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Lithium Diffusion and Stress in a Polycrystalline Film Electrode

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Acta Mechanica Solida Sinica 2018年第3期31卷 290-309页

作者： YanFei Zhao Bo Lu Junqian Zhang Department of Civil Engineering Shanghai University Materials genome Institute Shanghai University and Shanghai Materials Genome Institute Shanghai Institute of Applied Mathematics and Mechanics Shanghai University Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai University Department of Mechanics Shanghai University

In the present work, the two-dimensional analytical solution for Li diffusion in grains and grain boundaries of a polycrystalline film electrode is established with consideration of Li-segregation at the grain boundary. The stress field induced by the inhomogeneity of Li con- centration, called chemical stress here for brevity, is analyzed via the finite element simulation. The effects of the grain boundary including its size, its diffusion coefficient as well as the segrega- tion phenomenon on the solute concentration and the chemical stress are examined. It shows that grain boundaries can assist fast diffusion and significantly affect the stress profile in the whole film. It proves that tailoring the grain boundary size or other grain boundary-related parameters may provide an alternative strategy for improving the overall diffusivity and mechanical stability of battery electrodes.

关键词： Polycrystalline film Two-dimensional diffusion Grain boundary Segregation Chemical stress

Targeting LncRNA LLNLR-299G3.1 with antisense oligonucleotide inhibits malignancy of esophageal squamous cell carcinoma cells in vitro and in vivo

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Oncology Research 2023年第4期31卷 463-479页

作者： LI TIAN YONGYI HUANG BAOZHEN ZHANG YI SONG LIN YANG QIANQIAN CHEN ZHENG WANG YILING WANG QIHAN HE WENHAN YANG SHUYONG YU TIANYU LU ZICHEN LIU KAIPING GAO XIUJUN FAN JIAN SONG RIHONG ZHAI School of Public Health International Cancer CenterGuangdong Key Laboratory for Genome Stability&Disease PreventionShenzhen University Medical SchoolShenzhenChina Shenzhen Institute of Advanced Technology Chinese Academy of ScienceShenzhenChina Department of Thoracic Surgery Shenzhen People’s HospitalShenzhenChina Department of Gastroenterology Hainan Tumor HospitalHaikouChina Department of Gastroenterology Southern University of Science and Technology HospitalShenzhenChina

Accumulating evidence has indicated that long non-coding RNAs(lncRNAs)play critical roles in the development and progression of cancers,including esophageal squamous cell carcinoma(ESCC).However,the mechanisms of lncRNAs in ESCC are still incompletely understood and therapeutic attempts for in vivo targeting cancer-associated lncRNA remain a *** RNA-sequencing analysis,we identified that LLNLR-299G3.1 was a novel ESCC-associated ***-299G3.1 was up-regulated in ESCC tissues and cells and promoted ESCC cell proliferation and *** of LLNLR-299G3.1 with ASO(antisense oligonucleotide)resulted in opposite ***,LLNLR-299G3.1 bound to cancerassociated RNA binding proteins and regulated the expression of cancer-related genes,including OSM,TNFRSF4,HRH3,and ***-seq(chromatin isolation by RNA purification and sequencing)revealed that these genes contained enriched chromatin binding sites for *** experiments confirmed that the effects of LLNLR-299G3.1 on ESCC cell proliferation were dependent on interaction with HRH3 and ***,intravenous delivery of placental chondroitin sulfate A binding peptide-coated nanoparticles containing antisense oligonucleotide(pICSA-BP-ANPs)strongly inhibited ESCC tumor growth and significantly improved animal survival in ***,our results suggest that LLNLR-299G3.1 promotes ESCC malignancy through regulating gene-chromatin interactions and targeting ESCC by pICSA-BP-ANPs may be an effective strategy for the treatment of lncRNA-associated ESCC.

