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Hepatobiliary Surgery and Nutrition 2019年第5期8卷 569-571页

作者： Hyun Yang Pil Soo Sung Jaejun Lee Seung Kew Yoon Eun Sun Jung Cheon-Soo Park Si Hyun Bae The Catholic University Liver Research center College of MedicineThe Catholic University of KoreaSeoulRepublic of Korea Department of Internal medicine College of MedicineEunpyeong St.Mary’s HospitalThe Catholic University of KoreaSeoulRepublic of Korea Department of Internal Medicine College of MedicineSeoul St.Mary’s HospitalThe Catholic University of KoreaSeoulRepublic of Korea Department of Hospital Pathology College of MedicineEunpyeong St.Mary’s HospitalThe Catholic University of KoreaSeoulRepublic of Korea Department of Surgery College of MedicineEunpyeong St.Mary’s HospitalThe Catholic University of KoreaSeoulRepublic of Korea

A recent report demonstrated immune heterogeneityof hepatocellular carcinoma(HCC)(1).The objectiveresponse rates of sorafenib-treated global and Asian patientsby nivolumab,the monoclonal antibody to programmedcell dea... 详细信息

关键词： hepatocellular nivolumab surgery

Bacterial infection after liver transplantation

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World Journal of Gastroenterology 2014年第20期20卷 6211-6220页

作者： Sang Il Kim Division of Infectious Disease Seoul St. Mary’s Hospital The Catholic University of Korea Seoul 137-701 South Korea

Infectious complications are major causes of morbidity and mortality after liver transplantation,despite recent advances in the transplant ***,fungi,viruses and parasites can cause infection before and after *** them,bacterial infections are predominant during the first two months posttransplantation and affect patient and graft *** might cause surgical site infections,including deep intra-abdominal infections,bacteremia,pneumonia,catheter-related infections and urinary tract *** risk factors for bacterial infections differ between the periods after transplant,and between ***,the emergence of multi-drug resistant bacteria is great concern in liver transplant(LT)*** instructive data about effects of infections with extended-spectrum beta lactamase producing bacteria,carbapenem-resistant gram-negative bacteria,and glycopeptide-resistant gram-positive bacteria were reported on a center-by-center *** prevent posttransplant bacterial infections,proper strategies need to be established based upon center-specific data and evidence from well-controlled *** article reviewed the recent epidemiological data,risk factors for each type of infections and important clinical issues in bacterial infection after LT.

关键词： Liver transplantation Bacterial infection Intraabdominal infections Resistant bacteria

Long-term survival of patients with stage Ⅱ and Ⅲgastric cancer who underwent gastrectomy with inadequate nodal assessment

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World Journal of Gastrointestinal Surgery 2021年第11期13卷 1463-1483页

作者： Jacopo Desiderio Andrea Sagnotta Irene Terrenato Eleonora Garofoli Claudia Mosillo stefano Trastulli Federica Arteritano Federico Tozzi Vito D'Andrea Yuman Fong Yanghee Woo Sergio Bracarda Amilcare Parisi Department of Digestive Surgery St.Mary’s HospitalTerni 05100Italy Department of Surgical Sciences Sapienza University of RomeRome 00161Italy Department of General Surgery and Surgical Oncology San Filippo Neri HospitalRome 00135Italy Biostatistics and Bioinformatic Unit Scientific DirectionIRCCS Regina Elena National Cancer InstituteRome 00144Italy Department of medical Oncology St.Mary’s HospitalTerni 05100Italy Division of Surgical Oncology and Endocrine Surgery Mays Cancer CenterUniversity of Texas Health Science Center San AntonioSan AntonioTX 78229United States Division of Surgical Oncology Department of SurgeryCity of Hope National Medical CenterDuarteLA91010United States

