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Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China

Frontiers of Medicine 2023年第6期17卷 1030-1046页

作者： Dong Wei Yusang Xie Xuefei Liu Rong Chen Min Zhou Xinxin Zhang Jieming Qu IDepartment of Infectious Diseases Research Laboratory of Clinical VirologyRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Pulmonary and Critical Care Medicine Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Institute of Respiratory Diseases Shanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai key laboratory of Emergency Prevention Diagnosis and Treatment of Respiratory InfectiousDiseasesShanghai 200025China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was reported at the end of 2019 as a worldwide health concern causing a pandemic of unusual viral pneumonia and many other organ damages,which was defined by the World Health Organization as coronavirus disease 2019(COVID-19).The pandemic is considered a significant threat to global public health till *** this review,we have summarized the lessons learnt during the emergence and spread of SARS-CoV-2,including its prototype and *** overall clinical features of variants of concern(VOC),heterogeneity in the clinical manifestations,radiology and pathology of COVID-19 patients are also discussed,along with advances in therapeutic agents.

关键词： coronavirus disease 2019 SARS-CoV-2 epidemiology clinical features

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Risk factors for adult death due to 2009 pandemic influenza A （H1N1） virus infection： a 2151 severe and critical cases analysis

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Chinese Medical Journal 2013年第12期126卷 2222-2228页

作者： ZHANG Peng-jun CAO Bin LI Xiao-li LIANG Li-rong YANG Shi-gui GU Li XU Zhen HU Ke ZHANG Hong-yuan YAN Xi-xin HUANG Wen-bao CHEN Wei ZHANG Jing-xiao LI Lan-juan WANG Chen Institute of Respiratory Medicine Beijing Hospital Ministry of Heath Beijing 100730 China Department of Infectious Diseases and Clinical Microbiology BeijingChao-Yang Hospital Capital Medical University Beijing Instituteof Respiratory Medicine Beijing key laboratory of Respiratory andPulmonary Circulation Disorders Beijing 100020 China staie key laboratory for diagnosis and treatment of infectiousdiseases Institute of Infectious Diseases First Affiliated HospitalSchool of Medicine Zhejiang University Hangzhou Zhejiang310003 China Disease Control and-Emergency Response Office Chinese Center for Disease Control and Prevention Beijing 100050 China Department of Respiratory Medicine Retain Hospital of Wuhan University Wuhan Hubei 430060 China Department of Respiratory Medicine First Affiliated Hospital of Anhui Medical University Hefei Anhui 230022 China Department of Respiratory Medicine Second Hospital of Hebei Medical University Shijiazhuang Hebei 050000 China Department of Respiratory Medicine Hangzhou No.1 People's Hospital Hangzhou Zhejiang 310006 China Department of Respiratory Medicine Shengjing Hospital of China Medical University Shenyang Liaoning 110004 China Department of Respiratory Medicine Second Affiliated Hospital Nanchang University Changchun Jilin 130041 China Beijing key laboratory of Respiratory and Pulmonary Circulation Disorders Beijing Institute of Respiratory Medicine Beijing 100020 China

Background The 2009 pandemic H1 N1 （pH1N1） influenza showed that relatively young adults accounted for the highest rates of hospital admission and *** preparation for pH1N1,the aim of the study is to identify factors associated with the mortality of patients with 2009 pH1N1 infection,especially for young patients without chronic medical *** Retrospective observational study of 2151 severe or critical adult cases （-≥14 years old） admitted to a hospital with pH1N1 influenza from September 1,2009 to December 31,2009 from 426 hospitals of 27 Chinese provinces.A confirmed case was a person whose pH1N1 virus infection was verified by real-time reverse-transcriptase polymerase chain reaction （rRT-PCR）.Severe and critical cases were defined according to the H1N1 2009 Clinical guidelines （Third Edition,2009） released by the Ministry of Health of *** Among the 2151 patients,the mean age was 34.0 *** hundred and ninty-three （13.6%） died during hospital *** thousand four hundred and forty-two patients （67.0%） had no comorbidities and 189 （13.1%） of them *** （OR 8.03）,pneumonia （OR 8.91）,dyspnea （OR 3.95）,central nervous system （CNS） symptom （OR 1.55）,higher APACHE （Acute Physiology and Chronic Health Evaluation） Ⅱ score （OR 1.06）,Alanine aminotransferase （ALT）（OR 1.002）,and the lactate dehydrogenase （LDH） level （OR 1.001） were independent risk factors for death among adults without chronic medical *** APACHE Ⅱ score （OR 1.08） and age （OR 1.06） were independent risk factors for death among adults with respiratory diseases.A multivariate analysis showed an association between mortality and CNS symptoms （OR 2.66）,higher APACHE Ⅱ score （OR 1.03）,ALT （OR 1.006）,and LDH level （OR 1.002） in patients with cardiovascular *** （OR 11.32） was an independent risk factor for patient death in patients with diabetes *** Clinical knowledge of identified prognostic factors for mortality may aid in the

关键词： mortality influenza A virus risk factors chronic disease

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