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Substrate topography as a powerful tool to modify glial cell biology and interactions

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Neural Regeneration Research 2025年第5期20卷 1390-1391页

作者： Pascal Achenbach Haktan Altinova Gary A.brook Institute of Neuropathology RWTH Aachen University Hospital Department of Neurosurgery RWTH Aachen University Hospital Aachen Germany Berlin state Office for Health and Social Affairs(LAGeSo) BerlinGermany

Traumatic injuries to the central nervous system(CNS) result in disruption of the intricate network of axons which connect functionally related neurons that are widely distributed throughout the brain and spinal *** normal conditions,maintenance of this complex system is structurally and functionally supported by astrocytes (ACs)and other glial cells,the processes of which form a framework surrounding neuronal cell bodies,dendrites,axons,and synapses.

关键词： injuries topography system

Automatic and Rapid Throughflow-Based Optimal Design Method for Multi-Stage Axial-Flow Compressors

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Journal of Thermal Science 2025年第1期34卷 77-91页

作者： LEI Fan ZHANG Xiawen JU Yaping ZHANG Chuhua Department of Fluid Machinery and Engineering School of Energy and Power EngineeringXi'an Jiaotong University Production and Environmental Department China Huaneng Group.Co.Ltd. state Key Laboratory for Strength and Vibration of Mechanical Structures Xi'an Jiaotong University

Throughflow design has the advantages of less time consumption and large optimization space,and thus is the corner stone of advanced design system of multi-stage axial-flow *** majority of relevant studies were limited to the throughflow inverse designs,and quite few works have been till now devoted to the throughflow optimal *** this work,an automatic and rapid throughflow-based optimal design method is proposed for axial-flow compressors in which a throughflow inverse design solver is embedded in optimal genetic algorithm to improve the design efficiency of axial-flow *** types of design parameters in the throughflow inverse design of axial-flow compressors,i.e.,swirl and shroud curve,are simultaneously used to optimize both the blade shape and flow *** proposed method is validated by the redesign optimization of the benchmark axial-flow compressor NASA Stage 35,and the CFD predictions show that the throughflow-based optimization leads to 1.18% efficiency benefit at design *** proposed method is then utilized to the two-dimensional throughflow optimal design of a large-scale 6.5-stage axial-flow industrial *** optimal design results are confirmed by CFD predictions,indicating that the proposed method can effectively improve the design adiabatic efficiency of the compressors by 1.09% within a few minutes on desk-top *** throughflow design implications are also obtained for advanced axial-flow industrial *** work could enhance the capability of throughflow design method and has engineering application value to explore the throughflow optimization space of multi-stage axial-flow compressors.

关键词： NASA

Numerical and Experimental Studies of Substrate Melting and Resolidification during Thermal Spraying

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Journal of Materials Science & Technology 2003年第Z1期19卷 137-140页

作者： H.Zhang G.Wei L.Zheng L.Li X.Y.Wang A.Vaidya Department of Mechanical Engineering State University of New York at Stony BrookStony BrookNY 11794USA Department of Materials Science and Engineering State University of New York at Stony BrookStony BrookNY 11794USA

A good understanding of melting and resolidification of the substrate will help us to achieve better *** model is developed to investigate the solidification of the droplet,and melting and resolidification of *** molybdenum powder spraying onto three different substrates:a stainless steel,brass(70%Cu)andaluminum by atmospheric plasma spraying has been *** maximum melting depth of the substrate hasbeen measured and compared with the numerical *** results show that the material propertiesof the splat and substrate and melting temperature of the substrate play the important roles on substrate melting.A dimensionless parameter,temperature factor,has been proposed and served as an indicator for substrate melting.

关键词： Thermal spraying Coating Melting Solidification Materials processing

Melting, Oxidation, Evaporation of Particle in-Flight in Plasma Spray Processes

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Journal of Materials Science & Technology 2003年第Z1期19卷 49-52页

作者： H.B.Xiong L.L.Zheng Department of Mechanical Engineering State University of New York at Stony Brook Stony Brook NY 11794-2300 USA Department of Mechanical Engineering State University of New York at Stony Brook Stony Brook NY 11794-2300 USA

A comprehensive numerical model has been developed to investigate the transient behaviors of particle characteristics, such as temperature, melting, evaporation, and oxidation status during argon-hydrogen DC plasma *** model includes heat, momentum and mass transfer of carrier gas, and particle heating, melting, evaporationand oxidation. Special attentions have been paid to the evaporation-induced mass transfer and oxidation-inducedevaporation as well as variable non-continuum phenomena.

