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stony brook’s Collaborations with Czech Scientists

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International Journal of Geosciences 2021年第5期12卷 487-498页

作者： Robert Cooper Liebermann Mineral Physics Institute and Department of Geosciences Stony Brook University NY USA

For the past half-century, I have been fortunate in maintaining collaborations with Czech scientists in the Czech Republic [formerly Czechoslovakia] from the Geofyzikální ústav-GFU [Institute of Geophysics] of the ?eskoslovenská Akademie Věd-?SAV [Czechoslovak Academy of Sciences]. These collaborations have included exchange visits by me to Prague [Praha] and convening international workshops in 1976, 1986 and 1996 in castles used by the ?SAV as well as visits by Czech colleagues to Stony Brook University. The objective of this report is to relate this history. This paper is dedicated to the memory of Vladislav Babu?ka.

关键词： Mineral Physics High Pressure High Temperature Anisotropy and Lateral Heterogeneity of the Earth’s Mantle

Formation of CoAl layered double hydroxide on the boehmite surface and its role in tungstate sorption

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Journal of Environmental Sciences 2018年第3期30卷 103-115页

作者： Hyuck Hur Richard J.Reeder Department of Chemistry Stony Brook University Stony Brook NY 11794 USA Department of Geosciences Stony Brook University Stony Brook NY 11794 USA

Sorption of tungstate on boehmite（γ-Al OOH）is increased by co-sorption with Co^（2＋）over the near-neutral p H *** uptake experiments show up to a 3-fold increase in tungstate uptake over the range WO4^（2-）=50–1000μmol/L compared to boehmite not treated with Co^（2＋）.Desorption experiments reveal a corresponding decrease in sorption reversibility for tungstate co-sorbed with Co^（2＋）.Reaction of boehmite with Co^（2＋）results in the formation of Co Al layered double hydroxide（LDH）,as confirmed by X-ray diffraction and X-ray absorption *** L3-edge X-ray absorption near edge structure（XANES）reveals that W（VI）is octahedrally coordinated in all sorption samples,with polymeric tungstate species forming at higher tungstate concentrations.X-ray diffraction and X-ray absorption spectroscopy indicate that the mechanism for enhancement of tungstate uptake is the formation of surface complexes on boehmite at low tungstate concentrations,while exchange into the Co Al LDH becomes important at higher tungstate *** results provide a basis for developing strategies to enhance tungstate sorption and to limit its environmental mobility at near-neutral pH conditions.

关键词： Tungsten Tungstate Cobalt Boehmite (AIOOH) Layered double hydroxide Adsorption

Customized Additive Manufacturing in Bone Scaffolds-The Gateway to Precise Bone Defect Treatment

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Research 2023年第4期2023卷 79-103页

作者： Juncen Zhou Carmine Wang See Sai Sreenivasamurthy Donghui Zhu Department of Biomedical Engineering Stony Brook UniversityStony BrookNYUSA

In the advancing landscape of technology and novel material development,additive manufacturing(AM)is steadily making strides within the biomedical *** away from traditional,one-sizefits-all implant solutions,the advent of AM technology allows for patient-specific scaffolds that could improve integration and enhance wound *** scaffolds,meticulously designed with a myriad of geometries,mechanical properties,and biological responses,are made possible through the vast selection of materials and fabrication methods at our *** the importance of precision in the treatment of bone defects,which display variability from macroscopic to microscopic scales in each case,a tailored treatment strategy is required.A patient-specific AM bone scaffold perfectly addresses this *** review elucidates the pivotal role that customized AM bone scaffolds play in bone defect treatment,while offering comprehensive guidelines for their *** includes aspects such as bone defect imaging,material selection,topography design,and fabrication ***,we propose a cooperative model involving the patient,clinician,and engineer,thereby underscoring the interdisciplinary approach necessary for the effective design and clinical application of these customized AM bone *** collaboration promises to usher in a new era of bioactive medical materials,responsive to individualized needs and capable of pushing boundaries in personalized medicine beyond those set by traditional medical materials.

