检索结果-南通市图书馆

AB035. Lactate receptor GPR81 modulates epigenetic modification in the subretina

Annals of eye Science 2018年第1期 441-441页

作者： Xiaojuan Yang Raphael Rouget Tang Zhu Christiane Quiniou Shasha Lv Suna Jung Francois Duhamel Houda Tahiri Samy Omri Baraa Noueihed Xin Hou JoséCarlos Rivera Mathieu Nadeau-Vallée Pierre Lachapelle Sylvain Chemtob Department of Pharmacology McGill UniversityMontréalQCCanada Department of Pharmacology Universitéde MontréalMontréalQCCanada Research Center CHU Sainte-Justine Universitéde MontréalMontréalQCCanada Department of Ophthalmology and Neurology-Neurosurgery Montréal Children’s Hospital-Research InstituteMcGill UniversityMontréalQCCanada Research Center Hôpital Maisonneuve-Rosemont Universitéde MontréalMontréalQCCanada Department of Ophthalmology Universitéde MontréalMontréalQCCanada Department of Pediatrics Universitéde MontréalMontréalQCCanada

Background:Retinal pigment epithelium(RPE)is vital for the homeostasis of the subretina including photoreceptors and ***,our previous results suggested that the recently discovered lactate receptor GPR81 is abundantly expressed in *** date,only one previous study has shown that activating GPR81 could enhance DNA repair by activating ***,we investigated whether GPR81 exhibits epigenetic modification in the subretina by using GPR81−/−***:GPR81−/−mice and wide type littermates were generated on a background of C57BL/6J *** thicknesses of their choroid were evaluated by ***,Q-PCR,western blot and choroid sprout assay were *** vitro,primary retinal pigment epithelium(pRPE)cells were isolated from mice,and cultured for ***:The thickness of choroid was reduced in GPR81−/−mice compared to GPR81+/+mice,suggesting that GPR81 is important for the integrity of *** the choroid sprout assay,lactate treated RPE/choroid complex showed a significant increase in angiogenesis compared to controls while lactate treated KO RPE/choroid complex showed no difference compared to their *** Q-PCR,most of the genes screened elevated their expression in GPR81−/−mice compared to WT mice,suggesting epigenetic modification may exist,which were confirmed by histone acetylation and HDACs activity ***:Taking together,the lactate receptor GPR81 in RPE is very important for maintaining homeostasis of the *** novel discovery sheds new light on the relationship between metabolism and epigenetic modification.

关键词： Subretina GPR81 epigenetic modification

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

More than Meets the eye: A Qualitative Investigation of the Complex Weight History Constructions of Brazilian Women Who Underwent Bariatric Surgery

引用

Journal of Psychological Research 2023年第4期5卷 50-67页

作者： Mariana Dimitrov Ulian Ramiro Fernandez Unsain Ruth Rocha Franco Marco Aurélio Santo Alexandra Brewis Sarah Trainer Cindi SturtzSreetharan Amber Wutich Bruno Gualano Fernanda Baeza Scagliusi School of Public Health University of São PauloDepartment of NutritionSão PauloSP01246-904Brazil Pediatric Endocrinology Unit Children’s InstituteHospital das Clínicas of the School of MedicineUniversity of São PauloSão PauloSP05403.000Brazil Bariatric and Metabolic Surgery Unity Digestive System Surgery DivisionUniversity of São PauloSão PauloSP05403.000Brazil School of Human Evolution and Social Change Arizona State UniversityTempeAZ85281United States of America Seattle University SeattleWA98122United States of America University of São Paulo Applied Physiology&Nutrition Research GroupSão PauloSP05403.000 Brazil

Most studies on bariatric surgery identify personal factors such as“non-compliance”to lifestyle changes as the cause of weight gain and subsequent inability to lose *** qualitative studies suggest that weight loss patients have complicated relationships with both self and weight,with significant emotional and psychological *** how do patients themselves understand the trajectories of their weight gain as related to intrinsic versus extrinsic factors?A qualitative analysis examined the aspects involved in the construction of higher body weight from the perspectives and life experiences of Brazilian women who underwent bariatric surgery,considering that Brazil has previously been reported as a highly anti-fat ***,semi-structured interviews were conducted with thirty women(15 aged 33-59 and 15 aged 63-72).Data were analyzed identifying the regular,expressive,and meaningful significance units identified through the *** it was expected that different life events were reported as crucial to the perceived aetiology of individual weight gain stories,the participants reported that the emotional aspects had more *** extremely high value attached to having a particular body weight negatively influenced the participants’concept of identity and harmed their interactions and understanding of what it meant to be fully loved and *** of the participants underscored the importance of food in women’s lived experiences and explanations of weight *** this somatic response being dysfunctionally directed to food,this mechanism seemed to be vital to keeping them alive and engaged in the ***,the participants faced layered vulnerabilities,which decreased their opportunities to access resources aimed at better body weight *** approaches that consider emotional and physical care strategies must be proposed to this population.

关键词： Mental health Bariatric surgery Obesity Body weight Stigma Brazil Qualitative investigation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：