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Neuroscience Bulletin 2023年第1期39卷 1-13页

作者： Ziwei Shang Junhao Huang Nan Liu Xiaohui Zhang state key laboratory of cognitive Neuroscience and Learning IDG/McGovern Institute for Brain ResearchBeijing Normal UniversityBeijing 100875China

Differing from other subtypes of inhibitory interneuron,chandelier or axo-axonic cells form depolarizing GABAergic synapses exclusively onto the axon initial segment(AIS)of targeted pyramidal cells(PCs).However,the debate whether these AIS-GABAergic inputs produce excitation or inhibition in neuronal processing is not resolved.Using realistic NEURON modeling and electrophysiological recording of cortical layer-5 PCs,we quantitatively demonstrate that the onset-timing of AIS-GABAergic input,relative to dendritic excitatory glutamatergic inputs,determines its bi-directional regulation of the efficacy of synaptic integration and spike generation in a PC.More specifically,AIS-GABAergic inputs promote the boosting effect of voltage-activated Na+channels on summed synaptic excitation when they precede glutamatergic inputs by>15 ms,while for nearly concurrent excitatory inputs,they primarily produce a shunting inhibition at the AIS.Thus,our findings offer an integrative mechanism by which AIS-targeting interneurons exert sophisticated regulation of the input-output function in targeted PCs.

关键词： GABAergic inputs Axon initial segment Synaptic integration Axo-axonic cell Chandelier cell NEURON simulation Dynamic clamp

Mechanical Force Remodeling the Adult brain

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Neuroscience Bulletin 2023年第5期39卷 877-879页

作者： Chen Zhang Shuai Liu Yong-Chun Yu Qingjian Han state key laboratory of Medical Neurobiology and MOE Frontiers Center for brain science Institutes of Brain ScienceFudan UniversityShanghai 200032China

The interactions between neural stem cells(NSCs)and their niche are essential for their maintenance,proliferation,differentiation,and migration,which contribute to brain plasticity,learning and memory,and cognition[1].As one of the key components of the NSC niche,astrocytes are vital in regulating the processes underlying brain development such as neuro-/gliogenesis,angiogenesis,axonal outgrowth,synaptogenesis,and synaptic pruning[2].Chemical and electrical signals mediated by adhesion molecules,the extracellular matrix,paracrine secretion.

关键词： vital maintenance migration

Ferrodifferentiation regulates neurodevelopment via ROS generation

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science China(Life sciences) 2023年第8期66卷 1841-1857页

作者： Shiyang Chang Peina Wang Yingying Han Qiang Ma Zeyuan Liu Suijuan Zhong Yufeng Lu Ruiguo Chen Le Sun Qian Wu Guofen Gao Xiaoqun Wang Yan-Zhong Chang laboratory of Molecular Iron Metabolism Ministry of Education Key Laboratory of Molecular and Cellular BiologyHebei Key Laboratory of Animal PhysiologyBiochemistryand Molecular BiologyCollege of Life SciencesHebei Normal UniversityShijiazhuang 050024China College of Basic Medicine Hebei Medical UniversityShijiazhuang 050017China State Key Laboratory of Brain and Cognitive Science CAS Center for Excellence in Brain Science and Intelligence Technology(Shanghai)Institute of BiophysicsChinese Academy of Sciences(CAS)BNU IDG/McGovern Institute for Brain ResearchBeijing 100101China state key laboratory of cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China Beijing Institute of brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersCapital Medical UniversityBeijing 100069China

Iron is important for life,and iron deficiency impairs development,but whether the iron level regulates neural differentiation remains elusive.In this study,with iron-regulatory proteins(IRPs)knockout embryonic stem cells(ESCs)that showed severe iron deficiency,we found that the Pax6-and Sox2-positive neuronal precursor cells and Tuj1 fibers in IRP1^(-/-)IRP2^(-/-)ESCs were significantly decreased after inducing neural differentiation.Consistently,in vivo study showed that the knockdown of IRP1 in IRP2^(-/-)fetal mice remarkably affected the differentiation of neuronal precursors and the migration of neurons.These findings suggest that low intracellular iron status significantly inhibits neurodifferentiation.When supplementing IRP1^(-/-)IRP2^(-/-)ESCs with iron,these ESCs could differentiate normally.Further investigations revealed that the underlying mechanism was associated with an increase in reactive oxygen species(ROS)production caused by the substantially low level of iron and the downregulation of iron-sulfur cluster protein ISCU,which,in turn,affected the proliferation and differentiation of stem cells.Thus,the appropriate amount of iron is crucial for maintaining normal neural differentiation that is termed ferrodifferentiation.

