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Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

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Neural Regeneration research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels Julie D.De Schutter Lies De Groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

Decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing Fang Liangming Zhang Bin Liu Limin Rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical products Administration(NMPA)Key Laboratory for Quality research and Evaluation of Cell products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

Effects of Craddition on Charpy impact energy in austenitic 0.45C-24Mn-(0,3,6)Cr steels

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Journal of Materials Science & Technology 2020年第15期47卷 21-30页

作者： Seok Gyu Lee Bohee Kim Min Cheol Jo Kyeong-Min Kim Junghoon Lee Jinho Bae Byeong-Joo Lee Seok Su Sohn Sunghak Lee Center for Advanced Aerospace Materials Pohang University of Science and TechnologyPohang37673South Korea steel products Design Team Hyundai SteelDangjin31779South Korea steel products research group 1 Technical Research LaboratoriesPOSCOGwangyang57807South Korea Department of Materials Science and Engineering Korea UniversitySeoul02841South Korea

Effects of Cr addition(0,3,and 6 wt%) on Charpy impact properties of Fe-C-Mn-Cr-based steels were studied by conducting dynamic compression tests at room and cryogenic *** room temperature,deformation mechanisms of Charpy impacted specimens were observed as twinning induced plasticity(TWIP) without any transfo rmation induced plasticity(TRIP) in all the *** cryogenic temperature,many twins were populated in the Cr-added steels,but,interestingly,fine ε-martensite was found in the OCr steel,satisfying the Shoji-Nishiyama(S-N) orientation relationship,{111}γ//{0002}ε and γ//ε.Even though the cryogenic-temperature staking fault energies(SFEs) of the three steel were situated in the TWIP regime,the martensitic transformation was induced by Mn-and Cr-segregated *** the OCr steel,SFEs of low-(Mn,Cr) bands lay between the TWIP and TRIP regimes which were sensitively affected by a small change of *** dynamic compressive test results well showed the relation between segregation bands and the *** of Cr were known as not only increasing the SFE but also promoting the carbide *** order to identify the possibility of carbide formation,a precipitation kinetics simulation was conducted,and the predicted fractions of precipitated M23C6 were negligible,0.4-1.1×10-5,even at the low cooling rate of 10℃/s.

关键词： Austenitic high-Mn steels Charpy impact energy Split Hopkinson pressure bar Twinning induced plasticity(TWIP) Transformation induced plasticity(TRIP) Stacking fault energy(SFE)

Corrosion Behavior of Welded Joints for Cargo Oil Tanks of Crude Oil Carrier

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Journal of Iron and steel research International 2016年第9期23卷 955-962页

作者： Jin-shan WEI Yan-chang QI Zhi-ling TIAN Yun PENG State Key Laboratory of Advanced steel Processes and products Central Iron & Steel Research Institute

E32 grade corrosion resistant steel was welded with welding wires with three different S contents. The mi crostructure, mechanical properties, inclusions, and corrosion behavior of welded joint were investigated. The joint coupon corrosion test and potentiodynamic polarization test were carried out under the simulated corrosion environ- ment of the inner bottom plates of cargo oil tanks. The pitting initiation and propagation mechanism of the weld metal were studied by scanning electron microscopy and infinite focus. The results indicated that the microstructures of three kinds of weld metals are all composed of acicular ferrite, ferrite side-plate and proeutectoid ferrite. The micro- structure of heat affected zone is composed predominantly of bainite. Joint welded with low S filler wire has good me- chanical properties. S can decrease free corrosion potential and increase the corrosion tendency. The pitting initiation is oxide inclusion or sulfide oxide inclusion complex. S can induce the formation of occluded area and promote the corrosion propagation. The chemical compositions of weld metal is similar to base metal, which can limit the galvanic corrosion between weld metal and base metal, and avoid formation of corrosion step.

