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Effect of modifying matrix microstructures and nanosized precipitates on strengthening mechanisms and ductile-to-brittle-transitiontemperature in a 1000 MPa Ni-Cr-Mo-Cu steel

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Journal of Iron and steel research International 2022年第8期29卷 1257-1276页

作者： Fei Zhu Li Yang Feng Chai Xiao-bing Luo Cai-fu Yang Zheng-yan Zhang department of Structural steels Central Iron and Steel Research InstituteBeijing 100081China Material digital r&d Center China Iron and Steel Research Institute GroupBeijing 100081China

A superior combination of yield strength(1001 MPa)and-20℃ impact toughness(166 J)was obtained in Nb-V-Timicroalloyed Ni-Cr-Mo-Cu steel treated by direct quenching and tempering route(dQT).The tested steels treated by dQT route and re-austenitization and tempering route(QT)were compared with each other in terms of mechanical properties and microstructures characterized by optical microscopy,transmission electron microscopy,X-ray diffraction,electron back-scattered diffraction method and so *** and Vickers hardness of the tested steel treated by the above two routes vary with isothermal aging temperature(400-600℃),shown as under-aged state,peak-aged state and overaged *** dQT specimens show higher strength and Vickers hardness than QT specimens with the same aging ***,the largest difference of yield strength between dQT and QT specimens was shown in dQT600 and QT600 ***600 or QT600 specimens refers to direct quenched(dQ)or quenched(Q)specimens isothermally aged at 600℃.The main disparities in quenched microstructure between dQ and Q specimens are mainly in morphology of prior austenite grains,dislocation density of martensite matrix and solution amount of Nb and Mo elements dissolving in martensite matrix,which play key roles in affecting microstructure and mechanical properties of dQT and QT *** dislocation density of matrix and finer average diameter of both MC(M is any combination of Nb,Mo and V)and Cu-rich particles were shown in dQT600 specimens than in QT600 *** from dislocations and nanosized MC and Cu-rich particles mainly leads to the largest difference of yield strength between dQT600 and QT600 *** addition,strong dislocation strengthening and precipitation strengthening in dQT600 specimen also elevated its ductile-to-brittle-transition-temperature,compared with QT600 specimen.

关键词： Cu-bearing high-strength low-alloy steel direct quenching Nanosized precipitate Strengthening ductile-to-brittle-transition-temperature

EFFECT OF CArBON CONTENT ON MICrOSTrUCTUrE ANd PrOPErTIES OF HIGH STrENGTH ANd HIGH ELONGATION steelS

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Acta Metallurgica Sinica(English Letters) 2003年第1期16卷 65-71页

作者： Y.Chen X.Chen P.H.Li S.K.Pu Z.X.Yuan B.F.Xu d.X.Lou A.M.Guo S.B.Zhou Wuhan University of Science and Technology Wuhan 430081 China Technical Center of Wuhan Iron and steel corp. Wuhan 430080 China Technical Center of Wuhan Iron and steel corp. Wuhan 430080 China Wuhan University of Science and Technology Wuhan 430081 China

The micro structure and mechanical properties of new kind of hot-rolled high strength and high elongation steels with retained austenite were studied by discussing the influence of different carbon content. The research results indicate that carbon content has a significant effect on retaining austenite and consequently resulting in high elongation. Besides, new findings about relationship between carbon content and retained austenite as well as properties were discussed in the paper.

关键词： carbon content high strength high elongation steel retained austenite

reliability design optimization of composite structures based on PSO together with FEA

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Chinese Journal of Aeronautics 2013年第2期26卷 343-349页

作者： Chen Jianqiao Tang Yuanfu Ge rui An Qunli Guo Xiwei department of Mechanics Huazhong University of Science and Technology research and development Center Wuhan Iron and Steel (Group) Corp.

The present work aims to develop a method for reliability-based optimum design of composite structures. A procedure combining particle swarm optimization （PSO） and finite element analysis （FEA） has been proposed. Numerical examples for the reliability design optimization （rdO） of a laminate and a composite cylindrical shell are worked out to demonstrate the effectiveness of the method. Then a design for composite pressure vessels is studied. The advantages and necessity of rdO over the conventional equi-strength design are addressed. Examples show that the proposed method has good stability and is efficient in dealing with the probabilistic optimal design of composite structures. It may serve as an effective tool to optimize other complicated structures with uncertainties.