BACKGROUND Gastric cancer is an aggressive disease with frequent lymph node(LN)*** NCCN recommends a D2 lymphadenectomy and the harvesting of at least 16 *** threshold has been the subject of great debate,not only for the extent of surgery but also for more appropriate *** reclassification of stage IIB through IIIC based on N3b nodal staging in the eighth edition of the American Joint Committee on Cancer(AJCC)staging system highlights the efforts to more accurately discriminate survival expectancy based on nodal ***,studies have suggested that pathologic assessment of 30 or more LNs improve prognostic accuracy and is required for proper staging of *** To evaluate the long-term survival of advanced gastric cancer patients who deviated from expected survival curves because of inadequate nodal *** Eligible patients were identified from the Surveillance,Epidemiology,and End Results *** with stage II-III gastric cancer were considered for *** groups were compared based on the number of analyzed *** were inadequate LN assessment(ILA,st,hazard risk,and Cox proportional univariate and multivariate *** score matching(PSM)was used to compare the ALA and OLA *** The analysis included 11607 *** had advanced T stages(T3=48%;T4=42%).The pathological AJCC stage distribution was IIA=22%,IIB=18%,IIIA=26%,IIIB=22%,and IIIC=12%.The overall sample divided by the study objective included ILA(50%),ALA(35%),and OLA(15%).Median OS was 24 mo for the ILA group,29 mo for the ALA group,and 34 mo for the OLA group(P<0.001).Univariate analysis showed that the ALA and OLA groups had better OS than the ILA group[ALA hazard ratio(HR)=0.84,95%co

关键词： Gastric Cancer Lymphadenectomy Gastrectomy staging N stage Surveillance,Epidemiology,and End Results

Negative impact of bone-marrow-derived mesenchymal stem cells on dextran sulfate sodium-induced colitis

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World Journal of Gastroenterology 2015年第7期21卷 2030-2039页

作者： Young-Sun Nam Nayoun Kim Keon-Il Im Jung-Yeon Lim Eun-Sol Lee Seok-Goo Cho Institute for Translational Research and Molecular Imaging Laboratory of Immune Regulation Convergent Research Consortium for Immunologic Disease Seoul St. Mary's Hospital the Catholic University of Korea College of Medicine Department of Hematology Catholic Blood and Marrow Transplantation Center Seoul St. Mary’s Hospital Institute for Translational Research and Molecular Imaging Laboratory of Immune Regulation Convergent Research Consortium for Immunologic Disease the Catholic University of Korea College of Medicine

AIM:To investigate the effects of mesenchymal stem cells(MSCs)on dextran sulfate sodium-induced inflammatory bowel disease(IBD).METHODS:C57BL/6 mice were fed 3.5%(g/L)dextran sulfate *** day seven,the mice received intraperitoneal injections of 1×106 *** survival rate,disease activity index values,and body weight,were monitored *** day ten,colon lengths and histopathologic changes were *** addition,immunoregulatory changes following MSC administration were evaluated by determining the levels of effector T cell responses in the spleen and mesenteric lymph nodes,and the expression levels of inflammatory cytokines in homogenized ***:Intraperitoneal administration of MSCs did not prevent development of colitis and did not reduce the clinicopathologic severity of *** significant difference was evident in either survival rate or disease activity index score between the control and MSCtreated *** ten-sacrificed mice exhibited no significant difference in either colon length or histopathologic ***,the MSC-treated group exhibited elevated levels of interleukin(IL)-6 and transforming growth factor-β,and a reduced level of IL-10,in spleens,mesenteric lymph nodes,and homogenized *** IL-17 level was lower in the mesenteric lymph nodes of the MSC-treated group(P=0.0126).In homogenized colons,the IL-17 and tumor necrosis factor-α(P=0.0092)expression levels were also lower in the treated ***:MSC infusion provided no significanthistopathologic or clinical improvement,thus representing a limited therapeutic approach for *** enhancement of MSCs is needed in further study.

关键词： Crohn’s disease Dextran sulfate sodium Inflammator

Intraocular lens power calculation in eyes with previous corneal refractive surgery

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Eye and Vision 2018年第1期5卷 172-181页

作者： Giacomo Savini Kenneth J.Hoffer G.B.Bietti Eye Foundation RomeItaly. stein Eye Institute University of CaliforniaLos AngelesCAUSA.3 St.Mary’s Eye CenterSanta MonicaCAUSA

Background:This review aims to explain the reasons why intraocular lens(IOL)power calculation is challenging in eyes with previous corneal refractive surgery and what solutions are currently available to obtain more accurate ***:After IOL implantation in eyes with previous LASIK,PRK or RK,a refractive surprise can occur because (i)the altered ratio between the anterior and posterior corneal surface makes the keratometric index invalid;(ii)the corneal curvature radius is measured out of the optical zone;and (iii)the effective lens position is erroneously predicted if such a prediction is based on the post-refractive surgery corneal *** methods are currently available to obtain the best refractive outcomes in these eyes,even when the perioperative data(*** corneal power and surgically induced refractive change)are not *** this review,we describe the most accurate methods based on our clinical ***:IOL power calculation after myopic corneal refractive surgery can be calculated with a variety of methods that lead to relatively accurate outcomes,with 60 to 70%of eyes showing a prediction error within 0.50 diopters.

