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Multiple myeloma mesenchymal stromal cells: Contribution to myeloma bone disease and therapeutics

World Journal of Stem Cells 2014年第3期6卷 322-343页

作者： Antonio Garcia-Gomez Fermin Sanchez-Guijo M Consuelo del Caizo Jesus F San Miguel Mercedes Garayoa Cancer research Center IBMCC(University of Salamanca-CSIC) Institute of Biomedical research of Salamanca University Hospital network of Centers for Regenerative Medicine and cellular therapy fromCastilla y León spanish cooperative research network in cellular therapy Center for Applied Biomedical research Clinic University of Navarra

Multiple myeloma is a hematological malignancy inwhich clonal plasma cells proliferate and accumulate within the bone marrow. The presence of osteolytic le-sions due to increased osteoclast(OC) activity and sup-pressed osteoblast(OB) function is characteristic of the disease. The bone marrow mesenchymal stromal cells(MSCs) play a critical role in multiple myeloma patho-physiology, greatly promoting the growth, survival, drug resistance and migration of myeloma cells. Here, we specifically discuss on the relative contribution of MSCs to the pathophysiology of osteolytic lesions in light of the current knowledge of the biology of my-eloma bone disease(MBD), together with the reported genomic, functional and gene expression differences between MSCs derived from myeloma patients(pMSCs) and their healthy counterparts(dMSCs). Being MSCs the progenitors of OBs, pMSCs primarily contribute to the pathogenesis of MBD because of their reduced osteogenic potential consequence of multiple OB inhibi-tory factors and direct interactions with myeloma cells in the bone marrow. Importantly, pMSCs also readily contribute to MBD by promoting OC formation and ac-tivity at various levels(i.e., increasing RANKL to OPG expression, augmenting secretion of activin A, uncou-pling ephrinB2-EphB4 signaling, and through augment-ed production of Wnt5a), thus further contributing to OB/OC uncoupling in osteolytic lesions. In this review, we also look over main signaling pathways involved in the osteogenic differentiation of MSCs and/or OB activity, highlighting amenable therapeutic targets; in parallel, the reported activity of bone-anabolic agents(at preclinical or clinical stage) targeting those signaling pathways is commented.

关键词： Mesenchymal stromal cells Multiple myelo-ma Osteolytic lesions Myeloma bone disease Bone-directed therapy Bone-anabolic drugs

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Multi-scale modeling of hemodynamics in the cardiovascular system

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Acta Mechanica Sinica 2015年第4期31卷 446-464页

作者： Hao Liu Fuyou Liang Jasmin Wong Takashi Fujiwara Wenjing Ye Ken-iti Tsubota Michiko Sugawara Graduate School of Engineering Chiba University Shanghai Jiao Tong University and Chiba University International cooperative research Center (SJTU-CU ICRC) The Hong Kong University of Science and Technology(HKUST)

The human cardiovascular system is a closed- loop and complex vascular network with multi-scaled het- erogeneous hemodynamic phenomena. Here, we give a selective review of recent progress in macro-hemodynamic modeling, with a focus on geometrical multi-scale model- ing of the vascular network, micro-hemodynamic modeling of microcirculation, as well as blood cellular, subcellular, endothelial biomechanics, and their interaction with arter- ial vessel mechanics. We describe in detail the methodology of hemodynamic modeling and its potential applications in cardiovascular research and clinical practice. In addition, we present major topics for future study： recent progress of patient-specific hemodynamic modeling in clinical applica- tions, micro-hemodynamic modeling in capillaries and blood cells, and the importance and potential of the multi-scale hemodynarnic modeling.

