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Risk factors for biometry prediction error by Barrett Universal II intraocular lens formula in Chinese patients

International Journal of ophthalmology(English edition) 2025年第1期18卷 74-78页

作者： Xu-Hao Chen Ying Hong Xiang-Han Ke Si-Jia Song Yu-Jie Cen Chun Zhang Beijing key laboratory of Restoration of Damaged Ocular Nerve Department of OphthalmologyPeking University Third HospitalBeijing 100191China state key laboratory of ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou 510060Guangdong ProvinceChina

AIM:To investigate the influence of postoperative intraocular lens(IOL)positions on the accuracy of cataract surgery and examine the predictive factors of postoperative biometry prediction errors using the Barrett Universal II(BUII)IOL formula for ***:The prospective study included patients who had undergone cataract surgery performed by a single surgeon from June 2020 to April *** collected data included the best-corrected visual acuity(BCVA),corneal curvature,preoperative and postoperative central anterior chamber depths(ACD),axial length(AXL),IOL power,and refractive *** formula was used to calculate the IOL *** mean absolute error(MAE)was calculated,and all the participants were divided into two groups *** t-tests were applied to compare the variables between *** regression analysis was used to analyze the influence of age,AXL,corneal curvature,and preoperative and postoperative ACD on ***:A total of 261 patients were *** 243(93.1%)and 18(6.9%)had postoperative MAE1 D,*** number of females was higher in patients with MAE>1 D(χ^(2)=3.833,P=0.039).The postoperative BCVA(logMAR)of patients with MAE>1 D was significantly worse(t=-2.448;P=0.025).After adjusting for gender in the logistic model,the risk of postoperative refractive errors was higher in patients with a shallow postoperative anterior chamber[odds ratio=0.346;95% confidence interval(CI):0.164,0.730,P=0.005].CONCLUSION:Risk factors for biometry prediction error after cataract surgery include the patient’s sex and postoperative *** with a shallow postoperative anterior chamber are prone to have refractive errors.

关键词： intraocular lens power calculation gender anterior chamber depth biometry prediction error

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Anatomic characteristics of the lacrimal sac and adjacent bony structures–a computed tomographicdacryocystography research

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International Journal of ophthalmology(English edition) 2025年第2期18卷 251-257页

作者： Xin-Han Cui Yan-Wen Fang Li-Min Zhang Ji-Ni Qiu Chao-Ran Zhang Yan Wang Eye Institute and Department of ophthalmology Eye and ENT Hospital of Fudan UniversityShanghai 200031China NHC key laboratory of Myopia and Related Eye Diseases Key Laboratory of Myopia and Related Eye DiseasesChinese Academy of Medical SciencesShanghai 200031China Shanghai key laboratory of Visual Impairment and Restoration Shanghai 200031China Department of ophthalmology Children’s Hospital of KaifengKaifeng 475000Henan ProvinceChina

AIM:To describe the anatomic characteristics of the lacrimal sac and its adjacent bone structures and to provide surgical recommendations for endoscopic dacryocystorhinostomy(EN-DCR).METHODS:This retrospective comparative study involved 118 sides with complete nasolacrimal duct obstruction and 83 unaffected sides from 126 *** tomographic-dacryocystography(CT-DCG)scans were performed before lacrimal surgery,and image reconstruction was used to obtain continuous 0.75-mm axial,coronal,and segmental sections for *** morphology of the lacrimal sac and its relationship with adjacent bony structures were determined for measurement,as well as the obstructed ***:The height of the lacrimal sac was 12.99±2.10 mm in this *** operculum of the middle turbinate(OMT)was located vertically in the lower third of the lacrimal ***,the junction between the maxillary bone and the lacrimal bone(MB-LB)was close to,mostly(60.2%)posterior to,the lacrimal *** uncinate process was more frequently attached to the lacrimal bones(75.1%).The obstructions were generally located around the entrance of the nasolacrimal duct(NLD).However,some were placed higher,with 7.63%blocked not lower than the *** was a negative correlation between the diameter of the lacrimal sac and the level of obstruction(r=-0.35,P<0.01).CONCLUSION:In this study,the OMT and MB-LB can be served as the landmarks in *** uncinectomy should be performed in most *** obstructions were generally located around the entrance of the NLD,but some extreme individual variations strongly implies the importance of CT-DCG scanning before surgery.

