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Unlocking the potential of amorphous calcium carbonate: A star ascending in the realm of biomedical application

Acta Pharmaceutica Sinica B 2024年第2期14卷 602-622页

作者： Han Liu Zhiyang Wen Zihan Liu Yanfang Yang Hongliang Wang Xuejun Xia Jun Ye Yuling Liu State Key Laboratory of Bioactive substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Calcium-based biomaterials have been intensively studied in the field of drug delivery owing to their excellent biocompatibility and ***-based materials can also deliver contrast agents,which can enhance real-time imaging and exert a Ca^(2+)-interfering therapeutic *** on these characteristics,amorphous calcium carbonate(ACC),as a brunch of calcium-based biomaterials,has the potential to become a widely used *** functional ACC can be either discovered in natural organisms or obtained by chemical synthesis However,the standalone presence of ACC is unstable in *** are required to be used as stabilizers or core-shell structures formed by permeable layers or lipids with modified molecules constructed to maintain the stability of ACC until the ACC carrier reaches its *** has high chemical instability and can produce biocompatible products when exposed to an acidic condition in vivo,such as Ca^(2+) with an immune-regulating ability and CO_(2) with an imaging-enhancing *** to these characteristics,ACC has been studied for selfsacrificing templates of carrier construction,targeted delivery of oncology drugs,immunomodulation,tumor imaging,tissue engineering,and calcium *** in this paper has been placed on the origin,structural features,and multiple applications of ***,ACC faces many challenges in clinical translation,and long-term basic research is required to overcome these *** hope that this study will contribute to future innovative research on ACC.

关键词： Amorphous calcium carbonate Drugdelivery system Nanoparticle Acid sensitivity Water instability,Tumortherapy Tissue engineering Calcium supplement

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Dimethyl Sulfoxide/Visible-Light Comediated Chemoselective C-S Bond Formation Between Tryptophans and Thiophenols Enables Site-Selective Functionalization of Peptides

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CCS Chemistry 2024年第6期6卷 1547-1556页

作者： Guangjun Bao Peng Wang Jingyue Li Xinyi Song Tingli Yu Jiao Zhang Yiping Li Zeyuan He Ruiyao E Xiaokang Miao Junqiu Xie Jingman Ni Rui Wang Wangsheng Sun Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences&Research Unit of Peptide ScienceChinese Academy of Medical Sciences2019RU066Lanzhou UniversityLanzhou 730000 State Key Laboratory of Bioactive substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050

Late-stage peptide modification showcases a huge potential for the construction of peptide libraries,and the investigation of structure-activity *** we report a dimethyl sulfoxide/visible light comediated chemoselective modification of tryptophan residue by forging the C-S structure using thiophenols irradiated with blue light-emitting diodes at room *** method shows excellent chemoselectivity toward the C-2 position of the tryptophan residue and good compatibility with diverse thiophenol derivatives bearing various functional *** protected oligopeptides and unmasked bioactive peptides smoothly underwent site-selective modification,furnishing the corresponding *** all,this study provides a new competent toolkit for late-stage peptide modification,labelling,and peptide-drug conjugation and provides a clue for protein bioconjugation.

关键词： peptide modification late-stage diversification photocatalysis tryptophan thiophenol

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New perspectives on the genetic structure of dotted gizzard shad(Konosirus punctatus)based on RAD-seq

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Marine Life Science & Technology 2024年第1期6卷 50-67页

作者： Ying Peng Yifan Liu Jiasheng Li Kun Zhang Xun Jin Sixu Zheng Yunpeng Wang Zhenming Lu Liqin Liu Li Gong Bingjian Liu National Engineering Laboratory of Marine Germplasm Resources Exploration and Utilization Zhejiang Ocean UniversityZhoushan 316022China National Engineering research center for Facilitated Marine Aquaculture Marine Science and Technology CollegeZhejiang Ocean UniversityZhoushan 316022China

