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Differential role of Hedgehog signaling in human pancreatic(patho-)physiology:An up to date review

World Journal of Gastrointestinal Pathophysiology 2016年第2期7卷 199-210页

作者： Eckhard Klieser Stefan Swierczynski Christian Mayr Tarkan Jager Johanna Schmidt Daniel Neureiter Tobias Kiesslich Romana Illig Institute of Pathology Paracelsus Medical UniversitySalzburger Landeskliniken(SALK) Department of Surgery Paracelsus Medical UniversitySalzburger Landeskliniken(SALK) Department of Internal Medicine I Paracelsus Medical UniversitySalzburger Landeskliniken(SALK) Laboratory for Tumour Biology and Experimental Therapies(treat) Institute of Physiology and PathophysiologyParacelsus Medical University

Since the discovery of the Hedgehog(Hh)pathway in drosophila melanogaster,our knowledge of the role of Hh in embryonic development,inflammation,and cancerogenesis in humans has dramatically increased over the last *** is the case especially concerning the pancreas,however,real therapeutic breakthroughs are missing until *** general,Hh signaling is essential for pancreatic organogenesis,development,and tissue *** the case of acute pancreatitis,Hh has a protective role,whereas in chronic pancreatitis,Hh interacts with pancreatic stellate cells,leading to destructive parenchym fibrosis and atrophy,as well as to irregular tissue remodeling with potency of initiating *** vitro and in situ analysis of Hh in pancreatic cancer revealed that the Hh pathway participates in the development of pancreatic precursor lesions and ductal adenocarcinoma including critical interactions with the tumor *** application of specific inhibitors of components of the Hh pathway is currently subject of ongoing clinical trials(phases 1 and 2).Furthermore,a combination of Hh pathway inhibitors and established chemotherapeutic drugs could also represent a promising therapeutic *** this review,we give a structured survey of the role of the Hh pathway in pancreatic development,pancreatitis,pancreatic carcinogenesis and pancreatic cancer as well as an overview of current clinical trials concerning Hh pathway inhibitors and pancreas cancer.

关键词： Pancreatic cancer Hedgehog Pancreatitis Pancreas Development

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Wuzi Yanzong Pill Plays A Neuroprotective Role in Parkinson’s Disease Mice via Regulating Unfolded Protein Response Mediated by Endoplasmic Reticulum Stress

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Chinese Journal of Integrative Medicine 2023年第1期29卷 19-27页

作者： LI Yan-rong FAN Hui-jie SUN Rui-rui JIA Lu YANG Li-yang ZHANG Hai-fei JIN Xiao-ming XIAO Bao-guo MA Cun-gen CHAI Zhi The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine Shanxi University of Chinese MedicineJinzhongShanxi Province030619China Institute of Brain Science Department Neurology of First Affiliated HospitalShanxi Datong UniversityDatongShanxi Province037009China Department of Anatomy and Cell Biology Department of Neurological SurgerySpinal Cord and Brain Injury Research GroupStark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisIN46202USA Institute of Neurology Huashan HospitalInstitutes of Brain Science and State Key Laboratory of Medical NeurobiologyFudan UniversityShanghai200025China

Objective:To investigate the protective effects and its possible mechanism of Wuzi Yanzong Pill(WYP) on Parkinson’s disease(PD) model ***:Thirty-six C57BL/6 male mice were randomly assigned to 3 groups including normal,PD,and PD+WYP groups,12 mice in each *** week of intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP) was used to establish the classical PD model in ***,mice in the PD+WYP group were administrated with 16 g/kg WYP,twice daily by *** 14 days of administration,gait test,open field test and pole test were measured to evaluate the movement *** hydroxylase(TH) neurons in substantia nigra of midbrain and binding immunoglobulin heavy chain protein(GRP78) in striatum and cortex were observed by *** levels of TH,GRP78,p-PERK,p-elF2α,ATF4,p-IRE1α,XBP1,ATF6,CHOP,ASK1,p-JNK,Caspase-12,-9 and-3 in brain were detected by Western ***:Compared with the PD group,WYP treatment ameliorated gait balance ability in PD mice(Ptreatment significantly decreased the protein expressions of GRP78,p-PERK,p-elF2α,ATF4,p-IRE1α,XBP1,CHOP,Caspase-12 and Caspase-9(P<0.05or P<0.01).Conclusions:WYP ameliorated motor symptoms and pathological lesion of PD mice,which may be related to the regulation of unfolded protein response-mediated signaling pathway and inhibiting the endoplasmic reticulum stress-mediated neuronal apoptosis pathway.