关键词： Composite structures FEA PSO reliability analysis reliability design optimization

The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

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Neural regeneration research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying Chen Yinyi Xiong Qin Zhou Ling-Qiang Zhu dan Liu department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina department of rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

Microstructure ＆ texture evolution and magnetic properties of high magnetic-induction 6.5% Si electrical steel thin sheet fabricated by a specially designed rolling route

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Journal of Central South University 2016年第3期23卷 523-528页

作者：李昊泽刘海涛刘振宇王项龙骆忠汉张凤泉陈圣林黄景文王国栋 State Key Laboratory of rolling and Automation (Northeastern University) Shenyang 110819 China Institute of research of Iron and steel Shasteel Zhangjiagang 215625 China National Engineering research Center for Silicon steel (Wuhan Iron & steel (Group) corp. Wuhan 430083 China

Electrical steel sheets with 6.5%(mas fraction) Si with good shapes and superior magnetic inductions were successfully produced by a specially designed processing route including ingot casting, hot rolling and warm rolling both with interpass thermal treatment, and final annealing. The sheets were of 0.2 mm and 0.3 mm thick over 140 mm width. A detailed study of the microstructural and textural evolutions from the hot rolling to annealing was carried out by optical microscopy, X-ray diffraction and electron backscattered diffraction. The hot rolled sheet characterized by near-equiaxed grains was dominated by the mixture of //Nd fiber(λ-fiber), //rd fiber(α-fiber) and //Nd fiber(γ-fiber) textures owing to the partial recrystallization and strain induced boundary migration(SIBM) during the hot rolling interpass thermal treatment. The static recovery and SIBM during the warm rolling interpass thermal treatment result in large and elongated warm rolling grains. The warm rolling texture is dominated by obvious λ, Goss and strong γ-fiber textures. The application of the interpass thermal treatment during hot and warm rolling significantly enhances the impact of SIBM during annealing, which is responsible for the formation of the moderate λ-fiber, some near-λ fiber texture components and the obviously weakened γ-fiber texture in the annealed sheet, leading to a higher magnetic induction compared to the commercially produced 6.5% Si steel by chemical vapor deposition(CVd).

关键词： 6.5% Si electrical steel microstructure texture magnetic property

The development of Advanced HSLA steel in Angang in Low Carbon Age

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Journal of Iron and steel research International 2011年第S1期18卷 22-28页

作者： ZHANG Xiao-gang (Anshan Iron and steel Group corp.ration,Anshan 114001,Liaoning,china) Anshan Iron & steel Grp corp Anshan 114001 Liaoning Peoples R China

The structure steel industry has experienced a revolution during four *** the challenge of global change in climate and environments,the higher strength,higher ductility steels,environment friendly steel were *** r and d for high strength steel production and application in Angang has made impressive *** more attention had been paid on the development of new type high strength steels with higher strength and better *** multi-phase microstructure,lower y/s,and corrosion resistance performance structure steel results in new generation advanced high strength steel which have properties that are often much superior to those exhibited by the old *** paper presents a general review of new generation high strength steel research and development in Angang and predicts the development for advanced high strength steel in the foreseeable future.

关键词： high strength steel energy conservation emission reduction

Prior austenite grain boundary recognition in martensite microstructure based on deep learning

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Journal of Iron and steel research International 2023年第5期30卷 1050-1056页

作者： Xuan-dong Wang Nan Li Hang Su Hui-min Meng Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China department of Structural steel Central Iron and Steel Research Institute Co.Ltd.Beijing 100081China Material digital r&d Center China Iron&Steel Research Institute Group Co.Ltd.Beijing 100081China Central Laboratory Central Iron and Steel Research Institute Co.Ltd.Beijing 100081China

Grain size determination is essential in producing and testing iron and steel *** size determination of martensitic steels usually requires etching with picric acid to reveal the prior austenite grain ***,picric acid is toxic and explosive and belongs to hazardous chemicals,which makes it difficult for laboratories and testing institutions to obtain.A new experimental method was developed to use Nital etchant instead of picric *** deep learning method was used to recognize the prior austenite grain boundaries in the etched martensite microstructure,and the grain size could be determined according to the recognition ***,the polished martensite specimen was etched twice with Nital etchant and picric acid,respectively,and the same position was observed using an optical *** images of the martensitic structure and its prior austenite grain boundary label were obtained,and a data set was ***,based on this data set,a convolutional neural network model with a semantic segmentation function was trained,and the accuracy rate of the test set was 87.53%.Finally,according to the recognition results of the model,the grain size rating can be automatically determined or provide a reference for experimenters,and the difference between the automatic determination results and the measured results is about 0.5 level.

关键词： Prior austenite grain boundary Microstructure etching Image recognition deep learning

repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural regeneration research 2025年第3期20卷 821-835页

作者： Jing Wang Bing Zhang Lanfang Li Xiaomei Tang Jinyu Zeng Yige Song Chao Xu Kai Zhao Guoqiang Liu Youming Lu Xinyan Li Kai Shu department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina department of Graduate Student Chongqing Medical UniversityChongqingChina department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

Non-coding rNAs in acute ischemic stroke:from brain to periphery

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Neural regeneration research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan Qin Lin Zhu Teng Jiang Junshan Zhou Fuling Yan Qiwen deng department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding rNAs(ncrNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncrNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncrNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncrNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncrNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncrNAs(microrNAs,long ncrNAs,and circular rNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncrNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncrNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular rNAs excitatory toxicity long non-coding rNAs microrNAs neuroinflammation non-coding rNAs oxidative stress