检索结果-南通市图书馆

Parkin Somatic Mutations Link Melanoma and Parkinson's Disease

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2016年第6期43卷 369-379页

作者： Lotan Levin Shani Srour Jared Gartner Oxana Kapitansky Nouar Qutob Shani Dror Tamar Golan Roy Dayan Ronen Brener Tamar Ziv Mehdi Khaled Ora Schueler-furman Yardena Samuels Carmit Levy Department of Human Genetics and Biochemistry Sackler Faculty of MedicineTel Aviv University Surgery Branch National Cancer InstituteNIH Department of Molecular Cell Biology Weizmann Institute of Science Oncology institute Edith Wolfson Medical Center Technion Smoler Proteomics Center Faculty of BiologyTechnion e Israel Institute of Technology institut Gustave Roussy INSERM Department of Microbiology and Molecular Genetics Institute for Medical Research Israel-CanadaFaculty of MedicineHebrew University

Epidemiological studies suggest a direct link between melanoma and Parkinson＇s disease（PD）; however, the underlying molecular basis is unknown. Since mutations in Parkin are the major driver of early-onset PD and Parkin was recently reported to play a role in cancer development, we hypothesized that Parkin links melanoma and PD. By analyzing whole exome/genome sequencing of Parkin from 246 melanoma patients, we identified five non-synonymous mutations, three synonymous mutations, and one splice region variant in Parkin in3.6% of the samples. In vitro analysis showed that wild-type Parkin plays a tumor suppressive role in melanoma development resulting in cell-cycle arrest, reduction of metabolic activity, and apoptosis. Using a mass spectrometry-based analysis, we identified potential Parkin substrates in melanoma and generated a functional protein association network. The activity of mutated Parkin was assessed by protein structure modeling and examination of Parkin E3 ligase activity. The Parkin-E28 K mutation impairs Parkin ubiquitination activity and abolishes its tumor suppressive effect. Taken together, our analysis of genomic sequence and in vitro data indicate that Parkin is a potential link between melanoma and Parkinson＇s disease. Our findings suggest new approaches for early diagnosis and treatment against both diseases.

关键词： Melanoma Parkinson's disease Parkin Mutation

在线全文

学校读者我要写书评

暂无评论

利用机器学习研究隐粲五夸克态的性质

Science Bulletin 2023年第10期68卷 981-989,M0003页

作者：张振宇刘家豪胡继峰王倩 Ulf-G.Meißner Guangdong Provincial Key Laboratory of Nuclear Science Institute of Quantum MatterSouth China Normal UniversityGuangzhou 510006China Guangdong-Hong Kong Joint Laboratory of Quantum Matter Southern Nuclear Science Computing CenterSouth China Normal UniversityGuangzhou 510006China Helmholtz-institut für Strahlen-und Kernphysik and Bethe Center for Theoretical Physics Universität BonnBonn D-53115Germany institute for Advanced Simulation Institut für Kernphysik and Jülich Center for Hadron PhysicsForschungszentrum JülichJïlich D-52425Germany Tbilisi State University Tbilisi 0186Georgia

机器学习已经在生物、医学、生产等多个领域广泛应用并展现了其优势.最近,机器学习在物理领域也开始逐渐兴起并展现出其独特的优点.该文旨在探索机器学习在强子物理中的应用潜力.作者以隐粲五夸克态Pc(4312)、Pc(4440)和Pc(4457)为例,... 详细信息

机器学习已经在生物、医学、生产等多个领域广泛应用并展现了其优势.最近,机器学习在物理领域也开始逐渐兴起并展现出其独特的优点.该文旨在探索机器学习在强子物理中的应用潜力.作者以隐粲五夸克态Pc(4312)、Pc(4440)和Pc(4457)为例,在强子分子态图像下研究它们的性质.研究表明,神经网络方法和基于χ2的拟合方法都能够阐明基于领头阶接触势的基本物理性质.然而,χ2拟合方法无法区分Pc(4440)和Pc(4457)的量子数,神经网络方法则可以.由此,作者进一步分析了每个实验数据点对于神经网络预测的影响,以及在拟合方法中每个数据点对于关键物理参数的重要性.通过对比研究,作者发现神经网络方法可以多维度地利用实验数据信息,在强子物理中具有巨大的应用前景.

