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Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

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Neural Regeneration Research 2025年第2期20卷 533-547页

作者： Yanli Zhang Tian Li Jie Miao Zhina Zhang Mingxuan Yang Zhuoran Wang Bo Yang Jiawei Zhang Haiting Li Qiang Su Junhong Guo Department of Neurology First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Sixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina Department of Physiology Key Laboratory of Cellular PhysiologyMinistry of EducationShanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Hernia and Abdominal Wall Surgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Laboratory Medicine of Fenyang College Shanxi Medical UniversityFenyangShanxi ProvinceChina

In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial ***,the functional role of GGT5 in the development of Alzheimer’s disease remains *** study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying *** observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse ***,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive ***,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 *** effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa *** findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 *** findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1

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Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing Wang Bing Zhang Lanfang Li Xiaomei Tang Jinyu Zeng Yige Song Chao Xu Kai Zhao Guoqiang Liu Youming Lu Xinyan Li Kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

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MnO_(2)-coated nanodiamond-driven photodynamic therapy for enhanced antitumor effect by addressing hypoxia and glutathione depletion

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Particuology 2024年第9期92卷 305-315页

作者： Jicheng Cui Dongmei Zhang Hui Qiao Zeyu Yan Wenxia Zhang Yingqi Li Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Institute of Molecular ScienceShanxi UniversityTaiyuan030006China taiyuan central hospital Taiyuan030009China School of Chemistry and Chemical Engineering Shanxi UniversityTaiyuan030006China

The generation of reactive oxygen species(ROS)at the tumor site to induce destruction is emerging as a novel strategy for cancer treatment,which involves photodynamic therapy(PDT).Nevertheless,tumors typically create a hypoxic environment and are equipped with an endogenous antioxidant defense system that could potentially impede the efficiency of the therapeutic *** overcome these drawbacks,herein,a tumor microenvironment-responsive the ND-PAA-CD-Ce6@MnO_(2)(NPCC@M)delivery system was fabricated by disulfide bond coupling chlorin e6(Ce6)to nanodiamond(ND)and further wrapped by MnO_(2)nanosheets to facilitate *** use of disulfide bond not only stabilizes Ce6 in the blood circulation to prevent premature leakage,but also destroys the antioxidant barrier of overexpressed glutathione(GSH)in tumor ***,the outer MnO_(2)was rapidly degraded by the endogenous hydrogen peroxide(H_(2)O_(2))in the acidic pH and GSH within the tumor cells,which leads to an abundance of O_(2)and while increases the level of 1O_(2)under laser *** results eventually broke the redox homeostasis and attenuate hypoxia,thereby inducing apoptosis and necrosis of tumor *** in vitro and in vivo biological effect has revealed a good biosafety profile and a high tumor suppression *** a novel ND-based system with tumor microenvironment-modulating capability to elevate oxygen content and promote GSH consumption in tumor cells opens new opportunities for enhanced ROS treatment paradigms.

关键词： Nanodiamond Photodynamic Chlorin e6 MnO_(2) Tumor suppression

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Lung Nodule Image Retrieval Based on Convolutional Neural Networks and Hashing

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Journal of Beijing Institute of Technology 2019年第1期28卷 17-26页

作者： Yan Qiang Xiaolan Yang Juanjuan Zhao Qiang Cui Xiaoping Du College of Computer Science and Technology Taiyuan University of Science and Technology Shanxi Coal central hospital

Lung medical image retrieval based on content similarity plays an important role in computer-aided diagnosis of lung *** recent years,binary hashing has become a hot topic in this field due to its compressed storage and fast query *** hashing methods often rely on highdimensional features based hand-crafted methods,which might not be optimally compatible with lung nodule ***,different hashing bits contribute to the image retrieval differently,and therefore treating the hashing bits equally affects the retrieval ***,an image retrieval method of lung nodule images is proposed with the basis on convolutional neural networks and ***,apre-trained and fine-tuned convolutional neural network is employed to learn multilevel semantic features of the lung *** components analysis is utilized to remove redundant information and preserve informative semantic features of the lung ***,the proposed method relies on nine sign labels of lung nodules for the training set,and the semantic feature is combined to construct hashing ***,returned lung nodule images can be easily ranked with the query-adaptive search method based on weighted Hamming *** experiments and evaluations on the dataset demonstrate that the proposed method can significantly improve the expression ability of lung nodule images,which further validates the effectiveness of the proposed method.

