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Assembly and network of Rhei Radix et Rhizoma surface microbiome shaped by processing methods and sampling locations

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Chinese Herbal Medicines 2025年第1期17卷 189-199页

作者： Guangfei Wei Xiao Chen Guozhuang Zhang Conglian Liang Zhaoyu Zhang Bo Zhang Shilin Chen Linlin Dong state key laboratory for quality Ensurance and sustainable use of dao-di herbs Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences School of Biomedicine Beijing City University Shandong University of Traditional Chinese Medicine School of Pharmacy Linyi University Institute of Herbgenomics Chengdu University of Traditional Chinese Medicine

Objective:Rhei Radix et Rhizoma has five types of products,namely,raw rhubarb(RR),wine rhubarb(WR),vinegar rhubarb(VR),cooked rhubarb(CR),and rhubarb charcoal(RC).However,Rhei Radix et Rhizoma is easily contaminated with fungi and mycotoxins if not harvested or processed ***,we intend to analyze how microbiome assemblies and co-occurrence patterns are influenced by sampling locations and processing ***:High-throughput sequencing and internal transcribed spacer 2(ITS2) were carried out to study the diversities(α-and β-diversity),composition(dominant taxa and potential biomarkers),and network complexitity of surface fungi on RR, WR,VR,CR,and RC collected from Gansu and Sichuan provinces,***:The phyla Ascomycota and Basidiomycota;the genera Kazachstania,Malassezia,and Asterotremella;and the species Kazachstania exigua,Asterotremella pseudolonga,and Malassezia restricta were the dominant fungi and exhibited differences in the two provinces and the five processed *** α-diversity and network complexity were strongly dependent on processing *** 1,the Shannon index,and network complexity and connectivity were highest in the CR *** α-diversity and network complexity were influenced by sampling *** 1 and network complexity and connectivity were highest in the Gansu ***:The assembly and network of the surface microbiome on Rhei Radix et Rhizoma were shaped by processing methods and sampling *** paper offers a comprehensive understanding of microorganisms,which can provide early warning for potential mycotoxins and ensure the safety of drugs and consumers.

关键词： community assembly fungi processing methods Rhei Radix et Rhizoma sampling locations

Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu Liang Ni-Hui Zhang Zhi-Lai Zhan Guang-Lu Chang Yan Gao Xia Li Wen-Yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China state key laboratory for quality Ensurance and sustainable use of dao-di herbs China Academy of Chinese Medical SciencesBeijing 100700China key laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

TPMGD:A genomic database for the traditional medicines in Pakistan

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Chinese Herbal Medicines 2025年第1期17卷 87-93页

作者： Rushuang Xiang Huihua Wan Wei Sun Baozhong Duan Weiqian Chen Xue Cao Sifan Wang Chi Song Shilin Chen Yan Wang Atia-tul Wahab M.Iqbal Choudhary Xiangxiao Meng state key laboratory for quality Ensurance and sustainable use of dao-di herbs Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences key laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences College of Pharmaceutical Science Dali University H.E.J.Research Institute of Chemistry International Center for Chemical and Biological Sciences University of Karachi Dr.Panjwani Center for Molecular Medicine and Drug Research International Center for Chemical and Biological Sciences University of Karachi

Objective:In Pakistan,traditional medicines are an important component of the medical system,with numerous varieties and great ***,due to the scattered resources and the lack of systematic collection and collation,adulteration of traditional Pakistani medicine(TPM) is common,which severely affects the safety of their medicinal use and the import and export ***,it is urgent to systematically organize and unify the management of TPM and establish a set of standards and operable methods for the identification of ***:We collected and organized the information on 128 TPMs with regard to their medicinal parts,efficacy,usage,and genetic material,based on Pakistan Hamdard Pharmacopoeia of Eastern Medicine:Pharmaceutical *** genetic information of TPM is summarized from national center for biotechnology information(NCBI) and global pharmacopoeia genome database(GPGD).Furthermore,we utilized bioinformatics technology to supplement the chloroplast genome(cp-genome) data of 12 *** build the web server,we used the Linux+Apache+MySQL+PHP(LAMP) system and constructed the webpage on a PHP:Hypertext Preprocessor(PHP) model view controller(MVC) ***:We constructed a new genomic database,the traditional Pakistani medicine genomic database(TPMGD).This database comprises five entries,namely homepage,medicinal species,species identification,basic local alignment search tool(BLAST),and ***,TPMGD contains basic profiles of 128 TPMs and genetic information of 102 TPMs,including 140 cytochrome c oxidase subunit I(COI)sequences and 119 mitochondrial genome sequences from Bombyx mori,1 396 internal transcribed spacer 2(ITS2) sequences and 1 074 intergenic region(psbA-trnH) sequences specific to 92 and 83 plant species,***,TPMGD includes 199 cp-genome sequences of 82 ***:TPMGD is a multifunctional database that integrates species description,functional information inquiry,genetic information