关键词： Cataract Intraocular lens power LASIK PRK Excimer laser Corneal surgery Keratometry

Long-term effects of various types of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on changes in glomerular filtration rate in Korea

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Frontiers of Medicine 2019年第6期13卷 713-722页

作者： Seo Yeon Baik Hyunah Kim So Jung Yang Tong Min Kim Seung-Hwan Lee Jae Hyoung Cho Hyunyong Lee Hyeon Woo Yim Kun-Ho Yoon Hun-Sung Kim Department of medical Informatics College of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea College of Pharmacy Sookmyung Women’s UniversitySeoul 04310Republic of Korea Division of Endocrinology and Metabolism Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea Clinical Research Coordinating center Catholic Medical CenterThe Catholic University of KoreaSeoul 06591Republic of Korea Department of Preventive Medicine College of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea

Few long-term follow-up studies have compared the changes in renal function according to the type of statin used in *** compared the long-term effects of statin intensity and type on the changes in the glomerular filtration rate(GFR).We extracted data of patients who took statin for the first *** analyzed whether or not different statins affect the changes in GFR at 3 months after baseline and 4 years *** included 3678 patients and analyzed the changes in *** GFR decreased by 3.2%±0.4%on average 4 years after the first statin prescription,indicating statistically significant deterioration(from 83.5±0.4 mL/min/1.73 m2 to 79.9±0.4 mL/min/1.73 m2,Pstatins,significant differences were observed between atorvastatin and fluvastatin(−5.3%±0.7%vs.1.2%±2.2%,Pstatin and simvastatin(−5.3%±0.7%vs.−0.7%±0.8%,Pstatin(odds ratio[OR]=0.64,95%confidence interval[CI]=0.46-0.87,Pstatin(OR=0.69,95%CI=0.53-0.91,Pstatin intake,GFR changed with the type of *** work is the first in Korea to compare each statin in terms of changes in the GFR after the statin prescription.

关键词： statin glomerular filtration rate HMG-CoA reductase inhibitor chronic kidney disease

Major depressive disorders in patients with inflammatory bowel disease and rheumatoid arthritis

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World Journal of Clinical Cases 2023年第4期11卷 764-779页

作者： maryam Bilal Haider Brinda Basida Jasleen Kaur Department of Internal Medicine Detroit Medical CenterWayne State UniversitySinai Grace HospitalDetroitMI 48235United States Department of Geriatrics Rohde Island Hospital/Brown UniversityProvidenceRI 02903United States Department of Rheumatology St.Mary’s Ascension/Central Michigan UniversitySaginawMI 48601United States

BACKGROUND Various immune-mediated inflammatory diseases consisting of inflammatory bowel disease(IBD)and rheumatoid arthritis(RA),are found to have a substantial societal burden,increased healthcare costs,and progressive *** suggest that patients with vs without comorbid depression have a more significant disability,a lower likelihood of remission,and reduced adherence to *** interleukin(IL)-1β,tumor necrosis factor-α,and IL-6 contribute to developing depression by the impaired physiological responses to stress,resulting in increased pain,fever,fatigue,and lack thereof of interest,and thus poor long-term *** study emphasizes the timely recognition of the prevalence of major depressive disorder(MDD)in patients with RA and IBD combined,thus preventing *** To identify the prevalence level and temporal trends of depression in hospitalized IBD-RA *** All adult hospitalized patients from January 2000 to December 2019 in the nationwide inpatient sample(NIS)were *** study population included all patients with a primary or secondary IBD-RA overlap disease using corresponding international classification of diseases(ICD)-9 and ICD-10 *** includes Crohn’s disease and ulcerative *** study population was divided into IBD-RA without MDD(controls)and IBD-RA with MDD(cases).For group comparison between MDD vs no MDD,we used student’s t-test for continuous variables and RaoScott Chi-square tests for categorical *** univariate analyses,we used logistic regression,and for multivariate analysis,we used a weighted multi-level mixed-effects *** attested all hypotheses with two-tailed significance level of 0.05(P<0.05 was considered significant).The outcome is to examine the temporal trends and prevalence of depression in patients with IBD-RA by gender,race,and *** A total of 133315 records were identified with IBD-RA overlap,of which 26155 patients(19.62%)had *** the IBD-RA