关键词： Exotic hadrons Machine learning QCD mass spectrum Hidden charm pentaquarks

DET1-mediated COP1 regulation avoids HY5 activity over second-site gene targets to tune plant photomorphogenesis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2021年第6期14卷 963-982页

作者： Esther Canibano Clara Bourbousse Marta Garcia-Leon Borja Garnelo Gomez Lea Wolff Camila Garcia-Baudino Rosa Lozano-Duran Fredy Barneche Vicente Rubio Sandra Fonseca Centro Nacional de Biotecnología CNB-CSICMadrid 28049Spain institut de biologie de l’École normale supérieure(IBENS) École normale supérieureCNRSINSERMUniversitéPSLParis 75005France Shanghai Center for Plant Stress Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 201602China Department of Plant Biochemistry Centre for Plant Molecular Biology(ZMBP)Eberhard Karls University72076 TübingenGermany

DE-ETIOLATED 1(DET1)and CONSTITUTIVE PHOTOMORPHOGENESIS 1(COP1)are two essential repressors of Arabidopsis *** proteins can associate with CULLIN4 to form independent CRL4-based E3 ubiquitin ligases that mediate the degradation of several photomorphogenic transcription factors,including ELONGATED HYPOCOTYL 5(HY5),thereby controlling multiple gene-regulatory *** extensive biochemical and genetic analyses of their multi-subunit complexes,the functional links between DET1 and COP1 have long remained ***,we report that DET1 associates with COP1 in vivo,enhances COP1-HY5 interaction,and promotes COP1 destabilization in a process that dampens HY5 protein *** regulating its accumulation,DET1 avoids HY5 association with hundreds of second-site genomic loci,which are also frequently targeted by the skotomorphogenic transcription factor PHYTOCHROME-INTERACTING FACTOR ***,ectopic HY5 chromatin enrichment favors local gene repression and can trigger fusca-like *** study therefore shows that DET1-mediated regulation of COP1 stability tunes down the HY5 cistrome,avoiding hyper-photomorphogenic responses that might compromise plant viability.

关键词： HY5 DET1 COP1 photomorphogenesis light signaling fusca

Isospin-conserving hadronic decay of the D_(s1)(2460) into D_(s)π^(+)π^(-)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2023年第5期75卷 119-127页

作者： Meng-Na Tang Yong-Hui Lin Feng-Kun Guo Christoph Hanhart Ulf-G.Meißner CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Helmholtz-institut für Strahlen-und Kernphysik and Bethe Center for Theoretical Physics Universität BonnD-53115 BonnGermany Peng Huanwu Collaborative Center for Research and Education Beihang UniversityBeijing 100191China institute for Advanced Simulation and institut für Kernphysik Forschungszentrum JülichD-52425 JülichGermany Tbilisi State University 0186 TbilisiGeorgia

The internal structure of the charm-strange mesons D_(s0)^(*)(2317)and D_(s1)(2460)are the subject of intensive *** widths are small because they decay dominantly through isospinbreaking hadronic channels D_(s0)^(*)(2317)^(+)→D_(s)^(+)π^(0) and D _(s1)(2460)^(+)→D_(s)^(*+)π^(0).The D_(s1)(2460)can also decay into the hadronic final states D_(s)^(+)ππ,conserving *** that case there is,however,a strong suppression from phase *** study the transition D_(s1)(2460)^(+)→D_(s)^(+)π^(+)π^(-)in the scenario that the D_(s1)(2460)is a D^(*)K hadronic *** ππ final state interaction is taken into account through dispersion *** find that the ratio of the partial widths of the Γ(D_(s1)(2460)^(+)→D_(s)^(+)π^(+)π^(-)) / Γ(D_(s1)(2460)^(+)→D_(s)^(*+)π^(0))obtained in the molecular picture is consistent with the existing experimental *** interestingly,we demonstrate that theπ+π−invariant mass distribution shows a double bump structure,which can be used to disentangle the hadronic molecular picture from the compact state picture for the D_(s1)(2460)^(+).Predictions on the B_(s1)^(0)→B_(s)^(0)π^(+)π^(-)are also made.