关键词： lung nodule image retrieval convolutional neural networks informative semantic features hashing

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Deep learning in two-dimensional materials:Characterization,prediction,and design

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Frontiers of physics 2024年第5期19卷 57-84页

作者： Xinqin Meng Chengbing Qin Xilong Liang Guofeng Zhang Ruiyun Chen Jianyong Hu Zhichun Yang Jianzhong Huo Liantuan Xiao Suotang Jia State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Laser SpectroscopyCollaborative Innovation Center of Extreme OpticsShanxi UniversityTaiyuan 030006China College of Physics Taiyuan University of TechnologyTaiyuan 030024China taiyuan central hospital of Shanxi Medical University Taiyuan 030009China

Since the isolation of graphene,two-dimensional(2D)materials have attracted increasing interest because of their excellent chemical and physical properties,as well as promising ***,particular challenges persist in their further development,particularly in the effective identification of diverse 2D materials,the domains of large-scale and highprecision characterization,also intelligent function prediction and *** issues are mainly solved by computational techniques,such as density function theory and molecular dynamic simulation,which require powerful computational resources and high time *** booming deep learning methods in recent years offer innovative insights and tools to address these *** review comprehensively outlines the current progress of deep learning within the realm of 2D ***,we will briefly introduce the basic concepts of deep learning and commonly used architectures,including convolutional neural and generative adversarial networks,as well as U-net ***,the characterization of 2D materials by deep learning methods will be discussed,including defects and materials identification,as well as automatic thickness ***,the research progress for predicting the unique properties of 2D materials,involving electronic,mechanical,and thermodynamic features,will be evaluated ***,the current works on the inverse design of functional 2D materials will be *** last,we will look forward to the application prospects and opportunities of deep learning in other aspects of 2D *** review may offer some guidance to boost the understanding and employing novel 2D materials.

关键词： deep learning two-dimensional materials materials identification thickness characterization prediction inverse design convolutional neural networks generative adversarial networks

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Medical Sign Recognition of Lung Nodules Based on Image Retrieval with Semantic Features and Supervised Hashing

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Journal of Computer Science & Technology 2017年第3期32卷 457-469页

作者： Juan-Juan Zhao Ling Pan Peng-Fei Zhao Kiao-Xian Tang College of Computer Science and Technology Taiyuan University of Technology Taiyuan 030024 China Shanxi Provincial People's hospital Taiyuan 030012 China

Sign recognition is important for identifying benign and malignant nodules. This paper proposes a new sign recognition method based on image retrieval for lung nodules. First, we construct a deep learning framework to extract semantic features that can effectively represent sign information. Second, we translate the high-dimensional image features into compact binary codes with principal component analysis （PCA） and supervised hashing. Third, we retrieve similar lung nodule images with the presented adaptive-weighted similarity calculation method. Finally, we recognize nodule signs from the retrieval results, which can also provide decision support for diagnosis of lung lesions. The proposed method is validated on the publicly available databases： lung image database consortium and image database resource initiative （LIDC-IDRI） and lung computed tomography （CT） imaging signs （LISS）. The experimental results demonstrate our retrieval method substantially improves retrieval performance compared with those using traditional Hamming distance, and the retrieval precision can achieve 87.29%when the length of hash code is 48 bits. The entire recognition rate on the basis of the retrieval results can achieve 93.52%. Moreover, our method is also effective for real-life diagnosis data.

关键词： lung nodule medical sign recognition image retrieval supervised hashing adaptive weight

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Biomechanical analysis of an osteocyte model by considering bone matrix’s piezoelectricity

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Acta Mechanica Sinica 2024年第9期40卷 131-148页

作者： Xiyu Wang Zhengbiao Yang Yanru Xue Yixian Qin Meng Zhang Jing Chen Pengcui Li Xiaochun Wei Haoyu Feng Liming He Yanqin Wang Xiaogang Wu Weiyi Chen College of Biomedical Engineering Taiyuan University of TechnologyTaiyuan 030024China Shanxi Provincial Key Laboratory for Repair of Bone and Soft Tissue Injury Taiyuan 030001China Shanxi Bethune hospital Shanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuan 030032China

Osteocytes,the primary cells in bone,play a crucial role in sensing external load environments and regulating other bone *** to the piezoelectric effect of the mineralized matrix and collagen that make up bone,the mechanical stimulus received is converted into an electrical stimulus to affect the reconstruction of *** the importance of osteocyte,many studies have focused on the mechanical loading and fluid flow of it,there is still a gap in the study of the piezoelectric effects of various mechanosensors on the *** this paper,we developed a finite element model of osteocytes that incorporates the piezoelectric bone *** model is comprehensive,comprising the osteocyte cell body enclosed by lacuna,osteocyte processes enclosed by canaliculi,and the interposed charged ionic ***,it features mechanosensors such as collagen hillocks and primary *** our study,we subjected the piezoelectric bone matrix model to triaxial displacement,subsequently assessing the electrical signal variations across different mechanosensors within the *** observed disparities in mechanical perception by various mechanosensors were primarily attributable to greater liquid velocity changes in the polarization direction as opposed to other *** hillocks showed insensitivity to piezoelectric signals,serving predominantly to mechanically transmit signals through solid-to-solid *** contrast,processes and primary cilia were highly responsive to piezoelectric ***,the processes oriented in the direction of the electric field demonstrated a differential piezoelectric signal perception compared to those in other *** cilia were especially sensitive to fluid flow pressure changes,which were influenced both by loading rates and external piezoelectric ***,our findings illuminate the complexity of mechanical perception within osteocytes in a piezoelectric *** adds a new di

关键词： Osteocyte Primary cilia Cell process Collagen hillock Piezoelectric effect

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Thyrotoxicosis after a massive levothyroxine ingestion: A case report