关键词： Inflammatory bowel disease Rheumatoid arthritis Depression Multimorbidity Epidemiology Demographics

Efficacy and safety of vildagliptin/pioglitazone combination therapy in Korean patients with diabetes

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World Journal of Diabetes 2010年第5期1卷 153-160页

作者： Sun-Woo Kim Sei Hyun Baik Kun Ho Yoon Hyoung Woo Lee Claudia Filozof Kangbuk Samsung Hospital Korea University Guro Hospital Catholic University medical center Kangnam St.Mary's Hospital YeungNam University medical center Novartis Pharma AG PostfachBaselCH-4002 Switzerland

AIM:To assess the efficacy and safety of vildagliptin/pioglitazone combination therapy in Korean patients with type 2 diabetes mellitus(T2DM).METHODS:This was a post hoc analysis in Korean patients,from a 24-wk,randomized,active-controlled,double-blind,parallel-group,multicenter *** patients were aged between 18 and 80 years,drug naive,and had been diagnosed with T2DM [hemoglobin A1c(HbA1c):7.5-11.0 and fasting plasma glucose(FPG):mary outcome measure was change in HbA1c from baseline to ***:The distribution of baseline demographic and clinical parameters was well balanced between treatment *** overall mean age,body mass index,HbA1c,FPG,and duration of disease were 50.8 years,24.6 kg/m2,8.6,10.1 mmol/L,and 2.2 years,*** mean changes(± standard error) in HbA1c from baseline(~8.7) to week 24 endpoint were-2.03 ± 0.16(high-dose,N = 34),-1.88 ± 0.15(low-dose,N = 34),-1.31 ± 0.21(vildagliptin,N = 36),and-1.52 ± 0.16(pioglitazone,N = 36).The high-dose combination therapy demonstrated greater efficacy than monotherapies [vildagliptin(P = 0.029) and pioglitazone(P = 0.027)].Percentage of patients achieving HbA1c st in the high-dose group(76 and 68) followed by low-dose(58 and 47),vildagliptin(59 and 37),and pioglitazone(53 and 28) *** overall incidence of adverse events was ***:In Korean patients,first-line treatment with high-dose combination therapy improved glycemic control compared to pioglitazone and vildagliptin monotherapies,consistent with results published for the overall study population.

关键词： Type 2 diabetes mellitus Vildagliptin Pioglitazone

A systematic review and meta-analysis to determine the effect of sperm DNA damage on in vitro fertilization and intracytoplasmic sperm injection outcome

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Asian Journal of Andrology 2017年第1期19卷 80-90页

作者： Luke Simon Armand Zini Alina Dyachenko Antonio Ciampi Douglas T Carrell Department of Surgery (Urology) University of Utah School of Medicine Salt Lake City UT USA Division of Urology Department of Surgery St. Mary's Hospital Center St. Mary's Hospital 3830 Lacombe Avenue Montreal Quebec H3T 1M5 Canada Department of Human Genetics University of Utah School of Medicine Salt Lake City UT USA Department of Obstetrics and Gynecology University of Utah School of Medicine Salt Lake City UT USA.

Sperm DNA damage is prevalent among infertile men and is known to influence natural reproduction. However, the impact of sperm DNA damage on assisted reproduction outcomes remains controversial. Here, we conducted a meta-analysis of studies on sperm DNA damage （assessed by SCSA, TUNEL, SCD, or Comet assay） and clinical pregnancy after IVF and/or ICSI treatment from MEDLINE, EMBASE, and PUBMED database searches for this analysis. We identified 41 articles （with a total of 56 studies） including 16 IVF studies, 24 ICSI studies, and 16 mixed （IVF ＋ ICSI） studies. These studies measured DNA damage （by one of four assays： 23 SCSA, 18 TUNEL, 8 SCD, and 7 Comet） and included a total of 8068 treatment cycles （3734 IVF, 2282 ICSI, and 2052 mixed IVF ＋ ICSI）. The combined OR of 1.68 （95% Ch 1.49-1.89; P 〈 0.0001） indicates that sperm DNA damage affects clinical pregnancy following IVF and/or ICSI treatment. In addition, the combined OR estimates of IVF （16 estimates, OR = 1.65; 95% CI： 1.34-2.04; P 〈 0.0001）, ICSI （24 estimates, OR = 1.31; 95% Ch 1.08-1.59; P = 0.0068）, and mixed IVF ＋ ICSI studies （16 estimates, OR = 2.37; 95% Ch 1.89-2.97; P〈 0.0001） were also statistically significant. There is sufficient evidence in the existing literature suggesting that sperm DNA damage has a negative effect on clinical pregnancy following IVF and/or ICSI treatment.

