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Experimental and numerical simulation of the attenuation effect of blast shock waves in tunnels at different altitudes

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Defence Technology(防务技术) 2025年第1期43卷 120-141页

作者： Changjiang Liu Hujun Li Zhen Wang Yong He Guokai Zhang Mingyang Wang School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China state key laboratory of Disaster prevention and Mitigation of Explosion and Impact People's Liberation Army Engineering UniversityNanjing 210014China

Traffic engineering such as tunnels in various altitudinal gradient zone are at risk of accidental explosion,which can damage personnel and *** prediction of the distribution pattern of explosive loads and shock wave propagation process in semi-enclosed structures at various altitude environment is key research focus in the fields of explosion shock and fluid *** effect of altitude on the propagation of shock waves in tunnels was investigated by conducting explosion test and numerical *** on the experimental and numerical simulation results,a prediction model for the attenuation of the peak overpressure of tunnel shock waves at different altitudes was *** results showed that the peak overpressure decreased at the same measurement points in the tunnel entrance under the high altitude *** contrast,an increase in altitude accelerated the propagation speed of the shock wave in the *** average error between the peak shock wave overpressure obtained using the overpressure prediction formula and the measured test data was less than15%,the average error between the propagation velocity of shock waves predicted values and the test data is less than 10%.The method can effectively predict the overpressure attenuation of blast wave in tunnel at various altitudes.

关键词： Shock wave propagation Tunnel Altitude effect Peak overpressure Shock waves velocity Engineering safety

Data-Driven Fault-Tolerant Bipartite Consensus Tracking for Multi-Agent Systems With a Non-Autonomous Leader

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IEEE/CAA Journal of Automatica Sinica 2025年第1期12卷 279-281页

作者： Yan Zhou Guanghui Wen Jialing Zhou Tao Yang the Department of Systems Science Southeast University the state key laboratory of CNS/ATM Beijing Institute of Technology the Beijing Institute of Technology (Zhuhai) the state key laboratory of Synthetical Automation for Process Industries Northeastern University

Dear Editor,This letter studies the bipartite consensus tracking problem for heterogeneous multi-agent systems with actuator faults and a leader's unknown time-varying control input. To handle such a problem, the continuous fault-tolerant control protocol via observer design is developed. In addition, it is strictly proved that the multi-agent system driven by the designed controllers can still achieve bipartite consensus tracking after faults occur.

关键词： Time varying control systems

Low-cost and fluoride-free synthesis of MFI zeolite nanosheets with enhanced stability for benzene alkylation with ethanol

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Journal of Energy Chemistry 2025年第1期100卷 458-468页

作者： Peng Zhu Cun Liu Yiren Yu Guoshu Gao Yumeng Zhao Xiongfu Zhang Guodong Liu Guohui Yang state key laboratory of Fine Chemicals School of Chemical EngineeringDalian University of TechnologyDalian 116024 state key laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina

Zeolite nanosheets with a short b-axis thickness are highly desirable in lots of catalytic reactions due to their reduced diffusion resistance. Nevertheless, conventional synthesis methods usually require expensive structure-directing agents(SDAs), pricey raw materials, and eco-unfriendly fluorine-containing additives. Here, we contributed a cost-effective and fluoride-free synthesis method for synthesizing high-quality MFI zeolite nanosheets through a Silicalite-1(Sil-1) seed suspension and urea cooperative strategy, only with inexpensive colloidal silica as the Si source. Our approach was effective for synthesizing both Sil-1 and aluminum-containing ZSM-5 nanosheets. By optimizing key synthesis parameters,including seed aging time, seed quantity, and urea concentration, we achieved precise control over the crystal face aspect ratio and b-axis thickness. We also revealed a non-classical oriented nanosheet growth mechanism, where Sil-1 seeds induced the formation of quasi-ordered precursor particles, and the(010)crystal planes of these particles facilitated urea adsorption, thereby promoting c-axis-oriented *** obtained ZSM-5 nanosheets exhibited exceptional catalytic performance in the benzene alkylation with ethanol, maintaining stability for over 500 h, which is 5 times longer than traditional ZSM-5 catalysts. Furthermore, large-scale production of ZSM-5 nanosheets was successfully carried out in a 3 L highpressure autoclave, yielding samples consistent with those from laboratory-scale synthesis. This work marks a significant step forward in the sustainable and efficient production of MFI nanosheets using inexpensive and environmentally friendly raw materials, offering the broad applicability in catalysis.

