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Generating genuine multipartite entanglement via XY-interaction and via projective measurements

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Chinese Physics B 2014年第12期23卷 59-65页

作者： Mazhar Ali Department of Electrical Engineering COMSATS Institute of Information Technology22060 Abbottabad Pakistan Naturwissenschaftlich-technische Fakultt Universitt SiegenWalter-Flex-Straβe 357068 Siegen Germany

We have studied the generation of multipartite entangled states for the superconducting phase qubits. the experiments performed in this direction have the capacity to generate several specific multipartite entangled states for three and four qubits. Our studies are also important as we have used a computable measure of genuine multipartite entanglement whereas all previous studies analyzed certain probability amplitudes. As a comparison, we have reviewed the generation of multipartite entangled states via von Neumann projective measurements.

关键词： genuine multipartite entanglement superconducting qubits von Neumann measurements

Handheld diffuse optical breast scanner probe for cross-sectional imaging of breast tissue

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Journal of Innovative Optical Health Sciences 2019年第2期12卷 74-85页

作者： Majid Shokoufi Farid Golnaraghi School of Mechatronic Systems Engineering Simon Fraser University 250-13450102nd Avenue SurreyCanadaBC V3T 0A3

Diffuse optical spectroscopy is a relatively new,noninvasive and nonionizing technique for breast cancer *** the present study,we have introduced a novel handheld diffuse optical breast scan(DOB-Scan)probe to measure optical properties of the breast in vivo and create functional and compositional images of the *** addition,the probe gives more information about breast tissue's constituents,which helps distinguish a healthy and cancerous *** symmetrical light sources,each including four different wavelengths,are used to illuminate the breast tissue.A high-resolution linear array detector measures the intensity of the back-scattered photons at different radial destinations from the illumination sources on the surface of the breast tissue,and a unique image reconstruction algorithm is used to create four cross-sectional images for four different *** fromfiber optic-based illumination techniques,the proposed method in this paper integrates multi-wavelength light-emitting diodes to act as pencil beam sources into a scattering medium like breast *** unique design and its compact structure reduce the complexity,size and cost of a potential *** the introduced technique miniaturizes the probe,this study points to the reliability of this technique in the phantom study and clinical breast *** have received ethical approval to test the DOB-Scan probe on patients and we are currently testing the DOB-Scan probe on subjects who are diagnosed with breast cancer.

关键词： Breast cancer diffuse optical spectroscopy image reconstruction techniques medical and biological imaging optical breast phantom

A CK2-RNF4 interplay coordinates non-canonical SUMOylation and degradation of nuclear receptor FXR

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Journal of Molecular Cell Biology 2017年第3期9卷 195-208页

作者： Stephanie Bilodeau Veronique Caron Jonathan Gagnon Alexandre Kuftedjian Andre tremblay Research Center CHU Sainte-Justine Montreal Quebec H3T 1C5 Canada Department of Biochemistry and Molecular Medicine Faculty of Medicine University of Montreal Montreal Quebec H3T 1J4 Canada Department of Obstetrics & Gynecology Faculty of Medicine University of Montreal Montreal Quebec H3T 1J4 Canada

Farnesoid X receptor （FXR） is a ligand-activated nuclear receptor that plays a central role in regulating genes involved in bile acid homeostasis, and fat and glucose metabolism. Here, we demonstrate a post-translational interplay between FXR phosphoryl- ation, SUMOylation, and ubiquitination that directs the receptor into an activation-degradation pathway in hepatocytes. We iden- tify a non-canonical SUMOylation motif termed pSuM that conjugates SUM02 at Lys-325 of FXR under the direct control of casein kinase 2 （CK2）, which provides the required negative charge for Ubc9 and PIAS1 to perform SUMOylation, by phosphorylating Ser-327. Lys-325 SUMOylation is indispensable to the promotion of efficient ligand activation and transcriptional coactivation of FXR. Constitutive pSuM activation using a phospho-mimic Ser-327 mutant or catalytic CK2 expression strongly induces SUM02 conjugation, which directs FXR ubiquitination and proteasome-dependent degradation. We also determine that such SUMOylation-dependent ubiquitination of FXR is mediated by the E3 ubiquitin ligase RNF4, which is required to achieve maximal induction of FXR and optimal up- or downregulation of responsive genes involved in bile acid homeostasis and liver regeneration. Our findings identify a highly regulated atypical SUMO conjugation motif that serves to coordinate FXR transcriptional compe- tence, thereby expanding the intricate dynamics of the SUMOylation process used by incoming signals to govern metabolic gene regulation.