关键词： IRPs ESCs iron differentiation neurodevelopment ROS

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Neuronal Response to Reward and Luminance in Macaque LIP During Saccadic Choice

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Neuroscience Bulletin 2023年第1期39卷 14-28页

作者： Ziqi Wu Aihua Chen Xinying Cai key laboratory of brain Functional Genomics(Ministry of Education) East China Normal University(ECNU)Shanghai200062China New York University(NYU)Shanghai Shanghai200122China NYU-ECNU Institute of brain Cognitive Science at NYU ShanghaiShanghai200062China key laboratory of brain Functional Genomics(Ministry of Education) School of Psychology and Cognitive ScienceECNUShanghai200062China

Recent work in decision neuroscience suggests that visual saliency can interact with reward-based choice,and the lateral intraparietal cortex(LIP)is implicated in this process.In this study,we recorded from LIP neurons while monkeys performed a two alternative choice task in which the reward and luminance associated with each offer were varied independently.We discovered that the animal’s choice was dictated by the reward amount while the luminance had a marginal effect.In the LIP,neuronal activity corresponded well with the animal’s choice pattern,in that a majority of reward-modulated neurons encoded the reward amount in the neuron’s preferred hemifield with a positive slope.In contrast,compared to their responses to low luminance,an approximately equal proportion of luminance-sensitive neurons responded to high luminance with increased or decreased activity,leading to a much weaker population-level response.Meanwhile,in the non-preferred hemifield,the strength of encoding for reward amount and luminance was positively correlated,suggesting the integration of these two factors in the LIP.Moreover,neurons encoding reward and luminance were homogeneously distributed along the anterior-posterior axis of the LIP.Overall,our study provides further evidence supporting the neural instantiation of a priority map in the LIP in reward-based decisions.

关键词： Reward Luminance Attention Priority map Saccadic choice Lateral intraparietal cortex

TRPM7 Kinase Domain is Part of the Rac1-SSH2-cofilin Complex Regulating F-actin in the Mouse Nervous System

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Neuroscience Bulletin 2023年第6期39卷 989-993页

作者： Junzhuang Chang Cui Chen Wei Li Nashat Abumaria state key laboratory of Medical Neurobiology and MOE Frontiers Center for brain science Department of Laboratory Animal ScienceInstitutes of Brain ScienceFudan UniversityShanghai200032China

Dear Editor,The ion channel transient receptor potential melastatin-like 7(TRPM7)has a serine-threonineα-kinase domain(M7CK)on its intracellular C-terminal[1,2].In cell lines,M7CK is cleaved and translocated to the nucleus to regulate a variety of cellular processes including cell proliferation and survival[3].In neuroblastoma cells.

关键词： Rac1 SSH2 neuroblastoma

Signaling Mechanism for Modulation by GLP-1 and Exendin-4 of GABA Receptors on Rat Retinal Ganglion Cells

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Neuroscience Bulletin 2022年第6期38卷 622-636页

作者： Tao Zhang Hang-Ze Ruan Yong-Chen Wang Yu-Qi Shao Wei Zhou Shi-Jun Weng Yong-Mei Zhong state key laboratory of Medical Neurobiology and MOE Frontiers Center for brain science Institutes of Brain ScienceFudan UniversityShanghai 200032.China

Glucagon-like peptide-1(GLP-1)is expressed in retinal neurons,but its role in the retina is largely unknown.Here,we demonstrated that GLP-1 or the GLP-1 receptor(GLP-1R;a G protein-coupled receptor)agonist exendin-4 suppressed-aminobutyric acid receptor(GABAR)-mediated currents through GLP-1Rs in isolated rat retinal ganglion cells(GCs).Pre-incubation with the stimulatory G protein(G,)inhibitor NF 449 abolished the exendin-4 effect.The exendin-4-induced suppression was mimicked by perfusion with 8-Br-cAMP(a cAMP analog),but was eliminated by the protein kinase A(PKA)inhibitor RpcAMP/KT-5720.The_exendin-4 effect was accompanied by an increase in[Ca2+];of GCs through the IP3-sensitive pathway and was blocked in Ca2+-free solution.Furthermore,when the activity of calmodulin(CaM)and CaMdependent protein kinase II(CaMKII)was inhibited,the exendin-4 effect was eliminated.Consistent with this,exendin-4 suppressed GABAR-mediated light-evoked inhibitory postsynaptic currents in GCs in rat retinal slices.These results suggest that exendin-4-induced suppression may be mediated by a distinct G,/cAMP-PKA/IPs/Ca+/CaM/CaMKIl signaling pathway,following the activation of GLP-1Rs.

