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Diurnal Cycle of Summer Rainfall in Shandong of Eastern China

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Diurnal Cycle of Summer Rainfall in Shandong of Eastern Chin...

Mechanisms of Fractional Calcium Currents through TRPV1 Channels in primary sensory neurons

创新驱动发展提高气象灾害防御能力——第30届中国气象学会年会

作者： Hong Zhuo Ping Zhao Tianjun Zhou The Meteorological Center of North China Air Traffic Management Bureau state Key Laboratory of Severe Weather Chinese Academy of Meteorological Sciences LASG Institute of Atmospheric Physics Chinese Academy of Sciences

Using the hourly precipitation data at 123 gauge stations of Shandong province in eastern China during 1996-2008, the authors examine the spatial distribution of summer (June-July-August) precipitation amount (PA), precipitation intensity (PI), and precipitation frequency (pf) and their diurnal cycles. The results show that the diurnal peak of PA decreases from the southeastern to northwestern Shandong and mainly appears in the early morning and afternoon. The large diurnal peak of PA mainly appears in a large area from the hilly areas of southern Shandong to the eastern coasts. Large diurnal peak of PI mainly appears along the lower reaches of the Yellow River in northern Shandong. The diurnal peak of pf also decreases from southeastern to northwestern Shandong. The diurnal cycles of PA and PI have two peaks and they occur in the early morning and the afternoon, respectively. The diurnal cycle of pf has one peak in the morning. Large PA values show a southwestward time delay over northwestern Shandong, a northeastward time delay over central and southeastern Shandong in the afternoon, and a southeastward time delay over central and southeastern Shandong in the morning. Moreover, they also show a time delay from the central mountains of Shandong to its adjacent areas in the afternoon. When hourly precipitation is weaker, the diurnal cycles of PA and pf show a two-peak feature. With Following the increase of hourly precipitation, the diurnal peak number also tends to increase.

关键词： diurnal cycle summer precipitation Shandong of eastern China climatic characteristics

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Mechanisms of Fractional Calcium Currents through TRPV1 Chan...

Effect of induction chemotherapy with cisplatin, fluorouracil, with or without taxane on locoregionally advanced nasopharyngeal carcinoma: a retrospective, propensity score-matched analysis

第十一届全国钙信号和细胞功能研讨会

作者： Hu MQ Zheng LH Sun L Wu QH Shang SJ Liu T Wang YS Zhang XY Chai ZY Wu X Wang CH Jiang LH Zhu MX Zhou Z state Key Lab of Biomembrane and Membrane Biotechnology Institute of Molecular Medicine Peking University School of Biomedical Science Department of Integrative Biology and Pharmacology University of Texas Health Science Center at Houston

Transient receptor potential(TRP) channels are polymodal cation channels that provide one of the main pathways for cation influx in excitable and non-excitable cells. Among them, thermosensitive TRPV1 and TRPV2 channels are molecular sensors for high temperatures important for physiology and diseases. These channels are nonselective cation channels and permeate Ca on the plasma membrane. The Ca influx through these channels may play major roles in physiological functions, such as regulation of Ca homeostasis and transmitter release. Thus, it is important to determine fractional contribution of Ca to the total ion influx, or their fractional Ca current(pf) by combining patch-clamp(total current) and fura2(Ca influx) [1-2]. In the present work, by determining pf of pore-site-mutations systematically, we found,(1) pf of TRPV2 is 5 times of TRPV1(21.7 % vs. 5.5%);(2) Amino acid(AA) pore region ELFKFTIGMGX are same in TRPV1 and V2, except the last AA, where X = D and E for TRPV1 and V2, respectively. When the last AA of TRPV1(D) was switched to that of TRPV2(E), pf of TRPV1 was switched to f(TRPV2), and vice versa.(3) Outside the "GMGD"(known as the selective filter), other sites can also affect the pf which should be considered as function selective filter.(4) Only pf change without calcium influx change can affect the release from Dosal ganglion root neuron(DRG). Finally, our findings suggest a single mutation can switch pf between TRPV1 and TRPV2, and the physiological impact of pf(TRP) was examined in native DRG neurons.

