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China CDC weekly 2022年第25期4卷 535-540页

作者： Miaomiao Li Chang Song Aobo Dong Jing Hu Ruihua Kang Hui Xing Yuhua Ruan Yiming Shao Kunxue Hong Lingjie Liao state Key Laboratory of Infectious Disease prevention and control National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?While antiretroviral therapy(ART)has been rapidly scaled-up among the population living with human immunodeficiency virus or acquired immune deficiency syndrome(HIV/aids)... 详细信息

关键词： Therapy Impact patients

Nef Mutations in Long-term Non-progressors from Former Plasma Donors Infected with HIV-1 Subtype B in China

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Biomedical and Environmental Sciences 2008年第6期21卷 485-491页

作者： SHU-HUA WANG HUI XING XIANG HE FENG-XIA ZHU ZHE-FENG MENG Yu-HUA RUAN YI-MING SHAO state Key Laboratory for Infection Diseases prevention and control National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100050 China The General Hospital of Civil Aviation Administration of China Beijing 100025 China

Objective To study the specific amino acid variation in Nef that may be related to disease progression after infection with HIV-1 subtype B, a predominant strain circulating in China, and to determine whether changes in Nef secondary structure may influence different stages of aids development based on the concept that the Nef gene of HIV infection dramatically alter the severity of viral infection and virus replication and disease progression, and that long-term non-progressors （LTNP） of HIV infection are commonly associated with either a deletion of the Nef gene or the defective Nef alleles. Methods The study subjects were divided into LTNPI（n=14）, LTNP2 （n=16） and slow progressor （SP, n=19） groups for mutational analysis of the Nef sequence. The data were obtained by using Bioedit, MEGA, Anthewin and SAS software. Results Residues in Nef TA48/49 and K151 occurred more frequently in the LTNP group while AA48/49 was more frequently observed in the SP group. Of the differences observed in the secondary structure comparison using Nef consensus sequences of these three groups, one was roughly corresponding to the Nef48/49 mutation site. Conclusion TA48/49, Kiss, and AA48/49 in the Nef gene might be associated with the different stages of HIV infection, and there may be a link between the Nef secondary structure and the progression of HIV- 1 infection.

关键词： HIV-1 Nef Long-term nonprogressors Sequence mutations Secondary structure prediction

Changes in HIV-1 Subtypes/Sub-Subtypes,and Transmitted Drug Resistance Among ART-Naïve HIV-Infected Individuals—China,2004–2022

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China CDC weekly 2023年第30期5卷 664-671,I0010-I0012页

作者： Xiu Liu Dong Wang Jing Hu Chang Song Lingjie Liao Yi Feng Dan Li Hui Xing Yuhua Ruan state Key Laboratory of Infectious Disease prevention and control(SKLID) National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and Prevention(China CDC)Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijingChina.

Introduction:The efficacy of treatment and clinical outcomes may be jeopardized by factors such as transmitted drug resistance(TDR)and the genetic diversity of the human immunodeficiency virus type 1(HIV-1).This comprehensive study aims to examine the alterations in HIV-1 subtypes or sub-subtypes and TDR among Chinese individuals,who have been diagnosed with HIV infection and are previously untreated with antiretroviral therapy(ART),across the span of 2004 to ***:Sequences of the HIV-1 pol gene region were obtained from ART-naïve HIV-positive individuals across 31 provincial-level administrative divisions between 2004 and *** predict susceptibility to 12 antiretroviral drugs,the research utilized the Stanford HIV Drug Resistance *** Cochran-Armitage trend test facilitated the analysis of changes in HIV-1 subtype/sub-subtype prevalence and *** analysis was conducted in alignment with the progression of the National Free Antiretroviral Treatment Program’s stages between 2004 and ***:Among the 57,902 ART-naïve individuals infected with HIV,there was a notable decline in the prevalence of CRF01_AE,B,and C from 37.3%,24.1%,and 1.3%respectively in 2004–2007 to 29.4%,7.3%,and 0.2%respectively in 2020–***,a significant increase was observed in the proportions of CRF07_BC,CRF08_BC,CRF55_01B,other CRFs,and URFs,from 24.1%,11.5%,0.1%,0.4%,and 0.9%respectively in 2004–2007 to 40.8%,11.5%,3.8%,3.7%,and 2.8%respectively in 2020–2022(all P<0.001 for trend).The prevalence of TDR to overall,non-nucleoside reverse transcriptase inhibitor(NNRTI),efavirenz,and nevirapine also significantly increased from 2.6%,1.8%,1.6%,and 1.8%respectively in 2004–2007 to 7.8%,6.7%,6.3%,and 6.7%respectively in 2020–2022(all P<0.001 for trend).However,there were no meaningful changes in the TDR prevalence of nucleoside reverse transcriptase inhibitor and protease ***,in 2020–2022,the overall TDR prevalence exceeded 15%in ***

关键词： prevalence alterations drugs

Molecular Characterization of HIV-1-circulating Strains among Pre-Treatment Patients in Tibet

