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Quantifying multiple-site compositional turnover in an Afrotemperate forest, using zeta diversity

Forest Ecosystems 2018年第2期5卷 189-197页

作者： Cang Hui Wessel Vermeulen Graham Durrheim Centre for Invasion Biology Department of Mathematical SciencesStellenbosch University Mathematical and Physical Biosciences African Institute for Mathematical Sciences Garden Route Scientific services South African National Parks

Background： Species turnover is typically measured by partitioning diversity components into alpha and pairwise beta diversity. However, alpha and beta components cannot express the full spectrum of multiple-site compositional turnover. To this end, zeta diversity has been proposed as an extended framework to allow complete biodiversity partitioning and to measure multiple-site species turnover. We use a zeta-diversity framework to explore the turnover and potential community assembly processes of an African Montane Forest. Methods： Using a 20 m grid, we explore the species turnover in a 4.55 ha forest plot located in the Garden Route National park of South Africa, with 47 and 27 canopy and sub-canopy tree species in the regional poo We first calculate how zeta diversity declines and how the probability of retention of species with particular occupancies changes with increasing zeta orders （i.e. the number of sites [grid cells] involved in the calculation）. Using null models with row sums and column sums constrained respectively, we explore whether species turnover is driven by mechanisms of ecological differences （species-specific occupancies） or habitat heterogeneity （site-specific alpha diversity and thus environmental filters）. Results： The decline of zeta diversity with zeta order followed a power law; that is, the probability of retention increased with species occupancies, suggesting common species being more likely to be discovered in extra sites. The null model retaining row sums （species＇ occupancy） of the species-by-site matrix recreated perfectly the decline of zeta diversity, while the null model of habitat heterogeneity （retaining column sums） was rejected. This suggests that mechanisms driving species-specific occupancies （i.e. ecological differences between species） dictate the multi-site species turnover in the community. The spatial patterns of zeta diversity revealed little spatial structuring forces, supporting a fine-grain structure in these sou

关键词： Species turnover Diversity partitioning Zeta diversity Community assembly Southern cape forest Afromontane forest

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Co-inoculation of Lactiplantibacillus pentosus 1 and Saccharomyces cerevisiae 31 for a salt-free fish sauce production from channel catfish (Ietalurus punetaus) bone

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Food Bioscience 2022年第6期50卷 1531-1539页

作者： Pei Gao Zhiqing Zhang Yi Ge Shining Cao Xiaojing Zhang Qixing Jiang Yanshun Xu Wenshui Xia Shaoquan Liu State Key Laboratory of Food Science and Technology School of Food Science and TechnologyCollaborative Innovation Center of Food Safety and Quality Control in Jiangsu ProvinceJiangnan UniversityLihu 1800WuxiJiangsu214122China Department of Food Science and Technology National University of SingaporeScience Drive 2Singapore117546Singapore National University of Singapore (suzhou) Research institute No.377 Linquan StreetSuzhou Industrial ParkSuzhouJiangsu215123China

The study aimed to evaluate the co-inoculation of non-fish sauce strains for a fish sauce production made from Ietalurus punetaus fish bone hydrolysate (FBH) without salt addition. Individual inoculation (Lactiplantibacillus pentosus 1, LP and Saccharomyces cerevisiae 31, SC), and co-inoculation of both strains (FS) were employed, including an uninoculated control. Both strains exhibited good growth in FBH without salt addition. Compared with individual inoculation and uninoculated control, co-inoculation (FS) produced acid and amino nitrogen more quickly, as well as displaying higher sugar consumption. No significant difference was observed in trichloroacetic acid (TCA)-soluble peptides among all groups (P > 0.05). Moreover, significantly lower levels of six bitter amino acids were observed after co-fermentation (P < 0.05). In addition, more alcohols, esters and acids with pleasant notes and fewer unsaturated aldehydes with fishy note were generated after co-inoculation, in the absence of traditional fish sauce off-odor notes. The study demonstrated that the co-inoculation of non-fish sauce strains were appropriate for producing a salt-free fish sauce with better flavor.