关键词： lacrimal sac nasolacrimal duct obstruction endoscopic dacryocystorhinostomy computed tomographic-dacryocystography

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Assessing microcatheter-assisted 360-degree trabeculotomy combined with trabeculectomy for refractory glaucoma:1-year results

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International Journal of ophthalmology(English edition) 2025年第1期18卷 94-102页

作者： Jia-Yin Qin Yan Liu Tao Wang Department of ophthalmology Peking University International HospitalBeijing 102206China Beijing key laboratory of ophthalmology and Visual Science Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

AIM:To evaluate the efficacy and safety of microcatheterassisted 360-degree trabeculotomy combined with trabeculectomy(MATT-Trab)for treating refractory ***:Patients with refractory glaucoma who underwent MATT-Trab were retrospectively *** indicators for research statistics included the intraocular pressure(IOP)level,degree of decrease,changes in medication dosage,and success *** indicators included the best-corrected visual acuity and incidence of ***:This study comprised 31 patients,including 11 males and 20 females,with ages ranging from 8mo to 67y(mean age:29.40±22.10y).The average postoperative IOP at 1d,1wk,1mo,3mo,6mo,1y,and the last followup was significantly lower than the average preoperative IOP(31.33±9.24 mm Hg,P<0.05).The average number of postoperative medications at 1y was 0.48±1.51,which was significantly reduced compared to that used preoperatively(3.77±0.99,P=0.00).The absolute and qualified success rates were 45.16% and 83.87%,*** acuity exhibited no statistically significant difference between the postoperative and preoperative follow-up time points,except for the first day after *** most common postoperative complications were anterior chamber hemorrhage(25 cases,86.21%)and high IOP(10 cases,34.48%).CONCLUSION:Our results indicate that MATT-Trab is effective and safe for treating refractory glaucoma.

关键词： glaucoma refractor y glaucoma trabeculotomy trabeculectomy microcatheter

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Prevalence,risk factors and clinical features of sensory A-V pattern exotropia

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International Journal of ophthalmology(English edition) 2025年第2期18卷 323-329页

作者： Bin-Bin Zhu Shi-Yu Tang Xiang-Jun Wang Li-Cheng Fu Jian-Hua Yan state key laboratory of ophthalmology Zhongshan Ophthalmic CenterSun Yat-Sen UniversityGuangzhou 510060Guangdong ProvinceChina ophthalmology Department of Surgerythe Second People’s Hospital of FoshanFoshan 528000Guangdong ProvinceChina

AIM:To investigate the potential mechanisms of A-V pattern and evaluate the surgical outcomes used in the treatment of sensory ***:The medical records of patients with sensory A-V pattern exotropia who underwent strabismus surgery between May 2014 to June 2019 was retrospectively *** control group included sensory exotropia patients without A-V pattern and concomitant A-V pattern exotropia patients with normal vision who undergone strabismus surgery over this same time *** alignment,best corrected visual acuity,oblique muscle function,and stereopsis records were ***:Among the 843 eligible patients,91(10.79%;39 males and 52 females)had A-pattern(54,6.4%)or V-pattern(37,4.4%).Age at onset of vision impairment was 4±5y and at the time of surgery was 25±*** significant negative correlations were present between impaired visual acuity and the pre-operative exodeviation(r=-0.198,P=0.016)and patterns(r=-0.207,P=0.015).Age at surgery and exodeviation in patients with concomitant A-V pattern exotropia was significantly earlier as compared with that of sensory A-V pattern exotropia and sensory exotropia(both P<0.0001).There were no significant differences in these clinical variables between sensory exotropia with or without A-V *** and pattern were significantly reduced in patients receiving horizontal rectus surgery with or without oblique muscle surgery(both P<0.0001).CONCLUSION:The prevalence of sensory A-V pattern exotropia in our study is 10.79%.Visual acuity represents an important factor contributing to the occurrence and development of A-V *** horizontal rectus surgery can provide a good option for the correction of sensory A-V pattern exotropia.

关键词： sensory exotropia A-V pattern oblique muscle dysfunction horizontal rectus surgery

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Conjunctival microbiota variations in a subset of middleaged and elderly individuals from Beijing,China

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International Journal of ophthalmology(English edition) 2025年第2期18卷 237-243页

作者： Tian-Yao Zhao Yu-Chen Wang Ying-Juan Sun Jun-Yue Wang Xiao-Dan Jiang Xue-Min Li Ai-Hua Deng Department of ophthalmology Peking University Third HospitalBeijing Key Laboratory of Restoration of Damaged Ocular NerveBeijing 100191China Fangshan Hospital Beijing University of Chinese Medicine Beijing 102400China CAS key laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China state key laboratory of Animal Nutrition and Feeding Ministry of Agriculture and Rural Affairs Feed Industry CentreAgricultural UniversityBeijing 100193China