关键词： Glucagon-like peptide-1 Exendin-4 GABA current Retinal ganglion cells Neuromodulation

The Claustrum Controls Motor Activity Through Anterior Cingulate Cortex Input and Local Circuit Synchronization in a Preparatory Manner

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Neuroscience Bulletin 2023年第10期39卷 1591-1594页

作者： Zi-Qi Kou Chun-Yan Chen Mamatsali Abdurahman Xu-Chu Weng Chun Hu Hong-Yan Geng key laboratory of brain Cognition and Education ScienceMinistry of EducationSouth China Normal UniversityGuangzhou 510631China Institute for brain Research and Rehabilitation and Guangdong Key Laboratory of Mental Health and Cognitive ScienceSouth China Normal UniversityGuangzhou 510631China

Motor control has evolved in the nervous systems of animals and motor output is the final result of neural processing.Most previous studies have focused on the classical brain regions for motor coordination,including ... 详细信息

关键词： Cortex neural processing

Endogenous ceramide phosphoethanolamine modulates circadian rhythm via neural-glial coupling in Drosophila

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National science Review 2022年第12期9卷 104-123页

作者： Xiupeng Chen Jie Li Zhongbao Gao Yang Yang Wenqing Kuang Yue Dong Gek Huey Chua Xiahe Huang Binhua Jiang He Tian Yingchun Wang Xun Huang Yan Li Sin Man Lam Guanghou Shui state key laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences University of Chinese Academy of sciences State Key Laboratory of Brain and Cognitive Science Institute of Biophysics Chinese Academy of Sciences Lipid ALL Technologies Company Limited

While endogenous lipids are known to exhibit rhythmic oscillations,less is known about how specific lipids modulate circadian behavior.Through a series of loss-of-function and gain-of-function experiments on cer amide phosphoethanolamine(CPE) synthase of Drosophila,we demonstrated that pan-glial-specific deficiency in membrane CPE,the structural analog of mammalian sphingomyelin(SM),leads to arrhythmic locomotor behavior and shortens lifespan,while the reverse is true for increasing CPE.Comparative proteomics uncovered dysregulated synaptic glutamate utilization and transport in CPE-deficient flies.An extensive genetic screen was conducted to verify the role of differentially expressed proteins in circadian regulation.Arrhythmic locomotion under cpes1mutant background was rescued only by restoring endogenous CPE or SM through expressing their respective synthases.Our results underscore the essential role of CPE in maintaining synaptic glutamate homeostasis and modulating circadian behavior in Drosophila.The findings suggest that region-specific elevations of functional membrane lipids can benefit circadian regulation.

关键词： ceramide phosphoethanolamine sphingomyelin circadian longevity glutamate homeostasis

Anterograde Trans-Synaptic Tagging Mediated by Adeno-Associated Virus

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Neuroscience Bulletin 2017年第3期33卷 348-350页

作者： Fei Zhao Hai-Fei Jiang Wen-Bo Zeng Yousheng Shu Min-Hua Luo Shumin Duan state key laboratory of Virology Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences Wuhan Institute of Virology Chinese Academy of Sciences state key laboratory of cognitive Neuroscience and Learning IDG/Mc Govern Institute for Brain ResearchSchool of Brain and Cognitive Sciences the Collaborative Innovation Center for Brain Science Beijing Normal University Department of Neurobiology Key Laboratory of Medical Neurobiology of the Ministry of Health of China Key Laboratory of Neurobiology Zhejiang University School of Medicine

Trans-neuronal viral tracing is becoming one of the most important methods for mapping neuronal circuit connections,but an anterograde trans-synaptic tracer compatible with functional assays is still lacking.Adeno-associated virus（AAV）is replication-defective,and its production of offspring needs the help of adenovirus（AV）[1]or herpesvirus co-infection[2].The replication deficiency,non-pathogenicity,easy manipulability,

关键词： neuronal herpesvirus offspring replication pathogenicity synaptic tracing Associated adenovirus titer

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Hippocampal dopamine as a key regulator for learning deficits in Parkinson's disease

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Neural Regeneration Research 2024年第6期19卷 1193-1194页

作者： Kun Wu Shuai Liu Shanghai key laboratory of brain Functional Genomics (Ministry of Education) Affiliated Mental Health Center (ECNU) School of Psychology and Cognitive Science East China Normal University Shanghai Changning Mental Health Center NYU-ECNU Institute of brain and cognitive science at NYU Shanghai

Parkinson’s disease(PD) is a progressive neurodegenerative disorder with clinical symptoms of involuntary or uncontrollable movements such as tremors,rigidity,and incoordination.The learning deficit is largely overlo... 详细信息

关键词： MEMORY