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RSPSSL:A novel high-fidelity Raman spectral preprocessing scheme to enhance biomedical applications and chemical resolution visualization

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Light(Science & Applications) 2024年第2期13卷 366-386页

作者： Jiaqi Hu Gina Jinna Chen Chenlong Xue Pei Liang Yanqun Xiang Chuanlun Zhang Xiaokeng Chi Guoying Liu Yanfang Ye Dongyu Cui De Zhang Xiaojun yu Hong Dang Wen Zhang Junfan Chen Quan Tang Penglai Guo Ho-Pui Ho Yuchao Li Longqing Cong Perry Ping Shum state key laboratory of optical fiber and cable manufacture technology Guangdong Key Laboratory of Integrated Optoelectronics IntellisenseDepartment of EEESouthern University of Science and TechnologyShenzhen 518055China College of optical and Electronic technology China Jiliang UniversityHangzhou 310018China Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangzhou 510060China Department of Ocean Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Department of Nephrology Chaozhou People’s HospitalChaozhou 521011China Clinical Research Design Division Sun Yatsen Memorial HospitalGuangzhouGuangdong 510120China School of Automation Northwestern Polytechnical UniversityXi’anShaanxi 710072China Department of Biomedical Engineering The Chinese University of Hong KongHong KongChina Guangdong Provincial key laboratory of Nanophotonic Manipulation Institute of NanophotonicsJinan UniversityGuangzhou 511443China

Raman spectroscopy has tremendous potential for material analysis with its molecular fingerprinting capability in many branches of science and technology.It is also an emerging omics technique for metabolic profiling to shape precision medicine.However,precisely attributing vibration peaks coupled with specific environmental,instrumental,and specimen noise is problematic.Intelligent Raman spectral preprocessing to remove statistical bias noise and sample-related errors should provide a powerful tool for valuable information extraction.Here,we propose a novel Raman spectral preprocessing scheme based on self-supervised learning(RSPSSL)with high capacity and spectral fidelity.It can preprocess arbitrary Raman spectra without further training at a speed of~1900 spectra per second without human interference.The experimental data preprocessing trial demonstrated its excellent capacity and signal fidelity with an 88%reduction in root mean square error and a 60%reduction in infinite norm(L__(∞))compared to established techniques.With this advantage,it remarkably enhanced various biomedical applications with a 400%accuracy elevation(ΔAUC)in cancer diagnosis,an average 38%(few-shot)and 242%accuracy improvement in paraquat concentration prediction,and unsealed the chemical resolution of biomedical hyperspectral images,especially in the spectral fingerprint region.It precisely preprocessed various Raman spectra from different spectroscopy devices,laboratories,and diverse applications.This scheme will enable biomedical mechanism screening with the label-free volumetric molecular imaging tool on organism and disease metabolomics profiling with a scenario of high throughput,cross-device,various analyte complexity,and diverse applications.

关键词： spectral scheme resolution

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Controllable Synthesis of Au NRs and Its Flexible SERS optical fiber Probe with High Sensitivity

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Journal of Wuhan University of technology(Materials Science) 2024年第1期39卷 7-16页

作者：熊文豪 WANG Wenbo LONG Yuting 李宏 state key laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan 430070China National 111 Research Center Microelectronics and Integrated Circuits School of ScienceHubei University of TechnologyWuhan 430068China

The surface-enhanced Raman scattering(SERS) optical fiber probes were successfully prepared by self-assembling on polyelectrolyte multilayers. Gold nanorods(Au NRs) were used as SERS enhancement material to give excellent biological affinity and stability to the SERS optical fiber probes. Au NRs were synthesized by seed growth method. The synergistic effect between AgNO_(3) and surfactant was investigated, and the highest yield was found when AgNO_(3) was 500 uL. Meanwhile, different SERS optical fiber probes were obtained by selecting silane coupling agent, polyelectrolyte multilayer and graphene oxide(GO) to treat quartz fiber. It was found that the SERS optical fiber probes obtained by the self-assembled on polyelectrolyte multilayers method performed better than those by other methods. In addition, Mapping was combined with finite element simulation to analyze the electromagnetic field distribution at the fiber end face.The electromagnetic field distribution of Au NRs was investigated, the difference of electromagnetic field intensity around the Au NRs with different arrangements was compared, the strongest signal was obtained when the Au NRs were head-to-head. Finally, sensitivity of the optimized SERS optical fiber probes could reach 10^(-9)mol/L, with excellent stability and repeatability.

