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Genetic Structure and Eco-Geographical Differentiation of Cultivated Keng Rice(Oryza sativa ***) in China Revealed by Microsatellites

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Journal of Integrative Agriculture 2012年第11期11卷 1755-1766页

作者： ZHANG Dong-ling WANG Mei-xing QIYong-wen SUN Jun-li WANG Feng-mei LI Jin-jie ZHANG Hong-liang ELI Zi-chao Key Laboratory of Crop Heterosis and Utilization Ministry of Education/Beijing Key Laboratory of Crop Genetic Improvement China Agricultural University Beijing 100193 P.R. China Zhejiang Academy of Agricultural Sciences Hangzhou 310021 P.R.China Guangzhou Sugarcane Industry research institute Guangzhou 510316 P.R. China Ministry of Agriculture Beijing 100026 P.R. China

China is one of the largest centers of genetic diversity of Oryza sativa L. and is the original centers of Oryza sativa L. subspecies japonica. Using a genetically representative core collection of 1 442 rice landraces of japonica in China, the genetic structure, differentiation, and geographic diversity were analyzed. The model-based structure analysis on varieties within three ecotypes revealed 16 eco-geographical types, which are partially accorded with some of the ecological zones in China. The differentiation of eco-geographical types contributed to the local ecological adaption and physical isolation, and maybe could be used to develop the heterotic groups of japonica. To facilitate the identification of different ecotypes and eco-geographical types, we provided the SSR character alleles of each ecotype or geographical eco-group and a rapid discriminated method based on these character alleles. Lastly, investigation on genetic diversity, genetic differentiation indicated that southwest region of China, including south of Yunnan Province, northwest of Guangxi Zhuang Autonomous Region, and southwest of Guizhou Province, possessed the highest genetic diversity and all the necessary conditions as a center of genetic diversity and should be the center of genetic diversity of rice landraces of japonica in China.

关键词： japonica rice population structure eco-geographical differentiation China microsateltites

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Induced charge signal of a glass RPC detector

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Chinese Physics C 2014年第4期38卷 46-49页

作者： HAN Ran School of Nuclear Science and Engineering North China Electric Power University The institute of Nuclear physics of Lyon

A gas detector glass resistivity plate chamber （GRPC） is proposed for use in the hadron calorimeter （HCAL）. The read-out system is based on a semi-digital system and, therefore, the charge information from GRPC is needed. To better understand the charge that comes out from the GRPC, we started from a cosmic ray test to get the charge distribution. We then studied the induced charge distribution on the collection pad. After successfully comparing it with the prototype beam test data at CERN （European Council for Nuclear research）, the process was finally implanted into the Geant4 based simulation for future study.

关键词： glass resistivity plate chamber (GRPC) induced charge signal beam test data Geant4 simulation

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Eastward migration of the Qaidam basin and its implications for Cenozoic evolution of the Altyn Tagh fault and associated river systems

Eastward migration of the Qaidam basin and its implications ...

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中国科学院地质与地球物理研究所2006学术年会

作者： Erchie Wang Clark B.Burchfiel institute of Geology and Geophysics Chinese Academy of Sciences institute of Tibetan Plateau research Chinese Academy of Sciences Department of Earth Atmospheric and Planetary SciencesMIT Cambridge MA 02139USA

The Qaidam basin is the largest Cenozoic intermountain basin within the Tibetan plateau,bounded by the Qilian Shan range on the north,the East Kunlun range on the south,the Altyn Tagh range on the west and the Ela Shan range on the *** deposits consist of non-marine sedimentary rocks,with a maximum thickness of 15000 *** sedimentation mainly takes place along the marginal areas of the basin,where a number of alluvial fans build up along a series of rivers originated from the surrounding ***,drilling, sedimentary and seismic data reveal that the depocenter of the basin during much of Cenozoic time was not developed as foreland basins of the Qilian Shan belt to the north and the East Kunlun belt to the south,but instead the depocenter was in the center of the western part of the basin and had a northwest-southeast trend that shifted eastward about 400 km during Oligocene to Quaternary *** is the indication that most of the basin sediments were not derived from the areas of the surrounding mountain ***,the strata within the depocenter contrast in their sedimentary characteristics not only from underlying Paleocene-Eocene strata,but also from the contemporaneous strata along the foreland of the Qilian Shan thrust *** northwestern margin of the depocenter of the Qaidam basin lies to the east of the west corner of the Qaidam basin,which is a 400-km-long narrow valley flanked by the Altyn Tagh range along the Altyn Tagh strike-slip fault on the north and the East Kunlun thrust belt on the *** the southwest, this valley can be traced discontinuously to the northern margin of the Pamir folded belt north of the west syntaxis of the *** propose that most of the sediments within the depocenter of the Qaidam basin were transported from the northern margin of the Pamir folded belt along a progressively lengthening 2000-km-long longitudinal river,which developed along the left-lateral Altyn Tagh fault and its weste