To maintain,develop and rationally utilize marine organisms,understanding their genetic structure and habitat adaptation pattern is *** punctatus,which is a commercial fish species inhabiting the Indo-west Pacific Ocean,has shown an obvious annual global capture and aquaculture production decline due to climate changes and human *** the present study,restriction-site associated DNA sequencing(RAD-seq)was used to describe its genome-wide single nucleotide polymorphisms panel(SNPs).Among 146 individuals collected at nine locations scattered in China,Korea and Japan,a set of 632,090 SNPs were *** genetic analysis showed that *** individuals were divided into two significant genetic ***,potential genetic differentiation between northern and southern population of *** was *** results indicated that gene flow existed among sampling locations of ***,especially from southern Japan to ***,candidate genes associated with habitat adaptations of *** were identified,which are involved in diverse physiological processes of *** including growth and development(e.g.,KIDINS220,PAN3),substance metabolism(e.g.,PGM5)and immune response(e.g.,VAV3,CCT7,HSPA12B).Our findings may aid in understanding the possible mechanisms for the population genetic structure and local adaptation of ***,which is beneficial to establish the management and conservation units of ***,guiding the rational use of resources,with reference significance for a profound understanding of the adaptative mechanisms of other marine organisms to the environment.

关键词： Population structure Konosirus punctatus SNP RAD-seq Local adaptation

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Immunomodulatory and chemopreventive effects of resveratrol on the digestive system cancers

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Oncology research 2024年第9期32卷 1389-1399页

作者： MEIR DJALDETTI Laboratory for Immunology and Hematology research Rabin Medical CenterHasharon HospitalPetah-Tiqvathe Sackler School of MedicineTel-Aviv UniversityRamat Aviv69978Israel

Resveratrol(RSV),the primary polyphenol found in grapes,has been revealed to have anti-inflammatory properties by reducing the capacity of the peripheral blood mononuclear cells to produce pro-inflammatory cytokines,including IL-1β,IL-6,IL-1ra and TNFα.Considering the close association between chronic inflammation and cancer development,RSV’s immunomodulatory properties are one way by which the polyphenol may inhibit cancer initiation,proliferation,neovascularization,and *** influences the generation of microtumor environment which is one of the key factors in cancer *** addition to immunomodulation,RSV inhibits cancer development by expressing anti-oxidant effects,causing cell cycle arrest,stimulating the function of certain enzymes,and activating cell signaling *** end outcome is one of the various forms of cell death,including apoptosis,pyroptosis,necroptosis,and more,as it has been observed in *** has been shown to act against cancer in practically every organ,while its effects on colon cancer have been documented more *** is remarkable that longer-term clinical studies that may have established the potential for this natural substance to serve as a therapeutic adjuvant to traditional anti-cancer medications were not prompted by the encouraging outcomes seen with cancer cells treated with non-toxic doses of *** current review aims to assess the recent findings about the immunological and anti-cancer characteristics of RSV,with a particular emphasis on cancers of the digestive tract,as a challenge for future clinical research that may contribute to the better prognosis of cancer.

关键词： Resveratrol(RSV) Chemoprevention Digestive tract cancers Immunity Cell death Polyphenols

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A kinetic resolution accompanied chirality transformation process for asymmetric synthesis of chiral phenol, oxaziridine, and α-hydroxyl cyclic ketone

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Science China Chemistry 2024年第9期67卷 2989-2997页

作者： Pengxin Wang Xiaoyong Zhang Lingqing Wang Rui Wang Dongxu Yang Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences & Research Unit of Peptide ScienceChinese Academy of Medical Sciences Lanzhou University State Key Laboratory of Bioactive substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College School of Sciences Great Bay University Institute of Systems and Physical Biology Shenzhen Bay Laboratory

Chirality transformation is a basic, attractive, and important strategy for obtaining enantioenriched products with desired chiral elements. The reported chirality conversion reaction often involves the process from one type of chirality to another one. To better utilize the chirality transformation strategy for obtaining two or more products with different chiral elements in a single reaction, a new method of kinetic resolution accompanied by a chirality transformation protocol is proposed and successfully realized in this study. This process is used for the asymmetric oxidation of phenol compounds along with the kinetic resolution of oxaziridines. A wide scope of products, including axially chiral phenols, oxaziridines, and α-hydroxyl cyclic ketones were smoothly obtained in high levels of yields and enantioselectivities in the developed method. These products can be readily used for the synthesis of various types of chiral ligands, which are potential choices for other catalytic asymmetric reactions.