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Cancer Communications 2018年第1期38卷 237-246页

作者： Guo-Ying Liu Xing Lv Yi-Shan Wu Min-Jie Mao Yan-Fang Ye Ya-Hui Yu Hu Liang Jing Yang Liang-Ru Ke Wen-Ze Qiu Xin-Jun Huang Wang-Zhong Li Xiang Guo Yan-Qun Xiang Wei-Xiong Xia state Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine Sun Yat-Sen University Cancer CenterGuang-zhouGuangdongChina Department of Nasopharyngeal Carcinoma Sun Yat-Sen University Cancer CenterGuangzhouGuangdongChina Department of Clinical Laboratory Sun Yat-Sen University Cancer CenterGuangzhouChina The Sun Yat-Sen Memorial Hospital Sun Yat-Sen UniversityGuang-zhouChina Department of Radiation Oncology Shanghai Proton and Heavy Ion CenterShanghaiChina

Background:Available data in the literature comparing different induction chemotherapy(IC)regimens on locoregionally advanced nasopharyngeal carcinoma(NPC)are *** purpose of the present study was to evaluate the outcomes of locoregionally advanced NPC patients who were treated with taxane,cisplatin and 5-fluorouracil(Tpf)or cisplatin and 5-fluorouracil(pf)as IC followed by concurrent chemoradiotherapy(CCRT).Methods:In total,1879 patients with locoregionally advanced NPC treated with IC and CCRT from a prospectively maintained database were included in the present observational *** compared overall survival(OS),disease-specific survival(DSS),distant metastasis-free survival(DMFS),and locoregional relapse-free survival,using the pro-pensity score ***:In total,1256 patients received Tpf or pf as IC *** Tpf group showed significantly better OS(hazard ratio[HR],0.660;95%confidence interval[CI]0.442-0.986;P=0.042),DSS(HR,0.624;95%CI 0.411-0.947;P=0.027)and DMFS(HR,0.589;95%CI 0.406-0.855;P=0.005)compared with the pf group in multivariable *** score matching identified 294 patients in each cohort and confirmed that Tpf was associated with significantly improved 5-year OS(88.1%vs.80.7%;P=0.042),DSS(88.5%vs.80.7%;P=0.021)and DMFS(87.9%vs.78.6%;P=0.012)rates compared with the pf *** were no significant differences in locoregional relapse-free survival before or after ***:In our study,IC with the Tpf regimen combined with CCRT showed improved long-term survival for the patients with locoregionally advanced NPC compared with the pf ***,a prospective randomized clinical trial to validate these findings is necessary.

关键词： Nasopharyngeal carcinoma Induction chemotherapy Propensity score-matching Taxane

TRIB3-GSK-3β interaction promotes lung fibrosis and serves as a potential therapeutic target

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Acta Pharmaceutica Sinica B 2021年第10期11卷 3105-3119页

作者： Shanshan Liu Xiaoxi Lv Xupeng Wei Chang Liu Qiao Li Jiali Min Fang Hua Xiaowei Zhang Ke Li Pingping Li Yang Xiao Zhuowei Hu Bing Cui state Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaCAMS Key Laboratory of Molecular Mechanism and Target Discovery of Metabolic Disorder and TumorigenesisChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Department of Pharmacy Pharmacy CollegeHebei UniversityBaoding 071000China National Clinical Research Center for Metabolic Diseases Department of Metabolism and Endocrinologythe Second Xiangya HospitalCentral South UniversityChangsha 410011China Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Pulmonary fibrosis(pf)is a chronic,progressive,fatal interstitial lung disease with limited available therapeutic *** recently reported that the protein kinase glycogen synthase kinase-3β(GSK-3β)interacts with and inactivates the ubiquitin-editing enzyme A20 to suppress the degradation of the transcription factor CCAAT/enhancer-binding protein beta(C/EBPβ)in alveolar macrophages(AMs),resulting in a profibrotic phenotype of AMs and promoting the development of ***,we showed that chronic lung injury upregulated the stress response protein tribbles homolog 3(TRIB3),which interacted with GSK-3βand stabilized GSK-3βfrom ubiquitination and *** GSK-3βexpression phosphorylated A20 to inhibit its ubiquitin-editing activity,causing the accumulation of C/EBPβand the production of several profibrotic factors in AMs and promoting pf *** C/EBPβ,in turn,increased the transcription of TRIB3 and GSK-3β,thereby establishing a positive feedback loop in *** knockdown of TRIB3 expression or the pharmacologic disruption of the TRIB3-GSK-3βinteraction was an effective pf *** study reveals an intact profibrotic axis of TRIB3-GSK-3β-A20-C/EBPβin AMs,which represents a target that may provide a promising treatment strategy for pf.