关键词： Tibetan plateau Qaidam basin depocenter eastward shift longitudinal river

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Simultaneous flowering of umbrella bamboo (Fargesia murieliae) at its native home in Central China

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Journal of Forestry research 2006年第4期17卷 293-297页

作者： LI Zhao-hua Manfred DENICH Thomas BORSCH School of Resources and Environmental Science Hubei University Wuhan 430062 P. R. China Center for Development research University of Bonn D-53113 Bonn Germany institute of Botany University of Bonn D-53115 Bonn Germany

Flowering pattern and seedling establishment of umbrella bamboo （Fargesia murieliae （Gamble） Yi） were studied in its native habitat, Mount Shennongjia in Central China. Here in 1996-2000, over 95% of the bamboo plants simultaneously flowered and died, extending from lower elevations to the higher mountains along the altitude and from southwest to northeast along the mountain settings. Bamboo seedlings emerged after the simultaneous flowering, achieving an average density of 5 460 seedlings·m^-2 in the autumn of the year following the flowering. After a high mortality throughout the first winter, bamboo seedlings remained a stable density in following 2-4 years （1130-1230 seedlings·m^-2）. Seedling density positively related to the coverage of parent bamboo, but negatively to the herb layers.

关键词： Altitudinal scale bamboo sites flowering pattern seedling establishment Shennongjia.

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Performance of LHAASO-WCDA and observation of the Crab Nebula as a standard candle

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Chinese Physics C 2021年第8期45卷 166-181页