关键词： thereby offering custom

Primary cilia as a novel horizon between neuron and environment

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Neural Regeneration Research 2017年第8期12卷 1225-1230页

作者： Gregory W.Kirschen Qiaojie Xiong Medical Scientist Training Program Stony Brook University Stony Brook NY USA Department of Neurobiology & Behavior Stony Brook University Stony Brook NY USA

The primary cilium, a hair-like sensory organelle found on most mammalian cells, has gained recent attention within the field of neuroscience. Although neural primary cilia have been known to play a role in embryonic central nervous system patterning, we are just beginning to appreciate their importance in the mature organism. After several decades of investigation and controversy, the neural primary cilium is emerging as an important regulator of neuroplasticity in the healthy adult central nervous system. Further, primary cilia have recently been implicated in disease states such as cancer and epilepsy. Intriguingly, while primary cilia are expressed throughout the central nervous system, their structure, receptors, and signaling pathways vary by anatomical region and neural cell type. These differences likely bear relevance to both their homeostatic and neuropathological functions, although much remains to be uncovered. In this review, we provide a brief historical overview of neural primary cilia and highlight several key advances in the field over the past few decades. We then set forth a proposed research agenda to fill in the gaps in our knowledge regarding how the primary cilium functions and malfunctions in nervous tissue, with the ultimate goal of targeting this sensory structure for neural repair following injury.

关键词： G protein-coupled receptor sonic hedgehog seizure stroke stem cell neurogenesis plasticity

Widely accessible method for 3D microflow mapping at high spatial and temporal resolutions

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Microsystems & Nanoengineering 2022年第4期8卷 57-71页

作者： Evan Lammertse Nikhil Koditala Martin Sauzade Hongxiao Li Qiang Li Luc Anis Jun Kong Eric Brouzes Department of Biomedical Engineering Stony Brook UniversityStony BrookNY 11794USA Department of Mathematics and Statistics Department of Computer ScienceGeorgia State UniversityAtlantaGA 30302USA Laufer Center for Physical and Quantitative Biology Stony Brook UniversityStony BrookNY 11794USA Cancer Center Stony Brook School of MedicineStony BrookNY 11794USA Institute for Engineering Driven Medicine Stony Brook UniversityStony BrookNY 11794USA

Advances in microfluidic technologies rely on engineered 3D flow patterns to manipulate samples at the ***,current methods for mapping flows only provide limited 3D and temporal resolutions or require highly specialized optical ***,we present a simple defocusing approach based on brightfield microscopy and open-source software to map micro-flows in 3D at high spatial and temporal *** workflow is both integrated in ImageJ and *** track seed particles in 2D before classifying their Z-position using a reference *** compare the performance of a traditional cross-correlation method and a deep learning model in performing the classification *** validate our method on three highly relevant microfluidic examples:a channel step expansion and displacement structures as single-phase flow examples,and droplet microfluidics as a twophase flow ***,we elucidate how displacement structures efficiently shift large particles across ***,we reveal novel recirculation structures and folding patterns in the internal flow of microfluidic *** simple and widely accessible brightfield technique generates high-resolution flow maps and it will address the increasing demand for controlling fluids at the microscale by supporting the efficient design of novel microfluidic structures.

关键词： flow resolution method

Some new estimates for the complex Monge-Ampère equation

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Science China Mathematics 2019年第11期62卷 2073-2088页

作者： Xiuxiong Chen Jingrui Cheng Department of Mathematics SUNY Stony BrookStony BrookNY 11794USA Simons Center for Geometry and Physics SUNY Stony BrookStony BrookNY 11794USA

In this paper, we consider the complex Monge-Ampère equation posed on a compact K?hler manifold. We show how to get L^p(p < ∞) and L∞estimates for the gradient of the solution in terms of the continuity of the righ... 详细信息

关键词： complex Monge-Ampère equations gradient estimates Kahler manifold

Genetic targeting of astrocytes to combat neurodegenerative disease

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Neural Regeneration Research 2020年第2期15卷 199-211页

作者： Rachel Kéry Allen P. F. Chen Gregory W. Kirschen Medical Scientist Training Program MSTP)Stony Brook MedicineStony BrookNYUSA Department of Neurobiology & Behavior Stony Brook UniversityStony BrookNYUSA

