检索结果-南通市图书馆

Unraveling brain aging through the lens of oral microbiota

Neural Regeneration Research 2025年第7期20卷 1930-1943页

作者： Qinchao Hu Si Wang Weiqi Zhang Jing Qu Guang-Hui Liu state key laboratory of Membrane biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina CAS key laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina University of Chinese Academy of Sciences BeijingChina Institute for stem cell and Regeneration Chinese Academy of SciencesBeijingChina Aging Biomarker Consortium BeijingChina state key laboratory of stem cell and reproductive biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute for stem cell and Regenerative Medicine BeijingChina

The oral cavity is a complex physiological community encompassing a wide range of *** of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative *** studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention *** this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes contribute to brain aging and *** also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.

关键词： Alzheimer's disease brain aging multiple sclerosis neurodegeneration neurodegenerative diseases oral microbiota Parkinson's disease periodontitis bacteria Porphyromonas gingivalis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Single-cell sequencing delivers hematopoietic stem cell specification

引用

Science Bulletin 2016年第18期61卷 1419-1421页

作者： Jiani Cao Tongbiao Zhao state key laboratory of stem cell and reproductive biology Institute of Zoology Chinese Academy of Sciences

Recently,Zhou et al.[1]have successfully traced the hematopoietic stem cell(HSC)specification during the stepwise development of HSC from the pre-HSC stage at single-cell *** findings offer fundamental insights into mouse HSC fate decision and provide extensive information that may lead to novel discoveries in HSC ***,standing at the apex of the hierarchy

关键词：造血干细胞单细胞测序 HSC 细胞分化分辨率扩展性小鼠

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ng Ago: an exciting new tool for genome editing

引用

Science Bulletin 2016年第14期61卷 1074-1075页

作者： Haoyi Wang state key laboratory of stem cell and reproductive biology Institute of Zoology Chinese Academy of Sciences

Site-directed DNA endonucleases are powerful tools for genome *** introduced into cells,these systems can bind to a target DNA sequence in the genome and create a DNA double-strand break(DSB),the repair

关键词：编辑工具基因组 DNA双链断裂 DNA序列免疫系统核酸内切酶兴奋 RNA

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Derivation and application of pluripotent stem cells for regenerative medicine

引用

Science China(Life Sciences) 2016年第6期59卷 576-583页

作者： Jiaqiang Wang Qi Zhou state key laboratory of stem cell and reproductive biology Institute of Zoology Chinese Academy of Sciences

Pluripotent stem cells(PSCs) are cells that can differentiate into any type of cells in the body, therefore have valuable promise in regenerative medicine of cell replacement therapies and tissue/organ engineering. PSCs can be derived either from early embryos or directly from somatic cells by epigenetic reprogramming that result in customized cells from patients. Here we summarize the methods of deriving PSCs, the various types of PSCs generated with different status, and their versatile applications in both clinical and embryonic development studies. We also discuss an intriguing potential application of PSCs in constructing tissues/organs in large animals by interspecies chimerism. All these emerging findings are likely to contribute to the breakthroughs in biological research and the prosperous prospects of regenerative medicine.

关键词： pluripotent stem cells regenerative medicine reprogramming interspecies chimerism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Functional spermatid-like cells derived from the ground-state embryonic stem cells in vitro

引用

Science China(Life Sciences) 2016年第4期59卷 436-437页

作者： Yan Zhang Yixun Liu state key laboratory of stem cell and reproductive biology Institute of Zoology Chinese Academy of Sciences

Embryonic stem cells（ESCs）are pluripotent and can self-assemble to form cell clusters or embryoid bodies（EBs）,which can then differentiate into all cell types of the three germ layers,as among which one is the primordial germ cell（PGCs）（Daley,2007）.In vivo PGCs are the gamete founder cells（the ooctyes and sperms）,which transmit genetic information from one generation to the next generation to maintain mammalian life *** 15%of couples in China are infertile;

关键词： primordial pluripotent infertility embryonic PGCs maintain transmit founder differentiate methylation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Specification of functional neurons and glia from human pluripotent stem cells

引用

Protein & cell 2012年第11期3卷 818-825页

作者： Yuan Jiang Mei-Jiang Zhang Bao-Yang Hu state key laboratory of reproductive biology Key laboratory of Translational Stem Cell ResearchInstitute of ZoologyChinese Academy of SciencesBeijing 100101China