作者： F.Aharonian Q.An Axikegu L.X.Bai Y.X.Bai Y.W.Bao D.Bastieri X.J.Bi Y.J.Bi H.Cai J.T.Cai Z.Cao Z.Cao J.Chang J.F.Chang X.C.Chang B.M.Chen J.Chen L.Chen L.Chen L.Chen M.J.Chen M.L.Chen Q.H.Chen S.H.Chen S.Z.Chen T.L.Chen X.L.Chen Y.Chen N.Cheng Y.D.Cheng S.W.Cui X.H.Cui Y.D.Cui B.Z.Dai H.L.Dai Z.G.Dai Danzengluobu D.della Volpe B.D'Ettorre Piazzoli X.J.Dong J.H.Fan Y.Z.Fan Z.X.Fan J.Fang K.Fang C.F.Feng L.Feng S.H.Feng Y.L.Feng B.Gao C.D.Gao Q.Gao W.Gao M.M.Ge L.S.Geng G.H.Gong Q.B.Gou M.H.Gu J.G.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han H.H.He H.N.He J.C.He S.L.He X.B.He Y.He M.Heller Y.K.Hor C.Hou X.Hou H.B.Hu S.Hu S.C.Hu X.J.Hu D.H.Huang Q.L.Huang W.H.Huang X.T.Huang Z.C.Huang F.Ji X.L.Ji H.Y.Jia K.Jiang Z.J.Jiang C.Jin D.Kuleshov K.Levochkin B.B.Li C.Li C.Li F.Li H.B.Li H.C.Li H.Y.Li J.Li K.Li W.L.Li X.Li X.Li X.R.Li Y.Li Y.Z.Li Z.Li Z.Li E.W.Liang Y.F.Liang S.J.Lin B.Liu C.Liu D.Liu H.Liu H.D.Liu J.Liu J.L.Liu J.S.Liu J.Y.Liu M.Y.Liu R.Y.Liu S.M.Liu W.Liu Y.N.Liu Z.X.Liu W.J.Long R.Lu H.K.Lv B.Q.Ma L.L.Ma X.H.Ma J.R.Mao A.Masood W.Mitthumsiri T.Montaruli Y.C.Nan B.Y.Pang P.Pattarakijwanich Z.Y.Pei M.Y.Qi B.Q.Qiao D.Ruffolo V.Rulev A.Saiz L.Shao O.Shchegolev X.D.Sheng J.R.Shi H.C.Song Yu.V.Stenkin V.Stepanov Q.N.Sun X.N.Sun Z.B.Sun P.H.T.Tam Z.B.Tang W.W.Tian B.D.Wang C.Wang H.Wang H.G.Wang J.C.Wang J.S.Wang L.P.Wang L.Y.Wang R.N.Wang W.Wang W.Wang X.G.Wang X.J.Wang X.Y.Wang Y.D.Wang Y.J.Wang Y.P.Wang Z.Wang Z.Wang Z.H.Wang Z.X.Wang D.M.Wei J.J.Wei Y.J.Wei T.Wen C.Y.Wu H.R.Wu S.Wu W.X.Wu X.F.Wu S.Q.Xi J.Xia J.J.Xia G.M.Xiang G.Xiao H.B.Xiao G.G.Xin Y.L.Xin Y.Xing D.L.Xu R.X.Xu L.Xue D.H.Yan C.W.Yang F.F.Yang J.Y.Yang L.L.Yang M.J.Yang R.Z.Yang S.B.Yang Y.H.Yao Z.G.Yao Y.M.Ye L.Q.Yin N.Yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng M.Zha X.X.Zhai B.B.Zhang H.M.Zhang H.Y.Zhang J.L.Zhang J.W.Zhang L.Zhang L.Zhang L.X.Zhang P.F.Zhang P.P.Zhang R.Zhang S.R.Zhang S.S.Zhang X.Zhang X.P.Zhang Y.Zhang Y.Zhang Y.F.Zhang Y.L.Zhang B.Zhao J.Zhao L.Zhao L.Z.Zhao S.P.Zhao F.Zheng Y.Zheng B.Zhou H.Zhou J.N.Zhou Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray research Center ChengduSichuanChina State Key Laboratory of Particle Detection and Electronics China University of Science and Technology of China Hefei 230026China Department of Engineering Physics Tsinghua UniversityBeijing 100084China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China National Space Science Center Chinese Academy of SciencesBeijing 100190China School of Physics Peking UniversityBeijing 100871China Center for Astrophysics Guangzhou UniversityGuangzhou 510006China School of Physics and Astronomy&School of Physics(Guangzhou) Sun Yat-sen UniversityZhuhai 519082China School of Physical Science and Technology Guangxi UniversityNanning 530004China Hebei Normal University Shijiazhuang 050024China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China Key Laboratory for research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Tsung-Dao Lee institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031China College of Physics Sichuan UniversityChengdu 610065China Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000China School of Physics and Technology Wuhan UniversityWuhan 430072China School of Physics and Astronomy Yunnan University

The first Water Cherenkov detector of the LHAASO experiment(WCDA-1)has been operating since April *** data for the first year have been analyzed to test its performance by observing the Crab Nebula as a standard *** WCDA-1 achieves a sensitivity of 65 mCU per year,with a statistical threshold of 5 *** accomplish this,a 97.7%cosmic-ray background rejection rate around 1 TeV and 99.8%around 6 TeV with an ap proximate photon acceptance of 50%is achieved after applying an algorithm to separate gamma-induced *** angular resolution is measured using the Crab Nebula as a point source to be approximately 0.45°at 1 TeV and better than 0.2°above 6 TeV,with a pointing accuracy better than 0.05°.These values all match the design *** energy resolution is found to be 33%for gamma rays around 6 *** spectral energy distribution of the Crab Nebula in the range from 500 GeV to 15.8 TeV is measured and found to be in agreement with the results from other TeV gamma ray observatories.

关键词： LHAASO-WCDA Crab Nebula angular resolution spectral energy distribution

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Online electrophysiological spike discrimination with wavelet-fractal signatures

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Journal of Medical Colleges of PLA(China) 2006年第6期21卷 383-387页

作者：易东严中红郑永丽李辉智 Department of Health Statistics Third Military Medical University institute of Biotechnology University of Chongqing Technology and Industry southwest University of Political Science and Law

Objective: To study extracellular multi-neuron activity in the nervous system based on wavelet-fractal technique. Methods: The wavelet transform was employed to decompose the original signal and obtain 4 sub-patterns. The dividing fractal dimensions of these sub-patterns were computed. A knn-classier was used to classify feature vectors. Results: Not all the elements in feature vector DimDC were very powerful for this pattern recognition problem through the empirical study of noise signals. The most effective feature vector was defined as DimDC= (d3:d4) above. Conclusion:Wavelet fractal algorithm has high accuracy and provides a powerful tool for clinical application.

