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“设”“艺”之间

现代装饰 2018年第11期 100-107页

作者： Bodegón Cabinet Max Enrich Goula Figuera Thomas Feichtner Siba Sahabi Weez and Merl KIMU Design Sabine Marcelis Bower Pedro Paulo Venzon Akos Huber Christian Lo Nina Johanna Christensen 彭佳 studio os △ oos Bloc studios Regular Company

在工作中,接触到很多设计师都不是本专业出身,而是美术、手工等纯艺术专业。观察这类设计师的作品,我们往往可以发现其与众不同的跳脱气质：它们或是在平面视觉上有脱俗亮眼的表现,或是简约而不简单,虽然没有繁复的造型和精致的编排布局... 详细信息

在工作中,接触到很多设计师都不是本专业出身,而是美术、手工等纯艺术专业。观察这类设计师的作品,我们往往可以发现其与众不同的跳脱气质：它们或是在平面视觉上有脱俗亮眼的表现,或是简约而不简单,虽然没有繁复的造型和精致的编排布局,但就自然而然地让人感觉舒适、高雅。

关键词：室内装饰设计方案设计风格设计师

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细腻的“粗野主义”

现代装饰 2018年第3期 92-99页

作者： Atang Tshikare & OKHA Joost van Bleiswilk Jay Sae Jung Oh Gnstián Mohaded Christapher Gentner Hector Estawe & Manuel Bano & Age Salajoe Alessandro Zambelli Adate-C Stine Mikkelsen we+ 彭佳 studio os △ oos Uhuru Design & Constance Guisset

＂粗野主义＂（Brutalism）的建筑流派盛行于20世纪50年代至70年代中期,可以被归入现代建筑流派的一种。其建筑特色以整体的粗犷为特点,在材料上尽可能保持自然本色,力图真实地展现材料粗粝的质感;于形式上则摆脱了传统风格的束缚,将结... 详细信息

＂粗野主义＂（Brutalism）的建筑流派盛行于20世纪50年代至70年代中期,可以被归入现代建筑流派的一种。其建筑特色以整体的粗犷为特点,在材料上尽可能保持自然本色,力图真实地展现材料粗粝的质感;于形式上则摆脱了传统风格的束缚,将结构的毛糙、沉重和粗野感作为审美的标准,呈现出一种野性、朴野的面貌。

关键词：粗野主义建筑流派设计师设计灵感家具产品色彩搭配边角料设计手法

Extract of Fructus Schisandrae chinensis Inhibits Neuroinflammation Mediator Production from Microglia via NF-κB and MAPK Pathways

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Chinese Journal of Integrative Medicine 2019年第2期25卷 131-138页

作者： SONG Fang-jiao ZENG Ke-wu CHEN Jin-feng LI Yuan SONG Xiao-min TU Peng-fei WANG Xue-mei Research studio of Integration of Traditional and Western Medicine First HospitalPeking University State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking University

Objective: To investigate the anti-neuroinflammation effect of extract of Fructus Schisandrae chinensis(EFSC) on lipopolysaccharide(LPS)-induced BV-2 cells and the possible involved mechanisms. Methods: Primary cortical neurons were isolated from embryonic(E17-18) cortices of Institute of Cancer Research(ICR) mouse fetuses. Primary microglia and astroglia were isolated from the frontal cortices of newborn ICR mouse. Different cells were cultured in specific culture medium. Cells were divided into 5 groups: control group, LPS group(treated with 1 μg/mL LPS only) and EFSC groups(treated with 1 μg/mL LPS and 100, 200 or 400 mg/mL EFSC, respectively). The effect of EFSC on cells viability was tested by methylthiazolyldiphenyltetrazolium bromide(MTT) colorimetric assay. EFSC-mediated inhibition of LPS-induced production of pro-inflammatory mediators, such as nitrite oxide(NO) and interleukin-6(IL-6) were quantified and neuron-protection effect against microglia-mediated inflammation injury was tested by hoechst 33258 apoptosis assay and crystal violet staining assay. The expression of pro-inflammatory marker proteins was evaluated by Western blot analysis or immunofluorescence. Results: EFSC(200 and 400 mg/mL) reduced NO, IL-6, inducible nitric oxide synthase(iN os) and cyclooxygenase 2(COX-2) expression in LPS-induced BV-2 cel s(Posis and inflammation injury in neurons exposed to microglia-conditioned medium(Posphorylation and its nuclear translocation(P<0.01). The anti-inflammatory effect of EFSC occurred through suppressed activation of mitogen-activated protein kinase(MAPK) pathway(P<0.01 or P<0.05). Conclusion: EFSC acted as an anti-inflammatory agent in LPS-induced glia cel s. These effects might be realized through bl

