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E674Q(Shanghai APP mutant),a novel amyloid precursor protein mutation,in familial late-onset Alzheimer's disease

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Genes & Diseases 2024年第2期11卷 1022-1034页

作者： Yongfang Zhang Xinyi Xie Boyu Chen Lina Pan Jianping Li Wanbing Wang Jintao Wang Ran Tang Qiang Huang Xiaofen Chen Rujing Ren Zhentao Zhang Wei Fu Gang Wang Department of Neurology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Medicinal Chemistry School of PharmacyFudan UniversityShanghai 201203China Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research Institute of NeuroscienceSchool of MedicineXiamen UniversityXiamenFujian 361102China Shenzhen Research Institute of Xiamen University ShenzhenGuangdong 518063China

Identified as the pathogenic genes of Alzheimer's disease(AD),APP,PSEN1,and PSEN2 mainly lead to early-onset AD,whose course is more aggressive,and atypical symptoms are more common than sporadic ***,a novel missense mutation,APP E674Q(also named“Shanghai APP”),was detected in a Chinese index patient with typical late-onset AD(LOAD)who developed memory decline in his *** results from neuroimaging were consistent with AD,where widespread amyloidβdeposition was demonstrated in 18 F-florbetapir Positron Emission Tomography(PET).APP E674Q is close to theβ-secretase cleavage site and the well-studied swedish APP mutation(KM670/671NL),which was predicted to be pathogenic in *** dynamics simulation indicated that the E674Q mutation resulted in a rearrangement of the interaction mode between APP and BACE1 and that the E674Q mutation was more prone to cleavage by *** in vitro results suggested that the E674Q mutation was pathogenic by facilitating the BACE1-mediated processing of APP and the production of Aβ.Furthermore,we applied an adeno-associated virus(AAV)-mediated transfer of the human E674Q mutant APP gene to the hippocampi of two-month-old C57Bl/6 J ***-E674Q-injected mice exhibited impaired learning behavior and increased pathological burden in the brain,implying that the E674Q mutation had a pathogenicity that bore a comparison with the classical swedish ***,we report a strong amyloidogenic effect of the E674Q substitution in *** our knowledge,E674Q is the only pathogenic mutation within the amyloid processing sequence causing LOAD.

关键词： Alzheimer's disease Amyloid beta APP mutation E674Q Late onset

Structural design and mechanical performance of composite vascular grafts

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Bio-Design and Manufacturing 2022年第4期5卷 757-785页

作者： Abdul Wasy Zia Rong Liu Xinbo Wu school of Fashion and textiles The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARChina

This study reviews the state of the art in structural design and the corresponding mechanical behaviours of composite vascular grafts. We critically analyse surface and matrix designs composed of layered, embedded, and hybrid structures along the radial and longitudinal directions;materials and manufacturing techniques, such as tissue engineering and the use of textiles or their combinations;and the corresponding mechanical behaviours of composite vascular grafts in terms of their physical–mechanical properties, especially their stress–strain relationships and elastic recovery. The role of computational studies is discussed with respect to optimizing the geometrics designs and the corresponding mechanical behaviours to satisfy specialized applications, such as those for the aorta and its subparts. Natural and synthetic endothelial materials yield improvements in the mechanical and biological compliance of composite graft surfaces with host arteries. Moreover,the diameter, wall thickness, stiffness, compliance, tensile strength, elasticity, and burst strength of the graft matrix are determined depending on the application and the patient. For composite vascular grafts, hybrid architectures are recommended featuring multiple layers, dimensions, and materials to achieve the desired optimal flexibility and function for complying with user-specific requirements. Rapidly emerging artificial intelligence and big data techniques for diagnostics and the threedimensional(3D) manufacturing of vascular grafts will likely yield highly compliant, subject-specific, long-lasting, and economical vascular grafts in the near-future.

关键词： Vascular grafts Surface design Structural design Composite materials Mechanical properties

Recent Advances in Superhydrophobic and Antibacterial Cellulose‑Based Fibers and Fabrics:Bio‑inspiration,Strategies,and Applications

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Advanced Fiber Materials 2023年第5期5卷 1555-1591页

作者： Hua Zhou Qingshuo Li Zhong Zhang Xungai Wang Haitao Niu College of textiles and Clothing Qingdao UniversityQingdao 266071China Collaborative Innovation Center for Eco‑textiles of Shandong Province and the Ministry of Education Collaborative Qingdao UniversityQingdao 266071China JC STEM Lab of Sustainable Fibers and textiles School of Fashion and TextilesThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

Cellulose-based fabrics are ubiquitous in our daily *** are the preferred choice for bedding materials,active sportswear,and next-to-skin ***,the hydrophilic and polysaccharide characteristics of cellulose materials make them vulnerable to bacterial attack and pathogen *** design of antibacterial cellulose fabrics has been a long-term and on-going *** strategies based on the construction of surface micro-/nanostructure,chemical modification,and the application of antibacterial agents have been extensively investigated by many research groups *** review systematically discusses recent research on super-hydrophobic and antibacterial cellulose fabrics,focusing on morphology construction and surface ***,natural surfaces showing liquid-repellent and antibacterial properties are introduced and the mechanisms behind are ***,the strategies for fabricating super-hydrophobic cellulose fabrics are summarized,and the contribution of the liquid-repellent function to reducing the adhesion of live bacteria and removing dead bacteria is *** studies on cellulose fabrics functionalized with super-hydrophobic and antibacterial properties are discussed in detail,and their potential applications are also ***,the challenges in achieving super-hydrophobic antibacterial cellulose fabrics are discussed,and the future research direction in this area is proposed.

