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telencephalic stab wound injury induces regenerative angiogenesis and neurogenesis in zebrafish:unveiling the role of vascular endothelial growth factor signaling and microglia

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Neural Regeneration Research 2025年第10期20卷 2938-2954页

作者： Danielle Fernezelian Philippe Rondeau Laura Gence Nicolas Diotel Universitéde La Réunion INSERMUMR 1188Diabète athérothrombose Thérapies Réunion Océan Indien(DéTROI)Saint PierreLa RéunionFrance

After brain damage,regenerative angiogenesis and neurogenesis have been shown to occur simultaneously in mammals,suggesting a close link between these ***,the mechanisms by which these processes interact are not well *** this work,we aimed to study the correlation between angiogenesis and neurogenesis after a telencephalic stab wound *** this end,we used zebrafish as a relevant model of neuroplasticity and brain repair ***,using the Tg(fli1:EGFP×mpeg1.1:mCherry)zebrafish line,which enables visualization of blood vessels and microglia respectively,we analyzed regenerative angiogenesis from 1 to 21 days *** parallel,we monitored brain cell proliferation in neurogenic niches localized in the ventricular zone by using *** found that after brain damage,the blood vessel area and width as well as expression of the fli1 transgene and vascular endothelial growth factor(vegfaa and vegfbb)were *** the same time,neural stem cell proliferation was also increased,peaking between 3 and 5 days post-lesion in a manner similar to angiogenesis,along with the recruitment of ***,through pharmacological manipulation by injecting an anti-angiogenic drug(Tivozanib)or Vegf at the lesion site,we demonstrated that blocking or activating Vegf signaling modulated both angiogenic and neurogenic processes,as well as microglial ***,we showed that inhibition of microglia by clodronate-containing liposome injection or dexamethasone treatment impairs regenerative neurogenesis,as previously described,as well as injury-induced *** conclusion,we have described regenerative angiogenesis in zebrafish for the first time and have highlighted the role of inflammation in this *** addition,we have shown that both angiogenesis and neurogenesis are involved in brain repair and that microglia and inflammation-dependent mechanisms activated by Vegf signaling are important contributors to

关键词： angiogenesis cerebral damage inflammation neurogenesis stab wound telencephalon vascular endothelial growth factor zebrafish

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BLOW-UP OF POSITIVE SOLUTIONS OF A SEMILINEAR HEAT EQUATION

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Acta Mathematica Scientia 1993年第1期13卷 33-38页

作者：王明新 ACAD SINICA INST SYST SCISBEIJING 100080PEOPLES R CHINA

The initial value problem in R(n) in discussed, [GRAPHICS] where p > 1. It is well known that the solution u(x,t) blows up in finite time for some initial values phi. In this paper, it is proved that the blow-up occur... 详细信息

关键词： radial giving funct equil 日主于产诚书七公川七气主

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STRAIN REGULARITY IN REINFORCERS OF SHORT-FIBER/ WHISKER REINFORCED COMPOSIte AND ITS APPLICATION

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Chinese Journal of Aeronautics 2000年第4期13卷 204-210页

作者：王迺鹏刘秋云刘晓宇 stt. Key Lab. Nonlinear Mechanics Institute of Mechanics CAS Beijing 100080 China

Based on the study of strain distribution in short-fiber/whisker reinforced metal matrix composites, a deformation characteristic parameter λ is defined as the ratio of the root-mean-square strain of reinforcers to the macro-linear strain along the same direction. Quantitative relation between λ and microstructure parameters of the composite is obtained. As an example of applying and verifying λ, the stress-strain curve of ［AlBO］w/Al composite under tensile loading is predicted and favorably compared with experiments. By using λ, the stiffness modulus of the composite with arbitrary reinforcer orientation under any loading condition is predicted from the microstructure parameters of material.

关键词： short-fiber/whisker reinforced composite strain distribution stiffness prediction

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ON DEteRMINATION OF SOURCE teRMS IN THE 2ND ORDER LINEAR PARITAL DIFFERENTIAL EQUATIONS

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Acta Mathematica Scientia 1993年第1期13卷 23-32页

作者：喻文焕 Dept. of Comput. & Scys. scis. Nankai Univ. Tianjin 300071 China

In this paper we consider the existence of the solution to the inverse problem identifying the function pair (q, u) satisfyingUsing the fixed point theory, we obtain the definite answer to the above-mentioned problem ... 详细信息

关键词： answer inverse identifying hyperbolic elliptic definite operators mentioned SOURCE operations

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INITIAL VALUE PROBLEM FOR HIGH DIMENSIONAL DYNAMIC SYSteMS

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Applied Mathematics and Mechanics(English Edition) 1995年第3期16卷 279-282页

