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Therapeutic prospects of mesenchymal stem/stromal cells in co.ID-19 associated pulmonary diseases:From bench to bedside

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World Journal of Stem Cells 2021年第8期13卷 1058-1071页

作者： Lei-Sheng Zhang Yi Yu Hao Yu Zhong-Chao Han Qianfoshan Hospital&The First Affiliated Hospital Shandong First Medical UniversityJinan 250014Shandong ProvinceChina State Key Laboratory of Experimental Hematology&National Clinical Research Center for Blood Disease Institute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China School of Medicine Nankai UniversityTianjin 300071China Precision Medicine Division Health-Biotech(Tianjin)Stem Cell Research Institute Co.Ltd.Tianjin 301700China The First Affiliated Hospital Zhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Cell Products of National Engineering Center&National Stem Cell Engineering Research Center Tianjin IMCELL Stem Cell and Gene Technology Co.Ltd.Tianjin 300457China

The ongoing outbreak of co.onavirus disease 2019(co.ID-19)caused by the novel severe acute respiratory syndrome co.onavirus 2 has beco.e a sudden public emergency of international co.cern and seriously threatens millions of people’s life *** current studies have indicated a favorable role for mesenchymal stem/stromal cells(MSCs)in clinical remission of co.ID-19 associated pulmonary diseases,yet the systematical elaboration of the therapeutics and underlying mechanism is far from *** the present review,we summarize the therapeutic potential of MSCs in co.ID-19 associated pulmonary diseases such as pneumonia induced acute lung injury,acute respiratory distress syndrome,and pulmonary ***,we review the underlying mechanism of MSCs including direct-and trans-differentiation,autocrine and paracrine anti-inflammatory effects,homing,and neovascularization,as well as co.stitutive ***,we discuss the prospects and supervision of MSC-based cytotherapy for co.ID-19 management before large-scale application in clinical ***,this review supplies overwhelming new references for understanding the landscapes of MSCs in the remission of co.ID-19 associated pulmonary diseases.

关键词： Mesenchymal stem/stromal cells co.ID-19 Acute lung injury Acute respiratory distress syndrome Pulmonary fibrosis Molecular mechanism

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Safety and Effectiveness of SA58 Nasal Spray Against co.ID-19 Infection in Medical Personnel:An Open-Label,Blank-co.trolled Study—Hohhot City,Inner Mongolia Autonomous Region,China,2022

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China CDC weekly 2023年第10期5卷 218-222页

作者： Shujie Si Canrui Jin Jianping Li Yunlong Cao Biao Kan Feng Xue Xiaoliang Sunney Xie Liang Fang Gang Zeng Shuo Zhang Yaling Hu Xiaoping Dong Pharmacy Department Inner Mongolia Fourth HospitalHohhot CityInner Mongolia Autonomous RegionChina Clinical Research and Development Department Sinovac Biotech Co.Ltd.BeijingChina Biomedical Pioneering Innovation Center(BIOPIC) Peking UniversityBeijingChina Changping Laboratory BeijingChina State Key Laboratory for Infectious Disease Prevention and co.trol NHC Key Laboratory of Medical Virology and Viral DiseasesNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Research and Development Department Sinovac Life Sciences Co.Ltd.BeijingChina Inner Mongolia Blood Center Hohhot CityInner Mongolia Autonomous RegionChina Center for Biosafety Mega-Science Chinese Academy of SciencesWuhan CityHubei ProvinceChina China Academy of Chinese Medical Sciences BeijingChina Shanghai Institute of Infectious Diseases and Biosafety ShanghaiChina

Summary What is already known about this topic?The active ingredient of the SA58 Nasal Spray is a broad-spectrum neutralizing antibody with a high neutralizing capacity against different Omicron subvariants in vitro *** is added by this report?This study demonstrated the safety and effectiveness of SA58 Nasal Spray against co.onavirus disease 2019(co.ID-19)infection in medical personnel for the first *** are the implications for public health practice?This study provides an effective approach for the public to reduce their risk of co.ID-19 *** findings of this research have the potential to significantly reduce the risk of infection and limit human-to-human transmission in the event of a co.ID-19 outbreak.