关键词： assisted reproductive technology outcomes clinical pregnancy meta-analysis sperm DNA damage systematic review

Gender differences in clinical outcomes of acute myocardial infarction undergoing percutaneous coronary intervention: insights from the KAMIR-NIH Registry

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Journal of Geriatric Cardiology 2020年第11期17卷 680-693页

作者： Myunhee Lee Dae-Won Kim Mahn-Won Park Kyusup Lee Kiyuk Chang Wook Sung Chung Tae Hoon Ahn Myung Ho Jeong Seung-Woon Rha Hyo-Soo Kim Hyeon Cheol Gwon In Whan Seong Kyung Kuk Hwang Shung Chull Chae Kwon-Bae Kim Young Jo Kim Kwang Soo Cha Seok Kyu Oh Jei Keon Chae Ji-Hoon Jung 无 KAMIR-NIH registry investigators Division of Cardiology Daejeon St.Mary’s hospitalCollege of MedicineThe Catholic University of KoreaSeoulSouth Korea Division of Cardiology Seoul St.Mary’s hospitalCollege of MedicineThe Catholic University of KoreaSeoulSouth Korea Gachon University Gil Medical CenterIncheonSouth Korea Chonnam National University Hospital GwangjuSouth Korea d Korea University Korea University Guro Hospital SeoulSouth Korea Seoul National University Hospital SeoulSouth Korea Sungkyunkwan Universtiy Samsung Medical CenterSeoulSouth Korea Chungnam National University Hospital DaejeonSouth Korea Chungbuk National University Hospital CheongjuSouth Korea Kyungpook National University Hospital DaeguSouth Korea Keimyung University Dongsan medical center DaeguSouth Korea Yeungnam University Hospital DaeguSouth Korea Pusan National University Hospital BusanSouth Korea Wonkwang University Hospital IksanSouth Korea Chonbuk National University Hospital JeonjuSouth Korea Institute of Toxicology DaejeonSouth Korea 不详

Background There are numerous but conflicting data regarding gender differences in outcomes following percutaneous coronary intervention(PCI). Furthermore, gender differences in clinical outcomes with acute myocardial infarction(AMI) following PCI in Asian population remain uncertain because of the under-representation of Asian in previous trials. Methods A total of 13,104 AMI patients from Korea Acute Myocardial Infarction Registry-National Institute of Health(KAMIR-NIH) between November 2011 and December 2015 were classified into male(n = 8021, 75.9%) and female(n = 2547, 24.1%). We compared the demographic, clinical and angiographic characteristics, 30-days and 1-year major adverse cardiac and cerebrovascular events(MACCE) in women with those in men after AMI by using propensity score(PS) matching. Results Compared with men, women were older, had more comorbidities and more often presented with non-st segment elevation myocardial infarction(NstEMI) and reduced left ventricular systolic function. Over the median follow-up of 363 days, gender differences in both 30-days and 1-year MACCE as well as thrombolysis in myocardial infarction minor bleeding risk were not observed in the PS matched population(30-days MACCE: 5.3% vs. 4.7%, log-rank P = 0.494, HR = 1.126, 95% CI: 0.800-1.585;1-year MACCE: 9.3% vs. 9.0%, log-rank P = 0.803, HR = 1.032, 95% CI: 0.802-1.328;TIMI minor bleeding: 4.9% vs. 3.9%, log-rank P = 0.215, HR = 1.255, 95% CI: 0.869-1.814). Conclusions Among Korean AMI population undergoing contemporary PCI, women, as compared with men, had different clinical and angiographic characteristics but showed similar 30-days and 1-year clinical outcomes. The risk of bleeding after PCI was comparable between men and women during one-year follow up.

关键词： Acute myocardial infarction Asian population Gender difference Percutaneous coronary intervention