作者：朱长江 Inst. of Math. scis. Academia Sinica Wuhan

In this paper. we prove the existence of the global classical solutions and the uniform stability of the zero solution to the initial value problem for a class of high dimensional dynamic systems which contain the deg... 详细信息

关键词： maximum principle. global classical solution uniform stability

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Optical properties of titanium oxide films obtained by cathodic arc plasma deposition

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Plasma Science and technology 2017年第12期19卷 111-118页

作者： Vukoman JOKANOVIC Bozana COLOVIC Anka TRAJKOVSKA PETKOSKA Ana MRAKOVIC Bojan JOKANOVIC Milo NENADOVIC Manuela FERRARA llija NASOV Vinca Institute of Nuclear Sciences University of BelgradeMike Petrovica Alasa 12-1411001 BelgradeSerbia ALBOS Doo Orahovacka 1911000 BelgradeSerbia University St Kliment Ohridski Faculty of Technology and Technical SciencesVelesR.Macedonia4 GL groupWemer-von-Siemens-Straβe86405 MetingenGermany GL group Wemer-von-Siemens-Straβe86405 MetingenGermany te-stt-scis Laboratorio Sviluppo Componenti ed Impianti SolariPiazzale Enrico Fermi 180055Porfici(NA)Italia Plasma Doo 29 November 66/91000 SkopjeR.Macedonia

Structural and optical properties of nanometric titanium oxide（TixOy） films obtained by cathodic arc plasma deposition were investigated. Phase analysis by x-ray diffraction and Fouriertransform infrared spectroscopy showed the presence of anatase, rutile, Ti_2O_3, Ti_4O_7 and amorphous phases. Scanning electron microscopy images showed well-developed surface morphology with nano-patterns. Spectroscopic ellipsometry revealed film thicknesses of 53 and50 nm, variable refractive indices dependent on the light wavelength and close to zero extinction coefficients for wavelengths higher than 500 nm. On the basis of ultraviolet–visible spectroscopy data and using the Tauc equation, band gap values for direct and indirect electron transitions were determined.

关键词： optical materials plasma deposition thin films ellipsometry

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Synthesis,X-Ray Structure and Characterization of a Triruthenium Cluster Complex Ru3Ⅲ（μ3-O）(μ-CH3COO)6（py）2Cl with Four Steps One-electron Redox Processes

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Chinese Chemical Letters 2003年第5期14卷 519-522页

作者： Jing Lin CHEN, Gang Qiang YIN, Zhong Ning CHEN* State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Fuzhou 350002 stt. Key Lab. of Struct. Chemistry Fujian Inst. Res. Struct. of Matter Fuzhou 350002 China

The synthesis and crystal structure of oxo-centered carboxylate-bridge trinuclear ruthenium complex, Ru3O(CH3COO)6(py)2Cl (py = pyridine) (1), are reported herein. The complex 1 has been characterized by IR, cyclic voltammetry (CV), UV-Vis and X-ray crystal analysis. The complex 1 in 0.1 mol/L (n-C4H9)4NPF6-CH2Cl2 solution at room temperature shows four one- electron redox processes at E1/2 = -1.38, -1.20, -0.17 and 1.07 V vs. Ag/AgCl.

关键词： Crystal structure ruthenium carboxylate electrochemistry.

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Determination of Helmert transformation parameters for continuous GNSS networks:a case study of the Géoazur GNSS network

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Geo-Spatial Information Science 2023年第1期26卷 125-138页

作者： Dinh Trong Tran Jean-Mathieu Nocquet Ngoc Dung Luong Dinh Huy Nguyen Department of Geodesy and Geomatics Engineering Hanoi University of Civil EngineeringHanoiVietnam UniversitéCôte d’Azur CNRSObservatoire de la Côte d’AzurIRDValbonneFrance

In this paper,we propose an approach to determine seven parameters of the Helmert transfor-mation by transforming the coordinates of a continuous GNSS network from the World Geodetic System 1984(WGS84)to the International terrestrial Reference *** includes(1)convert-ing the coordinates of common points from the global coordinate system to the local coordinate system,(2)identifying and eliminating outliers by the Dikin estimator,and(3)estimating seven parameters of the Helmert transformation by least squares(LS)estimation with the“clean”data(*** removed).Herein,the local coordinate system provides a platform to separate points’horizontal and vertical ***,the Dikin estimator identifies and eliminates outliers in the horizontal or vertical component *** is significant because common points in a continuous GNSS network may contain *** proposed approach is tested with the Géoazur GNSS network with the results showing that the Dikin estimator detects outliers at 6 out of 18 common points,among which three points are found with outliers in the vertical compo-nent ***,instead of eliminating all coordinate components of these six common points,we only eliminate all coordinate components of three common points and only the vertical component of another three common ***,the classical LS estimation is applied to“clean”data to estimate seven parameters of the Helmert transformation with a significant accuracy *** Dikin estimator’s results are compared to those of other robust estimators of Huber and Theil-Sen,which shows that the Dikin estimator performs ***,the weighted total least-squares estimation is implemented to assess the accuracy of the LS estimation with the same *** inter-comparison of the seven estimated parameters and their standard deviations shows a small difference at a few per million levels(E-6).

