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Molecular Plant 2017年第12期10卷 1477-1479页

作者： Miyuki Nakamura Iva Mozgova Lars Hennig Department of Plant Biology Uppsala BioCenter Swedish University of Agricultural Sciences and Linnean Center for Plant Biology 75007 Uppsala Sweden Institute of Microbiology of the Czech Academy of Sciences Centre Algatech Opatovický mlýn 37981 Třeboň Czech Republic Faculty of Science University of South Bohemia in Ceske Budejovice 37005 Ceske Budejovice Czech Republic

Vernalization, the acquisition of competence to flower after extended cold treatment, has puzzled researchers throughout the last century. Great progress in understanding the molecular mechanisms of vernalization in Arabidopsis has been made in the course of the last 20 years, placing the flowering repressor- encoding gene FLOWERING LOCUS C （FLC） in the limelight （Bouch6 et al., 2017）. In vernalization-dependent accessions, FRIGIDA （FRI） ensures strong expression of FLC that delays flowering, and extended exposure to low temperatures such as during winter leads to stable repression of FLC, which in turn clears the way for induction of flowering.

关键词： FLOWERING-LOCUS-C TRANSCRIPTION FACTOR VERNALIZATION INHERITANCE ARABIDOPSIS EXPRESSION

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秘鲁妇女胎盘早剥的危险因素

世界核心医学期刊文摘（妇产科学分册） 2006年第4期2卷 13-14页

作者： Sanchez S.E. Pacora P.N. Farfan J.H. M.A.Williams 李奎 Department of Epidemiology Swedish Medical Center Center for Perinatal Studies 747 Broadway Seattle WA 98122 United States Dr.

Objective: We examined the relation of maternal sociodemographic, medical, and behavioral characteristics with risk of abruptio placentae in Peruvian women. Study design: This case-control study included 255 abruptio placentae cases and 258 pregnant controls. Multivariable logistic regression models were fit to calculate odds ratios (OR) and 95%CIs adjusted for putative abruptio placentae risk factors. Results: History of delivering a stillborn infant (OR 10.0; 95%CI 4.0-25.2)-, pregnancy complicated by preeclampsia/eclampsia (OR 3.7; 95%CI 2.2-6.3); and a lowr ate of pregnancy weight gain ( < 0.15 kg/wk) (OR 2.5; 95%CI 1.3-4.7), were associated with significantly increased risk of abruptio placentae. Advanced maternal age, low educational attainment, male infant gender, cigarette smoking, and grand multiparity were not risk factors of abruptio placentae in this population. Conclusion: At present, the constellation of abruptio placentae risk factors do not provide clinically meaningful opportunities for identifying high-risk patients.

关键词：胎盘早剥孕期体重高龄孕妇多胎妊娠病例对照研究回归模型人口社会学研究设计

Emerging strategies and developments in oxygen reduction reaction using high-performance platinum-based electrocatalysts

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Nano Research 2024年第5期17卷 3516-3532页

作者： Asad Ali Aatto Laaksonen Guo Huang Shahid Hussain Shuiping Luo Wen Chen Pei Kang Shen Jinliang Zhu Xiaoyan Ji Energy Engineering Division of Energy ScienceLuleåUniversity of Technology97187 LuleåSweden Department of Materials and Environmental Chemistry Arrhenius LaboratoryStockholm UniversitySE-10691 StockholmSweden center of Advanced Research in Bionanoconjugates and Biopolymers “Petru Poni”Institute of Macromolecular ChemistryIasi 700469Romania State Key Laboratory of Materials-Oriented and Chemical Engineering Nanjing Tech UniversityNanjing 211816China College of Materials Science and Engineering Shenzhen UniversityShenzhen 518060China School of Resources Environment and MaterialsState Key Laboratory of Processing for Non-ferrous Metal and Featured MaterialsGuangxi UniversityNanning 530004China

The global practical implementation of proton exchange membrane fuel cells(PEMFCs)heavily relies on the advancement of highly effective platinum(Pt)-based electrocatalysts for the oxygen reduction reaction(ORR).To achieve high ORR performance,electrocatalysts with highly accessible reactive surfaces are needed to promote the uncovering of active positions for easy mass *** this critical review,we introduce different approaches for the emerging development of effective ORR electrocatalysts,which offer high activity and *** strategies,including morphological engineering,geometric configuration modification via supporting materials,alloys regulation,core-shell,and confinement engineering of single atom electrocatalysts(SAEs),are discussed in line with the goals and requirements of ORR performance *** review the ongoing development of Pt electrocatalysts based on the syntheses,nanoarchitecture,electrochemical performances,and *** eventually explore the obstacles and research directions on further developing more effective electrocatalysts.

