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analysis of In-hospital Neonatal Death in the Tertiary Neonatal Intensive Care Unit in China： A Multicenter Retrospective Study

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Chinese Medical Journal 2016年第22期129卷 2652-2658页

作者： Chen-Hong Wang Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Xiao-Mei Tong Hong Liu Guo-Fang Ding Bin Yi Xin-Nian Pan Dan-Ni Zhong Ling Liu Mei Li Cui-Qing Li Shi-Wen Xia Hong-Yun Wang Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Ruo-Bing Shan De-Zhi Mu Xiao-Hong Liu Si-Qi Zhuang Jing Guo Li Liu Jia-Jun Zhu Hong Xiong Department of Neonatal Intensive Care Unit Children's Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310051 China Department of Pediatrics Peking University Third Hospital Beijing 100191 China Department of Neonatology Beijing Children's Hospital Capital Medical University Beijing 100045 China Department of Pediatrics Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 China Department of Neonatology Gansu Provincial Maternity and Children-care Hospital Lanzhou Gansu 730050 China Department of Neonatology Guangxi Maternal and Child Health Hospital Nanning Guangxi 530003 China Department of Neonatology The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi 530021 China Department of Neonatology Guiyang Maternal and Child Health Care Hospital Guiyang Guizhou 550003 China Department of Neonatology Harbin Children's Hospital Harbin Heilongjiang 150010 China Department of Neonatology Children's Hospital of Hebei Province Shijiazhuang Hebei 050031 China Department of Neonatology Hubei Maternity and Child Heath Hospital Wuhan Hubei 430070 China Department of Neonatal Intensive Care Unit Inner Mongolia Maternal and Child Health Hospital Huhhot Inner Mongolia 010030 China Department of Neonatology Jiangxi Provincial Children's Hospital Nanchang Jiangxi 330006 China Department of Pediatric First Affiliated Hospital of Kunming Medical University Kunming Yunnan 650032 China Department of Neonatology Nanjing Children's Hospital of Nanjing Medical University Nanjing Jiangsu 320100 China Department of Neonatology Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University Nanjing Jiangsu 210004 China DeDartment of Neonatal Intensive Care Unit Ningbo Women and Children's Hospital Ningbo Zhejiang 315012 China Department of Neonatology General Hospital of Ningxia Medical University Yinchuan Ningxia 750004 China Department of Neonatology Qingdao Women and

Background：Globally,the proportion of child deaths that occur in the neonatal period remains a high level of 37-41%.Differences of cause in neonate death exist in different regions as well as in different economic development *** specific aim of this study was to investigate the causes,characteristics,and differences of death in neonates during hospitalization in the tertiary Neonatal Intensive Care Unit （NICU） of ***：All the dead neonates admitted to 26 NICUs were included between January 1,2011,and December 31,*** the data were collected retrospectively from clinical records by a designed *** collected from each NICU were delivered to the leading institution where the results were ***：A total of 744 newborns died during the l-year survey,accounting for 1.2% of all the neonates admitted to 26 NICUs and 37.6% of all the deaths in children under 5 years of age in these *** neonate death accounted for 59.3% of all the *** leading causes of death in preterm and term infants were pulmonary disease and infection,*** early neonate period,pulmonary diseases （56.5%） occupied the largest proportion ofpreterm deaths while infection （27%） and neurologic diseases （22%） were the two main causes of term *** late neonate period,infection was the leading cause of both preterm and term neonate *** two-thirds of neonate death occurred after medical care *** the cases who might survive if receiving continuing treatment,parents＇ concern about the long-term outcomes was the main reason of medical care ***：Neonate death still accounts for a high proportion of all the deaths in children under 5 years of *** study showed the majority of neonate death occurred in preterm *** of death varied with the age of death and gestational *** and prompt evaluation of the long-term outcomes should be carried out to guide the critical decision.

关键词： Cause-of-death Mortality Newbom Retrospective Survey

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An Assessment of Land Use and Land Cover Changes in Wuhan City During 1987-2006:Integrated Geospatial-Socioeconomic data Approach

An Assessment of Land Use and Land Cover Changes in Wuhan Ci...

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地球资源环境定量化理论与应用——2009年全国数学地球...

