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DETECTION OF Ca^(2+)-DEPENDENT NEURONAL ACTIVITY SIMULTANEOUSLY WITH DYNAMIC CHANGES IN CEREBRAL BLOOD VOLUME AND TISSUE OXYGENATION FROM THE LIVE RAT BRAIN

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Journal of Innovative Optical Health Sciences 2009年第2期2卷 189-200页

作者： CONGWU DU ZHONGCHI LUO MEI YU HELENE BENVENISTE MELISSA TULLY RUBING PAN BRITTON CHANCE Medical Department Brookhaven National Laboratory UptonNY 11973-5000USA Department of Biomedical Engineering SUNY at Stony Brook Stony BrookNY 11794USA Department of Anesthesiology SUNY at Stony Brook Stony BrookNY 11794USA Department of Biology University of Illinois at Urbana-Champaign UrbanaIL 61801 Department of Biophysics and Physical Chemistry University of Pennsylvania PhiladelphiaPA19104

We present a catheter-based optical diffusion and fluorescence(ODF)probe to study the functional changes of the brain in *** ODF probe enables the simultaneous detection ofthe multi-wavelength absorbance and fluorescence emission from the living rat *** previous studies,including a transient stroke experiment of the rat brain as well as the brainresponse to cocaine,have established the feasibility of simultaneously determining changes incerebral blood volume(CBV),tissue oxygenation(StO2)and intracellular calcium([Ca^(2+)]i,using the fluorescence indicator Rhod2).Here,we present our preliminary results of somatosensory response to electrical forepaw stimulation obtained from the rat cortical brain by using theODF probe,which indicate that the probe could track brain activation by directly detecting[Ca^(2+)]i along with separately distinguishing CBV and StO2 in real *** changes of CBV,StO2 and[Ca^(2+)]i are comparable with the blood-oxygen-level-dependent(BOLD)response tothe stimulation obtained using functional magnetic resonance imaging(fMRI).However,thehigh temporal resolution of the optical methodology is advanced,thus providing a new modalityfor brain functional studies to understand the hemodynamic changes that underlie the neuronalactivity.

关键词： Optical spectroscopy calcium fluorescence Rhod2 labeling brain ischemia and cocaine addiction forepaw stimulation.

Programmable Adaptive Security Scanning for Networked Microgrids

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Engineering 2021年第8期7卷 1087-1100页

作者： Zimin Jiang Zefan Tang Peng Zhang Yanyuan Qin Department of Electrical and Computer Engineering Stony Brook UniversityStony BrookNY 11794USA Department of Computer Science and Engineering University of ConnecticutStorrsCT 06269USA

Communication-dependent and software-based distributed energy resources(DERs)are extensively integrated into modern microgrids,providing extensive benefits such as increased distributed controllability,scalability,and ***,malicious cyber-attackers can exploit various potential *** this study,a programmable adaptive security scanning(PASS)approach is presented to protect DER inverters against various power-bot ***,three different types of attacks,namely controller manipulation,replay,and injection attacks,are *** approach employs both software-defined networking technique and a novel coordinated detection method capable of enabling programmable and scalable networked microgrids(NMs)in an ultra-resilient,time-saving,and autonomous *** coordinated detection method efficiently identifies the location and type of power-bot attacks without disrupting normal NM *** simulation results validate the efficacy and practicality of the PASS for securing NMs.

关键词： Networked microgrids Programmable adaptive security scanning Coordinated detection Software defined networking

A data-driven machine learning approach for yaw control applications of wind farms

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Theoretical & Applied Mechanics Letters 2023年第5期13卷 341-352页

作者： Christian Santoni Zexia Zhang Fotis Sotiropoulos Ali Khosronejad Department of Civil Engineering Stony Brook UniversityStony BrookNY 11794United States Mechanical and Nuclear Engineering Virginia Commonwealth UniversityVA 23284United States

This study proposes a cost-effective machine-learning based model for predicting velocity and turbulence kineticenergy fields in the wake of wind turbines for yaw control *** model consists of an auto-encoderconvolutional neural network(ACNN)trained to extract the features of turbine wakes using instantaneous datafrom large-eddy simulation(LES).The proposed framework is demonstrated by applying it to the Sandia NationalLaboratory Scaled Wind Farm Technology facility consisting of three 225 kW *** of this site is performedfor different wind speeds and yaw angles to generate datasets for training and validating the proposed *** is shown that the ACNN accurately predicts turbine wake characteristics for cases with turbine yaw angleand wind speed that were not part of the training ***,the ACNN is shown to reproduce thewake redirection of the upstream turbine and the secondary wake steering of the downstream turbine *** to the brute-force LES,the ACNN developed herein is shown to reduce the overall computational costrequired to obtain the steady state first and second-order statistics of the wind farm by about 85%.