关键词： farnesoid receptor SUMOylation ubiquitination 26S proteasome bile acid

Immunocamouflage of latex surfaces by grafted methoxypoly(ethylene glycol)(mPEG):Proteomic analysis of plasma protein adsorption

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Science China(Life Sciences) 2012年第3期55卷 191-201页

作者： LE Yevgeniya LI Li WANG DunCheng SCOtt Mark D Canadian Blood Services Vancouver V6T 1Z3 Canada Centre for Blood Research University of British Columbia Vancouver V6T 1Z3 Canada Department of Pathology and Laboratory Medicine University of British Columbia Vancouver V6T 1Z3 Canada

Grafting of methoxypoly(ethylene glycol)(mPEG) to cells and biomaterials is a promising non-pharmacological immunomodulation ***,due to the labile nature of cells,surface-plasma interactions are poorly understood;hence,a latex bead model was *** of beads resulted in a density and molecular weight dependent decrease in total adsorbed protein with a net reduction from(159.9±6.4) ng cm-2 on bare latex to(18.4±0.8) and(52.3±5.3) ng cm-2 on PEGylated beads(1 mmol L-1 of 2 or 20 kD SCmPEG,respectively).SDS-PAGE and itRAQ-MS analysis revealed differential compositions of the adsorbed protein layer on the PEGylated latex with a significant reduction in the compositional abundance of proteins involved in immune system ***,the biological efficacy of immunocamouflaged cells and materials is mediated by both biophysical obfuscation of antigens and reduced surface-macromolecule interactions.

关键词： PEGylation immunocamouflage itRAQ mass spectrometry polystyrene latex protein adsorption proteomics meth-oxypoly(ethylene glycol) polymer

tHE EFFECt OF BORON AND CARBON ADDItION ON WELDABILItY OF DS tMS-75 SUPERALLOY

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Acta Metallurgica Sinica(English Letters) 2005年第1期18卷 24-32页

作者： M.C. Chaturvedi N.L. Richards Department of Mechanical and Industrial Engineering University of Manitoba Winnipeg Manitoba R3T 5V6 CanadaDepartment of Mechanical and Industrial Engineering University of Manitoba Winnipeg Manitoba R3T 5V6 Canada

Four alloys tMS-75 (Base), Base+B, Base+C and tMD-103 (Base+B+C) with varying levels of B, C were directionally solidified (DS), and their weldability was investigated by bead-on-plate electron beam welding. It was found that cracking occurred in the weld-metal, as well as in the heat affected zone (HAZ). Both γ/γ' and/or γ/carbide eutectic contributed to the weld-metal cracking, and the γ/γ' eutectic was found to be mainly responsible for cracking in HAZ. However, constitutional liquation of carbides seems to have made some contribution also. the B addition had a detrimental effect on HAZ cracking susceptibility, while C addition improved it appreciably even in the presence of B. In addition, no obvious differences were observed in cracking susceptibility of weld-metal in the four alloys. the cracking modes and mechanisms underlying the effect of B and C addition on weldability could be explained on the basis of microstructures of the four alloys.

关键词： Ni-based superalloy low melting point constituents liquation cracking

Evacuating a First Nation Due to Wildfire Smoke:the Case of Dene tha’ First Nation

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International Journal of Disaster Risk Science 2020年第3期11卷 274-286页

作者： Kyla D.Mottershead tara K.McGee Amy Christianson Department of Earth and Atmospheric Sciences University of AlbertaEdmontonAB T6G 2E3Canada Canadian Forest Service Northern Forestry CentreEdmontonAB T6H 3S5Canada

Almost every year,First Nations are evacuated in Canada because of wildfire proximity and *** of wildfires,and remote locations,unique sociocultural characteristics,and limited emergency management resources present challenges for evacuation organizers and *** study explores how Dene tha’First Nation evacuated their tachécommunity in July 2012 due to wildfire smoke and how the evacuation process affected *** were completed with 31 evacuation organizers and residents to examine the factors that helped and hindered the evacuation *** of information about the nearby wildfire,smoke,and evacuation of the nearby small community of Zama City,combined with a generic evacuation plan,delayed and posed challenges during the evacuation of this Dene tha’*** leadership and its role in community organizing,keeping families together,providing the social support they needed,and using familiar host communities,demonstrated and contributed to the community’s resilience during the *** to improve evacuations and emergency management in the community and other First Nations in Canada are identified and discussed.