关键词： electrophysiological spike wavelet transform fractal

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A Diagnostic and Numerical Study on a Rainstorm in South China Induced by a Northward-Propagating Tropical System

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Acta meteorologica Sinica 2008年第3期22卷 284-302页

作者：赵玉春李泽椿肖子牛 Wuhan institute of Heavy Rain of CMA Wuhan Central Meteorological Observatory National Meteorological Center

A strong cyclonic wind perturbation generated in the northern South China Sea （SCS） moved northward quickly and developed into a mesoscale vortex in southwest Guangdong Province, and then merged with a southward-moving shear line from mid latitudes in the period of 21-22 May 2006, during which three strong mesoscale convective systems （MCSs） formed and brought about torrential rain or even cloudburst in South China. With the 1° ×1° NCEP （National Centers for Environment Prediction） reanalysis data and the Weather and research Forecast （WRF） mesoscale model, a numerical simulation, a potential vorticity inversion analysis, and some sensitivity experiments are carried out to reveal the formation mechanism of this rainfall event. In the meantime, conventional observations, satellite images, and the WRF model outputs are also utilized to perform a preliminary dynamic and thermodynamic diagnostic analysis of the rainstorm systems. It is found that the torrential rain occurred in favorable synoptic conditions such as warm and moist environment, low lifting condensation level, and high convective instability. The moisture transport by strong southerly winds associated with the rapid northward advance of the cyclonic wind perturbation over the northern SCS provided the warm and moist condition for the formation of the excessive rain. Under the dynamic steering of a southwesterly flow ahead of a north trough and that on the southwest side of the West Pacific subtropical high, the mesoscale vortex （or the cyclonic wind perturbation）, after its genesis, moved northward and brought about enormous rain in most parts of Guangdong Province through providing certain lifting forcing for the triggering of mesoscale convection. During the development of the mesoscale vortex, heavy rainfall was to a certain extent enhanced by the mesoscale topography of the Yunwu Mountain in Guangdong. The effect of the Yunwu Mountain is found to vary under different prevailing wind directions and in

关键词： rainstorm in South China mesoscale vortex topography potential vorticity inversion mesoscale convective system (MCS)

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Topically applied hypericin exhibits skin penetrability on nude mice

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中国药理学与毒理学杂志 2017年第10期31卷 1020-1020页

作者： Zhuo-heng LI Yuan-yuan LI Lai-chun LU Xiao-yu XU College of Pharmaceutical Sciences & Chinese Medicine Southwest University Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine Pharmacology of Chinese Materia Medica-The Key Discipline Constructed by the State Administration of Traditional Chinese MedicineChongqing 400042 China Department of Pharmacy Institute of Surgery ResearchDaping Hospital Third Military Medical University Chongqing 400042 China

OBJECTIVE Hypericin,a powerful naturally photosensitizer in photodynamic therapy(PDT),is suitable for treating skin diseases involving excess capillary *** the present study,we aimed to evaluate the skin penetrability of a topically applied hypericin,expecting reducing the risk of prolonged skin photosensitivity,which often occurs after systemic *** The Franz diffusion cell assay was performed to evaluate different penetration *** vivo studies,fluorescence microscopy was performed to examine the distribution of hypericin in the skin,macroscopic and microscopic analyses were also carried out to detect pathological changes in the skin after topical hypericin-PDT *** was used to determine the expression of PECAM-1 in the treated *** 5% menthol facilitated hypericin penetrate the skin of nude mice *** results of in vivo assays revealed that hypericin penetrated nude mice skin,spread to the dermis,and resulted in obvious photosensitivity reaction on the dermal ***,skin injured by the photosensitive reaction induced by hypericin was replaced by normal skin 7 d after hypericin-PDT *** Topical hypericin could penetrate nude mouse skin well and be great potential in PDT treatment of skin diseases.

