检索结果-南通市图书馆

World Journal of Clinical Cases 2025年第3期13卷 66-68页

作者： Takahiko Nagamine Department of psychiatric Internal Medicine Sunlight Brain Research CenterHofu 7470066YamaguchiJapan

Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and ***,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality(VR)*** has been demonstrated to be an effective treatment for pain associated with medical procedures,as well as for chronic pain conditions for which no effective treatment has been *** precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be ***,the provision of positive images through VR-based visual stimulation may enhance the functionality of brain *** salience network is diminished,while the default mode network is ***,the medial prefrontal cortex may establish a stronger connection with the default mode network,which could result in a reduction of pain and *** research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field.

关键词： Virtual reality Pain Anxiety Salience network Default mode network

Social function scores and influencing factors in patients with residual depressive symptoms

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2025年第1期15卷 117-127页

作者： Zong-Ling Liao Xiao-Li Pu Zhi-Yi Zheng Jie Luo Department 1 of Psychiatry Gele Mountain Hospital of Chongqing Mental Health CenterChongqing 400030China Department of Psychology Chongqing Jiangjin District Psychiatric HospitalChongqing 402260China Department of Psychiatry Chongqing Third Social Welfare InstituteChongqing 400036China Women and Children’s Mental Health center Affiliated Hospital of Chongqing Population and Family Planning Research InstituteChongqing 400020China

BACKGROUND At present,the influencing factors of social function in patients with residual depressive symptoms are still *** depressive symptoms are highly harmful,leading to low mood in patients,affecting work and interpersonal communication,increasing the risk of recurrence,and adding to the burden on *** the influencing factors of their social function is of great *** To explore the social function score and its influencing factors in patients with residual depressive *** This observational study surveyed patients with residual depressive symptoms(case group)and healthy patients undergoing physical examinations(control group).Participants were admitted between January 2022 and December *** functioning was assessed using the Sheehan Disability Scale(SDS),and scores were compared between *** influencing SDS scores in patients with residual depressive symptoms were analyzed by applying multiple linear regression while using the receiver operating characteristic curve,and these RESULTS The SDS scores of the 158 patients with depressive symptoms were 11.48±*** with the control group,the SDS scores and all items in the case group were *** scores were higher in patients with relapse,discon-tinuous medication,drug therapy alone,severe somatic symptoms,obvious residual symptoms,and anxiety scores≥*** history,medication compliance,therapy method,and residual symptoms correlated positively with SDS scores(r=0.354,0.414,0.602,and 0.456,respectively).Independent influencing factors included disease history,medication compliance,therapy method,somatic symptoms,residual symptoms,and anxiety scores(P<0.05).The areas under the curve for predicting social functional impairment using these factors were 0.713,0.559,0.684,0.729,0.668,and 0.628,respectively,with sensitivities of 79.2%,61.8%,76.8%,81.7%,63.6%,and 65.5%and specificities of 83.3%,87.5%,82.6%,83.3%,86.7%,and 92.1%,respectively.C

关键词： Depressive Residual symptoms Social function Influence factors

Glial response in the midcingulate cortex in Huntington’s disease

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration research 2025年第1期20卷 207-208页

作者： Thulani H.Palpagama Andrea Kwakowsky center for Brain research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

Huntington’s disease(HD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying HD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： Huntington degeneration cortex

The stanley Neuropathology Consortium Integrative Database (SNCID) for psychiatric Disorders

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2019年第2期35卷 277-282页

作者： Sanghyeon Kim Maree J.Webster stanley Brain research Laboratory Stanley Medical Research Institute

The stanley Medical research Institute(SMRI)is a nonprofit organization with a primary mission to fund research on the cause and treatment of severe mental *** SMRI also supports a brain bank as part of the mission to facilitate research into mental *** SMRI brain bank distributes postmortem samples from individuals with serious mental illness,free of charge,to scientists around the *** SMRI brain bank is recognized for the unique way it is set up,organized,and *** of demographically-matched groups of patients with schizophrenia,bipolar disorder(BP),or major depression(DEP)and unaffected controls are organized such that all researchers applying for tissue received samples from the same cohort.

