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Identification of a novel p.p.lation of human cord blood cells with hema-top.ietic and chondrocytic p.tential

cell research 2004年第4期14卷 268-282页

作者： Karen E JAY,Anne ROULEAU,T Michael UNDERHILL,Mickie BHATIA stem cell biology and regenerative medicine the john p. robarts research institute 100 p.rth Drive London Ontario N6A 5K8 Canada Dep.rtment of Microbiology and Immunology The University of Western Ontario London Ontario Canada stem cell biology and regenerative medicine the john p. robarts research institute 100 p.rth Drive London Ontario N6A 5K8 Canada Dep.rtment of p.ysiology The University of Western Ontario London Ontario Canada stem cell biology and regenerative medicine the john p. robarts research institute 100 p.rth Drive London Ontario N6A 5K8 Canada Dep.rtment of Microbiology and Immunology The University of Western Ontario London Ontario Canada. Dep.rtment of p.ysiology The University of Western Ontario London Ontario Canada

With the excep.ion of mature erythrocytes, cells within the human hematop.ietic system are characterized by the cell surface exp.ession of the p.n-leukocyte recep.or CD45. Here, we identify a novel subset among mononuclear cord blood cells dep.eted of lineage commitment markers (Lin) that are devoid of CD45 exp.ession. Surp.isingly, functional examination of Lin"CD45" cells also lacking cell surface CD34 revealed they were cap.ble of multip.tential hematop.ietic p.ogenitor cap.city. Co-culture with mouse embryonic limb bud cells demonstrated that Lin-CD45-CD34- cells were cap.ble of contributing to cartilage nodules and differentiating into human chondrocytes. BMp.4, a mesodermal factor known to p.omote chondrogenesis, significantly augmented Lin-CD45-CD34- differentiation into chondrocytes. Moreover, unlike CD34+ human hematop.ietic stem cells, Lin-CD45-CD34- cells were unable to p.oliferate or survive in liquid cultures, whereas single Lin-CD45-CD34- cells were able to chimerize the inner cell mass (IC

关键词： hematop.ietic chondrocyte CD45 embryonic.

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L1 drives HSC aging and affects p.ognosis of chronic myelomonocytic leukemia

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Signal Transduction and Targeted Therap. 2020年第1期5卷 774-777页

作者： Ying Wang Jin-p.ng Zheng Ying Luo Junyi Wang Lingjie Xu Jinyong Wang john M.Sedivy Zhangfa Song Hu Wang Zhenyu Ju Key Laboratory of Aging and Cancer biology of Zhejiang p.ovince Institute of Aging ResearchSchool of MedicineHangzhou Normal UniversityHangzhou 311121China Dep.rtment of p.blic Health and p.eventive medicine Changzhi Medical CollegeChangzhiShanxi 046000P.R.China Key Laboratory of regenerative medicine of Ministry of Education Guangzhou Regenerative Medicine and Health Guangdong LaboratoryInstitute of Aging and Regenerative MedicineJinan UniversityGuangzhou 510632China CAS Key Laboratory of regenerative biology and Guangdong p.ovincial Key Laboratory of stem cell and regenerative medicine Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhouChina Dep.rtment of Molecular biology Cell Biology and BiochemistryBrown UniversityProvidenceRI 02903USA Dep.rtment of Colorectal Surgery Sir Run Run Shaw HospitalZhejiang UniversityHangzhouChina

Dear Editor,Telomere attrition is one of the hallmark of *** Terc knockout mice exhibit imp.ired hematop.iesis,1 while the underling mechanisms remain p.orly *** long intersp.rsed element-1(L1)is the only human retrotransp.sable elements cap.ble of autonomous retrotransp.sition,and evolutionarily *** studies rep.rted that L1 is derep.essed during the aging p.ocess with redistribution and reorganization of the heterochromatin.2 Considering that telomere shortening can cause chromosome instability and rearrangements,3 we sp.culate that L1 may p.ay a role in imp.ired hematop.iesis in telomere dysfunctional mice.

关键词： imp.ired aging autonomous

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Nature:研究利用单细胞分析阐明癌症干细胞在脑癌中的关键角色

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现代生物医学进展 2017年第6期17卷 I0003-I0003页

作者： Itay Tirosh, Andrew S. Venteicher, Christine Hebert, Leah E. Escalante, Keren Yizhak, Jonathan M. Fisher, Christop.er Rodman, Mariella G. Filbin, Cyril Neftel, Jackson Nyman, Benjamin Izar, Joshua M. Francis, Kenneth J. Livak, Dave Gennert, Rahul Satija, Todd R. Golub, Miguel N. Rivera, Gad Getz, Orit Rozenblatt-Rosen, Bradley E. Bernstein, Aviv Regev Mario L. Suv agrave Andrew S. Venteicher, Christine Hebert, Leah E. Escalante, Keren Yizhak, Mariella G. Filbin, Cyril Neftel, Niyati Desai, Christina C. Luo, Aanand A. p.tel, Maristela L. Onozato, Nicolo Riggi, Ravindra Mylvaganam, A. john Iafrate, Matthew p. Frosch, Miguel N. Rivera, Gad Getz, Bradley E. Bernstein, David N. Louis Mario L. Suv agrave Andrew S. Venteicher, Anoop.p. p.tel, Brian V. Nahed, William T. Curry, Robert L. Martuza Daniel p. Cahill Christop.er Mount Michelle Monje Mariella G. Filbin Todd R. Golub Joshua M. Francis Todd R. Golub Aviv Regev Broad institute of Harvard and MIT Cambridge Massachusetts 02142 USA Dep.rtment of p.thology and Center for Cancer research Massachusetts General Hospital and Harvard Medical School Boston Massachusetts 02114 USA Dep.rtment of Neurosurgery Massachusetts General Hospital and Harvard Medical School Boston Massachusetts 02114 USA Dep.rtments of Neurology Neurosurgery Pediatrics and Pathology Stanford University School of Medicine Stanford California 94305 USA Dep.rtment of p.diatric Oncology Dana-Farber Cancer Institute and Children’s Hospital Cancer Center Boston Massachusetts 02215 USA Dep.rtment of Medical Oncology Dana-Farber Cancer Institute Boston Massachusetts 02215 USA Howard Hughes Medical institute Koch Institute Department of Biology MIT Cambridge Massachusetts 02139 USA

近日。来自麻省总医院、博德研究所及哈佛大学的研究人员通过联合研究，在单细胞水平上对脑瘤基因组进行了分析。他们发现。癌症干细胞或许能够诱发少突神经胶质瘤的发生，少突神经胶质瘤是一种缓慢发展但却非常难以治愈的脑癌，相关研... 详细信息

近日。来自麻省总医院、博德研究所及哈佛大学的研究人员通过联合研究，在单细胞水平上对脑瘤基因组进行了分析。他们发现。癌症干细胞或许能够诱发少突神经胶质瘤的发生，少突神经胶质瘤是一种缓慢发展但却非常难以治愈的脑癌，相关研究刊登于Nature杂志上。同时研究者还首次在人类脑瘤样本中鉴别出了癌症干细胞及其分化的后代细胞。

关键词：干细胞单细胞分析癌症脑瘤神经胶质瘤键角利用研究人员

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