检索结果-南通市图书馆

Tabernaesine J,a Novel Vincamine-Type Indole Alkaloid with 6/5/6/6/6/5/5 Heptacyclic-Ring System Scaffold from Tabernaemontana pachysiphon

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2022年第4期40卷 475-479页

作者： Wen-Fang Yi Tiwalade A.Adelakun Xue Bai Yu Zhang Xiao-Jiang Hao State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China

Comprehensive Summary Tabernaesine J(1),an unprecedented vincamine-type indole alkaloid with 6/5/6/6/6/5/5 heptacyclic-ring system,as well as one new biogenetically related vincamine-type indole alkaloid(2),were isolated from leaves of Tabernaemontana pachysiphon.Their structures were established by a combination of HRESIMS,NMR,single crystal X-ray diffraction,and ECD calculation.The unprecedented pen-ta-lactone ring in tabernaesine J(1)was postulated to be derived from acetyl-CoA enolate anion.Alkaloid 2 combined with fluconazole has the potential to overcome fluconazole resistance in Candida albicans.

关键词： Natural products Alkaloids Structure elucidation Tabernaemontana pachysiphon Tabernaesine J

Structural determination of eleven new preschisanartane-type schinortriterpenoids from two Schisandra species and structural revision of preschisanartanin J using NMR computation method

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2019年第12期17卷 970-981页

作者： HU Kun LI Xing-Ren TANG Jian-Wei Li Xiao-Nian PUNO Pema-Tenzin State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences

Nineteen preschisanartane-type schinortriterpenoids(SNTs),among which eleven ones were previously undescribed,were isolated from two Schisandra species,S.sphaerandra and S.rubriflora.Their structures were determined using 1 D and 2 D NMR spectroscopic analyses,NMR data comparison,quantum chemical calculation of NMR parameters,electronic circular dichroism(ECD),X-ray single crystal diffraction,and chemical derivation.Furthermore,structural re-examination of a few previously reported preschisanartane-type SNTs led to the structural revision of preschisanartanin J.Besides,it is suggested that the reported structures of arisanlactone D and schilancidilactone W should be re-checked.Finally,a few isolated SNTs were found to possess neurite outgrowthpromoting activities,and protective activities against neural injuries.

关键词： Schisandra sphaerandra Schisandra rubriflora Preschisanartane-type schinortriterpenoids Structural revision Quantum chemical calculation of NMR parameters

维普期刊数据库

Chemical constituents and biological activities of lycophytes and ferns

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2019年第12期17卷 887-891页

作者： ZHU Qin-Feng ZHAO Qin-Shi State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences

Lycophytes and ferns are unique and charismatic members of many terrestrial ecosystems and occupy the pivotal position in land plant origin and evolution.The Chinese lycophytes and ferns flora,with approximately 2000 species,contributes a substantial component to the global lycophytes and ferns diversity,with estimates of 12000 species.Among them,about 433 species are medicinally recorded and researches based on their phytochemical properties are important topics in natural medicines.This paper reviewed the research history and current status of chemical constituents and biological activities of lycophytes and ferns,which had highlighted the research progress of our group.

关键词： Lycophytes Ferns Chemical constituents Biological activities Lycopodium alkaloids

维普期刊数据库

Discovery of Natural Co-occurring Enantiomers of Monoterpenoid Indole Alkaloids

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2021年第4期39卷 866-872页

作者： Yang Yu Mei-Fen Bao Xiang-Hai Cai State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan650201 China

Main observation and conclusion Two new pairs of monoterpenoid indole alkaloids(MIAs)enantiomers as well as their new congeners were isolated from stems of Tabernaemontana bovina Lour.(Apocynaceae).Their structures were elucidated by spectroscopic analyses and confirmed by X-ray diffractions and computational calculations.Tabovine A,tabovine B and tabovines C-D possessed unprecedented 6/5/5/6/6,6/5/5/6/5 and 6/5/6/6/6 ring systems,respectively.It is the first time to report co-occurring enantiomers of MIAs.Additionally,the explanation concerning biogenesis of MIAs was provided.The findings would open a new window where we could disclose more diverse MIAs.