关键词： Melting, Oxidation, Materials processing, Multi-components reacting flow, Computational heat transfer

Widely accessible method for 3D microflow mapping at high spatial and temporal resolutions

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Microsystems & Nanoengineering 2022年第4期8卷 57-71页

作者： Evan Lammertse Nikhil Koditala Martin Sauzade Hongxiao Li Qiang Li Luc Anis Jun Kong Eric Brouzes Department of Biomedical Engineering Stony Brook UniversityStony BrookNY 11794USA Department of Mathematics and Statistics Department of Computer ScienceGeorgia State UniversityAtlantaGA 30302USA Laufer Center for Physical and Quantitative Biology Stony Brook UniversityStony BrookNY 11794USA Cancer Center Stony Brook School of MedicineStony BrookNY 11794USA Institute for Engineering Driven Medicine Stony Brook UniversityStony BrookNY 11794USA

Advances in microfluidic technologies rely on engineered 3D flow patterns to manipulate samples at the ***,current methods for mapping flows only provide limited 3D and temporal resolutions or require highly specialized optical ***,we present a simple defocusing approach based on brightfield microscopy and open-source software to map micro-flows in 3D at high spatial and temporal *** workflow is both integrated in ImageJ and *** track seed particles in 2D before classifying their Z-position using a reference *** compare the performance of a traditional cross-correlation method and a deep learning model in performing the classification *** validate our method on three highly relevant microfluidic examples:a channel step expansion and displacement structures as single-phase flow examples,and droplet microfluidics as a twophase flow ***,we elucidate how displacement structures efficiently shift large particles across ***,we reveal novel recirculation structures and folding patterns in the internal flow of microfluidic *** simple and widely accessible brightfield technique generates high-resolution flow maps and it will address the increasing demand for controlling fluids at the microscale by supporting the efficient design of novel microfluidic structures.

关键词： flow resolution method

Effectiveness of a fixed-depth sensor deployed from a buoy to estimate water-column cyanobacterial biomass depends on wind speed

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Journal of Environmental Sciences 2020年第7期32卷 23-29页

作者： Justin D.Chaffin Douglas D.Kane Alex Johnson F.T stone Laboratory and Ohio Sea Grant the Ohio State UniversityOH 43456USA Division of Natural Science Applied Scienceand MathematicsDefiance CollegeDefiance OHF.T Stone LaboratoryThe Ohio State University and Ohio Sea GrantOH 43456USA

Water quality sondes have the advantage of containing multiple sensors,extended deployment times,high temporal resolution,and telecommunication with stakeholder accessible data ***,sondes that are part of buoy deployments often suffer from typically being fixed at one *** water treatment plants are interested in water quality at a depth of the water intake and other stakeholders(*** and swimmers)are interested in the surface,we examined whether a fixed depth of approximately 1 m could cause over-or under-estimation of cyanobacterial *** sampled the vertical distribution of cyanobacteria adjacent to a water quality sonde buoy in the western basin of Lake Erie during the summers of 2015–2017.A comparison of buoy cyanobacteria RFU(Relative Fluorescence Unit)at 1 m to cyanobacteria chlorophyll a(chla)measured throughout the water column showed occurrences when the buoy both under and overestimated the cyanobacteria chl a at specific *** differences between buoy measurements and at-depth grab samples occurred during low wind speeds(4.5 m/sec)resulted in better agreement between the buoy and at-depth *** wind speeds 12 hr before sample collection decreased the difference between the buoy and at-depth samples for high wind speeds but not low *** suggest that sondes should be placed at a depth of interest for the appropriate stakeholder group or deploy sondes with the ability to sample at various depths.