关键词： chloroplast genome database DNA barcodes Pakistan traditional medicine

Peptide-based strategies for overcoming multidrug-resistance in cancer therapy

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Chinese Chemical Letters 2025年第1期36卷 110-118页

作者： Xiaofang Luo Ye Wu Xiaokun Zhang Min Tang Feiye Ju Zuodong Qin Gregory J Duns Wei-Dong Zhang Jiang-Jiang Qin Xin Luan Hunan Engineering Technology Research Center for Comprehensive Development and Utilization of Biomass Resources College of Chemistry and BioengineeringHunan University of Science and EngineeringYongzhou 425199China Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research and Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China Zhejiang Cancer Hospital Hangzhou Institute of Medicine(HIM)Chinese Academy of SciencesHangzhou 310022China state key laboratory for quality Ensurance and sustainable use of dao-di herbs Institute of Medicinal Plant DevelopmentChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100700China

Despite ongoing advancements in cancer treatment,the emergence of primary and acquired resistance poses a significant challenge for both traditional chemotherapy and immune checkpoint blockade *** demand for targeted therapeutics for multidrug-resistant cancer is more important than ***,as emerging alternatives to current anticancer drugs,offer exquisite versatility in facilitating the design of novel oncology drugs,with the core superiorities of good biocompatibility and a low tendency to induce drug *** review comprehensively introduces the pharmacological mechanisms of peptide-based drugs and strategies for overcoming multidrug resistance(MDR)in cancers,including inducing cell membrane lysis,targeting organelles,activating anticancer immune responses,enhancing drug uptake,targeting ATP-binding cassette(ABC)transporters,and targeting B-cell lymphoma-2(BCL-2)family ***,the current clinical applications of representative peptides in combating MDR cancers and their potential directions for medicinal chemistry research have been thoroughly *** review offers essential insights into the novel treatment approaches for MDR cancers and highlights the trends and perspectives in this field.

关键词： Drug resistance Antitumor peptides Mechanism of action Targeted therapeutics Immunotherapy Medicinal chemistry

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The complete mitochondrial genomes of five blind scolopendromorph centipedes and phylogenetic within Scolopendromorpha (Chilopoda)

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Zoological Systematics 2024年第4期49卷 299-308页

作者： Tianyun Chen Chao Jiang state key laboratory for quality Ensurance and sustainable use of dao-di herbs National Resource Center for Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China

Mitochondrial genomes of five Tykhepoda scolopendromorphs(Cryptopidae,Scolopocryptopidae and Plutoniumidae)are sequenced and analyzed using methods of comparative genomics to provide more information on the phylogeny of *** locations of 22 tRNAs,13 PCGs,and 2 rRNAs are *** heavy chain of mitochondrial genomes are 14,841-15,619 bp in length.A+T%vary from 64.79%to 77.40%,and mitochondrial genomes are CG and AT *** phylogenetic reconstructions showed the blind clade,recently named Tykhepoda,is monophyletic with high support values(BS=100%and PP=1).

关键词： Mt DNA phylogenomic Cryptopidae Scolopocryptopidae Plutoniumidae

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Feasible Synthesis of N,O-Bidentate difluoroboron Chromophores through direct Functionalization of Quinoxalin-2(1H)-ones with Ketones in One Shot

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Chinese Journal of Chemistry 2024年第13期42卷 1481-1486页

作者： Shuaichen Zhang Jing Zhang Xiang Ling Yifan Zhao Yue Ma Peng Sun state key laboratory for quality Ensurance and sustainable use of dao-di herbs Artemisinin Research Center and Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Department of Pharmaceutics School of PharmacyChina Pharmaceutical UniversityState Key Laboratory of Natural MedicinesNanjingJiangsu 210009China

Organic difluoroboron complexes are a kind of potential platforms for a wide range of applications owing to their excellent photophysical ***,we have explored a simple and direct synthesis methodology for a library of N,O-bidentate difluoroboron complexes from quinoxalin-2(1H)-ones and ketones in one *** photophysical properties of the generated complexes were evaluated and the application potential of these compounds on subcellular imaging was also explored.