关键词： hadronic molecule isospin symmetry heavy quark flavor symmetry

Dose-Dependent AGO1-Mediated Inhibition of the miRNA165/166 Pathway Modulates Stem Cell Maintenance in Arabidopsis Shoot Apical Meristem

在线全文

学校读者我要写书评

暂无评论

Plant Communications 2020年第1期1卷 179-189页

作者： Fei Du Wen Gong Sonia Bosca Matthew Tucker Herve Vaucheret Thomas Laux Signalling Research Centres BIOSS and CIBSS Faculty of BiologyUniversity of FreiburgSchanzlestrasse 179104 FreiburgGermany institut Jean-Pierre Bourgin INRAAgroParisTechCNRSUniversite Paris-Saclay78000 VersaillesFrance Sino-German Joint Research Center on Agricultural Biology Shandong Agricultural UniversityTai’anShandongChina State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China School of Agriculture Food and WineUniversity of AdelaideWaite CampusUrrbraeSAAustralia

Pluripotent stem cells localized in proliferating growth centers, the meristems, are the origin of life-long organ formation and growth in higher plants. In the shoot apical meristem of Arabidopsis thaliana, the closelyrelated ARGONAUTE proteins AGO1 and ZLL/AGO10 bind miR165/166 species to regulate mRNAs of HDZIP III transcription factors that are essential to maintaining stem cells. Several genetic studies showed thatAGO1 and ZLL/AGO10 act redundantly to maintain stem cells. By contrast, the reported biochemical datasuggested antagonistic functions: AGO1 utilizes miR165/166 to slice HD-ZIP III mRNAs, whereas ZLL/AGO10 promotes degradation of miR165/166 and thus stabilizes HD-ZIP III mRNAs. How these differentfunctions are balanced in stem cell regulation has remained enigmatic. Here, we show that autorepressionof AGO1 through miR168-mediated slicing of its own RNA is required to maintain the ability of AGO1 to suppress HD-ZIP III mRNAs. Increased AGO1 expression, either in the miR168a-2 mutant or by transgenicexpression, inhibits this ability despite the presence of high levels of miR165/166, effectively uncouplingHD-ZIP III and miR165/166 expression. AGO1 activity can be restored, however, by increasing the levelsof chaperones SQN and HSP90, which promote assembly of RNA-induced silencing complex (RISC). Thissuggests that cellular abundance of SQN and HSP chaperones limits AGO1-mediated RNA interferencein shoot meristem stem cell regulation. Localized misexpression of AGO1 indicates that the cells surrounding the shoot meristem primordium play a crucial role in stem cell development. Taken together, our studyprovides a framework that reconciles biochemical and genetic data, showing that restriction of AGO1 levelsby miR168-mediated autorepression is key to RISC homeostasis and the function of AGO1 in stem cellregulation.

关键词： Arabidopsis ARGONAUTE1 ZWILLE(ARGONAUTE10) HD-ZIP III stem cell shoot meristem

Rhizosphere microbial communities associated to rose replant disease:links to plant growth and root metabolites

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Horticulture Research 2020年第1期7卷 1031-1046页

作者： B.Yim A.Baumann G.Grunewaldt-Stöcker B.Liu L.Beerhues S.Zühlke M.Sapp J.Nesme S.J.Sørensen K.Smalla T.Winkelmann institute of Horticultural Production Systems Leibniz Universität Hannover30419 HannoverGermany Julius Kühn-institut(JKI) Institute for Epidemiology and Pathogen Diagnostics38104 BraunschweigGermany institute of Pharmaceutical Biology Technische Universität Braunschweig38106 BraunschweigGermany Faculty of Chemistry and Chemical Biology(CCB) Technische Universität Dortmund44227 DortmundGermany Cluster of Excellence on Plant Sciences(CEPLAS) Institute for Population GeneticsHeinrich Heine University40225 DüsseldorfGermany Section of Microbiology Department of BiologyUniversity of Copenhagen2100 CopenhagenDenmark

