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Leukocyte-Specific Morrbid Promotes Leukocyte Differentiation and Atherogenesis

research 2024年第2期2023卷 123-137页

作者： Di Xiang Lei Jiang Qiong Yuan Yang Yu Ruiming Liu Meiting Chen Zheng Kuai Wendy Zhang Fan Yang Tingting Wu Zhiyu He Zuhui Ke Wanzi Hong Pengcheng He Ning Tan Yeying Sun Zhen Shi Xuebiao Wei Jianfang Luo Xiaoqiu Tan Yuqing Huo Gangjian Qin Chunxiang Zhang Department of Cardiology Key Laboratory of Medical ElectrophysiologyMinistry of EducationInstitute of Cardiovascular ResearchThe Affiliated Hospital of Southwest Medical UniversitySouthwest Medical UniversityLuzhouSichuan 646000China Department of Biomedical Engineering School of Medicine The University of Alabama at BirminghamBirminghamAL 35233USA Department of Cardiology.Guangdong Cardiovascular institute Guangdong Provincial Key Laboratory of Coronary Heart Disease PreventionGuangdong Provincial Institute of Geriatric MedicineGuangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510100China Vascular Biology Center Medical College of GeorgiaAugusta UniversityAugustaGA 30912USA

Monocyte-to-M0/M1 macrophage differentiation with unclear molecular mechanisms is a pivotal cellular event in many cardiovascular diseases including *** non-coding RNAs(lncRNAs)are a group of protein expression regulators;however,the roles of monocyte-lncRNAs in macrophage differentiation and its related vascular diseases are still *** study aims to investigate whether the novel leukocyte-specific lncRNA Morrbid could regulate macrophage differentiation and *** identified that Morrbid was increased in monocytes and arterial walls from atherosclerotic mouse and from patients with *** cultured monocytes,Morrbid expression was markedly increased during monocyte to M0 macrophage differentiation with an additional increase during M0 macrophage-to-M1 macrophage *** differentiation stimuli-induced monocyte-macrophage differentiation and the macrophage activity were inhibited by Morrbid ***,overexpression of Morrbid alone was sufficient to elicit the monocyte-macrophage *** role of Morrbid in monocyte-macrophage differentiation was also identified in vivo in atherosclerotic mice and was verified in Morrbid knockout *** identified that PI3-kinase/Akt was involved in the up-regulation of Morrbid expression,whereas s100a10 was involved in Morrbid-mediated effect on macrophage *** provide a proof of concept of Morrbid in pathogenesis of monocyte/macrophage-related vascular disease,we applied an acute atherosclerosis model in *** results revealed that overexpression of Morrbid enhanced but monocyte/macrophage-specific Morrbid knockout inhibited the monocytes/macrophages recruitment and atherosclerotic lesion formation in *** results suggest that Morrbid is a novel biomarker and a modulator of monocyte-macrophage phenotypes,which is involved in atherogenesis.

关键词： inhibited Mor markedly

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An improved plant prime editor for efficient generation of multiple-nucleotide variations and structural variations in rice

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Plant Communications 2024年第9期5卷 21-24页

作者： Zhaohui Zhong Tingting Fan Yao He Shishi Liu Xuelian Zheng Yang Xu Jingqi Ren Hua Yuan Zhengyan Xu Yong Zhang Department of Biotechnology School of Life Sciences and TechnologyCenter for Informational BiologyUniversity of Electronic Science and Technology of ChinaChengdu 610054China Chongqing Key Laboratory of Plant Resource Conservation and Germplasm Innovation Integrative Science Center of Germplasm Creation in Western China(Chongqing)Science CitySchool of Life SciencesSouthwest UniversityChongqing 400715China State Key Laboratory of Crop Gene Exploration and Utilization in southwest China Rice Research InstituteSichuan Agricultural UniversityChengdu 611130SichuanChina

Dear Editor,The ability to manipulate single-nucleotide variations(SNVs),multiple-nucleotide variations(MNVs),and structural variations(SVs)in rice genomes is crucial for studying gene function and improving agricultural ***,these manipulations were achieved mainly through homology-directed repair,which has limited efficiency in plants.