关键词： MFI zeolite ZSM-5 Nanosheets Scale-up synthesis Aromatic alkylation

Deep learning identification of novel autophagic protein-protein interactions and experimental validation of Beclin 2-Ubiquilin 1 axis in triple-negative breast cancer

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Oncology Research 2025年第1期33卷 67-81页

作者： XIANG LI WENKE JIN LIFENG WU HUAN WANG XIN XIE WEI HUANG BO LIU state key laboratory of Southwestern Chinese Medicine Resources School of Pharmacy and College of Medical TechnologyChengdu University of Traditional Chinese MedicineChengdu611137China Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu610041China

Background:Triple-negative breast cancer(TNBC),characterized by its lack of traditional hormone receptors and HER2,presents a significant challenge in oncology due to its poor response to conventional *** is an important process for maintaining cellular homeostasis,and there are currently autophagy biomarkers that play an effective role in the clinical treatment of *** contrast to targeting protein activity,intervention with proteinprotein interaction(PPI)can avoid unrelated crosstalk and regulate the autophagy process with minimal interference ***:Here,we employed Naive Bayes,Decision Tree,and k-Nearest Neighbors to elucidate the complex PPI network associated with autophagy in TNBC,aiming to uncover novel therapeutic ***,the candidate proteins interacting with Beclin 2 were initially screened in MDA-MB-231 cells using Beclin 2 as bait protein by immunoprecipitation-mass spectrometry assay,and the interaction relationship was verified by molecular docking and CO-IP experiments after *** formation,cellular immunofluorescence,cell scratch and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)tests were used to predict the clinical therapeutic effects of manipulating candidate ***:By developing three PPI classification models and analyzing over 13,000 datasets,we identified 3733 previously unknown autophagy-related *** network analysis revealed the central role of Beclin 2 in autophagy regulation,uncovering its interactions with 39 newly identified ***,the CO-IP studies identified the substantial interaction between Beclin 2 and Ubiquilin 1,which was anticipated by our model and discovered in immunoprecipitation-mass spectrometry assay ***,in vitro investigations showed that overexpressing Beclin 2 increased Ubiquilin 1,promoted autophagy-dependent cell death,and inhibited proliferation and metastasis in MDA-MB-231 ***:This study not

关键词： Triple-negative breast cancer(TNBC) Autophagy Protein-protein interactions(PPI) Artificial intelligence(AI) Beclin 2 Ubiquilin 1

Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： Qiang Liu Xiang Li Shen Du Ming Gao Yanbin Yin Jiongming Zhang state key laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity

The machine learning implementation and theoretical foundations of intelligent control of accelerator particle beams

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Science China(Physics,Mechanics & Astronomy) 2025年第2期68卷 199-200页

作者： XueQing Yan state key laboratory of Nuclear Physics and Technology Peking UniversityBeijing 100871China

The intelligent control of accelerator particle beams,achieved through machine learning,offers a new opportunity for the design and regulation of high-power,high-intensity *** recent years,this technology has been applied in several practical *** instance,the DeepMind team successfully used reinforcement learning to control the plasma in a Tokamak device with 19 control magnets[1].