作者： Douty Chibamba Qiuming Cheng Jiangfeng Li Department of Land Resources Management State key laboratory for Geological Processes and Mineral Resources

This paper assesses land use and land cover change dynamics in Wuhan city during the period *** overall objective is to quantify urban expansion that has occurred during the period under review in order to better understand the drivers and implications of land use and land cover *** satellite imagery is acquired at six-time periods for 1987 through 2006 at approximately four-year intervals,with data collected for each of the years in late spring or late *** images are enhanced and georeferenced to the Wuhan local coordinate system:UTM zone 49N;Datum WGS *** images are then classified using four land use/cover classes(urban,water,forest,agriculture)and change detection analysis is performed on each image using ERDAS IMAGINE *** and visualising urban expansion that occurred during the period under review is done using Arc GIS *** study area(bulti-up area of the city)is delineated using a city boundary for *** use/cover conversion trends are measured and the rates and types of change are *** find fast urban expansion during 1987-1994(10.2%),a somewhat slowed down pace of growth during 1994-2000(6.6%),and a renewed fast pace during2000-2006(10.3%).Overall,urban land area expanded about 27%during the entire study *** expansion was mostly at the expense of the agricultural land use/cover category that was converted to urban uses at the highest rate of about 24.6%during the study *** population and urban per capita incomes are the major drivers of urban expansion during the period under review.

关键词： Land use and land cover change geospatial urban growth remote sensing GIS socioeconomic

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Genetic Architecture of Childhood Kidney and Urological Diseases in China

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Phenomics 2021年第3期1卷 91-104页

作者： Ye Fang Hua Shi Tianchao Xiang Jiaojiao Liu Jialu Liu Xiaoshan Tang Xiaoyan Fang Jing Chen Yihui Zhai Qian Shen Guomin Li Li sun Yunli Bi Xiang Wang Yanyan Qian Bingbing Wu Huijun Wang Wenhao Zhou Duan Ma Jianhua Mao Xiaoyun Jiang Shuzhen sun Ying Shen Xiaorong Liu Aihua Zhang Xiaowen Wang Wenyan Huang Qiu Li Mo Wang Xiaojie Gao Yubin Wu Fang Deng Ruifeng Zhang Cuihua Liu Li Yu Jieqiu Zhuang Qing sun Xiqiang Dang Haitao Bai Ying Zhu Siguang Lu Bili Zhang Xiaoshan Shao Xuemei Liu Mei Han Lijun Zhao Yuling Liu Jian Gao Ying Bao Dongfeng Zhang Qingshan Ma Liping Zhao Zhengkun Xia Biao Lu Yulong Wang Mengzhun Zhao Jianjiang Zhang Shan Jian Guohua He Huifeng Zhang Bo Zhao Xiaohua LI Feiyan Wang Yufeng Li Hongtao Zhu Xinhui Luo Jinghai Li Jia Rao Hong Xu Department of Nephrology Children’s Hospital of Fudan UniversityNational Pediatric Medical Center of CHINA399 Wanyuan RoadShanghaiChina Shanghai Kidney Development and Pediatric Kidney Disease Research Center ShanghaiChina Shanghai key Lab of Birth Defect Children’s Hospital of Fudan UniversityShanghai 201102China Department of Rheumatology Children’s Hospital of Fudan UniversityShanghaiChina Department of Urology Children’s Hospital of Fudan UniversityShanghaiChina Clinical Genetic Center Children’s Hospital of Fudan UniversityShanghaiChina key laboratory of Metabolism and Molecular Medicine Ministry of EducationDepartment of Biochemistry and Molecular BiologyInstitutes of Biomedical SciencesSchool of Basic Medical SciencesFudan UniversityShanghaiChina The Children Hospital of Zhejiang university School of Medicine HangzhouChina The First Affiliated Hospital of sun yat-sen university GuangzhouChina Shandong Provincial Hospital JinanChina Bejing Children’s Hospital Affiliated to Capital university of Medical Science BeijingChina Children’s Hospital of Nanjing Medical university NanjingChina Wuhan Children’s Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Shanghai Children’s Medical Centre Shanghai Jiaotong University School of MedicineShanghaiChina Children’s Hospital of Chongqing Medical university ChongqingChina Shenzhen Children’s Hospital ShenzhengChina Shengjing Hospital of China Medical university ShenyangLiaoningChina Anhui Provincial Children’s Hospital HefeiChina Xuzhou Children’s Hospital XuzhouChina Henan Children’s Hospital ZhengzhouChina Guangzhou First People’s Hospital GuangzhouChina The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical university WenzhouChina Qingdao Women and Children’s Hospital QingdaoChina Xiangya Hospital Central South university ChangshaHunanChina The First Affiliated Hospital of Xiamen university XiamenChina First Affiliated Hospital of Anhui Medical university HefeiC