关键词： LLNLR-299G3.1 Chromatin Esophageal squamous cell carcinoma(ESCC) Antisense oligonucleotide(ASO) Placental chondroitin sulfate A binding peptide(plCSA-BP)-coated nanoparticles

Identification of Key Genes as Potential Drug Targets for Gastric Cancer

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Tsinghua Science and Technology 2023年第4期28卷 649-664页

作者： Md.Tofazzal Hossain Md.Selim Reza Yin Peng Shengzhong Feng Yanjie Wei Center for High Performance Computing Joint Engineering Research Center for Health Big Data Intelligent Analysis TechnologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China School of Computer Science and Technology University of Chinese Academy of SciencesBeijing 100049China Department of Statistics Bangabandhu Sheikh Mujibur Rahman Science and Technology UniversityGopalganj 8100Bangladesh Guangdong Provincial Key Laboratory for genome stability and Disease Prevention and Regional Immunity and Diseases Department of PathologyShenzhen UniversityShenzhen 518060China

Gastric cancer(GC)is one of the most common cancers and ranks the third in cancer mortality all over the *** goal of this study was to identify potential hub-genes,highlighting their functions,signaling pathways,and candidate drugs for the treatment of GC *** used publicly available next generation sequencing(NGS)data to identify differentially expressed(DE)*** top DE genes were mapped to STRING database to construct the protein-protein interaction(PPI)network and top hub genes were selected for further *** found a total of 1555 DE genes with 870 upregulated and 685 downregulated genes in *** selected the top 400(200 upregulated and 200 downregulated)genes to construct a PPI network and extracted the top 15 hub *** gene ontology(GO)term and kyoto encyclopedia of genes and genomes(KEGG)pathway enrichment analyses of the 15 hub genes exposed some important functions and signaling pathways that were significantly associated with GC *** survival analysis of the hub genes disclosed that the lower expressions of the three hub genes CDH2,COL4A1,and COL5A2 were associated with better survival of GC *** three genes might be the candidate biomarkers for the diagnosis and treatment of ***,we considered 3 key proteins(genomic biomarkers)(COL4A1,CDH2,and CO5A2)as the drug target proteins(receptors),performed their docking analysis with the 102 meta-drug agents,and found Everolimus,Docetaxel,Lanreotide,Venetoclax,Temsirolimus,and Nilotinib as the top ranked 6 candidate drugs with respect to our proposed target proteins for the treatment against GC ***,the proposed drugs might play vital role for the treatment against GC patients.

关键词： gastric cancer hub genes candidate genes molecular docking candidate drugs

Leader-following flocking for unmanned aerial vehicle swarm with distributed topology control

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Science China(Information Sciences) 2020年第4期63卷 140-153页

作者： Chao LIU Meng WANG Qian ZENG Wei HUANGFU Beijing Advanced Innovation Center for Materials genome Engineering School of Computer and Communication Engineering University of Science and Technology Beijing

To address the flocking issues of an unmanned aerial vehicle(UAV) swarm operating at a leaderfollower mode, distributed control protocols comprising both kinetic controller and topology control algorithm must be implemented. For flocking the UAV swarm, a distributed control-input method is required for both maintaining a relatively steady state between neighboring vehicles(including velocity matching and distance maintenance) and avoiding vehicle-to-vehicle collision. Furthermore, the stability of control protocols should be analyzed using the potential energy function. In particular, a distributed β-angle test(BAT) rule in the proposed topology-control issue may allow each UAV to determine its neighboring set by exploiting the locally sensed information, thereby significantly reducing the communication overhead of the entire *** addition, node-degree bound is derived to demonstrate the feasibility of the proposed algorithm, in which the optimal value in terms of convergence is analyzed. The flocking of the flying ad-hoc network(FANET)can be achieved in a self-organizing way without the use of an external control center via the distributed control protocols. Ultimately, the proposed analysis is verified by numerical results.

关键词： flying ad hoc networks flocking leader-follower topology control neighbor selection

Novel Quasi Solid-State Succinonitrile-based Electrolyte with Low-flammability for Lithium-ion Battery

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Chinese Journal of Polymer Science 2023年第11期41卷 1695-1705,I0005页

作者： Yan-Kun Xie Lu-Kun Feng Dong-Dong Li Yin Tang Cai-Zhen Zhu Ming-Liang Wang Jian Xu Institute of Low-Dimensional Materials genome Initiative College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060China