关键词： Ietalurus punetaus Fish bone hydrolysate Fish sauce Co-inoculation Flavor

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Drinking alcohol increased the possibility of self-rated poor health and mortality risk among middle-aged and seniors: a longitudinal study conducted in China

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China Population and Development Studies 2021年第5期5卷 229-263页

作者： Jinhui Zhao Yana Ma Hongpeng Sun Canadian institute for Substance Use Research(CISUR) University of Victoria2300 McKenzie AveVictoriaBC V8N 5M8Canada Department of Child and Adolescent Health and Social Medicine School of Public HealthMedical College of Soochow UniversityChina199 Ren-Ai RoadSuzhou Industrial ParkSuzhou 215123JiangsuPeople’s Republic of China

There has been lack of studies that investigate the causal impact of alcohol consumption on health and mortality in middle-aged and older populations in *** cohort study aims to investigate whether alcohol use increases poor health and mortality risk in middle-aged and older Chinese *** study is a cohort study design that was based on the China Health and Retired Longitudinal study(CHARLS).Measures of poor health and alcohol use are self-rated poor/very poor and alcohol *** Cox proportional hazard regression model(CPHM)was used to model the data and the hazards ratio(HR)of poor health,mortality for current and former drinkers versus nondrinkers and current drinkers versus former drinkers was estimated using CPHM after adjusting for deign-effects and *** study found significantly increased risk of all-cause mortality among current(adjusted HR=1.54 and P=0.0423)and former drinkers(Adjusted HR=1.52 and P=0.0096)compared to lifetime nondrinkers among middle-aged and senior Chinese people;significantly increased hazard of poor health among current drinkers(Adjusted HR=1.26 and P=0.0443)compared with lifetime *** hazards of all-cause mortality and self-rated poor health increased with the amount and frequency of alcohol drinking,and drinking *** study found that either former or current drinkers self-rated having a poor health and had a significantly increased risk of all-cause mortality compared with *** drinkers had poor health status and higher risk of mortality compared with those who drank light or moderate amount of alcohol in middle-aged and senior Chinese population.

关键词： Self-reported poor heath Mortality Alcohol Cohort study Competing Cox-proportional hazard regression model

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Targeting IL-22 and IL-22R protects against experimental osteoarthritis

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Cellular & Molecular Immunology 2021年第5期18卷 1329-1331页

作者： Changhua Yi Yongxiang Yi Jie Wei Qingwen Jin Junwei Li Pradeep Kumar Sacitharan Department of Infectious Diseases The Second Hospital of NanjingThe Affiliated Hospital of Nanjing University of Chinese Medicine#1 Zhongfu RoadNanjingJiangsu ProvinceChina College of Medical Laboratory Shaoyang UniversityShaoYang422000Hunan ProvinceChina Department of General Surgery The Second Hospital of NanjingThe Affiliated Hospital of Nanjing University of Chinese Medicine#1 Zhongfu RoadNanjingJiangsu ProvinceChina Department of Neurology The Sir Run Run HospitalNanjing Medical University#109 Longmian AvenueJiangning DistrictNanjingJiangsu ProvinceChina College of Veterinary Medicine Qingdao Agricultural University266109QingdaoChina The institute of Ageing and Chronic Disease University of LiverpoolLiverpoolL78TXUK Department of Biological Sciences Xi’an Jiaotong-Liverpool University#111 Ren’ai RoadSuzhou Industrial ParkSuzhou215123Jiangsu ProvinceChina

Osteoarthritis(OA)is characterized by cartilage degradation,pain,and synovitis.1 Joint inflammation driven by cytokines has been demonstrated to cause cartilage degradation and pain.2 However,approaches to neutralize cytokines,such as IL-1 and TNF-α,known to be involved in OA have shown poor clinical efficacy.3 There is an unmet clinical need to find better anti-inflammatory and pain targets for OA therapy and to elucidate the role of other cytokines in OA *** studies have shown that IL-22 and its receptor IL-22R play central roles in inflammation and diseases such as psoriasis,ulcerative colitis,graft-versus-host disease,certain infections and tumors,as well as in liver and pancreas damage.4,5 The role of IL-22/IL-22R and the potential for therapeutic targeting of both proteins in OA remain largely unknown,which we sought to investigate.