关键词： SNCID for psychiatric Disorders DRD RNA

Reconstruct recent multi-population migration history by using identical-by-descent sharing

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第6期51卷 642-651页

作者： Wenxiao Zhang Kai Yuan Ru Wen Haifang Li Xumin Ni School of Mathematics and Statistics Beijing Jiaotong UniversityBeijing 100044China The stanley center for psychiatric research Broad Institute of MIT and HarvardCambridgeMA 02142USA Baidu Incorporated Beijing 100085China

Identical-by-descent(IBD)is a fundamental genomic characteristic in population genetics and has been widely used for population history ***,limited by the nature of IBD,which could only capture the relationship between two individuals/haplotypes,existing IBD-based history inference is constrained to two *** this study,we propose a framework by leveraging IBD sharing in multipopulation and develop a method,MatrixiBD,to reconstruct recent multi-population migration ***,we employ the structured coalescent theory to precisely model the genealogical process and then estimate the IBD sharing across multiple *** our model,we establish a theoretical connection between migration history and IBD *** method is rigorously evaluated through simulations,revealing its remarkable accuracy and ***,we apply MatrixiBD to Central and South Asia in the Human Genome Diversity Project and successfully reconstruct the recent migration history of three closely related populations in South *** taking into account the IBD sharing across multiple populations simultaneously,MatrixlBD enables us to attain clearer and more comprehensive insights into the history of regions characterized by complex migration dynamics,providing a holistic perspective on intricate patterns embedded within the recent population migration history.

关键词： Population genetics IBD sharing Migration history Structured coalescent theory Gene flow

Pathway analysis for genome-wide genetic variation data:Analytic principles,latest developments,and new opportunities

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2021年第3期48卷 173-183页

作者： Micah Silberstein Nicholas Nesbit Jacquelyn Cai Phil H.Lee center for Genomic Medicine Massachusetts General HospitalBostonMA 02114USA Department of Psychiatry Harvard Medical SchoolBostonMA 02115USA stanley center for psychiatric research Broad Institute of MIT and HarvardCambridgeMA 02142USA

Pathway analysis,also known as gene-set enrichment analysis,is a multilocus analytic strategy that integrates a priori,biological knowledge into the statistical analysis of high-throughput genetics *** developed for the studies of gene expression data,it has become a powerful analytic procedure for indepth mining of genome-wide genetic variation *** discoveries were made in the past years,uncovering genes and biological mechanisms underlying common and complex ***,as massive amounts of diverse functional genomics data accrue,there is a pressing need for newer generations of pathway analysis methods that can utilize multiple layers of high-throughput genomics *** this review,we provide an intellectual foundation of this powerful analytic strategy,as well as an update of the state-of-the-art in recent method *** goal of this review is threefold:(1)introduce the motivation and basic steps of pathway analysis for genome-wide genetic variation data;(2)review the merits and the shortcomings of classic and newly emerging integrative pathway analysis tools;and(3)discuss remaining challenges and future directions for further method developments.

关键词： Pathway analysis Set-based association analysis Gene-set enrichment analysis Genome-wide association study Multilocus association analysis

Neuroinflammation as a therapeutic target in Huntington's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani H.Palpagama center for Brain research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George Huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. Huntington's disease(HD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： Huntington inflammation Medicine

Formal Verification of Temporal Properties for Reduced Overhead in Grid Scientific Workflows

在线全文

学校读者我要写书评

暂无评论

Journal of Computer Science & Technology 2011年第6期26卷 1017-1030页

作者：曹军威张帆许可刘连臣吴澄 CCF ACM IEEE research Institute of Information Technology Tsinghua University Tsinghua National Laboratory for Information Science and Technology National CIMS Engineering and research center Tsinghua University Morgan stanley