Kidney disease is manifested in a wide variety of phenotypes,many of which have an important hereditary *** delineate the genotypic and phenotypic spectrum of pediatric nephropathy,a multicenter registration system is being imple-mented based on the Chinese Children Genetic Kidney Disease database(CCGKDD).In this study,all the patients with kidney and urological diseases were recruited from 2014 to *** analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal *** genetic diagnosis was confirmed in 883 of 2256(39.1%)patients from 23 provinces in *** profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome(SRNS,23.5%),glomerulonephritis(GN,32.2%),congenital anomalies of the kidney and urinary tract(CAKUT,21.2%),cystic renal disease(3.9%),renal calcinosis/stone(3.6%),tubulopathy(9.7%),and chronic kidney disease of unknown etiology(CKDu,5.8%).The pathogenic variants of 105 monogenetic disorders were *** distinct genomic disorders were identified as pathogenic copy number variants(CNVs)in 11 *** diagnostic yield differed by subgroups,and was highest in those with cystic renal disease(66.3%),followed by tubulopathy(58.4%),GN(57.7%),CKDu(43.5%),SRNS(29.2%),renal calcinosis/stone(29.3%)and CAKUT(8.6%).Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic *** present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was *** data demonstrate the utility of family-based exome sequencing,and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease.

关键词： Chronic kidney disease(CKD) Exome sequencing(ES) Steroid-resistant nephrotic syndrome(SRNS) Congenital anomalies of the kidney and urinary tract(CAKUT) Nephronophthisis(NPHP) Polycystic kidney disease(PKD)

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Validity of the Chinese Version of the Patient-Generated Subjective Global Assessment (PG-SGA) in Lung Cancer Patients

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Journal of Nutritional Oncology 2016年第1期1卷 52-58页

作者： Zhen Ming Fu Hong Xia Xu Chun Hua Song Wei Li Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Chang Wang Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group Cancer Center Renmin Hospital of Wuhan University Wuhan Hubei 430060 China Department of Nutrition and Metabolism of Oncology Affiliated Provincial Hospital of Anhui Medical University Hefei Anhui 230031 China Department of Clinical Nutrition The First Hospital of Hebei Medical University Shijiazhuang Hebei 050031 China Department of Gastrointestinal Surgery Institute of Gastroenterology The First Affiliated Hospital of Kunming Medical University Kunming Yunnan 650032 China Department of Clinical Nutrition The First People's Hospital of Kashi Xinjiang 844000 China Department of Clinical Nutrition Chongqing General Hospital Chongqing 400014 China Department of Colorectal and Anal Surgery Huizhou Municipal Central Hospital Huizhou Guangdong 516001 China Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan University Wuhan Hubei 430071 China Department of Oncology Xingtai People’s Hospital Hebei Medical University Xingtai Hebei 054031 China The First Department of the Tumor Hospital of Harbin Medical university Harbin Heilongjiang 150085 China Department of Nutrition Guangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou Guangdong 510080 China Department of Nutrition Daping Hospital & Research Institute of Surgery Third Military Medical University Chongqing 400042 China Department of Oncology Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital Zhengzhou Henan 450008 China Department of General Surgery Xiangya Hospital Central South University Changsha Hunan 410008 China Comprehensive Oncology Department Cancer Hospital Chinese Academy of Medical Sciences Beijing 100021 China Department of Oncology Affiliated Hospital of Zunyi Medical University Zunyi Guizhou 563000 China The Fourth Affiliated Hospital Harbin Medical University Harbin Heilongjiang 150001 China Cancer center The First People's Hospital of Foshan Foshan Guangdong 528000 China Department of Gastrointestinal Tumor Surge