关键词： Cellulose fiber Super-hydrophobic Antibacterial Fabrication strategies Applications

Atmospheric-pressure Air Plasma Treatment of Polyester Fabrics for Inkjet Printing with Pigment Inks

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Journal of Donghua University(English Edition) 2009年第4期26卷 429-434页

作者：张春明房宽峻沈安京 Key Laboratory for Eco-textiles Ministry of EducationSchool of Textiles & ClothingJiangnan University Laboratory of Fiber Materials and Modern textiles The Growing Base for State Key LaboratoryQingdao University Shanghai Textile Research Institute

Without any preprocessing,polyester fabric has lower ability to hold on water and inks due to the smooth morphology of polyester fibers. Therefore, patterns directly printed with pigment inks have poor color yields and bleed easily. Pretreatments of polyester fabric were carried out with atmospheric air plasma under different experimental conditions. After plasma treatment the samples were printed with magenta pigment ink. Scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS) analyses indicated that the enhanced color performance was mainly contributed by not only the etching effect but also oxygen-containing polar groups induced onto fiber surfaces through plasma treatment. Thereby the surface modification of polyester fabrics using atmospheric-pressure air plasma offers a potential way to fabric pretreatment for pigment inkjet printing with the advantages of environmental friendly and energy saving over traditional pretreatment methods.

关键词： inkjet printing surface'modified plasma polyester fabric SEM XPS

Study on How to Design Knitted Fabric Pattern with Mathematical Theory

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Journal of Donghua University(English Edition) 2009年第2期26卷 204-206页

作者：陈莉张蕊叶介茂 school of textiles Tianjin Polytechnic University Tianjin Transportation Vocational College

To improve design capabilities for the knitted fabric pattern,a preliminary study is carried out for the design *** on mathematical theory,pattern could be created automatically by computer with inputting different parameters for mathematical *** knitted fabric simulation is realized by M1 CAD pattern preparation system of STOLL *** the pattern,different color unit is replaced by obverse stitch with different color,or by obverse stitch and reverse stitch with the same color separately,after that the effects of knitted fabrics could be *** with this method,it would not only help to acquire a great of diversity patterns,but also improve design efficiency and save cost.

关键词： knitted fabric mathematical theory patterndesign CAD fabric simulation

Tensile Behavior of the Flax/Polyester Composites after Water Treatment

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Journal of Donghua University(English Edition) 2010年第4期27卷 496-500页

作者：王秋红黄故 school of textiles Tianjin Polytechnic University school of Textile and Light Industry Dalian Polytechnic University

With flax fabric as the reinforcement and unsaturated polyester as the matrix,composites of two,three,and four layers were fabricated respectively by the vacuum assisted resin infusion(VARI)*** strength of the composites after being saturated in the water for different durations was *** tensile strength of the two-layer composites was decreased after being soaked in the water for two,three,and six month,*** the three and four layers specimens,the tensile strength was decreased initially with water *** reaching the minimum,the tensile strength was *** electron microscopy(SEM)confirmed that it might be contributed to the thickness of the two-layer *** thinner specimen is easier to be damaged by the penetrated moisture owing to the delamination between the fiber and the matrix after water *** the three and four layers specimens,their contradictory tensile strength suggests that the thicker specimen can delay the moisture permeation and is of better water durability.

关键词： flax/polyester composites water treatment tensile strength

Thermally Conductive and UV-EMI Shielding Electronic textiles for Unrestricted and Multifaceted Health Monitoring

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Nano-Micro Letters 2024年第10期16卷 149-162页

作者： Yidong Peng Jiancheng Dong Jiayan Long Yuxi Zhang Xinwei Tang Xi Lin Haoran Liu Tuoqi Liu Wei Fan Tianxi Liu Yunpeng Huang Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122People's Republic of China