Human pluripotent stem cells(PSCs)such as embryonic stem cells(ESCs)and induced pluripotent stem cells(iPSCs)hold great promise in regenerative medicine as they are an important source of functional cells for potential cell *** human PSCs,similar to their counterparts of mouse,have the full potential to give rise to any type of cells in the ***,for the promise to be fulfilled,it is necessary to convert these PSCs into functional specialized *** the developmental principles of neural lineage specification,human ESCs and iPSCs have been effectively differentiated to regional and functional specific neurons and glia,such as striatal gama-aminobutyric acid(GABA)-ergic neurons,spinal motor neurons and myelin sheath forming *** human PSCs,in general differentiate after the similar developmental program as that of the mouse:they use the same set of cell signaling to tune the cell fate and they share a conserved transcriptional program that directs the cell fate ***,the human PSCs,unlike their counterparts of mouse,tend to respond divergently to the same set of extracellular signals at certain stages of differentiation,which will be a critical consideration to translate the animal model based studies to clinical application.

关键词： pluripotent stem cells embryonic stem cells induced pluripotent stem cells neural stem cell regenerative medicine cell transplantation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Epigenetics: major regulators of embryonic neurogenesis

引用

Science Bulletin 2015年第20期60卷 1734-1743页

作者： Tianjin Shen Fen Ji Jianwei Jiao state key laboratory of stem cell and reproductive biology Institute of Zoology Chinese Academy of Sciences University of Chinese Academy of Sciences

Mammalian cortical development is a dynamically and strictly regulated process orchestrated by extracellular signals and intracellular mechanisms. Recent studies show that epigenetic regulation serves as, at least in part, interfaces between genes and the environment, and also provides insight into the molecular and cellular bases of early embryonic cortical development. It is becoming increasingly clear that epigenetic regulation of cortical development occurs at multiple levels and that comprehensive knowledge of this complex regulatory landscape is essential to delineating embryonic neurogenesis.

关键词： Neural stem cell Neurogenesis Epigenetic Brain development Neuron

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Editing base in mouse model

引用

Protein & cell 2017年第8期8卷 558-559页

作者： Haoyi Wang state key laboratory of stem cell and reproductive biology Institute of Zoology Chinese Academy of SciencesBeijing 100101 China

Genome editing technologies enable scientists to modify DNA sequence at specific genomic loci in various cells and species. There are several editing tools, including homing endonucleases （Silva et al., 2011）, zinc finger nucleases （ZFN）（Urnov et al., 2010）, transcription activator-like effector nucleases （TALENs）（Bogdanove and Voytas, 2011）, and clustered regularly interspaced short palindromic repeats （CRISPR） and the CRISPR-associated proteins （Cas） system （Doudna and CharDentier, 2014）.

关键词：

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The day after the 7th day of the Creation:Breakthrough of human embryo in vitro culture

引用

Science China(Life Sciences) 2017年第6期60卷 665-667页

作者： Hui Gao Wei Li state key laboratory of stem cell and reproductive biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China

Since the creation of intelligent creatures,we are no longer the puppets of the *** thousands of years,people have been thinking about the nature and the future of ourselves,and reconstruction of the process of life has become the ultimate dream for *** 1951,William Harvey,a British scientist,elaborated the theory of the structure and function of embryos for the first time in his book'the reproduction of animals',which established the foundation for people to explore the process and the mechanism of embryonic development.

关键词： embryo ultimate thinking Harvey intelligent Creation creation reproduction oocyte dream

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Induced Pluripotency for Translational Research

引用

Genomics, Proteomics & Bioinformatics 2013年第5期11卷 288-293页

作者： Menghua Wu Guilai Chen Baoyang Hu state key laboratory of reproductive biology and key laboratory of Translational stem cell Research Institute of ZoologyChinese Academy of Sciences

The advent of induced pluripotent stem cells （iPSCs） has revolutionized the concept of cellular reprogramming and potentially will solve the immunological compatibility issues that have so far hindered the application of human pluripotent stem cells in regenerative medicine. Recent findings showed that pluripotency is defined by a state of balanced lineage potency, which can be artificially instated through various procedures, including the conventional Yamanaka strategy. As a type of pluripotent stem cell, iPSCs are subject to the usual concerns over purity of differen- tiated derivatives and risks of tumor formation when used for cell-based therapy, though they pro- vide certain advantages in translational research, especially in the areas of personalized medicine, disease modeling and drug screening, iPSC-based technology, human embryonic stem cells （hESCs） and direct lineage conversion each will play distinct roles in specific aspects of translational medi- cine, and continue yielding surprises for scientists and the public.

关键词： iPSCs Pluripotency cell fate decision Translational medicine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：