关键词： Monoterpenoid indole alkaloid Enantiomers Tabovines A-D Structure elucidation Extraction and isolation

Melanin precursors mediated adaption to temperature changes in fungus and animal via inhibition of lipid-mediated ferroptosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science china(Life Sciences) 2023年第8期66卷 1800-1817页

作者： Xiaoyu Yang Yonghong Chen Longlong Zhang Jiangbo He Qunfu Wu Shuhong Li Donglou Wang Jianghui Gou Zhuang Wu Keqin Zhang Shenghong Li Xuemei Niu state key laboratory for Conservation and Utilization of Bio-resources in Yunnan and Key Laboratory for Southwest Microbial Diversity of the Ministry of EducationYunnan UniversityKunming 650032China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Kunming key laboratory of Respiratory Disease Kunming UniversityKunming 650214China

The discovery of biological activities of natural products plays a vital part in drug development.The mechanism by which organisms respond to temperature changes via biosynthesis of natural products remained largely cryptic.A thermophilic fungus under cold stress turned black and accumulated a polyketide metabolite 1 and lipid mass.Deficiency in 1 caused melanin loss and accumulated extra lipid mass,unexpectedly leading to seriously damaged mitochondria diagnostic for ferroptosis.Further analysis revealed that lipid mass induced by cold stress intensively increased ferroptosis risk and 1 functioned as cell wall reinforcer against mass lipid accumulation and as reactive oxygen species scavenger against lipid peroxidation.We also found that melanin in mice lowered lipid level but enhanced animal resistance to cold stress.Treatment with melanin precursors significantly increased mouse cell survival rate under cold stress.Our results unveiled a metabolite-lipid-ferroptosis-cold relationship,which provided mechanistic insights into the functions of most common metabolites and into diseases related to cold stress.These findings opened a perspective for developing anti-cold and anti-ferroptosis therapeutics and agents.

关键词： melanin precursor lipid ferroptosis temperature change anti-cold

维普期刊数据库

Guaiane-type Sesquiterpenoid Dimers from Artemisia zhongdianensis and Antihepatoma Carcinoma Activity via the p38MAPK Pathway

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2023年第19期41卷 2453-2468页

作者： Wei Dong Wen-Jing Ma Yun-Bao Ma Feng-Jiao Li Tian-Ze Li Yong-Cui Wang Xiao-Feng He Chang-An Geng Xue-Mei Zhang Ji-Jun Chen State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan650201 China University of Chinese Academy of Sciences Beijing100049 China

17 new guaiane-type sesquiterpenoid dimers(GSDs),artemzhongdianolides B1—B17(1—17),were isolated from Artemisia zhongdianensis under the guidance of bioassay,and elucidated by spectral analyses(HRESIMS,1D and 2D NMR,IR,ECD).The absolute configuration of compounds 1,3,7,9,10,and 13 was determined by single-crystal X-ray diffraction analyses.Structurally,artemzhongdianolides B1(1)and B2(2)were the first example of the GSDs fused via a C-13/C-13'single bond,and artemzhongdianolides B3—B17 were[4+2]Diels–Alder adducts of two monomeric guaianolides.Most of the compounds showed antihepatoma cytotoxicity with IC_(50) values ranging from 9.9 to 170.1μmol/L.Importantly,artemzhongdianolide B9(9)was the most active one against three hepatoma cell lines with IC_(50) values of 13.1μmol/L(HepG2),19.5μmol/L(Huh7),and 19.5μmol/L(SK-Hep-1),and dose-dependently inhibited cell migration and invasion,induced G1 cell cycle arrest and cell apoptosis in HepG2 cells.Compound 9 might suppress HepG2 cells via affecting the p38MAPK signaling pathway suggested by machine learning approach,and significantly upregulated expression of phosphorylated p38 validated by western blot assay.

关键词： Artemzhongdianolides B1-B17 Artemisia zhongdianensis Guaiane-type sesquiter penoid dimers Antihepatoma activity p38MAPK pathway Cancer NMR spectroscopy X-ray diffraction

Bousmekines A-E,New Alkaloids from Two Bousigonia Species:B.angustifolia and B.mekongensis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Products and Bioprospecting 2021年第2期11卷 207-213页

作者： Zong‑Qing Huo Qian Zhao Wen‑Tao Zhu Xiao‑Jiang Hao Yu Zhang State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201PR China

Four new monoterpenoid indole alkaloids,bousmekines A-D(1-4),and one new pyranopyridine alkaloid,bousmekine E(5),were isolated from the twigs and leaves of Bousigonia angustifolia and Bousigonia mekongensis.Their structures including absolute configurations were elucidated by a combination of MS,NMR,ECD calculation,and single-crystal X-ray diffraction analysis.Compound 2 was an eburnea-type MIAs characterized by a rare chlorine atom while 5 possessed a novel pyranopyridine moiety.Their cytotoxicities against several human cancer cell lines were evaluated and compound 1 exhibited significant cytotoxicity with IC50 values of 0.8-7.4μM.