关键词： Multi-scale modeling. Macro-hemodynamics.Micro-hemodynamics Cardiovascular system Endothelialcell

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Exosomes as mediators of neuron-glia communication in neuroinflammation

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Neural Regeneration research 2020年第5期15卷 796-801页

作者： María Pascual Francesc Ibánez Consuelo Guerri Department of Molecular and cellular Pathology of Alcohol Príncipe Felipe Research CenterValenciaSpain Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain

In recent years,a type of extracellular vesicles named exosomes has emerged that play an important role in intercellular communication under physiological and pathological *** nanovesicles (30–150 nm) contain proteins,RNAs and lipids,and their internalization by bystander cells could alter their normal *** review focuses on recent knowledge about exosomes as messengers of neuron-glia communication and their participation in the physiological and pathological functions in the central nervous *** emphasis is placed on the role of exosomes under toxic or pathological stimuli within the brain,in which the glial exosomes containing inflammatory molecules are able to communicate with neurons and contribute to the pathogenesis of neuroinflammation and neurodegenerative *** the small size and characteristics of exosomes,they can cross the blood-brain barrier and be used as biomarkers and diagnosis for brain disorders and ***,although the application potential of exosome is still limited,current studies indicate that exosomes represent a promising strategy to gain pathogenic information to identify therapeutically targets and biomarkers for neurological disorders and neuroinflammation.

关键词： biomarkers exosomes glial cells neuroinflammation neuron-glia commuication neurons neuropathology therapy

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On Energy Efficient Design for Dynamic CoMP Transmission in K-Tier Heterogeneous cellular networks

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China Communications 2016年第6期13卷 147-153页

作者： Min Xu Xiaofeng Tao Fan Yang Huici Wu Wireless Technology Innovation (WTI) Institute National Engineering Laboratory for Mobile Network Security Beijing University of Posts and Telecommunications

Motivated by the objective of pursuing revenue, improvement in coverage and reduction in energy cost for wireless communication networks have been of great significance for mobile operators. Therefore, heterogeneous cellular networks(HCNs) and Coordinated Multipoint(Co MP) transmission are considered as promising solutions to enhance the performances of wireless communication systems. This paper analyzed the K-tier HCNs with a dynamic downlink Co MP scheme, in which the flexible clusters of cooperative stations are determined by a connecting threshold θ. Using stochastic geometry, the coverage probability(CP) and energy efficiency(EE) of a K-tier HCN operating under this scheme are derived, based on which the trade-off between CP and EE is discovered and discussed. Simulation results show the validity of our derivations. The proposed schememay significantly reduce energy consumption sacrificing a small amount of CP, and outperforms the fixed scheme as well. The CP-EE trade-off are also revealed, whichsuggests suitable trade-off points between CP and EE that will deliver the maximum economic profitability. Tendencies discovered in this paper may provide the operators with opportunities for further optimization in pursuit of economic profitability.

关键词：多点传输蜂窝网络协作异构最大经济效益移动运营商设计节能

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Machine Learning-Based Radio Access Technology Selection in the Internet of Moving Things

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China Communications 2021年第7期18卷 13-24页

作者： Ramon Sanchez-Iborra Luis Bernal-Escobedo Jose Santa Dept.Engineering and Applied Techniques University Centre of Defence at the Spanish Air Force Academy30729 San JavierSpain Dept.Information and Communication Engineering University of Murcia30100 MurciaSpain Dept.of Electronics Computing Technology and ProjectsTechnical University of Cartagena30202 CartagenaSpain

The Internet of Moving Things(IoMT)takes a step further with respect to traditional static IoT *** this line,the integration of new eco-friendly mobility devices such as scooters or bicycles within the cooperative-Intelligent Transportation Systems(C-ITS)and smart city ecosystems is crucial to provide novel *** this end,a range of communication technologies is available,such as cellular,vehicular WiFi or Low-Power Wide-Area network(LPWAN);however,none of them can fully cover energy consumption and Quality of Service(QoS)***,we propose a Decision Support System(DSS),based on supervised Machine Learning(ML)classification,for selecting the most adequate transmission interface to send a certain message in a multi-Radio Access Technology(RAT)set *** ML algorithms have been explored taking into account computing and energy constraints of IoMT enddevices and traffic ***,a real implementation of a decision tree-based DSS for micro-controller units is presented and *** attained results demonstrate the validity of the proposal,saving energy in communication tasks as well as satisfying QoS requirements of certain urgent *** footprint of the real implementation on an Arduino Uno is 444 bytes and it can be executed in around 50µs.