关键词： structural editor nucleotide

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Process-driven susceptibility assessment of glacial lake outburst debris flow in the Himalayas under climate change

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Advances in Climate Change research 2024年第3期15卷 500-514页

作者： Bin ZHOU Qiang ZOU Hu JIANG Tao YANG Wen-Tao ZHOU Si-Yu CHEN Hong-Kun YAO institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China University of Chinese Academy of Sciences Beijing 100049China School of Environment and Resource Southwest University of Science and TechnologyMianyang 621010China

Global warming is causing glaciers to retreat and glacial lakes to expand in the Himalayas,which amplifies the risk of glacial lake outburst debris flows(GLODFs)and poses a significant threat to downstream lives and ***,the complex interplay between GLODF occurrences and associated indicators,coupled with the lack of a comprehensive susceptibility indicator system that considers the entire GLODF process,presents a substantial challenge in assessing GLODF susceptibility in the *** study proposes a process-driven GLODF susceptibility assessment indicator system responding to climate change that considers the complete process of GLODF formation,incorporating relevant parameters about upstream,themselves,and downstream of glacial ***,to mitigate subjective factors associated with traditional evaluation methods,we developed three novel hybrid machine-learning models by integrating classic machine-learning algorithms with the whale optimization algorithm(WOA)to delineate the distribution of GLODF susceptibility in the *** the hybrid models effectively predicted the GLODFs occurrence,with the WOA-SVC model demonstrating the highest prediction *** 34%of the catchments exhibit high and very high susceptibility levels,primarily concentrated along the north and south sides of the Himalayan ridge,particularly in the eastern and central *** capturing the physical formation process of hazards,such as topographic potential(highest relative importance value of 40%),can precisely identify GLODF.A total of 128 catchments pose potential transboundary threats,with 24 classified as having a very high susceptibility level and 25 as having a high susceptibility ***,the border region between China and Nepal is a prominent hotspot for transboundary threats of *** findings can provide valuable clues for disaster prevention,mitigation,and cross-border coordination in the Himalayas.

关键词： Glacial lake outburst debris flow Susceptibility assessment Climate change Himalayas

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Investigation of a falling film tube bank heat exchanger with baffle design for water recovery applications

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Energy and Built Environment 2024年第5期5卷 817-828页

作者： Liang Tang Xiaoling Cao Wei Zhong Long Yu Linlin Yin Shandong Electric Power Engineering Consulting institute Corp. LTD.Jinan 250013PR China School of Mechanical Engineering Southwest Jiaotong UniversityChengdu 610031PR China

Shell and tube heat exchangers(STHE)are essential thermal equipment and widely used in daily life.A novel thermosyphon system called falling-film thermosyphon(FFTS)is introduced and integrated into STHE system,resulting in a better thermal *** this study,a rectangular solid tube bank of FFTS bundles with a baffle design is *** numerical simulation for heat and mass transfer of the FFTS heat exchanger is developed to predict the condensation rate of the vapor in the flue gas,and a lab-scale prototype is also built up in *** prediction is validated with the experimental data from references,and the model’s accuracy is verified within 10%-12%***,the Non-dominated Sorting Genetic Algorithm,version 2(NSGA-II)is implemented to improve the thermal performance of rectangular tube banks in this *** parameters,e.g.,baffle number,tube number,and tube space,are *** a result,compact configurations with more baffles are preferred to enhance the performance associated with a high-pressure drop *** optimized layout for the lab-scale prototype can increase by 18 to 32%condensation with a pressure loss of less than 200 Pa.