关键词： E3 ligase Lung injury Protein phosphorylation Protein-protein interaction Ubiquitination TRIB3 GSK-3β

Bionic boron/silicon-modified phenolic resin system with multifunctional groups:synthesis,thermal properties and ablation mechanism

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Biosurface and Biotribology 2018年第3期4卷 85-93页

作者： Fengyi Wang Zhixiong Huang Zhiguang Guo School of Material Science and Engineering Wuhan University of TechnologyLuoshi Road No.122430070 WuhanPeople's Republic of China Hubei Colla borative Innovation Centre for Advanced Organic Chemical Materials and Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials Hubei UniversityWuhan 430062People's Republic of China state Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000People's Republic of China

A kind of silicon-and-boron-modified phenolic-formaldehyde resin(SBpf)with excellent thermal stability was fabricated via a simple two-step method and used for the matrix of ablation *** structure and thermal stability of the modified phenolic-formaldehyde resins(pfs)were *** results showed that boron and silicon e lements have been incorporated into SBpf in the form of a chemical ***,the cured products showed an increase in graphite structure and a decrease in disordered structure due to the incorporation of boron and *** with the ordinary phenolic resin,the initial thermal degradation temperature and charring yield at 800℃ of SBpf increased by 73℃ and 15 wt%,***,the modified pfs,nano-Al_(2)O_(3) powders,glass powders and vitreous silica fibres were used to obtain a novel cer amizable phenolic mou lding com *** morphology,chemical composition and ablative characteristics of the composites were *** results showed that a compact and homogeneous SiO_(2)-Al_(2)O_(3) layer formed on the ablated surface and protected the carbonised matrix and fibres from further *** with the ordinary pf composites,the SBpf composites showed a highly decreased linear/mass ablation rates,indicating the synergistic effect of boron and silicon modification on the enhanced ablation property.

关键词： composites boron phenolic

2D polyaniline with exchangeable interlayer fluid for fast and stable volumetric dual ion storage

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Journal of Energy Chemistry 2021年第3期30卷 587-594页

作者： Xiaochen Yang Jiaxing Liang Aditya Rawal Kefeng Xiao Yuan Pu Xiao Li Zhang Ruopian Fang Da-Wei Wang Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic Inorganic CompositesBeijing University of Chemical TechnologyBeijing 100029China School of Chemical Engineering The University of New South WalesSydneyNSW 2052Australia NMR Facility Mark Wainwright Analytical CentreThe University of New South WalesSydney 2052NSWAustralia Research Centre of the Ministry of Education for High Gravity Engineering and Technology Beijing University of Chemical TechnologyBeijing 100029China School of Materials Science and Engineering Zhengzhou University450001China UNSW Digital Grid Futures Institute The University of New South WalesSydney 2052NSWAustralia

Two-dimensional(2D) layered materials are widely applied in energy devices including lithium-ion battery and supercapacitor due to their unique properties,such as tunable interlayer structure,numerous active sites,large aspect ratio versatile interlayer *** this work,2D layered tungstate acidlinked polyaniline(TALP) presented a fluid-in-solid structure,which allowed facile exchange of the interlayer fluid from moisture to conventional Li^(+) containing *** fast and stable dual ion storage(Li^(+) and pf_(6)^(-)),TALP demonstrates high-rate volumetric capacity(39 mAh cm_(-3) at 2000 mA g^(-1)) and good stability(2000 cycles at 200 mA g^(-1)) within the working potential window of 1.5-4.5 V versus Li^(+)/Li.

关键词： Tungsten acid-linked polyaniline 2D material Fluid-in-solid Lithium-ion capacitor Volumetric

Multi-orientation of [BMIM] Cations at the Air/Liquid Interface of Room Temperature Ionic Liquid [BMIM][pf6] Studied by Sum Frequency Generation Vibrational Spectroscopy

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Multi-orientation of [BMIM] Cations at the Air/Liquid Interf...

Boric Acid-Based Dual Modulation Photoluminescent Glucose Sensor Using Thioglycolic Acid-Capped CdTe Quantum dots

第十三届全国化学动力学会议

作者： Gang-hua Deng Xia Li You-qi Guo Shi-lin Liu Zhou Lu Yuan Guo Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of China Beijing National Laboratory for Molecular Sciences State Key Laboratory of Molecular Reaction Dynamics Institute of Chemistry Chinese Academy of Sciences

The orientation of 1-butyl-3-methylimidazolium （[bmim]） cations at the air/liquid interface of the room temperature ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate （[bmim][pf6]） was investigated by polarization- and configuration-dependent sum frequency generation vibrational spectroscopy （SFG-VS）. Detailed polarization and experimental configuration analyses revealed the coexistence of two distinct orientation angles for the methyl group in the interfacial [bmim] cations , one between 34° and 42°, the other larger than 54°. These spectral observations clarify the discrepancies amid several previous reports on the orientations of the interfacial [bmim] cations and provided the direct evidences to reveal the complexity of the ionic liquid surfaces. It was demonstrated that polarization and experimental configuration analysis are instrumental in the interpretation of SFG spectra.