关键词： Buoyancy Harmful algal bloom Lake Erie Microcystis Water quality

Haptics-equiped interactive PCI simulation for patient-specific surgery training and rehearsing

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Science China(Information Sciences) 2016年第10期59卷 233-238页

作者： Shuai LI Qing XIA Aimin HAO Hong QIN Qinping ZHAO state Key Laboratory of Virtual Reality Technology and Systems Beihang University Department of Computer Science Stony Brook University

Despite the long history of medical simulations, suffering from the patient-specific heterogeneous heart physiological structure and complex intravascular procedures, it is still challenging for patient-specific percutaneous coronary intervention(PCI) surgery simulation. In this paper, we advocate a haptics-equiped interactive prototype system towards PCI surgeons training and patient-specific surgery rehearsing, which can afford trainees the opportunity to approximately experience the entire PCI procedures and customized emergency cases that might occur in common clinical settings. The full simulation covers tissue deformation, catheter and wire simulation, X-ray simulation, haptic feedback, and 3D realistic rendering, which in all give rise to the integrated physical, visual, haptic, and procedural realism. Our system can accommodate various comprehensive operations involved in PCI-related procedures, including feeding wires, releasing stents, injecting contrast medium, simulating X-ray, bleeding, etc. Moreover, our system framework is fully built upon CUDA, and thus can achieve real-time performance even on a common desktop. The high-fidelity, real-time efficiency and stableness of our system show great potentials for its practical applications in clinical training fields.

关键词： percutaneous coronary intervention(PCI) PCI surgery simulation patient-specific surgery rehearsing physically-based modeling haptics

Preparation of active carbons from corn stalk for butanol vapor adsorption

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Journal of Energy Chemistry 2017年第1期26卷 35-41页

作者： Yuhe Cao Keliang Wang Xiaomin Wang Zhengrong Gu Tyler Ambrico William Gibbons Qihua Fan Al-Ahsan Talukder Agricultural and Biosystems Engineering Department South Dakota State UniversityBrookingsSDUSA Department of Physics and Astronomy Stony Brook UniversityStony BrookNYUSA Department of Biology and Microbiology South Dakota State UniversityBrookingsSDUSA Electrical Engineering and Computer Science Department South Dakota State UniversityUSA

Active carbons(ACs) were prepared through chemical activation of biochar from whole corn stalk(WCS)and corn stalk pith(CSP) at varying temperatures using potassium hydroxide as the activating agent. ACs were characterized via pore structural analysis and scanning electron microscopy(SEM). These adsorbents were then assessed for their adsorption capacity for butanol vapor. It was found that WCS activated at900 °C for 1 h(WCS-900) had optimal butanol adsorption characteristics. The BET surface area and total pore volume of the WCS-900 were 2330 m2/g and 1.29 cm3/g, respectively. The dynamic adsorption capacity of butanol vapor was 410.0 mg/g, a 185.1% increase compared to charcoal-based commercial AC(143.8 mg/g).

关键词： Corn stalk KOH Active carbon Gas stripping Butanol adsorption

Wave-Mean Flow Interaction: the Role of Continuous-Spectrum Disturbances

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Advances in Atmospheric Sciences 2000年第1期17卷 1-17页

作者：曾庆存张明华 Institute of Atmospheric Physics Chinese Academy of Sciences Beijing Institute for Terrestrial and Planetary Atmospheres State University of New York at Stony Brook Stony Brook

Traditionally, “ eddy feeds zonal flow” in the atmosphere is considered as a result of decaying unstable waves. We show that disturbances made of non-modal solutions -the continuous-spec-trum disturbances-can also effectively transport zonal angular momentum and interact with the zonal basic flow. These disturbances, though stable, eventually decay, losing their energy to strengthen the westerly jets in the atmosphere. Calculations with observational data illustrate that the atmospheric zonal flow is maintained primarily by continuous-spectrum disturbances rather than by unstable waves. Angular momen-tum transport by continuous-spectrum disturbances is one order of magnitude larger than that by all kinds of normal modes (referred as discrete-spectrum disturbances) including unstable waves. Key words Maintenance of zonal flow - Continuous-spectrum - Angular momentum - Transport This research was partly supported by the Chinese Program on Basic Research and by the Institute of Atmospheric Physics, Chinese Academy of Sciences. It was also supported by NASA Grant NAGW 3517, and DOE Grant DEFG0285-ER60314 to the state university of New York at Stony brook.

关键词： Maintenance of zonal flow Continuous-spectrum Angular momentum Transport