关键词： surface-enhanced Raman scattering(SERS) optical fiber probe gold nanorods(Au NRs) polyelectrolyte multilayers controllable synthesis

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Sensitivity-Enhanced Hot-Wire Anemometer by Using Cladding-Etched fiber Bragg Grating

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Photonic Sensors 2023年第3期13卷 1-7页

作者： Yuhan TANG Xuke CHEN Jiarui ZHANG Dajuan LV Liangming XIONG Xinyong DONG School of Physics and Optoelectronic Engineering Guangdong University of TechnologyGuangzhou 510006China Guangdong Provincial key laboratory of Information Photonics technology Guangzhou 510006China Institute of Optoelectronic technology China Jiliang UniversityHangzhou 310018China School of Information Engineering Guangdong University of TechnologyGuangzhou 510006China state key laboratory of optical fiber and cable manufacture technology Wuhan 430073China Southern Marine Science and Engineering Guangdong laboratory Zhuhai 519000China

A sensitivity-enhanced hot-wire anemometer based on a cladding-etched optical fiber Bragg grating(FBG)coated with a layer of silver film and optically heated by using a 1480nm laser diode is demonstrated.The silver film absorbs the laser power to heat the FBG to a certain high temperature and the airflow cools down the FBG hot-wire with the cooling effect and hence the Bragg wavelength of the FBG is determined by the airflow velocity.Experimental measurement results show that the heating efficiency of the FBG hot wire is improved by 3.8times in magnitude by etching the fiber cladding from 125μm down to 73.4μm,and the achieved airflow velocity sensitivities,under a laser power of 200mW,are–3180pm/(m/s),–889pm/(m/s),–268pm/(m/s),and–8.7pm/(m/s)at different airflow velocities of 0.1m/s,0.5m/s,1.5m/s,and 17m/s,respectively.In comparison,the sensitivities are only–2193 pm/(m/s),–567 pm/(m/s),–161 pm/(m/s),and–4.9pm/(m/s)for the reference anemometer without cladding etching even at a much higher heating laser power of 530mW.These results prove that the method by using a cladding-etched FBG to improve sensitivity of FBG-based hot-wire anemometers works and the sensitivity is improved significantly.

关键词： fiber Bragg grating hot-wire anemometer optical fiber sensors

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Uncovering the Phase Transition of Berlinite (α-AlPO_(4)) under High Pressure:Insights from First-principles Calculations

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Journal of Wuhan University of technology(Materials Science) 2021年第2期36卷 248-254页

作者：李能 HU Hai 郭飞 TAO Haizheng state key laboratory of optical fiber and cable manufacture technology(Yangtze optical fiber and cable Joint Stock Limited Company) Wuhan 430073China state key laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan 430070China

We investigated the mechanism of crystalline-to-amorphous phase transition(CAPT)for amorphous berlinite(a-AlPO_(4))under high pressure using ab initio constant-pressure techniques.Our results show that the pressure to the change in phase transition takes place at around 20 GPa,which is inconsistent with the previous results of around 15 GPa.To confirm the feasibility of our model,the calculated X-ray powder diffraction for crystal berlinite is concordant with the standard PDF card.By assessing a full spectrum of properties including atomic structure,bonding characteristics,electron density of states and real-space pair distribution function at each pressure,we reveal the details of phase transition.Importantly,all the information from our present results elucidates that Al-O bonds play an irreplaceable role during the process of phase transition to uncover the structural and electronic properties of berlinite.Overall,our work substantiates that it is essential to utilize a wide range of changes in order to provide a comprehensive understanding on the nature of the CAPT in other inorganic oxides.

关键词： aluminophosphate atomic and electronic structures phase transition ab initio calculation

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Research on photodarkening in rare earth doped fibers

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Journal of Rare Earths 2012年第11期30卷 1102-1105页

作者：成煜 state key laboratory of optical Fibre and cable manufacture technology R&D CentreYangtze Optical Fibre and Cable Company Ltd.