Growth depression of Rosa plants at sites previously used to cultivate the same or closely related species is a typical symptom of rose replant disease(RRD).Currently,limited information is available on the causes and the etiology of RRD compared to apple replant disease(ARD).Thus,this study aimed at analyzing growth characteristics,root morphology,and root metabolites,as well as microbial communities in the rhizosphere of the susceptible rootstock Rosa corymbifera‘Laxa’grown in RRD-affected soil from two sites(Heidgraben and Sangerhausen),either untreated or disinfected byγ-*** a greenhouse bioassay,plants developed significantly more biomass in theγ-irradiated than in the untreated soils of both *** plant metabolites detected in ***‘Laxa’roots were site-and *** aloesin was recorded in significantly higher concentrations in untreated than inγ-irradiated soils from Heidgraben,the concentrations of phenylalanine were significantly lower in roots from untreated soil of both *** microbial communities of 8-week-old plants were studied by sequencing of 16S rRNA,ITS,and cox gene fragments amplified from total community *** by microscopic observations,sequences affiliated to the bacterial genus Streptomyces and the fungal genus Nectria were identified as potential causal agents of RRD in the soils *** relative abundance of oomycetes belonging to the genus Pythiogeton showed a negative correlation to the growth of the ***,the RRD symptoms,the effects of soil treatments on the composition of the rhizosphere microbial community revealed striking similarities to findings related to ARD.

关键词： soil roots plant

利用机器学习研究隐粲五夸克态的性质（英文）

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science Bulletin 2023年第10期 981-989页

作者：张振宇刘家豪胡继峰王倩 Ulf-G.Meiβner Guangdong Provincial Key Laboratory of Nuclear Science Institute of Quantum Matter South China Normal University Guangdong-Hong Kong Joint Laboratory of Quantum Matter Southern Nuclear Science Computing Center South China Normal University Helmholtz-institut für Strahlen-und Kernphysik and Bethe Center for Theoretical Physics Universit?t Bonn institute for Advanced Simulation Institut für Kernphysik and Jülich Center for Hadron Physics Forschungszentrum Jülich Tbilisi State University

机器学习已经在生物、医学、生产等多个领域广泛应用并展现了其优势.最近,机器学习在物理领域也开始逐渐兴起并展现出其独特的优点.该文旨在探索机器学习在强子物理中的应用潜力.作者以隐粲五夸克态Pc(4312)、Pc(4440)和Pc(4457)为例,...

关键词：

Bioactive lipids and cancer metastasis to bone

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Metastasis and Treatment 2021年第1期7卷 604-627页

作者： Lou Saier Hira Niazi Leyre Brizuela Bodo Levkau Olivier Peyruchaud INSERM Unit 1033LYOSLyon 69372France UniversitéClaude Bernard Lyon 1 Lyon 69372France INSERM Unit 970 Paris Cardiovascular Research CentreParis 75015France Universitéde Paris Paris 75015France CNRS UMR 5246 INSA LyonInstitut de Chimie et Biochimie Moléculaires et Supramoléculaires(ICBMS)Lyon 69622France institute for Molecular Medicine III and University Hospital Düsseldorf DüsseldorfHeinrich Heine UniversitätDüsseldorf 40225Germany

Bioactive lipids constitute a large family of molecules considered as inflammatory *** them,lysophosphatidic acid(LPA),sphingosine 1-phosphate(S1P),and eicosanoids(prostanoids such as PGE2 and leukotrienes such as LTB4,LTC4,and LTD4)play a central role in the pathophysiology of several inflammatory ***,it has long been known that these bioactive lipids are also involved in cancer,mainly because of their ability to control the pro-inflammatory microenvironment of tumors as well as their ability to act directly on tumor cells promoting cell proliferation,migration,and ***,there has been increased interest in determining how these lipid mediators orchestrate tumor development and *** metastases result from a complex dialogue between tumor cells and bone *** findings demonstrate that all these bioactive lipids can profoundly affect bone metabolism by acting positively or negatively on both osteoblasts and *** review gives an overview of previous findings demonstrating direct involvement of LPA,S1P,and PGE2 in bone *** review also emphasizes the recent findings that characterize the activity of these bioactive lipids directly on bone cells and how these activities could be integrated into the complex molecular mechanisms leading to bone metastasis formation and progression.