关键词： Falling film Heat transfer Condensation NSGA-II algorithm Heat exchanger

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The optimal atropine concentration for myopia control in Chinese children: a systematic review and network Metaanalysis

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1128-1137页

作者： Xiao-Yan Wang Hong-Wei Deng Jian Yang Xue-Mei Zhu Feng-Ling Xiang Jing Tu Ming-Xue Huang Yun Wang Jin-Hua Gan Wei-Hua Yang School of Nursing Southwest Medical UniversityLuzhou 646600Sichuan ProvinceChina Shenzhen Eye institute Shenzhen Eye HospitalJinan UniversityShenzhen 518040Guangdong ProvinceChina Luzhou Traditional Chinese Medicine Hospital Luzhou 646000Sichuan ProvinceChina The Affiliated Hospital of southwest Medical University Luzhou 646099Sichuan ProvinceChina

AIM:To figure out whether various atropine dosages may slow the progression of myopia in Chinese kids and teenagers and to determine the optimal atropine concentration for effectively slowing the progression of ***:A systematic search was conducted across the Cochrane Library,PubMed,Web of Science,EMBASE,CNKI,CBM,VIP,and Wanfang database,encompassing literature on slowing progression of myopia with varying atropine concentrations from database inception to January 17,*** extraction and quality assessment were performed,and a network Meta-analysis was executed using Stata version 14.0 *** were visually represented through ***:Fourteen papers comprising 2475 cases were included;five different concentrations of atropine solution were *** network Meta-analysis,along with the surface under the cumulative ranking curve(SUCRA),showed that 1%atropine(100%)>0.05%atropine(74.9%)>0.025%atropine(51.6%)>0.02%atropine(47.9%)>0.01%atropine(25.6%)>control in refraction change and 1%atropine(98.7%)>0.05%atropine(70.4%)>0.02%atropine(61.4%)>0.025%atropine(42%)>0.01%atropine(27.4%)>control in axial length(AL)***:In Chinese children and teenagers,the five various concentrations of atropine can reduce the progression of *** the network Meta-analysis showed that 1%atropine is the best one for controlling refraction and AL change,there is a high incidence of adverse effects with the use of 1%***,we suggest that 0.05%atropine is optimal for Chinese children to slow myopia progression.

关键词： atropine China children and adolescents myopia network Meta-analysis

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Bioinspired Hemostatic Strategy via Pulse Ejections for Severe Bleeding Wounds

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research 2024年第1期2023卷 281-299页

作者： Bitao Lu Enling Hu Weiwei Ding Wenyi Wang Ruiqi Xie Kun Yu Fei Lu Guangqian Lan Fangyin Dai State Key Laboratory of Silkworm Genome Biology College of SericultureTextile and Biomass SciencesSouthwest UniversityChongqing 400715China Chongqing Engineering research Center of Biomaterial Fiber and Modern Textile Chongqing 400715China Division of Trauma and Surgical Intensive Care Unit Research Institute of General SurgeryJinling HospitalMedical School of Nanjing UniversityNanjing210002 Jiangsu ProvinceChina Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHong KongChina

Efficient hemostasis during emergency trauma with massive bleeding remains a critical challenge in prehospital ***,multiple hemostatic strategies are critical for treating large bleeding *** this study,inspired by bombardier beetles to eject toxic spray for defense,a shape-memory aerogel with an aligned microchannel structure was proposed,employing thrombin-carrying microparticles loaded as a built-in engine to generate pulse ejections for enhanced drug *** aerogels,after contact with blood,can rapidly expand inside the wound,offering robust physical barrier blocking,sealing the bleeding wound,and generating a spontaneous local chemical reaction causing an explosivelike generation of CO_(2) microbubbles,which provide propulsion thrust to accelerate burst ejection from arrays of microchannels for deeper and faster drug *** ejection behavior,drug release kinetics,and permeation capacity were evaluated using a theoretical model and experimentally *** novel aerogel showed remarkable hemostatic performance in severely bleeding wounds in a swine model and demonstrated good degradability and biocompatibility,displaying great potential for clinical application in humans.