Samarium doped aluminosilicate fiber was fabricated by modified chemical vapor deposition （MCVD） process. The optical properties of this fiber were characterized by white light source and OSA. The photodarkening property of the fiber was measured by an Ar^＋ laser. The experiment results proved that the samarium doped aluminosilicate fiber had better photodarkening resistance than that of the samarium doped germanosilicate fiber. A brief explanation showed that the photodarkening loss could be reduced by changing the fiber core＇s material from germanosilicate to aluminosilicate. Samarium doped aluminosilicate fiber was very promising for the red fiber laser application.

关键词： fiber fabrication MCVD samarium photodarkening rare earths

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A Double-Cladding Seven-Core Photonic Crystal fiber for Hundred-Watts-Level All-fiber-Integrated Supercontinuum Generation

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Chinese Physics Letters 2016年第6期33卷 25-28页

作者：韦会峰陈胜平侯静陈抗抗李进延 Wuhan National laboratory for Optoelectronics School of Optical and Electronic InformationHuazhong University of Science and Technology state key laboratory of optical fiber and cable manufacture technology Yangtze Optical Fiber and Cable Joint Stock Limited Company College of Optoelectric Science and Engineering National University of Defense Technology Wuhan YSL Photonics Co.Ltd

A seven-core photonic crystal fiber （PCF） is fabricated and shown to possess a Gaussian-like far-field-intensity distribution. The seven-core PCF, designed with double-cladding structure and zero dispersion wavelength at 927nm, is utilized to build up a 104 W all-fiber-integrated supercontinuum （SC） source with total conversion efficiency up to 74.3%. The average output power of SC can be further sealed based on this multi-core PCF.

关键词： PCF is as with SC of MOPA for

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1-Pbps orbital angular momentum fibre-optic transmission

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Light(Science & Applications) 2022年第8期11卷 1823-1833页

作者： Junyi Liu Jingxing Zhang Jie Liu Zhenrui Lin Zhenhua Li Zhongzheng Lin Junwei Zhang Cong Huang Shuqi Mo Lei Shen Shuqing Lin Yujie Chen Ran Gao Lei Zhang Xiaobo Lan Xinlun Cai Zhaohui Li Siyuan Yu state key laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologySun Yat-Sen UniversityGuangzhou510006China Yangtze optical Fibre and cable Joint Stock Limited Company State Key Laboratory of Optical Fibre and Cable Manufacture TechnologyNo.9 Guanggu AvenueWuhanHubeiChina School of Information and Electronics Beijing Institute of TechnologyBeijing100081China

Space-division multiplexing(SDM),as a main candidate for future ultra-high capacity fibre-optic communications,needs to address limitations to its scalability imposed by computation-intensive multi-input multi-output(MIMO)digital signal processing(DSP)required to eliminate the crosstalk caused by optical coupling between multiplexed spatial channels.By exploiting the unique propagation characteristics of orbital angular momentum(OAM)modes in ring core fibres(RCFs),a system that combines SDM and C+L band dense wavelength-division multiplexing(DWDM)in a 34 km 7-core RCF is demonstrated to transport a total of 24960 channels with a raw(net)capacity of 1.223(1.02)Peta-bit s−1(Pbps)and a spectral efficiency of 156.8(130.7)bit s−1 Hz−1.Remarkably for such a high channel count,the system only uses fixed-size 4×4 MIMO DSP modules with no more than 25 time-domain taps.Such ultra-low MIMO complexity is enabled by the simultaneous weak coupling among fibre cores and amongst non-degenerate OAM mode groups within each core that have a fixed number of 4 modes.These results take the capacity of OAM-based fibre-optic communications links over the 1 Pbps milestone for the first time.They also simultaneously represent the lowest MIMO complexity and the 2nd smallest fibre cladding diameter amongst reported few-mode multicore-fibre(FM-MCF)SDM systems of>1 Pbps capacity.We believe these results represent a major step forward in SDM transmission,as they manifest the significant potentials for further up-scaling the capacity per optical fibre whilst keeping MIMO processing to an ultra-low complexity level and in a modularly expandable fashion.