关键词： internet of moving things multi-RAT CITS classification personal mobility

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Adaptive Handover Decision Inspired By Biological Mechanism in Vehicle Ad-hoc networks

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Computers, Materials & Continua 2019年第9期61卷 1117-1128页

作者： Xuting Duan Jingyi Wei Daxin Tian Jianshan Zhou Haiying Xia Xin Li Kunxian Zheng Beijing Advanced Innovation Center for Big Data and Brain Computing Beijing100191China Beijing Key Laboratory for cooperative Vehicle Infrastructure Systems&SafetyControl Beijing100191China School of Transportation Science and Engineering Beihang UniversityBeijing100191China Department of Engineering and Design University of SussexBrightonBN19RHUK research Institute of Highway Ministry Transport Beijing100088China Department of Computer Science and Technology Tsinghua UniversityHaidian DistrictBeijing100088China

In vehicle ad-hoc networks(VANETs),the proliferation of wireless communication will give rise to the heterogeneous access environment where network selection becomes *** by the self-adaptive paradigm of cellular attractors,this paper regards an individual communication as a cell,so that we can apply the revised attractor selection model to induce each connected *** at improving the Quality of Service(QoS),we presented the bio-inspired handover decision-making *** addition,we employ the Technique for Order Preference by Similarity to an Ideal Solution(TOPSIS)for any vehicle to choose an access *** paper proposes a novel framework where the bio-inspired mechanism is combined with *** a dynamic and random mobility environment,our method achieves the coordination of performance of heterogeneous networks by guaranteeing the efficient utilization and fair distribution of network resources in a global *** experimental results confirm that the proposed method performs better when compared with conventional schemes.

关键词： Revised attraction selection model TOPSIS VANETs QoS

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Endothelial progenitor cells as a therapeutic option in intracerebral hemorrhage

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Neural Regeneration research 2017年第4期12卷 558-561页

作者： Juan Pías-Peleteiro Francisco Campos José Castillo Tomás Sobrino Clinical Neurosciences research Laboratory Department of NeurologyStroke UnitUniversity Clinical HospitalUniversidade de Santiago de CompostelaHealth Research Institute of Santiago de Compostela (IDIS)

Intracerebral hemorrhage （ICH） is the most severe cerebrovascular disease, which represents a leading cause of death and disability in developed countries. However, therapeutic options are limited, so is mandatory to investigate repairing processes after stroke in order to develop new therapeutic strategies able to promote brain repair processes. Therapeutic angiogenesis and vasculogenesis hold promise to improve outcome of ICH patients. In this regard, circulating endothelial progenitor cells （EPCs） have recently been suggested to be a marker of vascular risk and endothelial function. Moreover, EPC levels have been associated with good neurological and functional outcome as well as reduced residual hematoma volume in ICH patients. Finally, experimental and clinical studies indicate that EPC might mediate endothelial cell regeneration and neovascularization. Therefore, EPC-based therapy could be an excellent therapeutic option in ICH. In this mini-review, we discuss the present status of knowledge about the possible therapeutic role of EPCs in ICH, molecular mechanisms, and the future perspectives and strategies for their use in clinical practice.

关键词： cellular therapy endothelial progenitor cells growth factors intracerebral hemorrhage neurorepair outcome

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An Efficient Scheduling Scheme for Fronthaul Load Reduction in Fog Radio Access networks

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China Communications 2019年第11期16卷 146-153页

作者： Sovit Bhandari Hong Ping Zhao Hoon Kim IoT and Big-data research Center Department of Electronics Engineering Incheon National University