关键词： Wind energy Machine learning Yaw controlLarge eddy simulations Convolutional neural networks

3D Bioprinting with Live Cells

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Engineered Regeneration 2022年第3期3卷 292-309页

作者： Alicia Persaud Alexander Maus Lia Strait Donghui Zhu Department of Biomedical Engineering Stony Brook UniversityUSA

In recent years,the shortage of available organs for transplant patients has grown exponentially across the ***,the healthcare industry is in dire need of artificial *** recent research studies and tissue engineering groups have decided to utilize 3D bioprinting to produce these artificial *** synthetic organ printing is made possible by advancements in the materials required for the constructs,the printing method-ologies used to produce them,and the final physical structures’varying *** cutting-edge research and technology related to 3D and 4D live cell bioprinting have recently allowed researchers to produce multiple types of artificial organs and *** tissues can be utilized for drug screening and organ replacement *** article provides an extensive review of all the pertinent 3D live cell bioprinting ***,we describe scaffolding methods and their comparison with the traditional ***,we explain the 3D bioprinting technology,its evolution,and its multiple ***,we describe the pros and cons of each bioprinting ***,we have discussed the critical bioink properties and their impact on the formation of 3D bioprinting *** addition,we also describe the mechanical properties of ***,we have thoroughly discussed the various types of hydrogels and their *** kind of hydrogel is utilized in specific applications,and we have presented a comprehensive list of its advantages and ***,we have discussed various applications of 3D bioprinting *** have considered a case study of human or-gans and elaborated on how bioprinters can revolutionize the organ replacement ***,we evaluated the possibility of 4D printing in the future organ industry,incorporating temporal factors into the bioprinting process.

关键词： Bioprinting Three-dimensional Scaffolding Live cell Hydrogels 4D bioprinting Applications

AN EMBEDDED BOUNDARY METHOD FOR ELLIPTIC AND PARABOLIC PROBLEMS WITH INTERFACES AND APPLICATION TO MULTI-MATERIAL SYSTEMS WITH PHASE TRANSITIONS

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Acta Mathematica Scientia 2010年第2期30卷 499-521页

作者： Shuqiang Wang Roman Samulyak Tongfei Guo Department of Applied Mathematics and Statistics Stony Brook University Stony Brook NY 11794 USA Computational Science Center Brookhaven National Laboratory Upton NY 11973 USA

The embedded boundary method for solving elliptic and parabolic problems in geometrically complex domains using Cartesian meshes by Johansen and Colella （1998, J. Comput. Phys. 147, 60） has been extended for elliptic and parabolic problems with interior boundaries or interfaces of discontinuities of material properties or solutions. Second order accuracy is achieved in space and time for both stationary and moving interface problems. The method is conservative for elliptic and parabolic problems with fixed interfaces. Based on this method, a front tracking algorithm for the Stefan problem has been developed. The accuracy of the method is measured through comparison with exact solution to a two-dimensional Stefan problem. The algorithm has been used for the study of melting and solidification problems.

关键词： embedded boundary method elliptic interface problem front tracking Ste-fan problem

Nanofabrication in Polymer Solutions

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应用化学 2001年第5期18卷 259-266页

作者： Tianbo LIU Li Zhi LIU Benjamin CHU Department of Chemistry State University of New York at Stony BrookStony BrookNY 117903400USA

This review covers recent advances in fabrication of nanomaterials in polymer solutions with emphasis on using the self assembled amphiphilic block copolymers in solution to fabricate organic/inorganic composites with nanoscale modifications. The phase behavior of block copolymers in water and the use of templates to form ordered nanostructures are reviewed in detail. Modern physical techniques for nanoscale characterization are also introduced. The authors suggested that this approach should provide new routes to create materials with interesting morphologies for many different applications.