关键词： Lysophosphatidic acid sphingosine 1-phosphate eicosanoids prostaglandins leukotrienes cancer bone cells

Evidence of a J/ψΛstructure and observation of excited■^(-)states in the■b^(-)→J/ψΛK^(-) decay

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science Bulletin 2021年第13期66卷 1278-1287,M0003页

作者： R.Aaij C.Abellán Beteta T.Ackernley B.Adeva M.Adinolfi H.Afsharnia C.A.Aidala S.Aiola Z.Ajaltouni S.Akar J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche G.Alkhazov P.Alvarez Cartelle S.Amato Y.Amhis L.An L.Anderlini A.Andreianov M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmayer J.J.Back S.Baker P.Baladron Rodriguez V.Balagura W.Baldini J.Baptista Leite R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay M.Becker F.Bedeschi I.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Bencivenni E.Ben-Haim A.Berezhnoy *** D.Berninghoff H.C.Bernstein C.Bertella E.Bertholet A.Bertolin C.Betancourt F.Betti Ia.Bezshyiko S.Bhasin J.Bhom L.Bian M.S.Bieker S.Bifani P.Billoir M.Birch F.C.R.Bishop A.Bizzeti M.Bj┆rn M.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska J.A.Boelhauve O.Boente Garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar S.Borghi M.Borisyak M.Borsato J.T.Borsuk S.A.Bouchiba T.J.V.Bowcock A.Boyer C.Bozzi M.J.Bradley S.Braun A.Brea Rodriguez M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu A.Buonaura C.Burr A.Bursche A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese L.Calefice L.Calero Diaz S.Cali R.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes A.Camboni P.Campana A.F.Campoverde Quezada S.Capelli L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini I.Carli P.Carniti L.Carus K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero S.Celani J.Cerasoli A.J.Chadwick M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis C.A.Chavez Barajas M.Chefdeville C.Chen S.Chen A.Chernov S.-G.Chitic V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek P.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu P.Collins T.Colombo L.Congedo A.Contu N.Cooke G.Coombs G.Corti C.M.Costa Sobral B.Couturier D.C.Craik J.Crkovská M.Cruz Torres R.Currie C.L.Da Silva E.Dall’ Centro Brasileiro de Pesquisas Físicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of Sciences BeijingChina institute Of High Energy Physics(IHEP) BeijingChina institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIN2P3-LAPPAnnecyFrance UniversitéClermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance UniversitéParis-Saclay CNRS/IN2P3IJCLabOrsayFrance Laboratoire Leprince-ringuet(llr) PalaiseauFrance LPNHE Sorbonne UniversitéParis Diderot Sorbonne Paris CitéCNRS/IN2P3ParisFrance I.Physikalisches institut RWTH Aachen UniversityAachenGermany Fakultät Physik Technische Universität DortmundDortmundGermany Max-Planck-institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches institut Ruprecht-Karls-Universität HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano-Bicocca MilanoItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Cagliari MonserratoItaly Universita degli Studi di Padova Universita e INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma Tor Vergata RomaItaly INFN Sezione di Roma La Sapienza RomaItaly Nikhef National institute for Subatomic Physics AmsterdamNetherlands Nikhef National institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands Henryk Niewodniczanski institute of Nuclear Physics Polish Academy of Sciences KrakówPoland AGH-University of Science and Techno

First evidence of a structure in the J/ψΛinvariant mass distribution is obtained from an amplitude analysis of■b^(-)J/ψΛK^(-)*** observed structure is consistent with being due to a charmonium pentaquark with strangeness with a significance of 3.1r including systematic uncertainties and lookelsewhere *** mass and width are determined to be 4458:8±2:9t4:7-1:1 MeV and 17:3±6:5t8:0-5:7 MeV,respectively,where the quoted uncertainties are statistical and *** structure is also consistent with being due to two *** addition,the narrow excited■^(-)states,N■(1690)and■(1820),are seen for the first time in a■b^(-)decay,and their masses and widths are measured with improved *** analysis is performed using pp collision data corresponding to a total integrated luminosity of 9 fb^(-1),collected with the LHCb experiment at centre-of-mass energies of 7,8 and 13 TeV.

关键词： QCD Exotics Pentaquark Spectroscopy Quarkonium Particle and resonance production