关键词： neuroinflammation microglia Fructus Schisandrae chinensis nuclear factor-κB mitogen- activated protein kinase

Durable natural killer cell response after three doses of SARS-CoV-2 inactivated vaccine in HIV-infected individuals

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Chinese Medical Journal 2023年第24期136卷 2948-2959页

作者： Xiaodong Yang Xiuwen Wang Xin Zhang Haifeng Ding Hu Wang Tao Huang Guanghui Zhang Junyi Duan Wei Xia Bin Su Cong Jin Hao Wu Tong Zhang Beijing Key Laboratory for HIV/AIDS Research Sino-French Joint Laboratory for Research on Humoral Immune Response to HIV InfectionClinical and Research Center for Infectious DiseasesBeijing Youan HospitalCapital Medical UniversityBeijing 100069China National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Tian Yuan studio Beijing Youan HospitalCapital Medical UniversityBeijing 100069China

Background:Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)vaccine can induce a potent cellular and humoral immune response to protect against SARS-CoV-2 ***,it was unknown whether SARS-CoV-2 vaccination can induce effective natural killer(NK)cell response in people living with human immunodeficiency virus(PLWH)and healthy ***:Forty-seven PLWH and thirty healthy controls(HCs)inoculated with SARS-CoV-2 inactivated vaccine were enrolled from Beijing Youan Hospital in this *** effect of SARS-CoV-2 vaccine on NK cell frequency,phenotype,and function in PLWH and HCs was evaluated by flow cytometry,and the response of NK cells to SARS-CoV-2 Omicron Spike(SARS-2-os)protein stimulation was also ***:SARS-CoV-2 vaccine inoculation elicited activation and degranulation of NK cells in PLWH,which peaked at 2 weeks and then decreased to a minimum at 12 weeks after the third dose of ***,in vitro stimulation of the corresponding peripheral blood monocular cells from PLWH with SARS-2-os protein did not upregulate the expression of the aforementioned ***,the frequencies of NK cells expressing the activation markers CD25 and CD69 in PLWH were significantly lower than those in HCs at 0,4 and 12 weeks,but the percentage of CD16^(+)NK cells in PLWH was significantly higher than that in HCs at 2,4 and 12 weeks after the third dose of ***,the frequency of CD16^(+)NK cells was significantly negatively correlated with the proportion of CD107a^(+)NK cells in PLWH at each time point after the third ***,this phenomenon was also observed in HCs at 0,2,and 4 weeks after the third ***,regardless of whether NK cells were stimulated with SARS-2-os or not,we did not observe any differences in the expression of NK cell degranulation markers between PLWH and ***:SARS-CoV-2 vaccine elicited activation and degranulation of NK cells,indicating that the inoculation of

关键词： HIV SARS-CoV-2 inactivated vaccine COVID-19 Omicron variant NK cell response Immunologic memory

操作系统美少女——Windows ME os娘(高达装)

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模型世界 2006年第12期 34-35页

作者：杨凡 igloo studio工作室

'os娘'是日本漫画爱好者将微软著名的电脑操作系统Windows系列拟人化的产众多的漫画爱好者集思广益,为每一款Windows操作系统设计出一个美少女卡通形象,'os'是操作系统的英文缩写,而'娘'在日语中包含有美女的意思,所以'os娘'直译过来就... 详细信息

'os娘'是日本漫画爱好者将微软著名的电脑操作系统Windows系列拟人化的产众多的漫画爱好者集思广益,为每一款Windows操作系统设计出一个美少女卡通形象,'os'是操作系统的英文缩写,而'娘'在日语中包含有美女的意思,所以'os娘'直译过来就是操作系统美少女的意思了.

关键词： Windows ME os 美少女操作系统 ME