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Biomedical and Environmental Sciences 2020年第12期33卷 953-958页

作者： Dorjiwangmo GAN Meng Ze DONG Ao Bo Baimayangjin Tashibazong LIU Lei LIAO Ling Jie RUAN Yu Hua SHAO Yi Ming FENG Yi XING Hui Tibet Autonomous Region Center for Disease control and prevention Lhasa 850000TibetChina state Key Laboratory of Infectious Disease prevention and control National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijing 102206China

The Tibet Autonomous Region(referred to as‘Tibet’)is located in southwestern China,bordering the Yunnan Province,Sichuan Province,Xinjiang Uygur Autonomous Region,and other provinces with high HIV/aids prevalence,as well as India,Nepal,and other high-risk border *** 1994,the first patient with HIV-1 infection was detected at Zhangmu port,Namu County,Shigatse,Tibet.

关键词： Tibet southwestern border

Premature Stop Codon at Residue 101 within HIV-1 Rev Does Not Influence Viral Replication of Clade BC but Severely Reduces Viral Fitness of Clade B

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Virologica Sinica 2020年第2期35卷 181-190页

作者： Zheng Wang Xiaolin Ji Yanling Hao Kunxue Hong Liying Ma Dan Li Yiming Shao state Key Laboratory of Infectious Diseases prevention and control Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesChinese Center for Disease Control and PreventionBeijing 102206China Division of Research of Virology and Immunology National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

HIV-1 Rev is an accessory protein that plays a key role in nuclear exportation,stabilization,and translation of the viral *** of HIV-1 clade BC often shows a truncation of 16 AAs due to a premature stop codon at residue *** stop codon presents the highest frequency in clade BC and the lowest frequency in clade *** order to discover the potential biological effect of this truncation on Rev activity and virus replication of clade BC,we constructed Rev expression vectors of clade BC with or without 16 AAs within C-terminal separately,and replaced the stop codon by Q in a CRF07_BC infectious *** found that 16 AAs truncation had no effect on expression and activity of Rev in clade ***,the mutation from the stop codon to Q had no effect on virus replication of clade ***,to investigate the effect of this truncation on Rev activity and replication capacity of clade B,Rev expression vectors of clade B carrying or lacking 16 AAs in C-terminal were constructed respectively,and residue Q at position 101 within Rev was substituted by the stop codon in a clade B infectious *** was found that 16 AAs truncation significantly down-regulated Rev expression and impaired clade B Rev ***,a Q-to-stop codon substitution within Rev significantly reduced viral replication fitness of clade *** results indicate that the premature stop codon at residue 101 within Rev exerts diverse impact on viral replication among different HIV-1 clades.

关键词： HIV-1 CRF_BC Rev Premature stop codon Replication

National and Regional Molecular Epidemiology of HIV-1—China,2004–2023

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China CDC weekly 2024年第48期6卷 1257-1263,I0001页

作者： Dong Wang Yi Feng Jingjing Hao Hongping Hu Fangyuan Li Jialu Li Yuhua Ruan Lingjie Liao Jing Hu Chang Song Yiming Shao Hui Xing National Center for aids/STD control and prevention(NCaids) Chinese Center for Disease Control and Prevention(China CDC)State Key Laboratory of Infectious Disease Prevention and Control(SKLID)BeijingChina

Introduction:The genetic diversity of human immunodeficiency virus(HIV)-1 subtypes significantly influences the effectiveness of diagnostic tools,antiretroviral therapy(ART),and vaccine *** study aimed to assess the regional and national prevalence of HIV-1 subtypes and recombinants in China between 2004 and 2023 using pol gene segment ***:We analyzed annual HIV/aids reports and pol gene segment sequences from all Chinese provinces between 2004 and *** distribution of HIV-1 subtypes and recombinants across China and within its regions was estimated by multiplying the proportion of each subtype,circulating recombinant form(CRF),and unique recombinant form(URF)in each province by the corresponding number of reported HIV ***:Analysis of 94,476 pol gene segments from 31 provinces revealed that CRF01_AE strain accounted for 32.1%of HIV-1 infections during 2004–2023,while CRF07_BC lineage represented 39.1%.CRF08_BC strain contributed 9.2%,followed by subtype B(8.7%)and CRF55_01B(2.4%).Other CRFs collectively comprised 6.0%of infections,while URFs and other subtypes accounted for 1.3%and 1.1%,***:The study revealed significant regional variations and temporal changes in the proportions of HIV-1 CRFs,subtypes,and URFs across China,emphasizing the importance of continued surveillance of strain distribution patterns.

关键词： collective continued analysis.