关键词： Community resilience Evacuation planning First Nations Indigenous peoples Wildfire smoke

Exploring bouncing cosmologies with cosmological surveys

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Science China(Physics,Mechanics & Astronomy) 2014年第8期57卷 1414-1430页

作者： CAI Yi-Fu Department of Physics McGill UniversityMontréal QC H3A 2T8 Canada

From recent observational data two significant directions have been made in the field of theoretical cosmology recently. First, we are now able to make use of present observations, such as the Planck and BICEP2 data, to examine theoretical predictions from the standard inflationary ACDM which were made decades of years ago. Second, we can search for new cosmological signatures as a way to explore physics beyond the standard cosmic paradigm. In particular, a subset of early universe models admit a nonsingular bouncing solution that attempts to address the issue of the big bang singularity. these models have achieved a series of considerable developments in recent years, in particular in their perturbative frameworks, which made brand-new predictions of cosmological signatures that could be visible in current and forthcoming observations. Herein we present two representative paradigms of early universe physics. the first is the reputed new matter （or matter-ekpyrotic） bounce scenario in which the universe starts with a matter-dominated contraction phase and transitions into an ekpyrotic phase. In the setting of this paradigm, we have proposed some possible mechanisms of generating a red tilt for primordial curvature perturbations and confront the general predictions with recent cosmological observations. the second is the matter-bounce inflation scenario which can be viewed as an extension of inflationary cosmology with a matter contraction before inflation. We present a class of possible model constructions and review the implications on the current CMB experiments. Lastly a review of significant achievements of these paradigms beyond the inflationary ACDM model is made, which is expected to shed new light on the future direction of observational cosmology.

关键词： bouncing cosmology big bang singularity CMB observations

3D bioprinting for biomedical devices and tissue engineering: A review of recent trends and advances

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Bioactive Materials 2018年第2期3卷 144-156页

作者： Soroosh Derakhshanfar Rene Mbeleck Kaige Xu Xingying Zhang Wen Zhong Malcolm Xing Department of Mechanical Engineering University of ManitobaWinnipegR3T 2N2Canada Department of Biosystems Engineering University of ManitobaWinnipegR3T 2N2Canada

3D printing,an additive manufacturing based technology for precise 3D construction,is currently widely employed to enhance applicability and function of cell laden *** on novel compatible biomaterials for bioprinting exhibiting fast crosslinking properties is an essential prerequisite toward advancing 3D printing applications in tissue *** to improve fabrication process and cell encapsulation are two of the main factors to be considered in development of 3D *** important factors include but are not limited to printing fidelity,stability,crosslinking time,biocompatibility,cell encapsulation and proliferation,shear-thinning properties,and mechanical properties such as mechanical strength and *** this review,we recite recent promising advances in bioink development as well as bioprinting ***,an effort has been made to include studies with diverse types of crosslinking methods such as photo,chemical and ultraviolet(UV).We also propose the challenges and future outlook of 3D bioprinting application in medical sciences and discuss the high performance bioinks.

关键词： Bioprinting Hydrogel Extrusion Inkjet Stereolithography Laser-assisted Review 3D printing

Efficiency and superefficiency in one-parameter two-sided truncated distribution families

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Chinese Science Bulletin 1997年第21期42卷 1771-1774页

作者： James C. Fu Department of Statistics University of Manitoba Winnipeg R3T 2N2 Canada

whereθis an unknown parameter, φ(θ) is a continuous differentiable function such that θ0, θ∈R, and f(x;θ) is a positive continuous density func-tion on [θ,φ(θ)]. the one-parameter two-sided truncated distrib... 详细信息

whereθis an unknown parameter, φ(θ) is a continuous differentiable function such that θ<φ(θ), s(θ)=dφ(θ)/dθ>0, θ∈R, and f(x;θ) is a positive continuous density func-tion on [θ,φ(θ)]. the one-parameter two-sided truncated distribution families (1)

关键词： one-parameter two-sided truncated family super-efficiency a new efficiency asymptotically median unbiased efficient estimate.