关键词： neutral co. Nasal

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A Novel Human Antibody,HF,against HER2/erb-B2 Obtained by a co.puter-Aided Antibody Design Method

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Engineering 2021年第11期7卷 1566-1576页

作者： Chunxia Qiao Ming Lv Xinying Li Xiaoling Lang Shouqin Lv Mian Long Yan Li Shusheng Geng Zhou Lin Beifen Shen Jiannan Feng State Key Laboratory of Toxico.ogy and Medical co.ntermeasures Institute of Pharmacology and ToxicologyBeijing 100850China Beijing Key Laboratory of Therapeutic Gene Engineering Antibody Beijing 100850China Institute of Military co.nitive and Brain Sciences Beijing 100850China Beijing Mabworks biotech co.Ltd. Beijing 100176China Institute of Mechanics Chinese Academy of SciencesBeijing 100190China

Fully human antibodies have minimal immunogenicity and safety *** present,most potential antibody drugs in clinical trials are humanized or fully *** antibodies are mostly generated using the phage display method(in vitro)or by transgenic mice(in vivo);other methods include B lymphocyte immortalization,human–human hybridoma,and single-cell polymerase chain ***,we describe a structure-based co.puter-aided de novo design technology for human antibody *** on the co.plex structure of human epidermal growth factor receptor 2(HER2)/Herceptin,we first designed six short peptides targeting the potential epitope of HER2 reco.nized by ***,these peptides were set as co.plementarity determining regions in a suitable immunoglobulin frame,giving birth to a novel anti-HER2 antibody named "HF,"which possessed higher affinity and more effective anti-tumor activity than *** work offers a useful tool for the quick design and selection of novel human antibodies for basic mechanical research as well as for imaging and clinical applications in immune-related diseases,such as cancer and infectious diseases.

关键词： HER2/erb-B2 Human antibody co.puter-aided design

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A novel mouse model of hyperuricemia and gouty nephropathy

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Chinese Medical Journal 2020年第16期133卷 2012-2014页

作者： Jin Guan Xiao-Qi Huang Jia-Le Dong Hui-Min Lu Yue-Wei Lin Mei Liu Zhi-Biao Yi Li-Min Wu Yong-Ming Huang Tian Lan Department of Pharmaco.ogy School of PharmacyGuangdong Pharmaceutical UniversityGuangzhou 510006China Guangzhou University of Chinese Medicine Math Engineering Academic Chinese MedicineGuangdong Province of Key Lab New Drug Dev&Res ChineseGuangzhouGuangdong 510006China Guangzhou University of Chinese Medicine Dongguan Math Engineering Academic Chinese MedicineDongguanGuangdong 523808China Foshan Santanyi biotech co. LtdFoshanGuangdong 528031China Seco.d Affiliated Hospital of Guangzhou University of Chinese Medicine GuangzhouGuangdong 510006China

To the Editor:Hyperuricemia,the seco.d most co.mon metabolic disease after diabetes mellitus in China,is characterized by the elevated serum uric co.centration which is due to the overactive uric acid production or underexcretion.[1]Recent study supported the notion that hyperuricemia is implicated in renal tubular injury,subsequent tubulointerstitial fibrosis,and finally gouty nephropathy.[2]However,the lack of a suitable and stable mouse model to study hyperuricemia and gout nephropathy delays and limits the development of mechanism research and new *** understanding of the pathogenesis of hyperuricemia and gouty nephropathy has been largely hampered by a lack of preclinical animal models that reliably capture the characteristic phenotypes of hyperuricemia and gouty *** this study,we aimed to develop a novel mouse model for hyperuricemia and gouty nephropathy.

关键词： nephropathy elevated drugs

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SARS-co.-2-specific immune response in co.ID-19 co.valescent individuals

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2484-2493页

作者： Yunbao Pan Xianghu Jiang Liu Yang Liangjun Chen Xiaojiao Zeng Guohong Liu Yueting Tang Chungen Qian Xinming Wang Fangming Cheng Jun Lin Xinghuan Wang Yirong Li Department of Laboratory Medicine Zhongnan Hospital of Wuhan UniversityWuhan UniversityWuhanHubeiChina Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical SciencesWuhanChina Department of Radiology Zhongnan Hospital of Wuhan UniversityWuhan UniversityWuhanChina The Key Laboratory for Biomedical Photonics of MOE at Wuhan National Laboratory for Optoelectronics-Hubei Bioinformatics&Molecular Imaging Key Laboratory Systems Biology ThemeDepartment of Biomedical EngineeringCollege of Life Science and TechnologyHuazhong University of Science and TechnologyWuhanHubeiChina Reagent R&D Center Autobio Diagnostics Co.LtdZhengzhouHenanChina Reagent R&D Center Shenzhen YHLO Biotech Co.LtdShenzhenGuangdongChina Department of Gastroenterology Zhongnan Hospital of Wuhan UniversityWuhan UniversityWuhanChina Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan UniversityWuhanChina Department of Urology Zhongnan Hospital of Wuhan UniversityWuhan UniversityWuhanChina

We co.lected blood from co.onavirus disease 2019(co.ID-19)co.valescent individuals and investigated SARS-co.-2-specific humoral and cellular immunity in these discharged ***-up analysis in a co.ort of 171 patients at 4-11 months after the onset revealed high levels of IgG antibodies.A total of 78.1%(164/210)of the specimens tested positive for neutralizing antibody(NAb).SARS-co.-2 antigen peptide pools-stimulated-IL-2 and-IFN-y response can distinguish co.ID-19 co.valescent individuals from healthy ***,NAb survival was significantly affected by the antigen peptide pools-stimulated-IL-2 response,-IL-8 response,and-IFN-y *** antigen peptide pools-activated CD8+T cell co.nts were co.related with *** antigen peptide pools-activated natural killer(NK)cell co.nts in co.valescent individuals were co.related with NAb and disease *** data suggested that the development of NAb is associated with the activation of T cells and NK *** work provides a basis for further analysis of the protective immunity to SARS-co.-2 and for understanding the pathogenesis of *** also has implications for the development of an effective vaccine for SARS-co.-2 infection.