关键词： inflammation clinical pain

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Frame Construction and Task Analysis of Smart Energy in the Construction of Smart City

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Energy and Power Engineering 2020年第4期12卷 25-36页

作者： Linyu Wang Jiawei Zhou Hui Qi Yifan Ding Junping Yin State Grid (suzhou) City & Energy Research institute Suzhou China State Grid Energy Research institute Beijing China State Grid Taizhou Power Supply Company Taizhou China

Smart energy is the foundation and important component of smart cities, and it is the source of energy that guarantees the efficient and reliable operation of each subsystem of the city. Based on the practical experience in the exploration of the construction of smart energy at home and abroad, and the goal of achieving “three transformations and one center”, the basic principles of the frame construction as well as display construction and physical construction of smart energy have been proposed. Four main tasks of the construction of smart energy have been discussed: infrastructure, energy supply, energy consumption, and management services.

关键词： Smart Energy Smart City Display Construction Physical Construction

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Fungal diversity rather than bacterial diversity drives the ecosystem multifunctionality of vineyards in a semi-arid region

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International Journal of Agricultural and Biological Engineering 2021年第6期14卷 126-136页

作者： Bingbing Duan Yizhao Ren Leqi Zhang Chenxing suzhou Guoqiao Chen Ping Cui Yusong Zhangyang Wei Liu Hasmik Merkeryan Xu Liu College of Enology Northwest A&F UniversityYangling 712100ShaanxiChina Penglai Wine College Yantai Institute of Science and TechnologyYantai 265600ShandongChina Grape industrial park Management Committee of the Eastern Foot of Helan Mountain in Ningxia Yinchuan 750004China Horticulture Research institute Sichuan Academy of Agricultural SciencesChengdu 610066China Ningxia Helan Mountain’s East Foothill Wine Experiment and Demonstration Station of Northwest A&F University Yongning 750104NingxiaChina

The presence of multiple ecosystem functions and services(i.e.,ecosystem multifunctionality)has been proven to be maintained by biodiversity in natural terrestrial ***,the mechanisms by which microbial diversity drives ecosystem functions in vineyards and the effects of ecosystem functions on wine quality remain ***,fifteen vineyards from five wine sub-regions(Shizuishan,Yinchuan,Yuquanying,Qingtongxia,and Hongsipu)in Ningxia were selected to assess the microbial community structure,ecosystem multifunctionality,and wine ***,each index differed among the vineyards from these five wine sub-regions in ***-throughput sequencing revealed that bacterial and fungal communities varied among these *** communities were dominated by Actinobacteria,Proteobacteria,Chloroflexi,and *** was the dominant fungal phylum,followed by Basidiomycota and *** addition,fungal Shannon diversity rather than bacterial Shannon diversity showed a positive relationship with ecosystem *** analysis revealed that ecosystem multifunctionality was positively correlated with wine acidity and negatively correlated with pH value and residual sugar content of *** chemical functions exhibited relationships with wine quality being similar to those of ecosystem multifunctionality;i.e.,positively related to wine acidity but negatively related to wine pH and residual sugar ***,soil physical functions were negatively correlated with the alcohol and anthocyanin content of *** research results show that the ecosystem functions maintained by fungal diversity could be attributed to wine quality of vineyards.

关键词： microbial diversity multifunctionality terroir wine quality wine sub-regions

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Droplet Laplace valve-enabled glaucoma implant for intraocular pressure management

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Droplet 2024年第2期3卷 125-137页

作者： Yuyang Wang Zecong Fang Sen Li Kexin Lin Zhifeng Zhang Junyi Chen Tingrui Pan Center for Intelligent Medical Equipment and Devices(iMED) Institute for Innovative Medical DevicesUniversity of Science and Technology of ChinaHefeiChina suzhou institute for Advanced Research University of Science and Technology of ChinaSuzhouChina Department of Precision Machinery and Precision Instrumentation University of Science and Technology of ChinaHefeiChina Bionic Sensing and Intelligence Center(BSIC) Institute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenChina School of Engineering Hangzhou Normal UniversityHangzhouChina School of Biomedical Engineering Division of Life Science and MedicineUniversity of Science and Technology of ChinaHefeiChina Engineering Science and Mechanics Department Penn State UniversityUniversity ParkPennsylvaniaUSA Department of Ophthalmology and Visual Science Eye and ENT HospitalShanghai Medical CollegeFudan UniversityShanghaiChina NHC Key Laboratory of Myopia Chinese Academy of Medical Sciences and Shanghai Key Laboratory of Visual Impairment and Restoration(Fudan University)ShanghaiChina