With quick development of grid techniques and growing complexity of grid applications, it is becoming critical for reasoning temporal properties of grid workflows to probe potential pitfalls and errors, in order to ensure reliability and trustworthiness at the initial design phase. A state Pi calculus is proposed and implemented in this work, which not only enables fexible abstraction and management of historical grid verification of grid workflows. Furthermore, a relaxed region system events, but also facilitates modeling and temporal analysis （RRA） approach is proposed to decompose large scale grid workflows into sequentially composed regions with relaxation of parallel workflow branches, and corresponding verification strategies are also decomposed following modular verification principles. Performance evaluation results show that the RRA approach can dramatically reduce CPU time and memory usage of formal verification.

关键词： grid computing workflow management formal verification state Pi calculus

Small-cell neuroendocrine carcinoma of the prostate： are heterotransplants a better experimental model？

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2010年第3期12卷 308-314,I0007页

作者： Lluis-A. Lopez-Barcons stanley S. Scott Cancer center Louisiana State University Health Sciences Center New Orleans LA 70112 USA

Small-cell neuroendocrine carcinoma of the prostate （SCNCP） is an uncommon type of prostate cancer. However, it is of clinical importance because it is one of the most aggressive tumors of the prostate with a very poor prognosis. There exist few artificially cultured tumor cell lines to study SCNCE Then, another approach to that study consists in the use of fresh tumor tissue obtained from patients and its heterotransplantation into host mice. The purpose of this review is to integrate data from more than 20 years of heterotransplantation research in the study of small-cell neuroendocrine carcinoma of the prostate （SCNCP）. Heterotransplantation has provided data regarding the histopathology, karyotype, DNA content, cell cycle frequency, tumor markers, androgen receptor expression, metastasis and take rate of this prostate disease. When possible, comparisons between original in situ specimens removed from patients and heterotransplanted tissue from host mice have been made. There are advantages, as well as limitations, that have been identified for SCNCP heterotransplants versus xenotransplantation of cultured cells. Overall, heterotransplanted tumors are better than conventional tumor xenografts at retaining tumor morphology, pathology, secretory activity and expression of tumor markers of the patient＇s original specimen. Furthermore, heterotransplanted tissue preserves the three-dimensional tumor architecture of the prostate to maintain critical stromal-epithelial cell interactions.

关键词： heterotransplant nude mice prostate small-cell neuroendocrine carcinoma xenotransplant

Upregulation of Spinal Voltage-Dependent Anion Channel 1 Contributes to Bone Cancer Pain Hypersensitivity in Rats

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2017年第6期33卷 711-721页

作者： Xiangpeng Kong Jinrong Wei Diyu Wang Xiaoju Zhu Youlang Zhou Shusheng Wang Guang-Yin Xu Guo-Qin Jiang Jiangsu Key Laboratory of Translational research and Therapy for Neuro-psychiatric Diseases and Institute of Neuroscience The Second Affiliated Hospital Soochow University center for Translational Medicine Affiliated Zhangjiagang Hospital of Soochow University

Voltage-dependent anion channel 1（VDAC1） is thought to contribute to the progression of tumor development. However, whether VDAC1 contributes to bone cancer pain remains unknown. In this study, we found that the expression of VDAC1 was upregulated in the L2–5 segments of the spinal dorsal horn at 2 and 3 weeks after injection of tumor cells into the tibial cavity. Intrathecal injection of a VDAC1 inhibitor significantly reversed the pain hypersensitivity and reduced the over-expression of Toll-like receptor 4（TLR4）. Intrathecal injection of minocycline, an inhibitor of microglia, also attenuated the pain hypersensitivity of rat models of bone cancer *** results suggest that VDAC1 plays a significant role in the development of complicated cancer pain, possibly by regulating the expression of TLR4.

关键词： Cancer-induced pain Spinal dorsal horn Voltage-dependent anion channel 1 Toll-like receptor 4 Microglia