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An optimal fracture geometry design method of fractured horizontal wells in heterogeneous tight gas reservoirs

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Science China(Technological Sciences) 2016年第2期59卷 241-251页

作者： ZENG FanHui KE YuBiao GUO JianChun state key laboratory of Oil & gas Reservoir Geology and Exploitation Southwest Petroleum University

In this work, the unified fracture design （UFD） is extended for the first time to the fractured horizontal wells in heterogeneous closed box-shaped tight gas reservoirs. Utilizing the direct boundary element method and influence function, the dimensionless fracture productivity index is obtained and expressed in the function of proppant volume and fracture geometry at the pseu- do-steady state. With the iterative method, the effectively propped permeability, kfe, is corrected using the i^-situ Reynolds number, NRe. The goal of this paper is to present a new UFD extension to design the proppant volume and the optimal fracture geometry. The results show that there exists an optimal proppant volume for a certain reservoir. The small aspect ratio （yJXe） and high permeability reservoirs need short and wide fractures to diminish the non-Darcy effect. On the contrary, long and narrow fractures are required for the large aspect ratio and low permeability reservoirs. A small proppant volame is prone to creating long fractures, while a relatively large proppant volume creates wide fractures. The new extension can be used to evaluate the previous fracture parameters and design the following fracture parameters of the fractured horizontal well in heterogeneous tight gas reservoirs, with the non-Darcy effect taken into account.

关键词： tight gas reservoir heterogeneity non-Darcy effect fractured horizontal well fracture geometry design

Roles of integrin in tumor development and the target inhibitors

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Chinese Journal of natural Medicines 2019年第4期17卷 241-251页

作者： LI Zhao-He ZHOU You DING You-Xiang GUO Qing-Long ZHAO Li state key laboratory of natural Medicines Jiangsu Key Laboratory of Carcinogenesis and Intervention China Pharmaceutical University

Integrin is a large family of cell adhesion molecules(CAMs) which involves in the interaction of cells/cells and cells/extracellular matrix(ECM) to mediate cell proliferation, differentiation, adhesion, migration, etc. In recent years, aberrant expression of integrin has been clearly found in many tumor studies, indicating that integrin is closely related to tumor formation and development. Meanwhile, it has effects on tumor cell differentiation, cell migration, proliferation and tumor neovascularization. The study of drugs targeting integrins is of great significance for the clinical treatment of tumors. Because of its important role in tumorigenesis and development, integrin has become a promising target for the treatment of cancer. This review summarizes the role of integrin in tumor development and the current state of integrin inhibitors to provide a valuable reference for subsequent research.

关键词： Integrin Tumor development Target therapy natural medicines

Experimental Investigation of Vibration Response of A Free-Hanging Flexible Riser Induced by Internal gas-Liquid Slug Flow

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China Ocean Engineering 2018年第6期32卷 633-645页

作者： ZHU Hong-jun ZHAO Hong-lei GAO Yue state key laboratory of Oil and gas Reservoir Geology and Exploitation Southwest Petroleum University

The vibration response of a free-hanging flexible riser induced by internal gas-liquid slug flow was studied experimentally in a small-diameter tube model based on Froude number criterion. The flow regime in a curved riser model and the response displacements of the riser were simultaneously recorded by high speed cameras. The gas superficial velocity ranges from 0.1 m/s to 0.6 m/s while the liquid superficial velocity from 0.06 m/s to 0.3 m/*** slugging type 3, unstable oscillation flow and relatively stable slug flow were observed in the considered flow rates. Severe slugging type 3 characterized by premature gas penetration occurs at relatively low flow rates. Both the cycle time and slug length become shorter as the gas flow rate increases. The pressure at the riser base undergoes a longer period and larger amplitude of fluctuation as compared with the other two flow regimes. Additionally, severe slugging leads to the most vigorous in-plane vibration. However, the responses in the vertical and horizontal directions are not synchronized. The vertical vibration is dominated by the second mode while the horizontal vibration is dominated by the first mode. Similar to the vortex-induced vibration, three branches are identified as initial branch, build-up branch and descending branch for the response versus the mixture velocity of gas-liquid flow.