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World Journal of Clinical Cases 2022年第11期10卷 3624-3629页

作者： Fang Du Shi-Wei Liu Hua Yang Rui-Xue Duan Wen-Xia Ren Department of Endocrinology Taiyuan Central Hospital of Shanxi Medical UniversityTaiyuan 030009Shanxi ProvinceChina Department of Endocrinology and Metabolism West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Endocrinology Shanxi Bethune HospitalShanxi Academy of Medical SciencesTaiyuan 030032Shanxi ProvinceChina

BACKGROUND The literature on thyrotoxicosis caused by excessive ingestion of exogenous thyroid hormone is limited,and most cases reported have involved pediatric clinical *** SUMMARY A 21-year-old woman initially presented with palpitation and chest tightness after an overdose of levothyroxine(10 mg).The patient transiently lost consciousness and developed atrial fibrillation during *** used propylthiouracil to decrease the peripheral conversion of T4 to T3 and inhibit the synthesis of endogenous thyroxine,propranolol to control heart rate,hydrocortisone to correct severe thyrotoxicosis,and hemoperfusion to increase levothyroxine *** patient recovered and was *** For patients with thyrotoxicosis after taking excess levothyroxine,it is critical to monitor vital signs and initiate effective treatment.

关键词： Levothyroxine Overdose Thyrotoxicosis Thyroid crisis Treatment Case report

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Lysophosphatidylcholine acyltransferase 1 is involved in the regulation of exosome secretion and uptake in colorectal cancer cells

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BIOCELL 2022年第2期46卷 453-462页

作者： HAIZHENG LIU SHAOFEI CHANG Anorectal Surgery Yuncheng City Central HospitalYuncheng044000China Department of Gastrointestinal and Pancreatic Surgery Shanxi Provincial People’s HospitalTaiyuan030012China

Lysophosphatidylcholine acyltransferase 1(LPCAT1)is a phospholipid acyltransferase that promotes phospholipid synthesis and plasma membrane *** play an important role in tumor *** release and uptake of exosomes are key steps of their functions and depend on plasma membrane fusion and plasma membrane receptors,*** purpose of this study was to explore whether LPCAT1-induced plasma membrane remodeling would change the secretion and uptake behavior of exosomes in tumor *** first confirmed the abnormally high expression of LPCAT1 in colorectal cancer cells by quantitative real-time PCR(qPCR)and Western blot ***,SW620 cells were used as exosome source cells,and SW480 cells were used as exosome receiver *** from SW620 cells could effectively promote the migration of SW480 *** LPCAT1 expression was reduced via siRNA knockdown in the source cells,the secretion of exosomes was downregulated,thus weakening the pro-migratory effects of exosomes on target ***,when LPCAT1 was knocked down in target cells,the uptake of exosomes in target cells also decreased *** results undoubtedly revealed that LPCAT1 is functionally associated with the release and internalization of exosomes in colorectal cancer cells and could affect the paracrine effects of exosomes,preliminarily extending the classical metabolic function of LPCAT1 to exosome-related pathways.

关键词： LPCAT1 Exosomes Colorectal cancer

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Fibroblast activation protein (FAP) as a prognostic biomarker in multiple tumors and its therapeutic potential in head and neck squamous cell carcinoma

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Oncology Research 2024年第8期32卷 1323-1334页

作者： RUIFANG LI XINRONG NAN MING LI OMAR RAHHAL School of Stomatology Shanxi Medical UniversityTaiyuan030001China Department of Stomatology The First Hospital of Shanxi Medical UniversityTaiyuan030001China Department of Oral and Maxillofacial Surgery Xiangya Stomatology HospitalCentral South UniversityChangsha410005China

Background:Fibroblast activation protein(FAP),a cell surface serine protease,plays roles in tumor invasion and immune ***,there is currently no pan-cancer analysis of ***:We aimed to assess the pan-cancer expression proﬁle of FAP,its molecular function,and its potential role in head and neck squamous cell carcinoma(HNSC).Methods:We analyzed gene expression,survival status,immune inﬁltration,and molecular functional pathways of FAP in The Cancer Genome Atlas(TCGA)and Genotype Tissue Expression(GTEx)***,to elucidate the role of FAP in HNSC,we performed proliferation,migration,and invasion assays post-FAP overexpression or ***:FAP expression was elevated in nine tumor types and was associated with poor survival in eight of *** the context of immune inﬁltration,FAP expression negatively correlated with CD8+T-cell inﬁltration inﬁve tumor types and positively with regulatory T-cell inﬁltration in four tumor *** enrichment analysis highlighted FAP’s involvement in the PI3K-Akt signaling *** HNSC cells,FAP overexpression activated the PI3K-Akt pathway,promoting tumor proliferation,migration,and ***,FAP knockdown showed inhibitory ***:Our study unveils the association of FAP with poor tumor prognosis across multiple cancers and highlights its potential as a therapeutic target in HNSC.

关键词： FAP Head and neck squamous cell carcinoma Cancer Prognosis Tumor microenvironment Molecular function

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