关键词： chirality transformation kinetic resolution accompanied axially chiral phenols chiral oxaziridines

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CuO催化拜尔液中有机物的降解

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Journal of Central South University 2024年第3期31卷 813-826页

作者：李梦楠刘战伟颜恒维马文会夏成成刘强 Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming 650093China National Engineering research center for Vacuum Metallurgy Kunming University of Science and TechnologyKunming 650093China Aluminum Industry Engineering research center of Yunnan Province Kunming 650093China School of Science and Technology Pu′er UniversityPu′er 665000China

本研究采用以O_(2)为氧化剂、CuO为催化剂的催化湿法氧化技术去除拜尔液中的有机物。首先,在O_(2)添加量为13.98 g/L、氧化温度为220℃、氧化时间为100 min、不添加CuO的条件下,总有机碳、腐植酸钠和草酸钠的去除率分别为86.59%、92.96%... 详细信息

本研究采用以O_(2)为氧化剂、CuO为催化剂的催化湿法氧化技术去除拜尔液中的有机物。首先,在O_(2)添加量为13.98 g/L、氧化温度为220℃、氧化时间为100 min、不添加CuO的条件下,总有机碳、腐植酸钠和草酸钠的去除率分别为86.59%、92.96%和71.36%。在此基础上,研究了O_(2)氧化拜尔液中有机物的自由基链式反应机理。然后,在CuO添加量为6%、O_(2)添加量为13.98 g/L、催化温度为250℃、催化时间为100 min的最佳条件下,总有机碳去除率为98.36%,腐植酸钠和草酸钠基本能够被全部去除。CuO形成的铜羟基络合物([Cu(Ⅱ)(OH)_x]~(2-x))基于络合反应机理是催化有机物降解的主要原因,溶解的CuO直接催化的自由基链式反应是第二个原因。催化湿法氧化技术能够有效去除拜尔液中的有机物,尤其是对氧化铝生产危害较大的草酸钠。

关键词：有机物催化湿法氧化 CuO 有机物去除

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Arecoline causes cognitive impairment and potential addiction via disturbing Kenyon cells in bumblebee brain

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Food Science and Human Wellness 2024年

作者： Huiling Liu Xiaohuan Mu Rongrong Fan Jieteng Chen Jie Ma Liang Meng Xiaosong Hu Hao Zheng Shanshan Liu Xiaofei Wang College of Food Science and Nutritional Engineering National Engineering research center for Fruit and Vegetable Processing Key Laboratory of Fruits and Vegetables Processing Ministry of Agriculture Engineering research Centre for Fruits and Vegetables Processing Ministry of Education China Agricultural University BGI-Qingdao

Areca nut is the basic ingredient of betel quid， which is chewed by hundreds of millions of people in south-eastern Asia. Chewing of areca nut has been associated with oral cancers potentially due to its specific alkaloids， among which arecoline constitutes about 90% of total fraction. Being the world’s fourth most commonly used psychoactive substance， arecoline evokes stimulation， addiction， and other direct neurological effects， while its misuse correlates to neurotoxic effects. However， what might underlie its neurotoxic mechanisms has been poorly documented. The brain is encoded by a complex network of neuronal and glial cell types， and neurotoxicity of hazardous compounds present transcriptional heterogeneity. Recently， the eusocial bumblebee has been used as a model for studying brain effects， with sophisticated cognitive capability and precisely measured brain architecture. Here， we decipher cell-type-specific mental risks to arecoline using bumblebees. Arecoline induced locomotor hyperactivity and cognitive impairment. Single nucleus RNA sequencing (snRNA-seq) unearthed arecoline-induced cell-specific responses， primarily targeted on Kenyon cells (KC). Moreover， high-dose arecoline induced distinctive cell responses among KC subtypes， particularly class I large Kenyon cell (lKC)， leading to DNA damage， excitatory/inhibitory (E/I) imbalance， and calcium dyshomeostasis， which potentially resulted in cognitive impairment. Given arecoline’s popularity and growing exposure risks to humans， neurological health risks of areca nut warrant serious consideration.