关键词： N,O-Bidentate difluoroboron Chromophores Quinoxalin-2(1H)-ones Ketones/Green chemistry Synthetic method C-CcouplingI Boron

Rapid toxicity characterization of Aconitum herbal medicines using perfusion nano-electrospray ionization mass spectrometry

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Journal of Pharmaceutical Analysis 2024年第9期14卷 1393-1395页

作者： Chaofa Wei Liping Kang Yaqiu Zhao Li Zhou Xiang Li Shuanglong Wang Luqi Huang Zidong Qiu state key laboratory for quality Ensurance and sustainable use of dao-di herbs National Resource Centre for Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing100700China Jiangxi key laboratory for Mass Spectrometry and Instrumentation East China University of TechnologyNanchang330013China

Accurate analysis of the key substances in traditional Chinese medicines(TCMs)is the prerequisite and foundation for the quality evaluation and pharmacological substance research of TCMs[1].However,the extremely complex characteristics of medicinal origins,preparation processes and chemical compositions make it difficult to accurately analyze TCMs in complex multi-scenarios[2].

关键词： TCM foundation medicines

Theory and scientificity of traditional Chinese medicine

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Science of Traditional Chinese Medicine

Science of Traditional Chinese Medicine 2023年第1期1卷 26-34页

作者： Lanping Guo Wenjin Zhang Luqi Huang state key laboratory for quality Ensurance and sustainable use of dao-di herbs Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijingChina School of Pharmacy Ningxia Medical UniversityYinchuanChina

TheNobelPrize for artemisinin and theCOVID-19pandemic have heightened interest in the disease prevention and treatment of traditional Chinesemedicine(TCM).However,uncertainty andmisinformation remain about some key ***,wediscuss the current literature showing that,despite TCM gaining recognition,the theoretical systems of TCM and Western medicine rooted in different cultural backgrounds have huge differences in their theories and *** to achieve accurate diagnosis in TCM,how to give scientific treatment,what is the mechanismof treatment,and what are the effect and safety of treatment,all need to be more clearly explained and require high-quality modern scientific *** emerging consensus exists that,with the help ofmodern technology and scientificmethods,it is necessary to excavate the essence of TCM that truly conforms to the laws of human life movement and disease development,realize cross-complementation with Western medicine,enhance human understanding of diseases,enrich diagnosis and treatment methods,and promote a new level in the field of life sciences.

关键词： Basic theory Scientific connotation Traditional Chinese medicine

Identification of missing CYP450 enzymes involved in paclitaxel biosynthesis and heterologous reconstitution of baccatin III

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Chinese Journal of Natural Medicines 2024年第4期22卷 291-292页

作者： DU Jinfa LIAO Pan LU Xu state key laboratory of Natural Medicines School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 210009China Department of Biology Hong Kong Baptist UniversityKowloon TongHong KongChina state key laboratory of Agrobiotechnology The Chinese University of Hong KongHong KongChina state key laboratory for quality Ensurance and sustainable use of dao-di herbs Beijing 100700China Medical Botanical Garden China Pharmaceutical UniversityNanjing 210009China

Paclitaxel,a tetracyclic diterpenoid,has garnered attention for its potent anti-cancer properties and intricate molecular structure,making it a significant target for chemical synthesis and biosynthesis[1].However,its natural sources are extremely limited,as it is derived exclusively from the bark of endangered genus Taxus plants,which contain paclitaxel in very low concentrations(0.01%−0.05%)[2-3].Recent advances in synthetic biology present promising opportunities to enhance paclitaxel levels in Taxus cell cultures or to enable the reconstitution of its production in heterologous hosts,such as yeast or tobacco(Nicotiana benthamiana).

关键词： Paclitaxel biosynthesis Baccatin III Cytochrome P450 Taxane oxetanase 1 Heterologous reconstitution

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