关键词： Continuous GNSS tectonic geodesy Dikin estimation Helmert transformation

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Effects of Andrade and Burgers rheologies on glacial isostatic adjustment modeling in Antarctica

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Geodesy and Geodynamics 2024年第5期15卷 429-440页

作者： Alexandre Boughanemi Anthony Mémin UniversitéCôte d'Azur CNRSObservatoire de la Côte d'AzurIRDGéoazur250 rue Albert EinsteinSophia Antipolis 06560 ValbonneFrance

Variations in ice mass deform the Earth and modify its gravity field,a process known as Glacial Isostatic Adjustment(GIA).GIA in Antarctica remains poorly constrained due to the cumulative effect of past and present ice-mass changes,the unknown history of the past ice-mass change,and the uncertainties on the mechanical properties of the *** paper investigates the effect of using Andrade and Burgers viscoelastic rheologies,rather than the commonly used Maxwell rheology,to model GIA-induced deformation in *** Love number and Green's function formalism are used to compute the radial surface displacements and the gravity changes induced by the past and present ice-mass *** consider an Earth model whose elastic properties and radial structure are averaged from the Preliminary Reference Earth Model and two viscosity profiles to account for the recently published results on the present ice-mass *** the three rheological laws affects the temporal response of the Earth differently,leading to smaller discrepancies than those induced by the two viscosity *** differences are the largest between Maxwell and Burgers rheologies during the 100-1000 years following the beginning of the surface-mass *** show that using the Andrade and Burgers rheologies allows the Earth to respond on decennial to centennial time scales,up to 10 m more than *** only the recent ice-mass changes,the deformation rates derived from Burgers and Andrade rheologies are several times larger than those estimated by Maxwell rheology.

关键词： GIA Antarctica Modeling Rheology Displacement Viscosity GNSS

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team experience of nasopharyngeal samples reception,decontamination,and sorting during the COVID-19 pandemic(2020)at Institut Pasteur Côte d’Ivoire

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Journal of Biosafety and Biosecurity 2021年第2期3卷 120-124页

作者： KouaméInnocent Kolia KipréBertin Guédé Kan Stéphane Kouassi Koby Albert Obro Kpadraux Danielle Odegue Sylvie Mireil Sina-Kouaméle Banga Victor Yepri Mireille Dosso Molecular Biology Platform/Institut Pasteur Côte d’Ivoire Central Laboratory/University Hospital Center of Yopougon(Côte d’Ivoire)Cote d’Ivoire Bacteriology and Virology Department National Reference Center for Antibiotics/Institut Pasteur Côte d’IvoireCôte d’Ivoire Molecular Biology Platform/Institut Pasteur Côte d’Ivoire Côte d’Ivoire Cell Biology Unit/Institut Pasteur Côte d’Ivoire Côte d’Ivoire Transport and packaging unit/Institut Pasteur Côte d’Ivoire Côte d’Ivoire Institut Pasteur Côte d’Ivoire Côte d’Ivoire

Molecular testing sensitivity,which allows for early diagnosis of the 2019 coronavirus disease(COVID-19),could be affected by sample quality,storage,and transportation timeframe to the laboratory,along with bias related to the pre-analytic *** present study reports the selection and decontamination of nasopharyngeal samples during COVID-19 management at the Institut Pasteur Côte d’*** objective of this work was to organize sample reception management and report a complete picture of sample selection and decontamination in the context of diagnosis activity *** administrative note creating the selection and decontamination unit of nasopharyngeal samples initiated activities in May *** required human resources and necessary materials were identified and put in *** activity consisted of receiving,sorting,decontaminating,and sending nasopharyngeal samples to different diagnostic *** were recorded *** a six-month period of activities,from a total amount of 11,401 containers received and decontaminated,174,085 samples were selected.A proportion of 92.0%of these specimens met the diagnostic standards,while 7.0%that were found acceptable showed minor ***,a rate of 1.0%of samples with major abnormalities could not be used for COVID-19 testing and,therefore,were ***,the non-conformity rate was reduced by 2.4%after the first term *** and decontamination of nasopharyngeal samples are crucial steps in biosafety optimization for the technical staff and quality improvement of sample care.

关键词： Sorting and decontamination Nasopharyngeal sample COVID-19 Côte d’Ivoire

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