关键词： gas-liquid two-phase flow severe slugging liquid slug flexible riser flow-induced vibration

The gas recovery of water-drive gas reservoirs

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Journal of Hydrodynamics 2015年第4期27卷 530-541页

作者：李闽李滔蒋琼杨海刘世常 state key laboratory of Oil and gas Reservoir Geology and Exploitation Southwest Petroleum University

This paper proposes a method for determining the gas recovery of water-drive gas reservoirs. First, the water influx coefficient B in the theoretical formula Pr =（1-Rg）/（1-RgB） is used to determine the influence of the aquifer behavior. According to the theoretical formula, the relationship between the norrnalized pressure Pr and the degree of the reserve recovery Rg can be obtained with different values of B, which can be used to determine the activity level of the aquifer behavior. Second, according to Pra = （1-Rga）/（1-aEva）（where a = 1-Sgr/Sgi ）, the relationship between the normalized abandonment pressure Pra and the ultimate gas recovery Rga can be obtained, as the Agarwal end-point line. The intersection of the above two lines represents the value of the estimated ultimate gas recovery and the normalized abandonment pressure pra. Finally, an evaluation table and a set of demarcation charts are established, with different values of Sgr/Sgi and Eva as well as the water influx coefficient B, which can be used to determine the gas recovery of water-drive gas reservoirs with different activity levels of the aquifer behavior.

关键词： water-drive gas reservoirs degree of reserve recovery water influx coefficient evaluation table demarcation charts

Pressure transient behavior of a slanted well with an impermeable fault

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Journal of Hydrodynamics 2014年第6期26卷 980-985页

作者：冯国庆刘启国 state key laboratory of Oil and gas Reservoir Geology and Exploitation Southwest Petroleum University

Analytical solution is obtained for the pressure response of a slanted well in a slab reservoir with an impermeable fault. Based on the basic point source solution in an infinite space, the basic point source solution is obtained by using the mirror image principle. Wellbore pressure response of a slanted well is obtained by integration of the basic point source solution along the trajectory of a slanted well and the type curves are computed. The dimensionless bottom hole pressure and type curves are obtained and the sensitivities of related parameters are discussed. The model presented in this paper could be used for the well test analysis of a slanted well in a reservoir bounded by an impermeable fault.

关键词： slanted well point source solution impermeable fault type curves

Transient flow model and pressure dynamic features of tree-shaped fractal reservoirs

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Journal of Hydrodynamics 2014年第4期26卷 654-663页

作者：谭晓华李晓平 state key laboratory of Oil and gas Reservoir Geology and Exploitation Southwest Petroleum University

A transient flow model of tree-shaped fractal reservoirs is built by embedding a fracture network simulated by a tree-shaped fractal network into a matrix system. The model can be solved using the Laplace conversion method. The dimensionless bottom hole pressure can be obtained using the Stehfest numerical inversion method. The bi-logarithmic type curves for the trce-shaped fractal reservoirs are thus obtained. The pressure transient responses under different fractal factors are discussed. The factors with a primary effect on the inter-porosity flow regime include the initial branch number N, the length ratio α, and the branch angle θ. The diameter ratio β has a significant effect on the fracture radial flow, the inter-porosity and the total system radial flow regimes. The total branch level M of the network mainly influences the total system radial flow regime. The model presented in this paper provides a new methodology for analyzing and predicting the pressure dynamic characteristics of naturally fractured reservoirs.

关键词： tree-shaped fractal transient flow pressure dynamic characteristic naturally fractured reservoir type curve

Construction of complex digital rock physics based on full convolution network

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Petroleum Science 2022年第2期19卷 651-662页

作者： Jia Kang Nian-Yin Li Li-Qiang Zhao Gang Xiong Dao-Cheng Wang Ying Xiong Zhi-Feng Luo state key laboratory of Oil and gas Reservoir Geology and Exploitation Engineering Southwest Petroleum UniversityChengdu610500SichuanChina Research Institute of natural gas Technology Southwest Oil and Gas Field CompanyPetroChinaChengdu610213SichuanChina