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Recent antibacterial agents from biomass derivatives:Characteristics and applications

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Journal of Bioresources and Bioproducts 2024年第3期9卷 283-309页

作者： Nissa Nurfajrin Solihat Alif Faturahman Hidayat R.A.Ilyas Senthil Muthu Kumar Thiagamani Nur Izyan Wan Azeele Fahriya Puspita Sari Maya Ismayati Mohammad Irfan Bakshi Zaharaddeen N.Garba M.Hazwan Hussin Witta Kartika Restu Wasrin Syafii Harits Atika Ariyanta Widya Fatriasari research center for Biomass and Bioproducts National Research and Innovation Agency(BRIN)Kawasan KST SoekarnoJl Raya Bogor KM 46 Cibinong Bogor 16911Indonesia Department of Bioproducts and Biosystems School of Chemical EngineeringAalto UniversityEspoo 16300Finland Department of Chemical Engineering Faculty of Chemical and Energy EngineeringUniversiti Teknologi MalaysiaJohor 81310Malaysia Centre for Advanced Composite Materials Universiti Teknologi MalaysiaJohor 81310Malaysia Institute of Tropical Forestry and Forest Products Universiti Putra MalaysiaSerdang 43400Malaysia Centre of Excellence for Biomass Utilization Universiti Malaysia PerlisPerlis 02600Malaysia Department of Mechanical Engineering Kalasalingam Academy of Research and EducationKrishnankoil 626126India Institute of Bioproduct Development(IBD) Universiti Teknologi MalaysiaJohor 81310Malaysia Department of Chemistry Ahmadu Bello UniversityZaria 810211Nigeria Materials Technology research Group(MaTReC) School of Chemical SciencesUniversiti Sains MalaysiaMinden 11800Malaysia research center for Chemistry National Research and Innovation Agency(BRIN)Kawasan Puspiptek SerpongSouth Tangerang 15314Indonesia Department of Forest Products Faculty of Forestry and EnvironmentIPB UniversityBogor 16680Indonesia Department of Pharmacy Gunadarma UniversityDepok 16424Indonesia research Collaboration center of Biomass-Based Nano Cosmetic In collaboration with National Research and Innovation Agency(BRIN)SamarindaEast KalimantanIndonesia

Enhancing awareness of personal cleanliness and antibacterial resistance has intensified the antibacterial substance request on consumable products. Antibacterial agents that have been commercialized nowadays are produced from inorganic and non-renewable substances. This provides several drawbacks, particularly against health and environmental issues. Therefore, many scientists work on substituting fossil-fuel-based antibacterial agents with natural ones such as from biomass. Biomass derivatives, natural abundances of biopolymers in the world, amount to major compounds including polysaccharides (cellulose, hemicellulose, and chitosan) and polyphenol (tannin and lignin) substances which are capable to combat the growth of Gram-positive bacteria and Gram-negative bacteria. To date, no report focuses on a deep understanding of antibacterial properties derived from biomass and the internal and external factors effects. This work provides that gap because comprehensive knowledge is necessary before applying biomass to the products. The potency of biomass derivatives as antibacterial additives is also summarized. Basic knowledge of antibacterial characteristics to the application in products is highlighted in this review. Besides, the discussion about challenges and future perspectives is also delivered.