关键词： wound sealing offering

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Greenhouse gas emissions mitigation and economic viability of sugar crops in China

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Frontiers of Agricultural Science and Engineering 2024年第3期11卷 397-408,I0004页

作者： Linsheng YANG Xiaozhong WANG Wushuai ZHANG Prakash LAKSHMANAN Yan DENG Xiaojun SHI Xinping CHEN Fusuo ZHANG Interdisciplinary research Center for Agriculture Green Development in Yangtze River Basin College of Resources and EnvironmentSouthwest UniversityChongqing 400716China Key Laboratory of Low-carbon Green Agriculture in southwestern China(Ministry of Agriculture and Rural Affairs) Southwest UniversityChongqing 400716China Rice research institute Anhui Academy of Agricultural SciencesHefei 230031China Key Laboratory of Sugarcane Biotechnology and Genetic Improvement(Guangxi) Ministry of Agriculture and Rural AffairsGuangxi Key Laboratory of Sugarcane Genetic ImprovementGuangxi Academy of Agricultural SciencesSugarcane Research InstituteGuangxi Academy of Agricultural SciencesNanning 530007China Center for Resources Environment and Food SecurityChina Agricultural UniversityBeijing 100193China

Climate change mitigation is a major challenge of human ***,to this end,many countries including China are committed to achieving carbon neutrality within a few *** is a major sugarcane and sugar beet producing country and has one of the largest carbon footprint for sugarcane and sugar beet production globally.A comprehensive study was conducted on sugarcane and sugar beet crops grown in China for greenhouse gas(GHG)emissions mitigation potential,economic crop production from a sustainable sugar production ***-term trend analysis showed that yield and GHG emissions of sugarcane and sugar beet crops increased but the ratio of income to cost *** equation model analysis revealed nitrogen fertilizer and labor as the major drivers of GHG emissions for both sugarcane and sugar *** sugarcane and sugar beet,the path coefficient of N fertilizer were‒0.964 and‒0.835 and that of labor were 0.771 and 0.589,*** transitioning the current cropping system to an improved model with optimized labor,N input and machinery use,the GHG emissions and total annual cost of sugarcane and sugar beet production can be reduced by 32%and 24%,respectively,by 2030,compared to a business-as-usual *** is the first integrated and comparative study of environmental and economic sustainability of sugarcane and sugar beet production in *** findings will enable all stakeholders of Chinese sugarcane and sugar beet industries to transform them into environmentally and economically sustainable sugar production.

关键词： Economic profits GHG emissions labor input nitrogen input sugar

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Multidimensional Analgesia of Acupuncture by Increasing Expression of MD2 in Central Nervous System

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Chinese Journal of Integrative Medicine 2024年第11期30卷 1035-1044页

作者： LI Wan-rong REN Lu-lu ZHAO Tian-tian DAI Dan-qing GAO Xiao-fei LIANG Hua-zheng XIONG Li-ze Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation Shanghai Fourth People's Hospital School of Medicine Tongji University Clinical research Center for Anesthesiology and Perioperative Medicine Shanghai Fourth People's Hospital School of Medicine Tongji University Translational research institute of Brain and Brain-Like Intelligence Shanghai Fourth People's Hospital School of Medicine Tongji University Department of Anesthesiology and Perioperative Medicine Shanghai Fourth People's Hospital School of Medicine Tongji University School of Rehabilitation Southwest Jiaotong University Monash Suzhou research institute

Objective:To investigate changes of myeloid differentiation factor 2（MD2） in inflammationinduced pain and acupuncture-mediated ***:Mice were randomly divided into three groups by a random number table method:saline group（n=16）,complete Freund's adjuvant（CFA） group（n=24） and CFA+electroacupuncture（EA） group（n=26）.Inflammation-induced pain was modelled by injecting CFA to the plantar surface of the hind paw of mice and EA was applied to bilateral Zusanli（ST 36） to alleviate *** mice in the CFA+EA group received EA treatment（30 min/d for 2 weeks） 24 h after *** in the saline and CFA groups received sham ***-Frey test and Hargreaves test were used to assess the pain *** and spinal tissues were collected for immunofluorescence staining or Western blotting to quantify changes of MD2 ***:CFA successfully induced plantar pain and EA significantly alleviated pain 3 days after modelling（P0.05）.Fluorescence staining showed significant decrease in the level of MD2 in periagueductal gray（PAG） and locus coeruleus（LC） after CFA injection on day 7（P<0.01 for PAG,P<0.05 for LC） and EA significantly reversed this decrease（P<0.01 for PAG,P<0.05 for LC）.Conclusion:The unique changes of MD2 suggest that EA may exert the analgesic effect through modulating neuronal activities of the superficial laminae of the spinal cord and certai