AIM:To isolate and identify the conjunctival microbiota of cataract patients and analyze the associated influencing ***:This study recruited 216 participants(216 eyes)from April 2022 to July *** the condition of no antibiotic use prior to cataract surgery,sterile swabs were used to collect samples from the lower conjunctival *** cultures were then conducted,followed by species identification through 16S rDNA gene *** factors associated with positive or negative bacterial isolation rates were analyzed,including age,gender,meibomian gland dysfunction(MGD),history of hypertension,history of diabetes,history of cancer,history of infectious diseases and the habit of wearing ***:Among the 216 eyes,78 eyes yielded isolates,with an isolation rate of 36.11%,detecting a total of 122 ***-positive rods accounted for 49.18%(60 strains),gram-positive cocci accounted for 45.08%(55 strains),gram-negative bacteria accounted for 4.92%(6 strains),and fungi accounted for 0.82%(1 strain).This study found that the most abundant genera in the conjunctival sac were Corynebacterium(42.62%),Staphylococcus(31.15%),Micrococcus(9.84%),Acinetobacter(4.10%),and Bacillus(3.28%).Furthermore,age(P=0.006),gender(P=0.039),diabetes(P=0.003),history of infectious diseases(P=0.02),and duration of mask replacement(P<0.001)were important factors influencing the positive bacterial culture of the conjunctival *** hypertensive patients exhibited a higher isolation rate of conjunctival bacteria,it did not reach statistical significance,and the history of cancer did not affect the isolation rate of the conjunctival microbial community in cataract patients before ***:Potential changes are observed in the conjunctival microbiota among a sample of middleaged and elderly individuals from Beijing,***,an increased isolation rate of Corynebacterium and Micrococcus is detected,suggesting a possible change in the mic

关键词： conjunctival microbiota 16S rDNA middle-aged and elderly population mask cataract surgery

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Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min Xing Hai-Dong Qian Qiao Gao Sheng-Lan Xu Hua Ma Zai-Long Chi state key laboratory of ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

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A dynamic peripheral immune landscape during human pregnancy

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Fundamental Research 2025年第1期5卷 391-406页

作者： Xiuxing Liu Lei Zhu Zhaohao Huang Zhaohuai Li Runping Duan He Li Lihui Xie Xiaozhen Chen Wen Ding Binyao Chen Yuehan Gao Juan Su Xianggui Wang Wenru Su state key laboratory of ophthalmology Zhongshan Ophthalmic CenterGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceSun Yat-Sen UniversityGuangzhou 510060China Eye Center of Xiangya Hospital Central South UniversityChangsha 410078China Hunan key laboratory of Skin Cancer and Psoriasis Xiangya HospitalCentral South UniversityChangsha 410008China Guangzhou Women and Children's Medical Center Guangzhou Medical UniversityGuangzhou 510623China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Engineering Research Center of Skin Health and Disease Central South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Hunan key laboratory of ophthalmology Changsha 410078China

Extensive immune adaptations occur during pregnancy to ensure successful ***,these changes can increase the risk of disease in the ***,we conducted single-cell RNA sequencing on peripheral blood mononuclear cells from pregnant women at different stages of pregnancy to elucidate the dynamic transcriptional changes in the maternal immune *** reduced cytotoxicity phenotype in highly variable cytotoxic T and natural killer cell types were observed during *** T-and B-cell response-related MHC-II and CD40 signaling as well as enhanced protolerance inducible costimulator and activin signaling may underlie the pregnancy-related weakening of adaptive ***,pro-inflammatory genes and pathways were upregulated in monocytes,possibly to compensate for the reduced T-cell ***,the transition from adaptive immune reduction to activation in late pregnancy in dendritic cells and CD4^(+)T cells was also ***,we proposed a novel view of the pro-aging effect of pregnancy from the perspective of immunity,and this effect may be restored *** work expands our knowledge of pregnancy immunity and may provide insights into the altered disease risks during pregnancy.

关键词： Single-cell RNA sequencing Pregnancy Maternal immune system Aging Immune tolerance Dampened adaptive immunity

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Clinical manifestation and management of severe blepharokeratoconjunctivitis combined with corneal perforation

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International Journal of ophthalmology(English edition) 2025年第2期18卷 229-236页

作者： Xu Li Ping Hou Xiao-Lin Qi Su-Xia Li Wei-Yun Shi Hua Gao Ting Zhang Eye Hospital of Shandong First Medical University Jinan 250021Shandong ProvinceChina state key laboratory Cultivation Base Shandong Provincial Key Laboratory of OphthalmologyEye Institute of Shandong First Medical UniversityQingdao 266071Shandong ProvinceChina School of ophthalmology Shandong First Medical UniversityJinan 250117Shandong ProvinceChina Shandong Provincial Third Hospital Jinan 250031Shandong ProvinceChina