关键词： Antibacterial Application Biomass derivatives Challenge Future perspectives

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Nitrosamines crisis in pharmaceuticals Insights on toxicological implications, root causes and risk assessment: A systematic review

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Journal of Pharmaceutical Analysis 2024年第5期14卷 639-652页

作者： Hemanth P.R.Vikram Tegginamath Pramod Kumar Gunjan Kumar Narasimha M.Beeraka Rajashree Deka Sheik Mohammed Suhail Sandeep Jat Namitha Bannimath Gayatiri Padmanabhan Ravandur S.Chandan Pramod Kumar Bannimath Gurupadayya Department of Pharmaceutical Chemistry JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Xenone Healthcare Pvt.Ltd. New Delhi110076India Department of Pharmaceutics JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of Human Anatomy I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow119991Russian Federation Department of Pharmacology Raghavendra Institute of Pharmaceutical Education and Research(RIPER)Ananthapuramu515721India Herman B.Wells center for Pediatric research Department of PediatricsIndiana University School of MedicineIndianapolisIN46202USA Animal Physiology and Biochemistry Laboratory Department of ZoologyGauhati UniversityGuwahati781014India Department of Pharmacology JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of Pharmaceutical Analysis National Institute of Pharmaceutical Education and Research(NIPER)-GuwahatiChangsari781101India Department of Pharmacology University of GalwayGalwayH91 TK33Ireland

The presence of N-nitroso compounds,particularly N-nitrosamines,in pharmaceutical products has raised global safety concerns due to their significant genotoxic and mutagenic *** systematic review investigates their toxicity in active pharmaceutical ingredients(APIs),drug products,and pharmaceutical excipients,along with novel analytical strategies for detection,root cause analysis,reformulation strategies,and regulatory guidelines for *** review emphasizes the molecular toxicity of N-nitroso compounds,focusing on genotoxic,mutagenic,carcinogenic,and other physiological ***,it addresses the ongoing nitrosamine crisis,the development of nitrosamine-free products,and the importance of sensitive detection methods and precise risk *** comprehensive overview will aid molecular biologists,analytical scientists,formulation scientists in research and development sector,and researchers involved in management of nitrosamine-induced toxicity and promoting safer pharmaceutical products.

关键词： Carcinogenicity Genotoxicity Mutagenicity Molecular toxicity Nitrosamine impurities Nitrosamine drug substance-related impurities

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Effect of preload forces on multidimensional signal dynamic behaviours for battery early safety warning

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Journal of Energy Chemistry 2024年第5期92卷 484-498页

作者： Kuijie Li Jiahua Li Xinlei Gao Yao Lu Depeng Wang Weixin Zhang Weixiong Wu Xuebing Han Yuan-cheng Cao Languang Lu Jinyu Wen Shijie Cheng Minggao Ouyang School of Electrical and Electronic Engineering Huazhong University of Science and TechnologyWuhan 430074HubeiChina State Key Laboratory of Automotive Safety and Energy Tsinghua UniversityBeijing 100084China Energy and Electricity research center Jinan UniversityZhuhai 519070GuangdongChina Department of Mechanical Engineering Imperial College LondonLondon.SW7:2AZ.UK

Providing early safety warning for batteries in real-world applications is *** this study,comprehensive thermal abuse experiments are conducted to clarify the multidimensional signal evolution of battery failure under various preload *** time-sequence relationship among expansion force,voltage,and temperature during thermal abuse under five categorised stages is *** characteristic peaks are identified for the expansion force,which correspond to venting,internal short-circuiting,and thermal *** particular,an abnormal expansion force signal can be detected at temperatures as low as 42.4°C,followed by battery thermal runaway in approximately 6.5 ***,reducing the preload force can improve the effectiveness of the early-warning method via the expansion ***,reducing the preload force from 6000 to 1000 N prolongs the warning time(i.e.,227 to 398 s)before thermal runaway is *** on the results,a notable expansion force early-warning method is proposed that can successfully enable early safety warning approximately 375 s ahead of battery thermal runaway and effectively prevent failure propagation with module *** study provides a practical reference for the development of timely and accurate early-warning strategies as well as guidance for the design of safer battery systems.

关键词： Lithium-ion battery Thermal runaway Preload force Expansionforce Early warning Multidimensional signal

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