关键词： Bousigonia B.angustifolia B.mekongensis Monoterpenoid indole alkaloids Bousmekines A-E

Artematrovirenolides A—D and Artematrolides S—Z,Sesquiterpenoid Dimers with Cytotoxicity against Three Hepatoma Cell Lines from Artemisia atrovirens

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2022年第1期40卷 104-114页

作者： Li-Hua Su Tian-Ze Li Yun-Bao Ma Chang-An Geng Xiao-Yan Huang Xin Zhang Zhen Gao Ji-Jun Chen State Key Laboratory of Phytochemistry and Plant Resources in West China Yunnan Key Laboratory of Natural Medicinal ChemistryKunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China University of Chinese Academy of Sciences Beijing 100049China

Inspired by the intriguing structures and remarkable activities of sesquiterpenoid dimers,12 new sesquiterpenoid dimers,artematrovirenolides A—D(1—4)and artematrolides S—Z(8—12),were isolated from the EtOAc fraction of Artemisia atrovirens through a bioactivity-guided approach.Their structures were elucidated by comprehensive spectroscopic data and absolute configuration was assigned based on single crystal X-ray diffraction data and ECD calculations.Structurally,all compounds are presumably formed via[4+2]cycloaddition involving three connecting model.Compounds 1—4 are four novel hetero-dimeric[4+2]Diels-Alder adducts dimerized from a rotundane-type unit and a guaiane-type monomer,and compounds 5—12 are eight new homo-dimeric[4+2]adducts derived from two guaianolide moieties.A putative biosynthetic pathway for compounds 1—4 was also proposed.Compounds 4,6,7,and 10 demonstrated moderate cytotoxicity against HepG2,SMMC-7721,and Huh7 cell lines with IC50 values ranging from 9.3 to 62.3μmol/L.Interestingly,compounds 5 and 11 manifested cytotoxicity with IC50 values of 13.6 and 12.8(HepG2),18.5 and 13.1(SMMC-7721),and 16.5 and 19.4μmol/L(Huh7),respectively,which were equivalent to the positive control,sorafenib.This investigation suggests that compounds 5 and 11 might be considered as potent antihepatoma candidates and deserve further structural modification and mechanism study.

关键词： Artemisia atrovirens Sesquiterpenoid dimers Structure elucidation X-ray diffraction Antihepatoma activity

The application and perspective of NMR and MS based strategies for functional compounds mining in medicinal and dietary plants

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Bodou Zhang Sheng Li Zhenzhen Liang Yinling Wei Jing Dong Hongyan Wen Lingli Guo Xiaojiang Hao Yu Zhang University of Chinese Academy of Sciences State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences

Medicinal and dietary plants provide numerous nutritional and functional compounds and also have various potential health benefits to humanity. The specific and efficient techniques for accurate identification of nutritional compounds and functional metabolites is crucial for the development of functional foods from medicinal and dietary plants. Nuclear magnetic resonance (NMR) and mass spectrometry (MS) are indispensable and essential technologies that provide an unsurpassed wealth of untargeted identification， quantitative and qualitative analysis， and structural information in the study of food and plant products. In the past decade， the rapid development of modern analytical technology has led to the emergence of new approaches and strategies for natural products discovery. Especially the application of novel NMR- and MS-based identification and dereplication strategies aided by artificial intelligence and machine learning algorithms have brought about a significant shift in the natural products discovery process. These developments and changes in the natural products filed have given us insights into how to accurately target and mining nutritional， functional， and bioactive compounds. Thus， we have summarized recent research on novel NMR and MS based strategies and methods focusing on functional compounds， accurate identification and efficient discovery mainly in medicinal and dietary plants. This review could provide a comprehensive perspective for a better understanding of novel strategies and methods based on NMR and MS technologies， which could provide valuable insights and ideas for functional compounds mining.

关键词：