Frequency of HLA-A*03 associates with HIV-1 infection in a Chinese cohort

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Science China(Life Sciences) 2013年第11期56卷 1014-1019页

作者： ZHANG WeiLun WANG Li HONG KunXue LIU YanXin SU Bing XU Cheng XU JianQin RUAN YuHua SHAO YiMin ZHENG DeXian Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & Peking Union Medical College state Key Laboratory for Infectious Disease prevention and control National Center for AIDS/STD Control and Prevention Anhui Center for Disease control and prevention Fuyang Center for Disease control and prevention

During the early mid-1990s, a number of rural farmers across central China were employed to the unregulated plasma- selling-activity and many of them were infected by HIV-1. However, aids progression in the former blood donors （FBDs） is various. The aim of this study is to assess human leukocyte antigen （HLA） class I allele distribution in FBDs and evaluate its association with HIV-1 infection and disease progression. A total of 353 FBDs were enrolled in the cohort including 294 ART na＇fve HIV-1 seropositive and 59 HIV-1 seronegative age-matched subjects. The viral load and CD4/CD8 T cell counts were assessed in all subjects. Compared with HIV-seropositive group, the frequency of HLA-A＊03 in control was significantly higher. After classifying the HLA-B alleles of the subjects according to the presence of Bw4/Bw6 serological epitopes, detri- mental effect of HLA Bw6/Bw6 homozygosity was also confirmed in the HIV-seropositive subjects. This study provides nov- el evidence on HLA class I allele distribution and association of HLA-A＊03 frequency with HIV-1 infection and viremia in the HIV-1 infected FBDs, which may throw light on intervention strategy for the HIV-1 infection and our understanding how host immunity and genetic background affect HIV infection and aids progression.

关键词： leukocyte antigen class I HIV-1 infection viremia control Chinese former blood donor cohort

Relationship Between Drug Resistance and Death in HIV-Infected Patients Receiving Antiretroviral Therapy—7 PLADs,China,2010−2019

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China CDC weekly 2021年第14期3卷 291-297页

作者： Tianhao Zhang Lingjie Liao Yiming Shao Yi Feng Yuhua Ruan Hui Xing state Key Laboratory of Infectious Disease prevention and control(SKLID) National Center for AIDS/STD Control and Prevention(NCAIDS)Chinese Center for Disease Control and Prevention(China CDC)Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijingChina

Summary What is already known about this topic?With increasing coverage of antiretroviral therapy(ART)for HIV-infected patients,more and more attention has been paid to the impact of HIV drug resistance on death in those patients in *** is added by this report?Among HIV-infected patients receiving ART,the risk of death is higher in patients with HIV drug resistance[adjusted odds ratio(AOR)=4.25.

关键词： death patients Infect

Changing Proportions of HIV-1 Subtypes and Transmitted Drug Resistance Among Newly Diagnosed HIV/aids Individuals—China,2015 and 2018

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China CDC weekly 2021年第53期3卷 1133-1138页

作者： Jingjing Hao Shan Zheng Mengze Gan Aobo Dong Ruihua Kang Miaomiao Li Shuai Zhao Jing Hu Chang Song Lingjie Liao Yi Feng Yiming Shao Yuhua Ruan Hui Xing state Key Laboratory of Infectious Disease prevention and control(SKLID) National Center for AIDS/STD Control and Prevention(NCAIDS)Chinese Center for Disease Control and Prevention(China CDC)Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijingChina.

Introduction:With the expansion of human immunodeficiency virus(HIV)antiretroviral therapy(ART),HIV drug resistance is becoming more and more *** study describes the changing prevalence of HIV-1 subtypes and transmitted drug resistance(TDR)among newly diagnosed individuals in China,2015 and ***:A total of 8,980 individuals in 2015 and 2018 from 31 provincial-level administrative divisions(PLADs)were enrolled in this *** RNAs were amplified and sequenced using an in-house polymerase chain reaction(PCR)*** Stanford HIV Drug Resistance Database(HIVdb)was used to predict susceptibility to 12 antiretroviral ***:The prevalence of TDR was not significantly increased over *** prevalence of TDR was 3.8%and 4.4%in 2015 and 2018,respectively(P=0.13).The prevalence of CRF55_01B increased from 2.3%in 2015 to 3.9%in 2018(Pcontrol the transmission of HIV drug resistance.

关键词： drugs Stanford HIV/aids

Benefits of Early and Immediate Initiation of Antiretroviral Therapy among HIV Patients in Chongqing, China

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Biomedical and Environmental Sciences 2020年第4期33卷 282-285页

作者： ZHOU Chao ZHANG Wei LU Rong Rong OUYANG Lin XING Hui SHAO Yi Ming WU Guo Hui RUAN Yu Hua Chongqing Municipal Center for Disease control and prevention Chongqing 400042China state Key Laboratory of Infectious Disease prevention and control National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijing 102206China

In an effort to end the HIV epidemic by 2030, the Joint United Nations Program on HIV/aids(UNaids)set the ‘90-90-90’ target and aimed to expand the timely use of ART worldwide. By the end of 2017,21.7 million people living with HIV, amounting to59% of HIV patients worldwide, were receiving antiretroviral therapy(ART)[1]. In China, the National Free Antiretroviral Treatment Program(NFATP),which was initiated in 2002, continued to progress.

关键词： Therapy Chongqing continued