The prevalence of malnutrition is high among oncology patients in China. Although the Patient- Generated Subjective Global Assessment (PG-SGA) is widely recognized as an important nutritional assessment tool, it has not been validated for Chinese cancer patients. The purpose of this study was to conduct an analysis of nutrition screening and assessment data to validate the Chinese version of the PG-SGA in Chinese patients with lung cancer. This was an observational, cross-sectional study of 2,000 consecutive adult patients with lung cancer treated at several tertiary hospitals in China. Anthropometric and patient descriptive data were collected. The PG-SGA generated a score for the nutritional risk and a global rating for the nutritional status. The internal consistency, external consistency, and construct validity were evaluated, and a known-groups comparison and principal component analyses were conducted to evaluate the reliability and validity of the PG-SGA. The known-groups comparison demonstrated the ability of the PG-SGA to differentiate lung cancer patients of different nutritional and body mass index (BMI) groups. A confirmatory factor analysis supported the original four-factor structure of the PG-SGA. In terms of the internal and external consistency, the PG-SGA demonstrated intra-class correlation coefficients (ICC) up to 0.987. Alternative form validity was also demonstrated between Box 4 of the PG-SGA and the Karnofsky Performance Status score, with excellent external consistency (r = 0.972, P analysis. Significant Spearman correlations (P < 0.001) were demonstrated. The Chinese version of the PG-SGA demonstrated significant reliability and sufficient exploratory properties to support its validity. It seems to be a valid tool that can be used to access the nutritional status of Chinese lung cancer patients. The validity of the P

关键词： Validation Nutrition status PG-SGA Chinese version Cancer

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华南至东南亚沿海全新世环境演变与史前农业

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科学通报 2024年第18期69卷 2553-2567页

作者：郑卓马婷汤永杰 Barry V.Rolett 宗永强黄康有万秋池陈聪张潇陈碧珊张绍轩中山大学地球科学与工程学院珠海519080 南方海洋科学与工程广东省实验室珠海519080 北京师范大学地表过程与资源生态国家重点实验室珠海基地珠海519087 Department of Anthropology University of Hawai'i at ManoaHawaii 96822USA 香港大学地球科学系中国香港999077 岭南师范学院地理科学学院湛江524048

华南至东南亚沿海地区新石器时期稻作农业的出现并成为主要经济形态显著滞后于长江下游.然而,对于制约华南沿海早期农业扩张的原因存在争议,而且一直以来缺少将考古证据与海岸带沉积与地貌演变的自然过程进行对比.本研究利用全新世孢粉... 详细信息

华南至东南亚沿海地区新石器时期稻作农业的出现并成为主要经济形态显著滞后于长江下游.然而,对于制约华南沿海早期农业扩张的原因存在争议,而且一直以来缺少将考古证据与海岸带沉积与地貌演变的自然过程进行对比.本研究利用全新世孢粉记录集成,结合沿海地区钻孔古环境数据集,探讨了华南至东南亚地区沿海平原的全新世沉积过程与时空演变特征,并对沉积孢粉记录进行了集成.研究区的时空对比表明,以丘陵海岸为主的华南沿海地区在中全新世因海平面上升和海侵作用,海岸线深入陆地丘陵边缘.从6~5 ka BP之后,沉积体系开始从海相为主过渡到陆相的沉积环境,但该时期的海岸带平原土地仍较狭窄,有限的可耕种土地限制了稻作农业的发展空间.虽然在一些南方的考古遗址中发现了5~4 ka BP的水稻相关遗存,但总体揭示的经济形态仍停留在采集、渔猎为主的范畴.三角洲的演变从4 ka BP开始,进入陆地扩张和湿地面积显著增加的阶段,大部分河口湿地和沿海陆地平原逐渐形成一定的规模.尤其在2.5 ka BP之后,三角洲进积作用使平原面积加速扩大,其快速变化与花粉记录指示的稻作农业发展阶段呈现高度的耦合.特别是秦汉前后大规模的农业人口南迁,新的移民带来了先进的集约化水稻种植农业技术,进一步促进了该地区水稻农业的快速发展,并加大了刀耕火种对森林的破坏和引发严重的水土流失.此外,从沿海平原到丘陵山地的早期农业发展也存在滞后现象.本研究揭示了华南和东南亚沿海地区海岸带平原的形成阶段与农业发展过程是基本同步的,印证了人类文明发展与自然环境变化相互制约与依存的人-地关系.