关键词： particle instance accelerator

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Long non-coding RNAs as promising targets for controlling disease vector mosquitoes

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Insect Science 2025年第1期32卷 24-41页

作者： Yujiao Han Qian Pu Ting Fan Tianqi Wei Yankun Xu Lu Zhao Shiping Liu state key laboratory of Resource Insects Southwest UniversityChongqing400716 China

Hematophagous female mosquitoes are important vectors of numerous devastating human diseases,posing a major public health *** prevention and control of mosquito-borne diseases rely considerably on progress in understanding the molecular mechanisms of various life activities,and accordingly,the molecules that regulate the various life activities of mosquitoes are potential targets for implementing future vector control *** long non-coding RNAs(lncRNAs)have been identified in mosquitoes and significant progress has been made in determining their ***,we present a comprehensive overview of the research advances on mosquito lncRNAs,including their molecular identification,function,and interaction with other non-coding RNAs,as well as their synergistic regulatory roles in mosquito life *** also highlight the potential roles of competitive endogenous RNAs in mosquito growth and development,as well as in insecticide resistance and virus–host *** into the biological functions and mechanisms of lncRNAs in mosquito life activities,viral replication,pathogenesis,and transmission will contribute to the development of novel drugs and safe vaccines.

关键词： competitive endogenous RNAs(ceRNAs) insecticide resistance long noncoding RNA(lncRNA) mosquito mosquito-borne diseases pathogen-host interaction

Sr-Nd isotopic characteristics and their significance in provenance tracing of detrital sediment in major rivers and marginal seas of eastern China

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Science China Earth Sciences 2025年第2期68卷 523-537页

作者： Xiaobao GAO Chao LI Zhifei DUAN Yulong GUO Shouye YANG state key laboratory of Marine Geology Tongji UniversityShanghai 200092China

Sr-Nd isotopes are widely utilized as reliable tracers in sediment provenance *** this study,we compiled 304 Sr and 335 Nd isotope data of fine-grained surface sediments collected from major rivers in eastern China,including the Huanghe River,Changjiang River,southeastern coastal rivers,and rivers in Taiwan Island,as well as from marginal seas(Yellow Sea and East China Sea)and the Okinawa *** comprehensive dataset allowed us to examine the spatial distribution patterns of these isotopes and their implications for provenance *** variations ofεNd values in the sediments in Changjiang and Huanghe Basins primarily reflect the diversity of sediment sources,whereas the^(87)Sr/^(86)Sr ratios are influenced by both grain size and source ***,the reduction in^(87)Sr/^(86)Sr ratios observed in the middle and lower Changjiang River is attributed to the inputs of sources characterized by distinct^(87)Sr/^(86)Sr signatures beyond mere grain size *** the southeastern coastal and Taiwan rivers,sediments in the tidal reaches of the Jiao River exhibit hybrid characteristics,a mix of Changjiang-derived sediment and those originating from local ***,the Min River and Jiulong River sediments predominantly reflect local sources,with minimal influence from the Changjiang *** significant isotopic variation of Sr-Nd isotopic characteristics observed between riverine sediments on the eastern and western sides of Taiwan Island underscores the diverse provenance heterogeneity of source rocks in the *** the marginal seas,our data indicates that the surface sediments in the central mud area of the South Yellow Sea and the southern Yellow Sea are predominantly sourced from the Changjiang River catchment,potentially augmented by inputs from Korean *** inner shelf sediments of the East China Sea are primarily influenced by Changjiang River inputs,whereas rivers in eastern Taiwan Island contribute to the sediments on

关键词： Sr-Nd isotope Provenance tracing Detrital sediments Eastern China rivers Marginal seas

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Advances in basic and translational research into nasopharyngeal carcinoma

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Oncology and Translational Medicine 2025年第1期11卷 10-16页

作者： Zhe Li Yupei Chen Jun Ma Department of Radiation Oncology State Key Laboratory of Oncology in South ChinaGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouChina

According to the International cancer Research Institute of the World Health Organization data,nasopharyngeal carcinoma(NPC)remains a significant health concern,particularly in regions such as Southeast Asia and southern ***,substantial progress has been made in the field of basic and translational research on NPC,enhancing our understanding of the molecular mechanisms underlying the disease and paving the way for precise therapeutic *** review summarizes the advances in NPC research,focusing on key areas that include radiotherapy and chemotherapy resistance and tumor metastasis,microenvironment,metabolism,microbiome,and ***,future research directions in NPC are discussed to provide valuable insights to advance the field further.

关键词： Nasopharyngeal carcinoma treatment resistance Tumor biomarkers Tumor microenvironment