Skin-attachable electronics have garnered considerable research attention in health monitoring and artificial intelligence domains,whereas susceptibility to elec-tromagnetic interference(EMI),heat accumulation issues,and ultraviolet(UV)-induced aging problems pose significant constraints on their potential ***,an ultra-elas-tic,highly breathable,and thermal-comfortable epidermal sensor with exceptional UV-EMI shielding performance and remarkable thermal conductivity is developed for high-fidelity monitoring of multiple human electrophysiological *** filling the elastomeric microfibers with thermally conductive boron nitride nanoparticles and bridging the insulating fiber interfaces by plating Ag nanoparticles(NPs),an interwoven thermal con-ducting fiber network(0.72 W m^(-1) K^(-1))is constructed benefiting from the seamless thermal interfaces,facilitating unimpeded heat dissipation for comfort skin *** excitingly,the elastomeric fiber substrates simultaneously achieve outstanding UV protection(UPF=143.1)and EMI shielding(SET>65,X-band)capabilities owing to the high electrical conductivity and surface plasmon resonance of Ag ***,an electronic textile prepared by printing liquid metal on the UV-EMI shielding and thermally conductive nonwoven textile is finally utilized as an advanced epidermal sensor,which succeeds in monitoring different electrophysiological signals under vigorous electromagnetic *** research paves the way for developing protective and environmentally adaptive epidermal electronics for next-generation health regulation.

关键词： Skin electronics Thermal regulating textiles Electromagnetic interference shielding Ultraviolet proof Health monitoring

一种可抑制脓毒症的促愈合短链抗菌肽（英文）

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Science China Materials 2024年第11期67卷 3727-3741页

作者：任泽凯丁鑫王玉梅吴晗刘鑫曹阳丛海林申有青于冰 College of Chemistry and Chemical Engineering College of Materials Science and EngineeringInstitute of Biomedical Materials and EngineeringQingdao University State Key Laboratory of Bio-Fibers and Eco-textiles Qingdao University school of Materials Science and Engineering Shandong University of Technology Key Laboratory of Biomass Chemical Engineering of Ministry of Education Center for Bionanoengineeringand Department of Chemical and Biological EngineeringZhejiang University

慢性伤口遭遇多药耐药菌感染是致命的,严重者会引发脓毒症.抗菌肽的广谱抗菌特性和良好的抗耐药性被广泛用于伤口护理领域.我们以SiO2微球为固定相,提取细菌的细胞膜制备细菌细胞膜色谱（BCMC）.固相法合成抗菌肽文库并经BCMC筛选出抗菌... 详细信息

慢性伤口遭遇多药耐药菌感染是致命的,严重者会引发脓毒症.抗菌肽的广谱抗菌特性和良好的抗耐药性被广泛用于伤口护理领域.我们以SiO2微球为固定相,提取细菌的细胞膜制备细菌细胞膜色谱（BCMC）.固相法合成抗菌肽文库并经BCMC筛选出抗菌肽LKAHR （简称LS5）.LS5具有生物安全、广谱抗菌以及抗耐药性等特点,制备明胶基抗菌水凝胶（LS5-gel）以更好应用于伤口.在伤口愈合模型中发现LS5-gel具有良好的体内杀菌性能以及促进伤口愈合能力.在脓毒症模型中发现LS5对脓毒症感染具有明显的抑制作用.本工作对下一代抗菌药物的选取及慢性伤口愈合治疗具有重要指导意义.

关键词： antimicrobial peptide chronic wounds sepsis antimicrobial hydrogel chronic wound healing

Enhanced visible-light photoelectrochemical performance via chemical vapor deposition of Fe2O3 on a WO3 film to form a heterojunction

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Rare Metals 2020年第7期39卷 841-849页

作者： Yi-Fei Zhang Yu-Kun Zhu Chun-Xiao Lv Shou-Juan Lai Wen-Jia Xu Jin Sun Yuan-Yuan Sun Dong-Jiang Yang school of Environmental Science and Engineering State Key Laboratory of Bio-fibers and Eco-textilesShandong Collaborative Innovation Center of Marine Biobased Fibers and Ecological TextilesInstitute of Marine Biobased MaterialsQingdao UniversityQingdao 266071China

A heterojunction photoanode of Fe2O3 loaded on a WO3 film on a fluorine-doped tin oxide substrate(FTO-WO3/Fe2O3)was prepared via a simple hydrothermal and chemical vapor deposition(CVD)growth *** photoanode showed higher photoelectrochemical(PEC)water-splitting activity than that of the pristine FTO-WO3 under simulated sunlight because of the synergistic effect of Fe2O3 and *** as-synthesized material was characterized by X-ray diffraction(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM),and X-ray photoelectron spectroscopy(XPS).The photocurrent density was estimated by linear sweep voltammetry and further confirmed using intensity-modulated photocurrent *** demonstrated that the coated Fe2O3 enhanced the separation and migration efficiencies of the photoinduced electrons and holes,improving the PEC water-splitting *** FTO-WO3/Fe2O3 photoanode showed a 1.25 times enhancement in photocurrent density compared with *** result suggests that facile chemical vapor deposition growth is an effective way to fabricate heterojunctions and improve the properties of WO3 photoanodes for PEC water-splitting applications.

关键词： WO3 Fe2O3 Heterojunction Water splitting