关键词： cargo oil tank welded joint pit corrosion corrosion step

Effects of Alloy Element and Microstructure on Corrosion Resistant Property of Deposited Metals of Weathering steel

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Journal of Iron and steel research International 2016年第2期23卷 171-177页

作者： Xiao-ming XIAO Yun PENG Cheng-yong MA Zhi-ling TIAN State Key Laboratory of Advanced steel Processes and products Central Iron & Steel Research Institute

Alloy element and microstructure are key factors that dominate mechanical and corrosion resistant properties of weathering steel. The effect of Mo on microstructure, mechanical properties and corrosion resistant property of depos ited metal was investigated. Experimental results show that with the increase of Mo content in deposited metals, the phase transformation temperature decreases, and the ferrite zone in CCT diagram moves rightward, resulting in en larged bainite zone and reduced ferrite and pearlite zone. The addition of 0.24 mass% Mo in deposited metal results in the increase of tensile strength, more M-A constituent and less high angle grain which reduce the low temperature toughness. It is found that Mo can raise the weathering resistance of deposited metal in industrial atmosphere. Analy sis indicates that Mo may enrich in the inner rust layer, produce MoO3, enhance the formation of compact rust film and impede the anode dissolution reaction. Granular bainite in deposited metals displays better corrosion resistance than acicular ferrite during the initial corrosion stage, but its long-term influence on the corrosion resistance is limited.

关键词： weathering steel deposited metal Mo microstructure mechanical property corrosion resistance

Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling Lü Chunchi Zhang Dong Liang Lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th research Institute of China Electronics Technology group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration research 2025年第3期20卷 836-844页

作者： Do-Hun Lee Dan Cao Younghye Moon Chen Chen Nai-Kui Liu Xiao-Ming Xu Wei Wu Spinal Cord and Brain Injury research group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

Influence of Ti on Weld Microstructure and Mechanical Properties in Large Heat Input Welding of High Strength Low Alloy steels

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Journal of Iron and steel research International 2015年第5期22卷 431-437页

作者： A-rong Lin ZHAO Chuan PAN Zhi-ling TIAN China Iron and steel research Institute group

The influence of Ti on weld microstructure and mechanical properties in large heat input welding of high strength low alloy steels is investigated. The results indicate that a moderate amount of Ti is still effective for grain refinement even under larger heat input and a large amount of acicular ferrite （AF） is formed in the weld metal when Ti content is within 0. 028%--0. 038%. With increasing Ti content, proeutectoid ferrite in the weld metal decreases, whereas bainite and M-A constituent increase. The type of inclusion in the welds varies from Mn-Si-AI-O to Ti-Mn- A1-O and finally to Ti-A1-O as Ti content increases from 0 up to 0. 064%. As for adding 0. 028%--0. 038% Ti, high weld toughness could be attained since most inclusions less than 2 tim which contain Ti20s provide the effective nu- clei for aeicular ferrite formation. However, the toughness of the weld metals severely reduces when Ti content is over the optimum ranRe of 0. 028%--0. 038%.

关键词： large heat input welding Ti microstructure acicular ferrite inclusion high strength low alloy steel

Effects of Temperature and Alloying Elements on γ Phase Fraction of Grain-oriented Silicon steel

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Journal of Iron and steel research International 2016年第6期23卷 573-579页

作者： Bing FU Hai-jun WANG Jian-xin YAN Li XIANG Sheng-tao QIU Guo-guang CHENG National Engineering research Center of Continuous Casting Technology China Iron and Steel Research Institute Group School of Metallurgical and Ecological Engineering University of Science and Technology Beijing State Key Laboratory of Advanced steel Processes and products Central Iron and Steel Research Institute Valin LY steel Co. Ltd.

The effects of temperature and alloying elements on γ phase fraction of grain-oriented silicon steel,which contained 2.97-3.42mass% Si and 0.028-0.058mass% C,were studied by microstructure observation and ***,the quantitative relationships of temperature as well as C,Si,and Mn contents to γ phase fraction were obtained by numerical *** experimental results show that γ phase fraction firstly increases with increasing temperature,reaches a maximum and then decreases in the temperature range of 900-1 250 ℃.The temperature corresponding to the maximum γ phase fraction is about 1 150-1 200℃.Meanwhile,the γ phase fractions in steels at the same temperature have some differences because of different contents of various alloying *** verification results show that the values of γ phase fractions to C,Si,and Mn contents at the specific temperatures,which were obtained by multiple linear regression method,agree well with the measured *** addition,the values of γ phase fractions to C,Si,and Mn contents in the temperature range of 900-1 250℃,which were obtained by binomial regression method,agree with the measured values when the contents of Mn and soluble Al are not more than 0.320mass% and 0.034mass%,*** obtained equations can carry out the approximate prediction of γ phase fractions of grain-oriented silicon steels during the hot rolling process.

关键词： fitting Grain steels approximate alloying carry agree reaches contained utilizing