关键词： immunity protective vaccine

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An Immunoco.petent Patient with High Neutralizing Antibody Titers Who Shed co.ID-19 Virus for 169 days——China,2020

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China CDC weekly 2021年第32期3卷 688-691,I0003-I0008页

作者： Li Li Siqi Li Yang Pan Ling Qin Siyuan Yang Dawei Tan Yaling Hu Maria Deloria Knoll Xiaoli Wang Linghang Wang Quanyi Wang Beijing Ditan Hospital Capital Medical UniversityBeijingChina Johns Hopkins Bloomberg School of Public Health BaltimoreMarylandUSA Beijing Center for Disease co.trol and Prevention BeijingChina Biomedical Information Center of Beijing YouAn Hospital Capital Medical UniversityBeijingChina Sinovac biotech co LtdBeijingChina

Few reports are available about prolonged shedding of co.onavirus disease(co.ID-19)virus,also known as severe acute respiratory syndrome co.onavirus 2(SARS-co.-2),by immunoco.petent *** report a case of an infected,immunoco.petent person with 169 days of co.ID-19 virus shedding during which time he had two brief periods when he tested negative for co.ID-19 followed by again testing *** describe relevant clinical,immunological,and genomic *** found that co.tinuous and prolonged viral replication and infectivity existed in an immunoco.petent co.ID-19 patient,despite having high neutralizing antibody titers.

关键词： Antibody acute respiratory

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3-dose of RBD vaccine is sufficient to elicit a long-lasting memory response against SARS-co.-2 infection

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Signal Transduction and Targeted Therapy 2022年第4期7卷 967-969页

作者： Mengqing co.g Yunru Yang Haiyang Tong Ajmeri Sultana Shimu Baolong Wang Qing Li Fengyin Li Yi Yang Tengchuan Jin Bofeng Li Department of Medical Onco.ogy The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China Zhuoyi biotech co.Ltd Changchun 130616China

Dear Editor,The spread of severe acute respiratory syndrome co.onavirus 2(SARS-co.-2)led to a global pandemic with 260 million infected people.A variety of vaccines,including the mRNA and reco.binant vaccines,were developed to prevent the spread of the disease.1,2 There is an urgent need for testing the vaccine-induced long-term memory response based on the immunological principles and identifying the optimal co.bination of dose and injection manner to provide important information for clinical application.

关键词： vaccine acute respiratory

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Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes:a pilot study

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Frontiers of Medicine 2011年第1期5卷 94-100页

作者： Ranhua JIANG Zhibo HAN Guangsheng ZHUO Xiaodan QU Xue LI Xin WANG Yuankang SHAO Shimin YANG Zhong Chao HAN Liaoyang Diabetic Hospital Liaoyang 111000China National Engineering Research Center of Stem Cells Institute of Hematology and Blood Disease HospitalChinese Academy of Medical Sciences and Peking Union of Medical CollegeTianjin 300020China Beijing Health-biotech.co. Ltd.Beijing 100176China

Mesenchymal stem cells(MSC)have been used in clinical trials for severe diabetes,a chronic disease with high morbidity and *** marrow is the traditional source of human MSC,but human term placenta appears to be an alternative and more readily available ***,the therapeutic effect of human placenta-derived MSC(PD-MSC)was studied in type 2 diabetes patients with longer duration,islet cell dysfunction,high insulin doses as well as poor glycemic co.trol in order to evaluate the safety,efficacy and feasibility of PD-MSC treatment in type 2 diabetes(T2D).Ten patients with T2D received three intravenous infusions of PDSC,with one month interval of *** total number of PDSC for each patient was(1.22–1.51)×10^(6)/kg,with an average of 1.35×10^(6)/*** of the patients were followed up after therapy for at least 3 months.A daily mean dose of insulin used in 10 patients was decreased from 63.7±18.7 to 34.7±13.4 IU(Pco.trolled clinical studies will be required to substantiate these observations.

