efficiency,and high-performance standards in the major real estate sectors:office,retail,industrial,multifamily,and *** efficiency gains and higher-quality buildings in each of these sectors will be essential to reducing emissions and energy *** the transportation sector implements its own standards and benchmarking tools to achieve greater levels of sustainability across all modes of transportation,one industry that stands at the nexus of every building type and the transportation modes used to access them is *** is a key consideration that links land use and transportation:Parking is often the connection between where we are and where we want to *** may not have been at the forefront of the sustainability discussion or the media surrounding it in previous years,but the professionals who work in the world of parking know exactly how important the role of their industry is to the success of our cities,towns,institutions,and *** is big business;it is conservatively estimated to be a$30 billion *** directly contributes to the economic vitality and accessibility of where we

关键词： Sustainability triple bottom line rating system parking garages transportation TDM

Emergence and Development of health Risk Communication Networks Among Street-Level health Bureaucrats During the COVID-19 Pandemic Crisis in Myanmar

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international Journal of Disaster Risk Science 2022年第4期13卷 507-520页

作者： Thein Myomin Seunghoo Lim Public Management and Policy Analysis program Graduate School of International RelationsInternational University of JapanMinamiuonumaNiigata 949-7277Japan

Street-level health bureaucrats have actively contributed to implementing the COVID-19 prevention,control,and treatment policies of the Myanmar ***,the need for bureaucrats on the frontlines of policy implementation to maintain a safe distance from others to prevent the spread of COVID-19 has posed challenges for the sharing and exchange of information related to health *** this context,this study examined what health risk communication patterns have emerged and developed among streetlevel health bureaucrats during the COVID-19 pandemic,and how this risk communication has been affected by streetlevel health bureaucrats'perceptions of client meaningfulness and willingness to implement COVID-19 *** results reveal that street-level health bureaucrats in the health risk communication network are embedded in reciprocally or transitively connected discussion relationships that sustain their health risk communication over ***,when specific healthcare staffmembers perceive more benefits of COVID-19 policies for their patients and are more willing to care for patients,other healthcare staffavoid them to protect themselves from COVID-19 *** to their higher level of understanding of the adopted measures,healthcare staffmembers who are highly willing to implement COVID-19 policies are frequently approached by other staffmembers to communicate about COVID-19 *** study empirically contributes to the literature on street-level bureaucrats in times of pandemic crisis by examining the formation of health risk communications in the context of street-level health bureaucrats'responses to and participation in public healthcare policy implementation processes.

关键词： Client meaningfulness COVID-19 crisis health risk communication Social network analysis Street-level bureaucrats Willingness to implement policy

Knockdown of long non-coding RNA LCPAT1 inhibits autophagy in lung cancer

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Cancer Biology & Medicine 2018年第3期15卷 228-237页

作者： Xiao Yu Xiaofei Ye Hongyan Lin Nannan Feng Sumeng Gao Xiaohong Zhang Yu Wang Herbert Yu Xiaobei Deng Biyun Qian Hongqiao international Institute of Medicine Shanghai Tongren Hospital and Faculty of Public Health Shanghai Jiao Tong University School of Medicine Cancer Epidemiology program University of Hawaii Cancer Center

Objective: Long non-coding RNAs(lnc RNAs) are involved in numerous biological processes in lung cancer cells. In our previous studies, we identified a lnc RNA, ENST00000439577, which is highly expressed in lung carcinomas, and termed it lung cancer progression-associated transcript 1(LCPAT1). To characterize the role of LCPAT1 in lung cancer, we conducted the current ***: Expression of LCPAT1 and autophagy-associated markers in tumor tissues and lung cancer cell lines was determined by real-time quantitative polymerase chain reaction(q PCR). Hematoxylin and eosin(HE) staining, q PCR, Western blot, and immunohistochemistry were performed to evaluate xenografted tumor tissues. Autophagy induced by rapamycin was detected by Western blot and immunofluorescence in lung cancer cell ***: Expression of LCPAT1 and microtubule-associated protein 1 light chain 3 beta(LC3B) was positively correlated in lung cancer. Knockdown of LCPAT1 inhibited tumor growth and suppressed cell autophagy in vivo. Moreover, LCPAT1 knockdown in lung cancer cell lines resulted in decreased autophagy-associated gene expression and alleviated the cell autophagy induced by ***: We speculate that LCPAT1 plays a crucial role in regulating autophagy in lung cancer.

关键词： Lung cancer autophagy long non-coding RNA LCAPT1 ENST00000439577

In vitro inhibitory effects of plumbagin,the promising antimalarial candidate,on human cytochrome P450 enzymes

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Asian Pacific Journal of Tropical Medicine 2015年第11期8卷 894-898页

作者： Wiriyaporn Sumsakul Wanna Chaijaroenkul Kesara Na-Bangchang Graduate program in Biomedical Sciences.Faculty of Allied health Sciences Thammasat University Center of Excellence in Pharmacology and Molecular Biology Graduate Program in Bioclinical SciencesChulabhorn International College of MedicineThammasat University

Objective:To investigate the propensity of plumbagin to inhibit the three isoforms of human cytochrome P450(CYP),ie.,CYP1A2,CYP2C19,and CYP3A4 using human liver microsomes in ***:Inhibitory effects of plumbagin on the three human CYP isoformswere investigated using pooled human liver *** O-deethylation,omeprazole hydroxylation and nifedipine oxidation were used as selective substrates for CYP1A2,CYP2C19 and CYP3A4 activities,*** of paracetamol,5-hydroxyomeprazole,and oxidized nifedipine were determined in microsomal incubation mixture using high performance liquid ***:Plumbagin showed significantinhibitory effects on all CYP *** with the most potent activity on CYP2C19-mediated omeprazole *** IC50(concentration that inhibits enzyme activity by 50%) values of plumbagin and nootkatone(selective inhibitor) for CYP2C19 were(0.78±0.01) and(27.31±0.66) μM,*** inhibitory activities on CYP1 A2-mediated phenacetin O-deethylation and CYP3A4-mediated nifedipine oxidation were *** IC_(50) values of plumbagin and-naphthoflavone(selective inhibitor) for CYP1A2 were(1.39±0.01) and(0.02±.0.36) μM,*** corresponding IC_(50) values of plumbagin and ketoconazole(selective inhibitor) for CYP3A4 were(2.37+0.10) and(0.18±0.06) μM,***:Clinical relevance of the interference of human drug metabolizing enzymes should be aware of for further development scheme of plumbagin as antimalarial drug when used in combination with other antimalarial drugs which are metabolized by these CYP isoforms.

关键词： Metabolism Human liver microsomes Plumbagin Cytoch