Astrocytes, glial cells that interact extensively with neurons and other support cells throughout the central nervous system, have recently come under the spotlight for their potential contribution to, or potential regenerative role in a host of neurodegenerative disorders. It is becoming increasingly clear that astrocytes, in concert with microglial cells, activate intrinsic immunological pathways in the setting of neurodegenerative injury, although the direct and indirect consequences of such activation are still largely unknown. We review the current literature on the astrocyte’s role in several neurodegenerative diseases, as well as highlighting recent advances in genetic manipulation of astrocytes that may prove critical to modulating their response to neurological injury, potentially combatting neurodegenerative damage.

关键词： Alzheimer's disease amyotrophic lateral sclerosis glia immune system inflammation Parkinson's disease reactive astrocyte regeneration

OPTICAL COHERENCE TOMOGRAPHY FOR BLADDER CANCER DIAGNOSIS:FROM ANIMAL STUDY TO CLINICAL DIAGNOSIS

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Journal of Innovative Optical Health Sciences 2008年第1期1卷 125-140页

作者： ZHIJIA YUAN HUGANG REN WAYNE WALTZER JASON KIM JINGXUAN LIU KEMIAO JIA HUIKAI XIE YINGTIAN PAN Departments of Biomedical Engineering Stony Brook UniversityStony BrookNYUSA Departments of Biomedical Urology Stony Brook UniversityStony BrookNYUSA Departments of Biomedical Pathology stony brook University Stony BrookNYUSA The ECE Department University of FloridaGainesvilleFLUSA

This paper summarizes the recent technological development in our lab on cystoscopic optical coherence tomography(COCT)by integrating time-domain OCT(TDOCT)and spectral-domain OCT(SDOCT)with advanced MEMS-mirror technology for endoscopic laser scanning *** COCT catheter can be integrated into the instrument channel of a commercial 22Fr rigid cystoscopic sheath for in vivo imaging of human bladder under the cystosocopic visual guidance;the axial/transverse resolutions of the COCT catheter are roughly 9μm and 12μm,respectively,and 2D COCT imaging can be performed with over 110dB dynamic range at 4–8 *** examine the utility and potential limitations of OCT for bladder cancer diagnosis,systemic ex vivo rat bladder carcinogenesis studies were performed to follow various morphological changes induced by tumor growth and in vivo porcine study was performed to examine the feasibility of COCT for in vivo *** by promising results of the animal studies,preliminary clinical study was conducted on patients scheduled for operating-room cystoscopy for bladder ***-blind clinical results reveal that COCT can delineate detailed bladder architectures(e.g.,urothelium,lamina propria,muscularis)at high resolution and detect bladder cancers based on enhanced urothelial heterogeneity as a result of excessive growing nature of bladder *** diagnostic sensitivity and specificity can be enhanced to 92%and 85%,*** also suggest that due to reduced imaging depth of COCT in cancerous lesions,staging of bladder cancers may be limited to Ta or T1 for non-outgrowing cancerous lesions.

关键词： Optical coherence tomography bladder cancer diagnosis microelectromechanical system

An Algorithm for Constructing 3D Struts

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Journal of Computer Science & Technology 2009年第1期24卷 56-64页

作者： George W.Hart Department of Computer Science Stony Brook UniversityStony BrookNY 11794U.S.A.

A simple robust ＂strut algorithm＂ is presented which, when given a graph embedded in 3D space, thickens its edges into solid struts. Various applications, crystallographic and sculptural, are shown in which smooth high-genus forms are the output. A toolbox of algorithmic techniques allow for a variety of novel, visually engaging forms that express a mathematical aesthetic. In sculptural examples, hyperbolic tessellations in the Poincare plane are transformed in several ways to three-dimensional networks of edges embodied within a plausibly organic organization. By the use of different transformations and adjustable parameters in the algorithms, a variety of attractive forms result. The techniques produce watertight boundary representations that can be built with solid freeform fabrication equipment. The final physical output satisfies the ＂coolness criterion,＂ that passers by will pick them up and say ＂Wow, that＇s cool!＂

关键词： sculpture solid modeling echinoderm algorithms fine arts computer-aided design