关键词： fibre momentum coupling

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Graphene-Oxide-Based Q-Switched fiber Laser with Stable Five-Wavelength Operation

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Chinese Physics Letters 2012年第11期29卷 81-84页

作者：赵俊清王勇刚闫培光阮双琛成建群杜戈果于永芹张格霖韦会峰罗杰 Yuen H.Tsang Shenzhen key laboratory of Laser Engineering College of Electronic Science and TechnologyShenzhen UniversityShenzhen 518060 Department of Applied Physics Hong Kong Polytechnic UniversityHong KongChina state key laboratory of optical fiber and cable manufacture technology Yangtze Optical Fiber and Cable Company Ltd.R&D CenterWuhan 430073

We demonstrate an erbium-doped ring-cavity fiber laser Q-switched by a graphene oxide-based saturable absorber(GOSA).The GOSA was fabricated by vertically evaporating GO-polyvinylalcohol(GO/PVA)composite dispersion,and has a good performance under room temperature.Utilizing a specially fabricated fiber Bragg grating(FBG),stable five-wavelength lasing is realized and stabilized at different pump powers under any polarization.When the pump power increases from 78.4 mW to 379.3 mW,the output power ranging from 1.9 mW to 16.6 mW could be obtained,with pulse duration from 6.8μs to 2.72μs,single pulse energy from 123.73 nJ to 229.74 nJ,and pulse repetition rate from 15.36 kHz to 72.25 kHz.To the best of our knowledge,it is the first simultaneous realization of five-wavelength operation and pulse output in a GO Q-switched all fiber laser system.

关键词： pump fiber switched

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Spectral Absorption Gas Sensor Based on Anti-Resonant Reflecting optical Waveguide

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Photonic Sensors 2014年第2期4卷 128-131页

作者： Haihu YU Yu ZHENG Huiyong GUO Beibei CAO Huifeng WEI National Engineering laboratory for fiber Optic Sensing technology Wuhan University of Technology Wuhan430070 China key laboratory of fiber Optic Sensing technology and Information Processing Ministry of Education WuhanUniversity of Technology Wuhan 430070 China state key laboratory of optical fiber and cable manufacture technology Yangtze Optical Fibre and Cable CompanyLtd. Wuhan 430073 China

空气硅石微观结构光纤维基于反反响的思考光波导(箭头) ，原则被用来发展一光谱吸收气体传感器。箭头纤维有一个空气核心和空气 cladding 层。有一段 725 公里的箭头纤维被用来构造一个察觉到的系统检测乙炔气体。气体从纤维的一结束被... 详细信息

空气硅石微观结构光纤维基于反反响的思考光波导(箭头) ，原则被用来发展一光谱吸收气体传感器。箭头纤维有一个空气核心和空气 cladding 层。有一段 725 公里的箭头纤维被用来构造一个察觉到的系统检测乙炔气体。气体从纤维的一结束被注入纤维。传播系列用一个光光谱分析器被收集。结果显示系统能检测不同集中的气体并且有好系统线性。系统的反应时间是大约 200 s。

关键词：气体传感器光谱吸收光波导反射谐振微结构光纤传感系统 ARROW

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C-band real-time 400/300 Gb/s OOK bidirectional interconnection over 20 km multicore fibers

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Chinese Optics Letters 2017年第8期15卷 12-16页

作者：冯振华计红林唐明义理林甘霖薛雷吴琼李博睿赵佳佳童维军付松年刘德明胡卫生 Wuhan National Lab for Optoelectronics (WNLO) & National Engineering laboratory for Next Generation Internet Access System School of Optical and Electronic Information Huazhong University of Science and Technology Wuhan 430074 China state key laboratory of Advanced optical Communication Systems and Network Shanghai Jiao Tong University Shanghai 200240 China state key laboratory of optical fiber and cable manufacture technology Yangtze Optical fiber and Cable Joint Stock Limited Company (YOFC) Wuhan 430073 China

With the increasing capacity demands fueled by the emerging heterogeneous and bandwidth-intensive applica- tions, such as cloud computing, 4K/8K videos, and virtual reality （VR）, the need for low-cost, power-efficient, and high-density short-reach optical interconnects operating at 100 Gb/s and beyond has drawn significant research efforts.

关键词： OOK ODI C-band real-time 400/300 Gb/s OOK bidirectional interconnection over 20 km multicore fibers over time real

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