Glaucoma,the leading cause of irreversible blindness worldwide,is closely linked to aqueous overaccumulation and elevated intraocular pressure(IOP).For refractory glaucoma,aqueous shunts with valves are commonly implanted for effective aqueous drainage control and IOP ***,existing valved glaucoma implants have the disadvantages of inconsistent valve opening/closing pressures,poor long-term repeatability due to their reliance on moving parts,and complex architectures and fabrication ***,we propose a novel valving concept,the droplet Laplace valve(DLV),a three-dimensional printable moving-parts-free microvalve with customizable and consistent threshold valving *** DLV uses a flow discretization unit governed by capillarity,comprising a droplet-forming nozzle,and a separated reservoir to digitize continuous flow into quantifiable *** the classic one-time-use Laplace valves,the DLV's unique design allows for its *** opening pressure is adjustable by varying the nozzle size,like the classic Laplace valves(following the Young–Laplace equation),while the closing pressure can be modified by tuning the separation distance and the reservoir *** DLVs with customizable opening pressures from 5 to 11 mmHg have been demonstrated,with opening/closing pressure differences suppressed down to0.99).Preliminary ex vivo validation in an enucleated porcine eye confirms the DLV's efficiency in aqueous shunting and prompt IOP *** DLV technology holds great promise in glaucoma implants for IOP management and various microsystems for flow control.

关键词： holds irreversible inconsistent

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Advances in BeiDou Navigation Satellite System(BDS)and satellite navigation augmentation technologies

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Satellite Navigation 2020年第1期1卷 126-148页

作者： Rui Li Shuaiyong Zheng Ershen Wang Jinping Chen Shaojun Feng Dun Wang Liwen Dai School of Electronic and Information Engineering Beihang UniversityNo.37 Xueyuan RoadHaidian DistrictBeijingChina suzhou institute Beihang UniversitySuzhou 215200China College of Electronic and Information Engineering Shenyang Aerospace UniversityNo.37 Daoyi South StreetDaoyi DistrictShenyangChina Beijing Satellite Navigation Center No.22 Beiqing RoadHaidian DistrictBeijingChina Qianxun Spatial Intelligence Inc. C5 BuildingNo.1688-38 North Guoquan RoadYangpu DistrictShanghaiChina Space Star Technology Co. Ltd.Blue Lake Industry ParkHaidian DistrictBei-jingChina John Deere-Intelligent Solution Group 20780 Madrona AvenueTorranceCAUSA

Several noteworthy breakthroughs have been made with the BeiDou Navigation Satellite System(BDS)and other global navigation satellite systems as well as the associated augmentation systems,such as the commissioning of the BDS-3 preliminary system and the successful launch of the first BDS-3 GEO satellite which carries the satellite-based augmentation ***,BDS can provide basic services globally,and its augmentation system is also being *** paper gives an overview of BDS and satellite navigation augmentation *** overview is divided into four parts,which include the system segment technologies,satellite segment technologies,propagation segment technologies,and user segment *** each part,these technologies are described from the perspectives of preliminary information,research progress,and ***,the significance and progress of the BeiDou Satellite-based Augmentation System(BDSBAS),low earth orbit augmentation,and the national BeiDou ground-based augmentation system are presented,along with the airborne-based augmentation ***,the conclusions and discussions covering popular topics for research,frontiers in research and development,achievements,and suggestions are listed for future research.

关键词： BeiDou Navigation Satellite System Satellite navigation augmentation systems System segment technologies Satellite segment technologies Propagation segment technologies User segment technologies

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Heteromeric Coassembly of TRPV4,TRPC1 and TRPP2 to Form a Flow-sensitive Channel

Heteromeric Coassembly of TRPV4,TRPC1 and TRPP2 to Form a Fl...