Quasi solid-state succinonitrile(SN)-based polymer electrolytes have emerged for lithium-metal batteries due to their excellent ionconductivity at room temperature,wide electrochemical stability window(ESW,usually>5 V).However,the practical application of these solid SN-based polymer electrolytes is hampered by the flammability and the inherent instability of SN to Li-metal *** this work,solid SN-based polymer electrolytes were prepared with succinonitrile,ethoxylated trimethylolpropane triacrylate(ETPTA),triethyl phosphate(TEP)and fluoroethylene carbonate for Li-metal battery via in situ polymerization *** SN-based polymer electrolytes with 5 wt%triethyl phosphate and FEC showed good nonflammability,superior ion-conductivity as high as 1.01×10^(-3)S/cm,and wide ESW of 5.41 *** SN-based polymer electrolyte also exhibited excellent interfacial compatibility to lithium metal *** it also delivered a high specific capacity of 156m Ah/g at 0.2 C at ambient temperature,and presented stable cycling at 1.0 C with a specific capacity retention of 98.4%after 1000 *** work provides an alternative and simple strategy to realize the practical application of the solid-state SN-based polymer electrolyte.

关键词： Solid polymer electrolyte Succinonitrile Solid-state battery In situ polymerization Low-flammability

RNA-directed DNA methylation and demethylation in plants

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Science China(Life Sciences) 2009年第4期52卷 331-343页

作者： CHINNUSAMY Viswanathan Institute for Integrative genome Biology and Department of Botany and Plant Sciences University of California Riverside

RNA-directed DNA methylation (RdDM) is a nuclear process in which small interfering RNAs (siRNAs) direct the cytosine methylation of DNA sequences that are complementary to the siRNAs. In plants, double stranded-RNAs (dsRNAs) generated by RNA-dependent RNA polymerase 2 (RDR2) serve as precursors for Dicer-like 3 dependent biogenesis of 24-nt siRNAs. Plant specific RNA polymerase IV (Pol IV) is presumed to generate the initial RNA transcripts that are substrates for RDR2. siRNAs are loaded onto an argonaute4-containing RISC (RNA-induced silencing complex) that targets the de novo DNA methyltransferase DRM2 to RdDM target loci. Nascent RNA transcripts from the target loci are generated by another plant-specific RNA polymerase, Pol V, and these transcripts help recruit com- plementary siRNAs and the associated RdDM effector complex to the target loci in a transcrip- tion-coupled DNA methylation process. Small RNA binding proteins such as ROS3 may direct tar- get-specific DNA demethylation by the ROS1 family of DNA demethylases. Chromatin remodeling en- zymes and histone modifying enzymes also participate in DNA methylation and possibly demethylation. One of the well studied functions of RdDM is transposon silencing and genome stability. In addition, RdDM is important for paramutation, imprinting, gene regulation, and plant development. Lo- cus-specific DNA methylation and demethylation, and transposon activation under abiotic stresses suggest that RdDM is also important in stress responses of plants. Further studies will help illuminate the functions of RdDM in the dynamic control of epigenomes during development and environmental stress responses.

关键词： abiotic stress plant development siRNAs DNA methylation demethylation RdDM

Poly(ethylene carbonate)-based electrolytes with high concentration Li salt for all-solid-state lithium batteries

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Rare Metals 2018年第6期37卷 488-496页

作者： Zi-Jian He Li-Zhen Fan Beijing Advanced Innovation Center for Materials genome Engineering Institute of Advanced Materials and Technology University of Science and Technology Beijing

High-performance solid polymer electrolyte （SPE） has long been desired for the next-generation high energy density and safe rechargeable lithium batteries. A SPE composed of 80 wt% lithium bis（trifluo-romethanesulfonyl）imide （LiTFSI）, 20% poly（ethylene carbonate）（PEC） and a polyamide （PA） fiber membrane backbone was prepared by solution-casting method. This solid electrolyte exhibits quite high ionic conductivity and lithium ion transference number （t＋）, and excellent mechanical strength. The as-prepared solid electrolyte shows good wettability to porous electrodes during cycles, which is beneficial to form ionically conductive phase throughout porous electrodes. All-solid-state LiFePO4lLi cells assembled with the as-prepared solid electrolyte deliver a high initial discharge specific capacity of 125.7 mAh·g^-1 and good cycling stability at 55 ℃ （93.4% retention at 1C after 200 cycles）, and superior cycle performance. Outstanding electrochemical performance can be mainly ascribed to the improved ionic conductivity in the entire porous electrodes due to the good wettability of SPE.