Fog radio access network(F-RAN) is one of the key technology that brings cloud computing benefit to the future of wireless communications for handling massive access and high volume of data traffic. The high fronthaul burden of a typical cellular system can be partially diminished by utilizing the storage and signal processing capabilities of the F-RANs, which is still not desirable as user throughput requirement is in the increasing trend with the increment of the internet of things(IoT) devices. This paper proposes an efficient scheduling scheme that minimizes the fronthaul load of F-RAN system optimally to improve user experience, and minimize latency. The scheduling scheme is modeled in a way that the scheduler which provides the lower fronthaul load while fulfilling the minimum user throughput requirement is selected for the data transmission process. Simulation results in terms of user selection fairness, outage probability, and fronthaul load for a different portion of user equipments(UEs) contents in fog access point(F-AP) are shown and compared with the most common scheduling scheme such as round robin(RR) scheme to validate the proposed method.

关键词： fog radio access networks fog access points fronthaul load user throughput

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SENSING TASKS ALLOCATION IN cellular-BASED COGNITIVE RADIO network

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Journal of Electronics(China) 2010年第5期27卷 618-624页

作者： Chen Lei Chen Jie Comunication Technologies research Dept. HuaweiChengdu 610041China

In Cognitive Radio(CR) networks,especially in cellular-based CR networks,in order to obtain the precise spectrum state which is available in the whole coverage,the spectrum sensing function need to be accomplished by the cooperation of multi-sensing nodes,i.e.,cooperative spectrum *** paper mainly focuses on the key question of the cooperative spectrum sensing:How many sensing nodes are required and how to allocate the sensing tasks to these sensing nodes in an effective way? In this paper,we classify the spectrum bands into three categories by a pre-sensing mechanism,in order to firstly exclude unavailable channels and select candidate channels for fine sensing in the next *** the required number of sensing node for each candidate channel is determined by the proposed *** the scheme proposed in this paper,the sensing tasks allocation in cellu-lar-based CR network can be accomplished in a high effective way and the sensing overhead could keep a low level.

关键词： Cognitive Radio (CR) Spectrum Sensing

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Bile-acid-induced cell injury and protection

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World Journal of Gastroenterology 2009年第14期15卷 1677-1689页

作者： Maria J Perez Oscar Briz research Unit University Hospital of Salamanca Laboratory of Experimental Hepatology and Drug Targeting CIBERehd University of Salamanca E.D. 129 37007 Salamanca Spain

Several studies have characterized the cellular and molecular mechanisms of hepatocyte injury caused by the retention of hydrophobic bile acids (BAs) in cholestatic diseases. BAs may disrupt cell membranes through their detergent action on lipid components and can promote the generation of reactive oxygen species that, in turn, oxidatively modify lipids, proteins, and nucleic acids, and eventually cause hepatocyte necrosis and apoptosis. Several pathways are involved in triggering hepatocyte apoptosis. Toxic BAs can activate hepatocyte death receptors directly and induce oxidative damage, thereby causing mitochondrial dysfunction, and induce endoplasmic reticulum stress. When these compounds are taken up and accumulate inside biliary cells, they can also cause apoptosis. Regarding extrahepatic tissues, the accumulation of BAs in the systemic circulation may contribute to endothelial injury in the kidney and lungs. In gastrointestinal cells, BAs may behave as cancer promoters through an indirect mechanism involvingoxidative stress and DNA damage, as well as acting as selection agents for apoptosis-resistant cells. The accumulation of BAs may have also deleterious effects on placental and fetal cells. However, other BAs, such as ursodeoxycholic acid, have been shown to modulate BA-induced injury in hepatocytes. The major beneficial effects of treatment with ursodeoxycholic acid are protection against cytotoxicity due to more toxic BAs; the stimulation of hepatobiliary secretion; antioxidant activity, due in part to an enhancement in glutathione levels; and the inhibition of liver cell apoptosis. Other natural BAs or their derivatives, such as cholyl-N- methylglycine or cholylsarcosine, have also aroused pharmacological interest owing to their protective properties.

关键词：肝细胞损伤胆汁酸保护肝细胞凋亡线粒体功能障碍熊去氧胆酸氧化损伤细胞毒性

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