Digital rock physics(DRP)is a paramount technology to improve the economic benefits of oil and gas fields,devise more scientific oil and gas field development plans,and create digital oil and gas ***,a significant gap is present between DRP theory and practical *** digital-core construction focuses only on simple cores,and the recognition and segmentation effect of fractures and pores of complex cores is *** identification of rock minerals is inaccurate,which leads to the difference between the digital and actual *** promote the application of DRP in developing oil and gas fields,based on the high-precision X-ray computed tomography scanning technology,the U-Net deep learning model of the full convolution neural network is used to segment the pores,fractures,and matrix from the complex rock core with natural fractures ***,the distribution of rock minerals is divided,and the distribution of rock conditions is corrected by X-ray diffraction.A pore—fracture network model is established based on the equivalent radius,which lays the foundation for fluid seepage ***,the accuracy of the established a digital core is verified by the porosity measured via nuclear magnetic resonance technology,which is of great significance to the development and application of DRP in oil and gas fields.

关键词： Digital rock physics Depth learning U-Net Complex core Complex fracture

Numerical Simulation of the Vortex-Induced Vibration of A Curved Flexible Riser in Shear Flow

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China Ocean Engineering 2018年第3期32卷 301-311页

作者： ZHU Hong-jun LIN Peng-zhi state key laboratory of Oil and gas Reservoir Geology and Exploitation Southwest Petroleum University state key laboratory of Hydraulics and Mountain River Engineering Sichuan University

A series of fully three-dimensional(3 D) numerical simulations of flow past a free-to-oscillate curved flexible riser in shear flow were conducted at Reynolds number of 185–1015. The numerical results obtained by the two-way fluid–structure interaction(FSI) simulations are in good agreement with the experimental results reported in the earlier study. It is further found that the frequency transition is out of phase not only in the inline(IL) and crossflow(CF) directions but also along the span direction. The mode competition leads to the non-zero nodes of the rootmean-square(RMS) amplitude and the relatively chaotic trajectories. The fluid–structure interaction is to some extent reflected by the transverse velocity of the ambient fluid, which reaches the maximum value when the riser reaches the equilibrium position. Moreover, the local maximum transverse velocities occur at the peak CF amplitudes, and the values are relatively large when the vibration is in the resonance regions. The 3 D vortex columns are shed nearly parallel to the axis of the curved flexible riser. As the local Reynolds number increases from 0 at the bottom of the riser to the maximum value at the top, the wake undergoes a transition from a two-dimensional structure to a 3 D one. More irregular small-scale vortices appeared at the wake region of the riser, undergoing large amplitude responses.

关键词： vortex-induced vibration flexible riser shear flow fluid–structure interaction computational fluid dynamics

Inhibiting effect of[HOEmim][BF_4]and[Amim]Cl ionic liquids on the cross-linking reaction of bituminous coal

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International Journal of Mining Science and Technology 2016年第2期26卷 353-359页

作者： Wang Lanyun Xu Yongliang Wang Shaokun Song Zhipeng state key laboratory Cultivation Base for gas Geology and gas Control Henan Polytechnic University state key laboratory of Coal Resources and Safe Mining China University of Mining and Technology

In order to reduce the hazard of coal spontaneous combustion,the cross-linking reaction between O-containing functional groups of coal should be *** the inhibitory effect of an ionic liquid(IL) on the cross-linking reaction was *** O-containing functional groups change the weight loss and H_2O,CO_2,CO yields of bituminous coal before and after[H0Emim][BF_4]and[Amim]Cl pre-treatment and were detected by Fourier Transform Infrared spectroscopy(FT1R) and Thermo Gravimetric(TC) *** results show that | AmimjCI has a weaker ability to inhibit the cross-linking reaction of bituminous coal compared to[HOEmim][BF_4].Besides,based on Quantum Chemistry calculation,it was found that the different inhibiting effects of |H0Emim][BF_4]and[Amim]Cl are greatly related to their anions and the H linked with C2 atom on the imidazole *** H-donor ability of coal will be enhanced by[HOEmim][BF_4]leading to a weaker cross-linking reaction of coal.

关键词： Ionic liquid Inhibit Cross-linking reaction Bituminous coal