关键词： Solid polymer electrolyte All-solid-state lithium batteries Poly(ethylene carbonate) Wettability Porous electrodes

Thermodynamic investigation of phase equilibria in Al–Si–V system

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Journal of Materials Science & Technology 2018年第9期34卷 1592-1601页

作者： Qun Luo Kang Li Qian Li State Key Laboratory of Advanced Special Steel & Shanghai Key Laboratory of Advanced Ferrometallurgy & School of Materials Science and Engineering Shanghai UniversityShanghai 200072 China Materials genome Institute Shanghai UniversityShanghai 200444 China Shanghai Institute of Materials genome Shanghai 200444 China

The Al-Si-V system is assessed to understand the phase equilibria of V-containing（3 d transition metal）Al-Si alloys, which are generally of great importance for technical applications. Four annealed alloys were prepared to study the phase equilibria of Al-rich corner（V ≤ 23.3 at.%, Si ≤ 57.6 at.%） in the temperature range of 500-930 ℃. The microstructure and phase constituents of the samples were determined by X-ray diffraction（XRD） and scanning electron microscopy（SEM） equipped with energy dispersive X-ray spectrometer（EDS）, The existence of ternary phase τ（Al（0.6） Si（1.4） V, TiSi2-type） was confirmed with the composition ranging from 17.98 to 18.59 at.% Al and 48.89-49.20 at.% Si. However, it did not equilibrate with fcc（Al） below 868℃, which was determined by differential scanning calorimetry（DSC）. The Si3 V5 appeared in Al58 5 Si（18.3） V（23.2） and Al64 7 Si（20.2） V（15.1） alloys annealed at 500 ℃. It nearly disappeared after3000 h-annealing and its thermodynamic stability was discussed. According to the measured phase relationships, the thermodynamic description of Al-Si-V system was optimized combing with the enthalpies of formation of binary and ternary compounds obtained by density functional theory（DFT）. The Si-V system was modified to obtain the congruent liquidus of Si3 V5 and enthalpy of formation of Si3 V5 and Si2 V with experimental data. By comparing the calculated phase equilibria and phase transitions with experimental data, it showed that a good agreement was reached. The description of Al-Si-V system could be used to guide the development of Al-Si alloys.

关键词： Phase equilibrium Al-Si alloy CALPHAD method Intermetallic compounds Enthalpy of formation

Deformation-induced martensitic transformation kinetics and correlative micromechanical behavior of medium-Mn transformation-induced plasticity steel

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Journal of Materials Science & Technology 2019年第8期35卷 1779-1786页

作者： Minghe Zhang Haiyang Chen Youkang Wang Shengjie Wang Runguang Li Shilei Li Yan-Dong Wang Beijing Advanced Innovation Center for Materials genome Engineering State Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology Beijing

An in situ high-energy X-ray diffraction(HE-XRD) technique was mainly used to investigate the micromechanical behavior of medium-Mn Fe-0.12 C-10.16 Mn-1.87 Al(in wt%) transformation-induced plasticit(TRIP) steel subjected to intercritical annealing at 625℃, 650℃, 675℃ and 700℃ for 1 h. As the intercritical annealing temperature increased, the volume fraction of retained austenite(RA) and ultimate tensilstress(UTS) increased, while the Lüders strain and yield stress(YS) decreased. The incremental workhardening exponent of experimental steel increased with increasing intercritical annealing temperatureThe overall trend of the transformation kinetics of the RA with respect to the true strain followed thsigmoidal shape predicted by the Olson and Cohen(OC) model. Load partitioning occurred among the ferrite, austenite and martensite immediately after entering the yielding stage. Because the stability of thRA decreased with increasing intercritical annealing temperature, the load undertaken by the martensitincreased. The moderate transformation kinetics of the RA and effective load partitioning among constituent phases were found to contribute to a favorable combination of strength and ductility for thimedium-Mn TRIP steel.

关键词： Medium-Mn TRIP steel High-energy X-ray diffraction Transformation kinetics Load partitioning