关键词： Wuzi Yanzong Pill Parkinson’s disease dopaminergic neurons endoplasmic reticulum stress apoptosis

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The prevalence of thyroid nodule in adults in high water iodine area

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China Medical Abstracts (Internal Medicine) 2017年第4期 202-202页

作者：郭俊敏 Dept Ultrasound Shanxi Endemic Dis Preve & Treat Instit

Objective To investigate the prevalence of thyroid nodules in the adults in high water iodine area and to reveal the risk factors of thyroid *** Questionnaire investigation,determination of urinary iodine and thyroid ultrasound were carried out for residents aged18 to 65 years old in Gaoche Village of Wenshui County in Shanxi Province,with the exception of pregnant and

关键词： The prevalence of thyroid nodule in adults in high water iodine area

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Grape Seed Extract Attenuates Demyelination in Experimental Autoimmune Encephalomyelitis Mice by Inhibiting Inflammatory Response of Immune Cells

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Chinese Journal of Integrative Medicine 2023年第5期29卷 394-404页

作者： WANG Qing CHEN Yang-yang YANG Zhi-chao YUAN Hai-jun DONG Yi-wei MIAO Qiang LI Yan-qing WANG Jing YU Jie-zhong XIAO Bao-guo MA Cun-gen Research Center of Neurobiology the Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese MedicineShanxi University of Chinese MedicineJinzhongShanxi Province(030619)China Department of Neurology the First Affiliated HospitalShanxi Medical UniversityTaiyuan(030001)China Institute of Brain Science Shanxi Key Laboratory of Inflammatory Neurodegenerative DiseasesShanxi Datong UniversityDatongShanxi Province(037009)China Department of Neurology Datong Fifth People's HospitalDatongShanxi Province(037009)China Institute of Neurology Huashan HospitalInstitutes of Brain Science and State Key Laboratory of Medical NeurobiologyFudan UniversityShanghai(200000)China

Objective: To examine the anti-inflammatory effect of grape seed extract(GSE) in animal and cellular models and explore its mechanism of action. Methods: This study determined the inhibitory effect of GSE on macrophage inflammation and Th1 and Th17 polarization in vitro. Based on the in vitro results, the effects and mechanisms of GSE on multiple sclerosis(MS)-experimental autoimmune encephalomyelitis(EAE) mice model were further explored. The C57BL/6 mice were intragastrically administered with 50 mg/kg of GSE once a day from the 3rd day to the 27th day after immunization. The activation of microglia, the polarization of Th1 and Th17and the inflammatory factors such as tumor necrosis factor-α(TNF-α), interleukin-1β(IL-1β), IL-6, IL-12, IL-17and interferon-γ(IFN-γ) secreted by them were detected in vitro and in vivo by flow cytometry, enzyme linked immunosorbent assay(ELISA), immunofluorescence staining and Western blot, respectively. Results: GSE reduced the secretion of TNF-α, IL-1β and IL-6 in bone marrow-derived macrophages stimulated by lipopolysaccharide(P<0.01), inhibited the secretion of TNF-α, IL-1β, IL-6, IL-12, IL-17 and IFN-γ in spleen cells of EAE mice immunized for 9 days(P<0.05 or P<0.01), and reduced the differentiation of Th1 and Th17 mediated by CD3 and CD28 factors(P<0.01). GSE significantly improved the clinical symptoms of EAE mice, and inhibited spinal cord demyelination and inflammatory cell infiltration. Peripherally, GSE downregulated the expression of toll-like-receptor 4(TLR4) and Rho-associated kinase(ROCKⅡ, P<0.05 or P<0.01), and inhibited the secretion of inflammatory factors(P<0.01 or P<0.05). In the central nervous system, GSE inhibited the infiltration of CD45+CD11b+and CD45+CD4+cells, and weakened the differentiation of Th1 and Th17(P<0.05). Moreover, it reduced the secretion of inflammatory factors(P<0.01), and prevented the activation of microglia(P<0.05). Conclusion: GSE had a beneficial effect on the pathogenesis and progression

关键词： grape seed extract experimental autoimmune encephalomyelitis demyelination inﬂammatory cell inﬂammatory factor

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Reproductive health status of female workers in a railway system and possible influencing factors

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China Medical Abstracts (Internal Medicine) 2017年第4期 201-201页

作者：黎海红 Guangxi Zhuang Autonomous Reg Prev & treat Occup Dis Instit

Objective To investigate the reproductive health status of female workers in a railway system and possible influencing *** From January to June,2016,a cross-sectional epidemiological investigation was performed to collect 2 165 female workers aged 17-55 years.A women’s health questionnaire was used to collect the data on their occupation and health,and their reproduc-

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Retrospective analysis of fasting blood glucose of adults in different water iodine areas in Shanxi Province