关键词： dorsal horn electroacupuncture inflammation-induced pain locus coeruleus myeloid differentiation factor 2 periaqueductal gray

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Extremely stable Li-metal battery enabled by piezoelectric polyacrylonitrile quasi-solid-state electrolytes

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Journal of Materiomics 2024年第1期10卷 134-144页

作者： Hongzhi Peng Zhong Xu Yunjie Zhou Junfeng Huang Tao Yang Jieling Zhang Yong Ao Yanting Xie Hanyu He Xiong Zhang Weiqing Yang Haitao Zhang Key Laboratory of Advanced Technologies of Materials Ministry of EducationInstitute of Smart City and Intelligent TransportationSouthwest Jiaotong UniversityChengdu610031China Chengdu Metro Operation No.3 Company Chengdu610031China institute of Electrical Engineering Chinese Academy of SciencesBeijing100190China

Polymer solid-state electrolytes(PSSEs)are promising for solving the safety problem of Lithium(Li)metal batteries(LMBs).However,PSSEs with low modulus in nature are prone to be penetrated by lithium dendrites,resulting in short circuit of ***,we design and prepare piezoelectric BaTiO_(3)doped polyacrylonitrile(PAN@BTO)quasi-solid-state electrolytes(PQSSEs)by electrostatic spinning method to suppress dendritic *** piezoelectric polymer electrolytes are squeezed by nucleation and growth processes of Li dendrites,which can generate a piezoelectric electric field to regulate the deposition of Li^(+)ions and eliminate lithium ***,piezoelectric PAN@BTO PQSSEs enables highly stable Li plating/stripping cycling for over 2000 h at 0.15 mA/cm^(2)at room temperature(RT,25℃).Also,LiFePO_(4)|PAN@BTO|Li full cells demonstrate excellent cycle performance(136.9 mA·h/g and 78%retention after 600 cycles at 0.5 C)at ***,LiFePO_(4)|PAN@BTO|Li battery show extremely high safety and can still work normally under high-speed impact(2 Hz,∼30 kPa).We construct an in-situ cell monitoring system and disclose that the mechanism of suppressed lithium dendrite is originated from the generation of opposite piezoelectric potential and the feedback speed of intermittent piezoelectric potential signals is extremely fast.

关键词： Polymer solid-state electrolytes Polyacrylonitrile Piezoelectric effect Lithium metal battery Long-term stability Lithium dendrites

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Deletion of Axin1 in aggrecan-expressing cells leads to growth plate cartilage defects in adult mice

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Genes & Diseases 2024年第4期11卷 149-151页

作者： Dan Yi Hongting Jin William W.Lu Chunxiang Zhang Guozhi Xiao Liping Tonag Di Chen research Center for Computer-aided Drug Discovery Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China PFaculty of Pharmaceutical Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China The First College of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhouZhejiang 310053China Department of Cardiology Basic Medicine Innovation Centerfor Cardiometabolic Diseases of Ministry of EducationInstitute of Cardiovascular ResearchThe Affiliated HospitalSouthwest Medical UniversityLuzhouSichuan 646000China School of Medicine Southern University of Science and TechnologyShenzhenGuangdong 518055China

In mammals,skeletal bone development begins at hyaline cartilage formation at the early embryonic stage.1Then osteoblasts from the periosteum,which are distributed surrounding the hyaline cartilage,build up compact bone to formdiaphysis and spongy bone known as primary ossification center.1 Next,osteoclasts from the hematopoietic system destroy spongy bone to generate a medullary cavity.

关键词： cartilage skeletal medullary

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