关键词：聚合物溶液纳米技术胶束纳米结构

The Hardy-Weinberg principle and its applications in modern population genetics

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Frontiers in Biology 2010年第4期5卷 348-353页

作者： John J.CHEN Department of Preventive Medicine State University of New York at Stony BrookStony BrookNY 11794-8036USA

The discovery of the Hardy-Weinberg principle marked the beginning of the field of population *** the past hundred years,it has provided a starting point for many population genetic *** this review,the Hardy-Weinberg principle,its statistical testing,and several of its applications in various modern population genetic research areas,including allelic variability and selection in the human leukocyte antigen region,microsatellite genotyping error detection,and accuracy of haplotype estimation,are discussed.

关键词： the Hardy-Weinberg principle statistical testing population genetics human leukocyte antigens microsatellite genotyping haplotype estimation

Repeated hydrogen peroxide dosing briefly reduces cyanobacterial blooms and microcystin while increasing fecal bacteria indicators in a eutrophic pond

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Journal of Environmental Sciences 2023年第2期124卷 522-543页

作者： Mark W.Lusty Christopher J.Gobler School of Marine and Atmospheric Sciences Stony Brook UniversitySouthamptonNY 11968USA

This study explored the effects of H_(2)O_(2)on Cyanobacteria and non-target microbes using fluorometry,microscopy,flow cytometry,and high throughput DNA sequencing of the 16S rRNA gene during a series of mesocosm and whole-ecosystem experiments in a eutrophic pond in NY,*** addition of H_(2)O_(2)(8 mg/L)significantly reduced Cyanobacteria concentrations during a majority of experiments(66%;6 of 9)and significantly increased eukaryotic green and unicellular brown algae in 78%and 45%of experiments,*** heterotrophic bacteria declined significantly following H_(2)O_(2)addition in all experiments,bacteria indicative of potential fecal contamination(Escherichia coli,Enterococcus,fecal coliform bacteria)consistently and significantly increased in response to H_(2)O_(2),evidencing a form of‘pollution swapping’.H_(2)O_(2)more effectively reduced Cyanobacteria in enclosed mesocosms compared to whole-ecosystem *** whole-pond H_(2)O_(2)applications over a twoyear period temporarily reduced cyanobacterial levels but never reduced concentrations below bloom thresholds and populations always rebounded in two weeks or *** bacterial phyla of Cyanobacteria,Actinobacteria,and Planctomycetes were the most negatively impacted by H_(2)O_(2).Microcystis was always reduced by H_(2)O_(2),as was the toxin microcystin,but Microcystis remained dominant even after repeated H_(2)O_(2)*** H_(2)O_(2)favored the growth of eukaryotic algae over potentially harmful Cyanobacteria,the inability of H_(2)O_(2)to end cyanobacterial blooms in this eutrophic waterbody suggests it is a non-ideal mitigation approach in high biomass ecosystems and should be used judiciously due to potential negative impacts on non-target organisms and promotion of bacteria indicative of fecal contamination.

关键词： Indicator bacteria Toxic cyanobacteria Microcystin Microcystis Hydrogen peroxide Bacteria Enterococcus E.coli Pollution swapping

Electrospun Nanofibrous Adsorption Membranes for Wastewater Treatment:Mechanical Strength Enhancement

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Chemical Research in Chinese Universities 2021年第3期37卷 355-365页

作者： XIN Rui MA Hongyang Shyam Venkateswaran Benjamin S.Hsiao State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing100029China Department of Chemistry Stony Brook UniversityStony BrookNY117943400USA

Functional nanofibrous membranes fabricated by electrospinning technology have attracted much attention in the removal of heavy metal ions from contaminated *** high specific surface area,high porosity and ease of functionality create an enhanced throughput and high adsorption capacity of the nanofibrous ***,the relatively poor mechanical properties of the membrane with a non-woven nanofibrous structure are one of the major concerns,which can limit the applications in wastewater *** strategies and methodologies were explored to address the problems and were reviewed in this work,highlighting the possibilities of overcoming the poor mechanical properties of the nanofibrous membrane and to ensure the recyclability and reusability of the membrane during the adsorption process.

关键词： Electrospun nanofibrous membrane Mechanical property Heavy metal ion Wastewater treatment