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中国医学文摘:内科学分册(英文版) 2023年第2期40卷 83-83页

作者：赵振林 Shanxi Instit Endemic Dis Prev&treat Linfen 041000

Objective To learn about the fasting blood glucose(FBG)level of adults in different water iodine areas in Shanxi Province,and to study the relationship between high iodine intake in drinking water and blood *** The ur... 详细信息

关键词： iodine residents Shanxi

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Clinical characteristics and drug susceptibility test of nontubercous mycobacterial lung disease

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China Medical Abstracts (Internal Medicine) 2020年第1期 41-41页

作者：楼海 Tuberc Diag & treat Center Shanghai Pulm HospTongji Univ

Objective To investigate the clinical characteristics and drug susceptibility test (DST) of patients infected with different nontuberculous mycobacteria (NTM).Methods The patients with nontuberculous mycobacterial lung disease (NMLD) in Shanghai Pulmonary Hospital from March 2014 to March 2015 were studied retrospectively by analyzing the clinical characteristics,radiologi-

关键词： Clinical characteristics and drug susceptibility test of nontubercous mycobacterial lung disease

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Investigate the thyroid function of radiation workers and analysis of influence factors

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China Medical Abstracts(Internal Medicine) 2022年第2期39卷 78-78页

作者： YANG Yong Hangzhou Occup Dis Prev&Treat HospHangzhou 310014

Objective To analyze the thyroid condition and influencing factors of radiation workers,and to provide scientific basis for radiation protection *** In April 2020, 4308 radiation workers from October1,2017 to September 30,2019 were collected for occupational health examination in Hangzhou Occupational Disease Prevention and treatment Hospital, and the data included basic information, thyroid hormone level and thyroid color doppler ultrasound results.

关键词： workers occupational management

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A cohort study on the outcome of multidrug-resistant tuberculosis in elderly patients

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China Medical Abstracts(Internal Medicine) 2014年第2期31卷 99-99页

作者：郝晓晖 Center Tuberc Diag & treat Shanghai Pulmon HospAffil Tongji Univ

Objective To investigate the clinical curative effect and outcomes of multidrug-resistant tuberculosis(MDRTB)in elderly *** Fifty-nine elderly patients with MDR-TB were enrolled from Shanghai Pulmonary Hospital from January 2007 to January 2010,and80 younger patients with MDR-TB during the same period served as the control *** characteristics,out-

关键词： tuberculosis elderly younger curative cohort enrolled served comes incidence mortality

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Biliary tract cancer stem cells-translational options and challenges

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World Journal of Gastroenterology 2017年第14期23卷 2470-2482页

作者： Christian Mayr Matthias Ocker Markus Ritter Martin Pichler Daniel Neureiter Tobias Kiesslich Department of Internal Medicine I Paracelsus Medical University Laboratory for Tumour Biology and Experimental Therapies Institute of Physiology and PathophysiologyParacelsus Medical University Tanslational Medicine Oncology Department of Gastroenterology CBF CharitéUniversity Medicine Berlin Laboratory for Tumour Biology and Experimental Therapies(treat) Laboratory for Functional and Molecular Membrane PhysiologyParacelsus Medical University Department for Radon Therapy Research Ludwig Boltzmann Cluster for Arthritis and RehabilitationInstitute of Physiology and PathophysiologyParacelsus Medical University Research Unit for Non-coding RNA and genome editing in cancer Division of OncologyDepartment of Internal MedicineMedical University of Graz Institute of Pathology Paracelsus Medical University Cancer Cluster Salzburg

Management of biliary tract cancer remains challenging. Tumors show high recurrence rates and therapeutic resistance, leading to dismal prognosis and short survival. The cancer stem cell model states that a tumor is a heterogeneous conglomerate of cells, in which a certain subpopulation of cells-the cancer stem cells-possesses stem cell properties. Cancer stem cells have high clinical relevance due to their potential contributions to development, progression and aggressiveness as well as recurrence and metastasis of malignant tumors. Consequently, reliable identification of as well as pharmacological intervention with cancer stem cells is an intensively investigated and promising research field. The involvement of cancer stem cells in biliary tract cancer is likely as a number of studies demonstrated their existence and the obvious clinical relevance of several established cancer stem cell markers in biliary tract cancer models and tissues. In the present article, we review and discuss the currently available literature addressing the role of putative cancer stem cells in biliary tract cancer as well as the connection between known contributors of biliary tract tumorigenesis such as oncogenic signaling pathways, micro-RNAs and the tumor microenvironment with cancer stem cells.

关键词： Biliary tract cancer cancer stem cells Cancer stem cell markers Tumor microenvironment Micro-RNAs

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