关键词：全新世新石器时代孢粉分析海岸线演变史前农业华南-东南亚

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锆石微量元素对成矿岩体的判别——来自大数据思维的应用

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地质通报 2019年第12期38卷 1992-1998页

作者：耿厅周永章李兴远王俊陈川王堃屹韩紫奇中山大学地球科学与工程学院广东广州510275 广东省地质过程与矿产资源探查重点实验室广东广州510275 中山大学地球环境与地球资源研究中心广东广州510275 中山大学地理科学与规划学院广东广州510275 Department of Geology University of ReginaReginaSaskatchewan S4S 0A2Canada 广东高质资源环境研究院广东广州510275

华南钦杭结合带燕山期岩浆活动异常活跃,且具有较明显的成矿专属性。近年来微区测试技术日益成熟,积累了大量锆石微量数据。通过全体数据挖掘的思维方法,对前人发表的数据进行了进一步数据挖掘,利用锆石稀土元素对岩体成矿潜力进行判别... 详细信息

华南钦杭结合带燕山期岩浆活动异常活跃,且具有较明显的成矿专属性。近年来微区测试技术日益成熟,积累了大量锆石微量数据。通过全体数据挖掘的思维方法,对前人发表的数据进行了进一步数据挖掘,利用锆石稀土元素对岩体成矿潜力进行判别,探讨有效的找矿地球化学标志。利用Python语言编程,对采用的13种稀土元素及元素比值进行穷举式组合,获得了4095个二元图解及121485个三元图解,并设计筛选算法,自动筛选出能有效区分锆石母岩成矿类型的图解。结果表明,锆石稀土元素含量及比值图解对不同成矿类型岩体的区分程度各异:与Ce、Eu有关的地球化学指标可以较清晰地对斑岩铜矿和钨锡(锡)矿床进行判别,这可能与岩体的氧逸度和含水量有关。此外,还挖掘出一些新的元素组合图解,如Dy/Lu-Er/Lu、Gd/Dy-Er/Yb等,可以有效区分岩体成矿类型,其隐含的地球化学机制尚待进一步解释。地球化学数据挖掘结果可以作为找矿标志使用,为华南燕山期岩浆-热液矿床研究及找矿勘查提供了科学依据,也是大数据技术在矿床学方面应用研究的积极探索。

关键词：锆石微量元素大数据分析地球化学图解钦杭结合带

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基于WorldView-2数据的基塘系统遥感分类研究

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湿地科学 2018年第5期16卷 587-596页

作者：黎丰收刘凯刘洋唐焕丽柳林彭力恒中山大学地理科学与规划学院综合地理信息研究中心、广东省城市化与地理环境空间模拟重点实验室广东广州510275 Department of Geography University of Cincinnati Cincinnati OH 45221 USA 广州市增城区城乡规划与测绘地理信息研究院广东广州511300 广州大学地理科学学院公共安全地理信息分析中心广东广州510006

分布在热带和亚热带低洼地区的基塘系统是一种典型的人工复合农业生态系统。通过水陆交互作用和能量多级利用,基塘系统创造出较高的生态价值和经济价值。掌握基塘系统土地利用的类型、面积和比例关系,有助于了解和分析基塘系统的现状及... 详细信息

分布在热带和亚热带低洼地区的基塘系统是一种典型的人工复合农业生态系统。通过水陆交互作用和能量多级利用,基塘系统创造出较高的生态价值和经济价值。掌握基塘系统土地利用的类型、面积和比例关系,有助于了解和分析基塘系统的现状及其生态模式和功能。以广东省佛山市顺德区西南部为研究区,利用高空间分辨率WorldView-2卫星影像数据,采用结合面向对象分类和基于像元的混合分类方法,提取基塘系统中的塘面和基面（基面又细分为道路、植被和裸土等）;从分类特征组合与分类器两个方面,通过对比分析,筛选出基塘系统遥感影像分类的最优方法;根据最优分类结果,计算出塘基与塘面的面积比例。研究结果表明,采用面向对象分类方法分离的塘面和塘基的总体精度为82.2%;在基于像元进一步对塘基进行分类的过程中,结合8个多光谱波段光谱反射率平均值、影像亮度值和8个红边波段指数特征组合方式的随机森林分类器的分类精度最高,达到85.6%;得到的基-塘面积比例约为4.9∶5.1,植被-塘面的面积比例约为3.5∶6.5。提出的结合面向对象和基于像元的混合分类方法能够对基塘系统进行精细的遥感影像分类,能准确估计基塘系统中各地物的面积和基-塘比例等指标,并为基塘系统生态功能的调查和基塘系统的合理保护与开发提供参考和数据支持。

关键词：基塘系统面向对象分类 WorldView-2 遥感分类

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