关键词： oxygen reduction reaction(ORR) Pt-based electrocatalysts proton exchange membrane fuel cells(PEMFCs) morphology and alloys strategies single atom electrocatalysts(SAEs)

Comparison of the SITA Faster–a new visual field strategy with SITA Fast strategy

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International Journal of Ophthalmology(English edition) 2021年第8期14卷 1185-1191页

作者： Chao-Xu Qian Qin Chen Qing Cun Yi-Jin Tao Wen-Yan Yang Yue Yang Zhong-Yin Hu Ying-Ting Zhu Hua Zhong The First Affiliated Hospital of Kunming medical University Kunming 650032Yunnan ProvinceChina The First Affiliated Hospital of Nanjing medical University Nanjing 210000Jiangsu ProvinceChina Tissue Tech Inc.7300 Corporate Center DriveSuite BMiamiFL 33126USA

AIM:To compare visual field defects using the swedish Interactive Thresholding Algorithm(SITA)Fast strategy with SITA Faster strategy,a newly developed time-saving threshold visual field ***:Ninety-three participants(60 glaucoma patients and 33 normal controls)were *** eye from each participant was selected randomly for the *** Fast and SITA Faster were performed using the 24-2 default mode for each *** differences of visual field defects between the two strategies were compared using the test duration,false-positive response errors,mean deviation(MD),visual field index(VFI)and the numbers of depressed test points at the significant levels of P0.05).Correlation analysis showed a high correlation for MD(r=0.986,P<0.001)and VFI(r=0.986,P<0.001)between the two ***-Altman analysis showed great agreement between the two ***:SITA Faster,which saves considerable test time,has a great test quality comparing to SITA Fast,but may be not directly interchangeable.

关键词： visual field SITA Faster strategy SITA Fast strategy glaucoma

Stand history is more important than climate in controlling red maple (Acer rubrum L.) growth at its northern distribution limit in western Quebec, Canada

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Journal of Plant Ecology 2015年第4期8卷 368-379页

作者： Yun Zhang Yves Bergeron Xiu-Hai Zhao Igor Drobyshev Institut de recherche sur les forêts Universitédu Québec en Abitibi-Témiscamingue(UQAT)445 boul.de l’UniversitéRouyn-NorandaQuébec J9X 5E4Canada Key Laboratory for Forest Resources&Ecosystem Processes of Beijing Beijing Forestry UniversityBeijing 100083P.R.China swedish University of Agricultural Sciences Southern Swedish Forest Research CentrePO Box 49Alnarp SE-23053Sweden Present address:National Plateau Wetlands Research center Southwest Forestry UniversityKunming 650224P.R.China.

Aims We examined growth of red maple(Acer rubrum l.)to evaluate environmental controls of its northern distributional limit in Eastern North america and its potential response to future climate *** We collected growth data from nine sites located along a 300-km transect(47-49°N),which included frontier population of red maple and covered three bioclimatic domains in western *** ana-lyzed three growth variables:growth rates during the first 30 years of maple lifespan,cumulative basal area increment(ba I)over the most recent decade(2000-2009)and annual growth rate over the whole tree lifespan ranging from 58 to 112 *** also examined growth sensitivity to climate by using response function *** Findingsthree different proxies of maple absolute growth(initial growth rate,ba I during 2000-09 and mean diameter growth rate)indicated a better growth with an increase in *** speculate that stand history effectively overrode the direct effects of colder climate on maple growth along the s-N *** of maple in the southern sites likely occurred in canopy gaps,whereas in the north it was contingent upon large disturbances such as stand-replacing fires,which apparently provided more favorable light environment for maple growth than canopy *** annual growth variability,which reflects effects of annual weather on growth and is largely independent from the absolute growth rate,was significantly affected by monthly climate,suggesting a positive effect of higher summer temperature in the northern part of the transect(48-49°N)and a negative effect of summer drought in the south(47-48°N).In the future,the natural and human disturbance regimes will be dominant controls of the actual biomass productivity of red maple at the northern limit of its present distribution *** effects of climate on maple growth would likely be less important in this context,and will likely entail negative effect of increased summer drought

关键词： biomass productivity climate change dendrochronology ecotone hardwoods species migration

The Effects of a Recovery-Focused Program for Stress Management in Women<br/>—An Exploratory Study

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Health 2014年第20期6卷 2825-2836页

作者： Jan Lisspers Niclas Almén Ö rjan Sundin Department of Psychology Mid Sweden University Campus &Ouml stersund &Ouml stersund Sweden swedish Winter Sports & Research center Mid Sweden University Campus &Ouml stersund &Ouml stersund Sweden

Current research indicates that stress problems primarily could be conceptualized as deficiencies in recovery and recuperation between stress periods. Accordingly, interventions should put more emphasis on this aspect. A group based intervention program focusing exclusively on recovery behavior in everyday life was evaluated in this quasi-experimental, waiting-list control group study, where the control group was also treated in a second phase. Thirty-two self-referred female subjects, considering themselves in need of treatment for stress related health problems, were available for analyzes. Fifteen of these constituted the first phase treatment group (INT), while the remaining 17 subjects were placed on waiting list (WLC). Adding a few late applicants leaved 20 subjects later treated in the second intervention phase. Significant and clinically meaningful positive effects emerged in the INT—compared to the WLC-group on recovery behaviors, stress—and recovery experiences, as well as on burnout symptoms, worry, anxiety and depression. Secondary analyzes of all treated subjects indicated that the positive change the primary clinical endpoint was predicted by the increase in frequency of recovery behaviors and by the decrease in the worry level. Thus, the present intervention model merits further research with more rigorous experimental design as well as with follow-up assessments.