AIM:To investigate the clinical signs of blepharokeratoconjunctivitis(BKC)and evaluate the efficacy of penetrating keratoplasty(PKP)for the ***:Sixteen patients(16 eyes)with BKC complicated by corneal perforation hospitalised at Shandong Eye Hospital were retrospectively *** patients received *** were assessed for symptoms,clinical manifestations,the activity and damage grading of BKC.A paired t-test was used to compare the uncorrected visual acuity(UCVA)before and after surgery for the perforated ***:The mean age of the patients was *** vision is the most common discomfort,followed by redness,and then *** duration of ocular discomfort lasted for 3.2y,on ***(18.8%)participants were associated with rosacea,while 11(68.8%)patients had recurrent chalazion or *** in eyelash follicles was positive in 11(68.8%)*** corneal perforations were≤3.0 mm in *** perforation was located mainly in the inferior cornea(68.8%).The mean area of corneal vascularisation was 3.0 *** patients manifested bilateral BKC,with the perforated eyes ranked as severely damaged and presenting with severe *** contralateral eyes manifested mild damage with no active ***(68.8%)of the perforated eyes were treated with PKP using a minimal *** UCVA increased significantly at the final follow-up(mean,21mo;P<0.001),with the manifestation of BKC alleviated *** of the patients developed immune rejection or other serious ***:BKC combined with corneal perforation occurs mainly among young people with a long history of ocular ***,especially using a minimal graft,is an effective and safe option for treating the disease.

关键词： blepharokeratoconjunctivitis corneal perforation penetrating keratoplasty

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Making stereopsis related to the ability of ocular deviation:a new paradigm for assessment of intermittent exotropia

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International Journal of ophthalmology(English edition) 2025年第2期18卷 308-314页

作者： Jian-Bing Li Wan-Ting Kong Tao Shen Yong-Guang Yuan Chong-Lin Chen Dan-Min Peng Min-Tong Liang Xuan He Dan Luo Jia-Yi Su Wei Wang Rui-Xin Wang Xin-Ping Yu state key laboratory of ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510623Guangdong ProvinceChina Department of ophthalmology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630Guangdong ProvinceChina Guangzhou Xinhua University Guangzhou 510520Guangdong ProvinceChina

AIM:To investigate the underlying factors by establishing a new paradigm for assessing control ability under stereopsis testing ***:This was a prospective observational *** evaluated the control ability of intermittent exotropia(IXT)patients in three conditions:natural 2D optotype viewing,2D optotype viewing with polarized glasses,and 3D optotype viewing with polarized *** with a smartphone,we captured videos to analyze the accurate time of spontaneous exodeviation and subsequent realignment before and after breaking ***,the correlation of stereopsis were also ***:A total of 48 patients(age range:4-33y;54.17%male)participated in the *** viewing 3D optotypes with polarized glasses,their median control scores were 1(interquartile range,0-4)at distance and 0(0-1)at *** scores were significantly better than those observed under natural viewing conditions,which were 2.5(1-5)at a distance and 1(0-3)at near(Friedman test,P=0.049).Furthermore,those subjects who exhibited exophoria(realignment within 2 seconds)while viewing 3D optotypes with polarized glasses were more likely to have measurable stereo vision(Kendall’sτb=-0.344,P=0.018).CONCLUSION:IXT patients exhibit enhanced control ability when using polarized glasses to view 3D optotypes,notably improving realignment *** expands our understanding of current tests and offers a potentially sensitive method for assessing IXT severity.

关键词： intermittent exotropia stereopsis control ability

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Glaucomatous retinal ganglion cells:death and protection

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International Journal of ophthalmology(English edition) 2025年第1期18卷 160-167页

作者： Na Cui Jun Jia Yuan He Department of ophthalmology the Second Affiliated Hospital of Xi’an Medical UniversityXi’an 710038Shaanxi ProvinceChina Xi’an key laboratory for the Prevention and Treatment of Eye and Brain Neurological Related Diseases Xi’an 710038Shaanxi ProvinceChina

Glaucoma is a group of diseases characterized by progressive optic nerve degeneration,with the characteristic pathological change being death of retinal ganglion cells(RGCs),which ultimately causes visual field loss and irreversible *** intraocular pressure(IOP)remains the most important risk factor for glaucoma,but the exact mechanism responsible for the death of RGCs is currently *** factor deficiency,impaired mitochondrial structure and function,disrupted axonal transport,disturbed Ca2+homeostasis,and activation of apoptotic and autophagic pathways play important roles in RGC death in *** review was conducted using Web of Science,PubMed,Project,and other databases to summarize the relevant mechanisms of death of RGCs in glaucoma,in addition to outlining protective treatments to improve the degradation of RGCs.

关键词： glaucoma retinal ganglion cells neuroprotection progressive death axonal deletion

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