关键词： hypericin photosensitizer skin penetrability photodynamic therapy

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Annual and interannual variations of sea-level anomaly in the Bay of Bengal and the Andaman Sea

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Acta Oceanologica Sinica 2007年第6期26卷 13-29页

作者： QIU Yun LI Li YU Weidong HU Jianyu State key laboratory of Marine Environmental Science College of Oceanography and Environmental Science Xiamen University Xiamen 361005 China Third institute of Oceanography State Oceanic Administration Xiamen 361005 China First institute of Oceanography State Oceanic Administration Qinddao 266061 China

Annual and interannual variations of sea-level anomaly （SLA） in the Bay of Bengal and the Andaman Sea are investigated using altimeter - derived SLA data from 1993 to 2003. It is found that the SLA annual variation in the study area can be divided into three phases with distinctive patterns. During the southwest monsoon （May -September）, positive SLA presents in the equatorial region and extends northward along the eastern boundary of the bay, and the SLA distribution in the interior bay appears to be high in the east and low in the west with two cyclonic ceils developing in the north and south of the western bay respectively, between which an anticyclonic cell exists. During the early northeast monsoon （ October - December） , the whole bay is dominated by a large cyclonic cell with the pattern of high SLA in the east and low in the west still retained, and the SLA distribution outside the bay is changed in response to the reversal of the Indian Monsoon Current （IMC） in November. During the late northeast monsoon （January -April） , a large anticyclonic cell of SLA develops in the bay with negative SLA prevailing in the equatorial region and extending northward along the eastern boundary of bay. Therefore, the SLA distribution in the interior bay reverses to be high in the west and low in the east. It is suggested that the SLA annual variation in the bay is primarily driven by the local wind stress curl, involving Sverdrup balance while the abrupt SLA variation during the peak of northeast monsoon may be partly caused by the semiannual fluctuation of wind in the equatorial region. This fast adjustment in the interior bay is induced by the upwelling coastal Kelvin wave excited by the decay of Wyrtki jet during December through January. Besides the annual variation, in the bay, there are obvious SLA fluctuations with the periods of 2 and 3 - 7 a, which are driven by the interannual variability of large - scale wind field in the equatorial region. The coastal Kelvin wav

关键词： Bay of Bengal sea-level anomaly low-frequency variation satellite altimeter

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EZH2-, CHD4-, and IDH-linked epigenetic perturbation and its association with survival in glioma patients

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Journal of Molecular Cell Biology 2017年第6期9卷 477-488页

作者： Le Zhang Ying Liu Mengning Wang Zhenhai Wu Na Li Jinsong Zhang Chuanwei Yang College of Computer Science Sichuan University Chengdu China College of Computer and Information Science Southwest University Chongqing China The Vivian Smith Department of Neurosurgery Center for Stem Cell and Regenerative Medicine The University of Texas Health Science Center at Houston Houston TX USA Harvard Stem Cell institute Harvard University Cambridge MA USA Department of neurosurgery ShouGuang People's Hospital Shandong China Pharmacological & Physiological Science School of Medicine Saint Louis University St. Louis MO USA Breast Medical Oncology The University of Texas MD Anderson Cancer Center Houston TX USA Systems Biology The University of Texas MD Anderson Cancer Center Houston TX USA

GUoma is a complex disease with limited treatment options. Recent advances have identified isocitrate dehydrogenase （IDH） mutations in up to 80% lower grade gUomas （LGG） and in 76% secondary gUoblastomas （GBM）. IDH mutations are also seen in 10%-20% of acute myeloid leukemia （AML）. In AML, it was determined that mutations of IDH and other genes involving epigenetic regulations are early events, emerging in the pre-leukemic stem cells （pre-LSCs） stage, whereas mutations in genes propa- gating oncogenic signal are late events in leukemia. IDH mutations are also early events in gUoma, occurring before TP53 mutation, 1p/19q deletion, etc. Despite these advances in gUoma research, studies into other molecular alterations have lagged considerably. In this study, we analyzed currently available databases. We identified EZH2, KMT2C, and CHD# as important genes in glioma in addition to the known gene IDH1/2. We also showed that genomic alterations of PIK3CA, CDKN2A, CDK#, FIPIL1, or FUBP1 collaborate with IDH mutations to negatively affect patients＇ survival in LGG. In LGG patients with TP53 mutations or IDH1/2 mutations, additional genomic alterations of EZH2, KMC2C, and CHD4 individually or in combination were associated with a markedly decreased disease-free survival than patients without such alterations. Alterations of EZH2, KMT2C, and CHD4, at gen- etic level or protein level could perturb epigenetic program, leading to malignant transformation in glioma. By reviewing current literature on both AML and gUoma and performing bioinformatics analysis on available datasets, we developed a hypothetical model on the tumorigenesis from premaUgnant stem cells to gUoma.

关键词： glioma epigenetics bioinformatics prognosis gene mutation

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