关键词： Stress Recovery Stress Management Intervention Cognitive Behavior Therapy

T cell receptor (TCR) signaling in health and disease

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Signal Transduction and Targeted Therapy 2022年第1期7卷 38-63页

作者： Kinjal Shah Amr Al-Haidari Jianmin Sun Julhash U.Kazi Division of Translational Cancer Research Department of Laboratory MedicineLund UniversityLundSweden Lund Stem Cell center Department of Laboratory MedicineLund UniversityLundSweden Clinical Genetics and Pathology SkSne University HospitalRegion SkineLundSweden Clinical Sciences Department Surgery Research UnitLund UniversityMalmoSweden NHC Key Laboratory of Metabolic Cardiovascular Diseases Research Science and Technology centerSchool of Basic Medical SciencesNingxia Medical UniversityYinchuanChina

Interaction of the T cell receptor(TCR)with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T *** outside environmental cues are translated into various signal transduction pathways within the cell,which mediate the activation of various genes with the help of specific transcription *** signaling networks propagate with the help of various effector enzymes,such as kinases,phosphatases,and *** of these disparate signal transduction pathways is done with the help of adaptor proteins that are non-enzymatic in function and that serve as a scaffold for various protein-protein *** process aids in connecting the proximal to distal signaling pathways,thereby contributing to the full activation of T *** review provides a comprehensive snapshot of the various molecules involved in regulating T cell receptor signaling,covering both enzymes and adaptors,and will discuss their role in human disease.

关键词： TCR connecting thereby

Early osteoimmunomodulation by mucin hydrogels augments the healing and revascularization of rat critical-size calvarial bone defects

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Bioactive Materials 2023年第7期25卷 176-188页

作者： Song Chen Huan Wang Dachuan Liu Jianzhong Bai Håvard Jostein Haugen Bin Li Hongji Yan Orthopedic Institute Department of Orthopedic SurgeryThe First Affiliated HospitalSchool of Biology&Basic Medical SciencesSuzhou Medical CollegeSoochow UniversitySuzhouJiangsuChina Department of Biomaterials Institute for Clinical DentistryUniversity of OsloPO Box 1109 BlindernOslo0376Norway AIMES-center for the Advancement of Integrated medical and Engineering Sciences at Karolinska Institute and KTH Royal Institute of Technology 17177StockholmSweden Department of Neuroscience Karolinska Institute17177StockholmSweden Division of Glycoscience Department of ChemistrySchool of Engineering Sciences in ChemistryBiotechnology and HealthKTH Royal Institute of TechnologyAlbaNova University Center10691StockholmSweden

The design principle of osteogenic bone grafts has shifted from immunological inertness to limiting foreign body response to combined osteoimmunomodulatory activity to promote high-quality endogenous bone *** developed immunomodulatory mucin hydrogels have been shown to elicit very low complement activation and suppress macrophage release and activation after implantation in ***,their immunoregulatory activity has not yet been studied in the context of tissue ***,we synthesized mucin-monetite composite materials and investigated their early osteoimmunomodulation using a critical-size rat bone defect *** demonstrated that the composites can polarize macrophages towards the M2 phenotype at weeks 1 and *** early osteoimmunomodulation enhanced early osteogenesis and angiogenesis and ultimately promoted fracture healing and engraftment(revascularization of the host vasculature)at weeks 6 and ***,we demonstrated the applicability of mucin-based immunomodulatory biomaterials to enhance tissue repair in tissue engineering and regenerative medicine.

关键词： Mucin hydrogels Monetite osteoimmunomodulation Bone Revascularization

Bioreactor technology for clonal propagation of plants and metabolite production

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Frontiers in Biology 2015年第2期10卷 177-193页

作者： Nazmul H. A. Mamun Ulrika Egertsdotter Cyrus K. Aidun G.W. WoodruffSchool of Mechanical Engineering Georgia Institute of Technology Atlanta GA 30332 USA Department of Forest Genetics and Plant Physiology Umea Plant Science Center Swedish University of Agricultural Sciences 901 83 Umea Sweden Parker H. Petit Institute for Bioengineering and Bioscience Georgia Institute of Technology Atlanta GA 30332 USA

Plant cell culture in bioreactors is an enabling tool for large scale production of clonal elite plants in agriculture, horticulture, forestry, pharmaceutical sectors, and for biofuel production. Advantages of bioreactors for plant cell culture have resulted in various types of bioreactors differing in design, operating technologies, instrumentations, and construction of culture vessels. In this review, different types of bioreactors for clonal propagation of plants and secondary metabolites production are discussed. Mechanical and biochemical parameters associated with bioreactor design, such as aeration, flow rate, mixing, dissolved oxygen, composition of built-up gas in the headspace, and pH of the medium, are pivotal for cell morphology, growth, and development of cells within tissues, embryos, and organs. The differences in such parameters for different bioreactor designs are described here, and correlated to the plant materials that have been successfully cultured in different types of bioreactors.

关键词： bioreactor types mechanical and biochemical parameters plant cell culture plant clonal propagation secondary metabolite production