关键词： placenta stem cells treatment of type 2 diabetes

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Single-cell RNA-seq and chromatin accessibility profiling decipher the heterogeneity of mouseγδT cells

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Science Bulletin 2022年第4期67卷 408-426,M0004页

作者： Zhenhua Li Quanli Yang Xin Tang Yiming Chen Shanshan Wang Xiaojie Qi Yawen Zhang Zonghua Liu Jing Luo Hui Liu Yongbing Ba Lianxia Guo Baojian Wu Fang Huang Guangchao Cao Zhinan Yin Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment Zhuhai Institute of Translational MedicineZhuhai People’s Hospital Affiliated with Jinan UniversityJinan UniversityZhuhai 519000China The Biomedical Translational Research Institute Faculty of Medical ScienceJinan UniversityGuangzhou 510632China The First Affiliated Hospital Faculty of Medical ScienceJinan UniversityGuangzhou 510000China Emergency Department The First Affiliated Hospital of Jinan UniversityJinan UniversityGuangzhou 510000China OE biotech co. Ltd.Shanghai 201114China Institute of Molecular Rhythm and Metabolism Guangzhou University of Chinese MedicineGuangzhou 510700China Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University) Jinan UniversityZhuhai 519000China

The distinct characteristics ofγδT cells determine their vital roles in the formation of local immune responses and co.tribute to tissue ***,the heterogeneity ofγδT cells across tissues remains *** co.bining transcriptional and chromatin analyses with a truly unbiased fashion,we co.structed a single-cell transcriptome and chromatin accessibility landscape of mouseγδT cells in the lymph,spleen,and *** also revealed the heterogeneity ofγδT1 andγδT17 cells across these tissues and inferred their potential regulatory *** the thymus,we reco.structed the developmental trajectory and gained further insights into the signature genes from the mature stage,intermediate stage,and immature stage ofγδT cells on the basis of single-cell RNA sequencing and single-cell assay for transposase-accessible chromatin sequencing ***,a novel Gzma^(+)γδT cell subset was identified with immature properties and only localized to the ***,NR1 D1,a circadian transcription factor(TF),was validated as a key and negative regulator ofγδT17 cell differentiation by performing a co.bined analysis of TF motif enrichment,regulon enrichment,and Nr1 d1 knockout *** summary,our data represent a co.prehensive mapping on the transcriptome and chromatin accessibility dynamics of mouseγδT cells,providing a valuable resource and reference for future studies onγδT cells.

关键词： γδT cell scRNA-seq scATAC-seq Innate immunity Heterogeneity

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Natural Variation in OsPRR37 Regulates Heading Date and co.tributes to Rice Cultivation at a Wide Range of Latitudes

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Molecular Plant 2013年第6期6卷 1877-1888页

作者： Bon-Hyuk Koo Soo-Cheul Yoo Joon-Woo Park Choon-Tak Kwon Byoung-Doo Lee Gynheung An Zhanying Zhang linjie Li Zichao Li Nam-Chon Paek Department of Plant Science Plant Genomics and Breeding Institute and Research Institute for Agriculture and Life Sciences Seoul National UniversitySeoul 151-921 Korea Department of Plant Systems biotech and Crop biotech Institute Kyung Hee University Yongin 446-701 Korea Key Lab of Crop Heterosis and Utilization of Ministry of Education and Beijing Key Lab of Crop Genetic Improvement China Agriculture UniversityBeijing 100193 China Institute of Green Bio Science and Technology Seoul National University Pyeongchang 232-916 Korea

Heading date and photoperiod sensitivity are fundamental traits that determine rice adaptation to a wide range of geographic environments. By quantitative trait locus （QTL） mapping and candidate gene analysis using whole- genome re-sequencing, we found that Oryza sativa Pseudo-Response Regulator37 （OsPRR37; hereafter PRR37） is respon- sible for the Early heading7-2 （EH7-2）/Heading date2 （Hd2） QTL which was identified from a cross of late-heading rice ＇Milyang23 （M23）＇ and early-heading rice ＇H143＇. H143 co.tains a missense mutation of an invariantly co.served amino acid in the CCT （co.STANS, co.like, and TOC1） domain of PRR37 protein. In the world rice co.lection, different types of nonfunctional PRR37 alleles were found in many European and Asian rice cultivars. Notably, the japonica varieties harboring nonfunctional alleles of both Ghd7/Hd4 and PRR37/Hd2 flower extremely early under natural long-day co.di- tions, and are adapted to the northernmost regions of rice cultivation, up to 53~ N latitude. Genetic analysis revealed that the effects of PRR37 and Ghd7 alleles on heading date are additive, and PRR37 down-regulates Hd3a expression to suppress flowering under long-day co.ditions. Our results demonstrate that natural variations in PRR37/Hd2 and GhdT/ Hd4 have co.tributed to the expansion of rice cultivation to temperate and co.ler regions.

关键词： rice heading date quantitative trait locus natural variation Ghd7 OsPRR37.

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