关键词： Ionic Liquid Sum Frequency Generation Spectroscopy Interface Orientation

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Journal of Analysis and Testing 2017年第4期1卷 291-297页

作者： Saadat Majeed WenyueGao Jianping Lai Chao Wang JianpingLi Zhongyuan Liu Guobao Xu state Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of Sciences5625 Renmin StreetChangchun 130022JilinPeople’s Republic of China University of Chinese Academy of Sciences Chinese Academy of SciencesNo.19A YuquanluBeijing 100049China Division of Analytical Chemistry Institute of Chemical SciencesBahauddin Zakariya UniversityMultan 60800Pakistan College of Chemistry and Bioengineering Guilin University of TechnologyGuilin 541004People’s Republic of China

Most luminescent glucose sensors based on the interaction of glucose with organic boric acids or ***,a new luminescent glucose sensor is designed using thioglycolic acid-capped CdTe quantum dots in the presence of cheap inorganic boric *** peak position and intensities change upon the addition of glucose because of the interaction of boric acid with glucose and thioglycolic acid-capped CdTe quantum dots,which enables glucose detection by either color change or intensity *** luminescent intensities change linearly with glucose concentrations in the ranges from 0.03 to 1 mM and 1–25 mM with a detection limit of 10μM(S/N=3).Moreover,glucose concentrations can be conveniently detected by color change in the range from 1 mM–25 *** displays a highly selective response to glucose over other interfering but biologically important saccharides,amino acids,and common *** Abstract A thioglycolic acid-capped CdTe QD-based sensor can detect glucose with wide linear range by change in intensity or color in the presence of cheap inorganic boric acid.

关键词： CdTe quantum dots Glucose sensor Thioglycolic acid

Concentration,sources and wet deposition of dissolved nitrogen and organic carbon in the Northern Indo-Gangetic Plain during monsoon

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Journal of Environmental Sciences 2021年第4期33卷 37-52页

作者： Hemraj Bhattarai Lekhendra Tripathee Shichang Kang Chhatra Mani Sharma Pengfei Chen Junming Guo Prakriti Sharma Ghimire Earth System Science Programme and Graduate Division of Earth and Atmospheric Sciences The Chinese University of Hong KongHong KongChina state Key Laboratory of Cryospheric Science Northwest Institute of Eco-environment and ResourcesChinese Academy of Sciences(CAS)Lanzhou 730000China Key Laboratory of Tibetan Environment Changes and Land Surface Processes Institute of Tibetan Plateau ResearchCASBeijing 100101China Chinese Academy of Sciences(CAS)Center for Excellence in Tibetan Plateau Earth Sciences Beijing 100085China Himalayan Environment Research Institute(HERI) KathmanduNepal Central Department of Environmental Science Tribhuvan UniversityKathmanduNepal Kathmandu Center for Research and Education(KCRE) KathmanduNepal

Precipitation represents an important phenomenon for carbon and nitrogen ***,the concentrations and fluxes of dissolved organic carbon(DOC)and total dissolved nitrogen(TDN)with their potential sources were analyzed in wet precipitation during summer monsoon from the Northern Indo-Gangetic Plain(IGP),important but neglected *** volume-weighted mean(VWM)concentration of DOC and TDN were 687.04 and 1210.23μg/L,***,the VWM concentration of major ions were in a sequence of NH_(4)^(+)>Ca^(2+)>SO_(4)^(2-)>Na^(+)>K^(+)>NO_(3)~->Cl~->Mg^(2+)>F~->NO_(2)~-,suggesting NH_(4)^(+)and Ca^(2+)from agricultural activities and crustal dust played a vital role in precipitation ***,the wet deposition flux of DOC and TDN were 9.95 and 17.06 kg/(ha year),*** wet deposition flux of inorganic nitrogen species such as NH_(4)^(+)-N and NO_(3)^(-)-N were 14.31 and 0.47 kg/(ha year),respectively,demonstrating the strong influence of emission sources and precipitation *** attribution from different analysis suggested the influence of biomass burning on DOC and anthropogenic activities(agriculture,animal husbandry)on nitrogenous *** air-mass back trajectory analysis indicated the influence of air masses originating from the Bay of Bengal,which possibly carried marine and anthropogenic pollutants along with the biomass burning emissions to the sampling *** study bridges the data gap in the less studied part of the northern IGP region and provides new information for policy makers to deal with pollution control.

关键词： Precipitation chemistry Dissolved organic carbon Total dissolved nitrogen Major ions Indo-Gangetic Plain