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第八届海峡两岸心血管科学研讨会

作者： Lutz Birnbaumer National institute of Environmenta Health Sciences National Institutes of HealthDepartment of Health and Human ServicesResearch Triangle ParkNorth CarolinaUSA

Background Transient receptor potential(TRP) channels function as cellular sensors to perceive and respond to a variety of environmental stimuli including temperature,pain,pressure and fluid *** channels can be divided into seven subfamilies,including TRPV,TRPC,TRPP,and four *** TRP channels are tetrameric complexes consisting of four pore - forming subunits,which could be identical (homotetrameric channels) or different(heterotetrameric channels).Tetrameric assembly usually occurs between members from the same *** and Finding In the present study,with the use of two -step co - immunoprecipitation,chemical cross - linking and fluorescence resonance energy transfer(FRET), we found that TRPV4,- C1,and - P2 associate together to form a physical *** function study,this TRPV4 - C1 - P2 complex mediates flow - induced Ca influx in HEK293 cells over - expressing TRPV4,- C1,and - P2 and in rat mesenteric artery endothelial cells(MAECs).Pore - dead mutant of each of these three TRP isoforms abolished or markedly reduced the flow - induced cation currents and Ca rises,suggesting all three TRPs contribute to the ion permeation pore of the *** Taken together,we identified the first heteromeric TRP channels composed of subunits from three different TRP subfamilies, namely heteromeric TRPV4 - C1- P2 *** type of heteromerization greatly increases the numeric numbers of different TRP channels that could be assembled,making the structure and function of TRP channels strikingly ***,heteromeric TRPV4 - C1- P2 are the main channels that mediate flow - induced Ca rises in native vascular endothelial cells,thus plays a key role in the control of vascular tone and blood pressure.

关键词： TRPV4 TRPC1 TRPP2 heteromeric coassembly flow-induced Ca2+ influx flow-induced cation current

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Exportin 1 governs the immunosuppressive functions of myeloid-derived suppressor cells in tumors through ERK1/2 nuclear export

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Cellular & Molecular Immunology 2024年第8期21卷 873-891页

作者： Saeed Daneshmandi Qi Yan Jee Eun Choi Eriko Katsuta Cameron R.MacDonald Mounika Goruganthu Nathan Roberts Elizabeth A.Repasky Prashant K.Singh Kristopher Attwood Jianmin Wang Yosef Landesman Philip L.McCarthy Hemn Mohammadpour Department of Immunology Roswell Park Comprehensive Cancer CenterBuffaloNYUSA Department of Cell Stress Biology Roswell Park Comprehensive Cancer CenterBuffaloNYUSA Department of Oncology Yokohama City UniversityGraduate School of MedicineYokohamaJapan Department of Cancer Genetics&Genomics Roswell Park Comprehensive Cancer CenterBuffaloNYUSA Department of Biostatistics&Bioinformatics Roswell Park Comprehensive Cancer CenterBuffaloNYUSA Karyopharm Therapeutics NewtonMAUSA Department of Medicine Roswell Park Comprehensive Cancer CenterBuffaloNYUSA

Myeloid-derived suppressor cells(MDSCs)are a main driver of immunosuppression in *** the mechanisms that determine the development and immunosuppressive function of these cells could provide new therapeutic targets to improve antitumor ***,using preclinical murine models,we discovered that exportin 1(XPO1)expression is upregulated in tumor MDSCs and that this upregulation is induced by IL-6-induced STAT3 activation during MDSC ***1 blockade transforms MDSCs into T-cell-activating neutrophil-like cells,enhancing the antitumor immune response and restraining tumor ***,XPO1 inhibition leads to the nuclear entrapment of ERK1/2,resulting in the prevention of ERK1/2 phosphorylation following the IL-6-mediated activation of the MAPK signaling ***,XPO1 blockade in human MDSCs induces the formation of neutrophil-like cells with immunostimulatory ***,our findings revealed a critical role for XPO1 in MDSC differentiation and suppressive functions;exploiting these new discoveries revealed new targets for reprogramming immunosuppressive MDSCs to improve cancer therapeutic responses.

关键词： MDSCs Tumor Exportin 1 MAPK pathway

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