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The importance of a potential phosphorylation site in enamelin on enamel formation

International Journal of Oral Science 2017年第4期9卷 210-215页

作者： Wen-Juan Yan Pan ma Ye Tian Jing-Ya Wang Chun-Lin Qin Jian Q Feng Xiao-Fang Wang Department of Biomedical Sciences and Center for Craniofacial Research and Diagnosis Texas A&M University College of DentistryDallasUSA Department of Endodontics Nanfang HospitalSouthern Medical UniversityGuangzhouChina

Enamelin （ENAm） has three putative phosphoserines （pSers） phosphorylated by a Golgi-associated secretory pathway kinase （FAm20C） based on their distinctive Ser-x-Glu （S-x-E） motifs. Fam2OC-knockout mice show severe enamel defects similar to those in the Enam-knockout mice, implying an important role of the pSers in ENAm. To determine the role of pSer5s in ENAm, we characterized ENAmRgsc514 mice, in which Sers5 cannot be phosphorylated by FAm20C due to an E57〉Gs7 mutation in the S-x-E motif, The enamel microstructure of 4-week-old mice was examined by scanning electron microscopy. The teeth of 6-day-old mice were characterized by histology and immunohistochemistry. The protein lysates of the first lower molars of 4-day-old mice were analyzed by Western immunoblotting using antibodies against ENAm, ameloblastin and amelogenin. ENAmRgsc514 heterozygotes showed a disorganized enamel microstructure, while the homozygotes had no enamel on the dentin surface. The N-terminal fragments of ENAm in the heterozygotes were detained in the ameloblasts and localized in the mineralization front of enamel matrix, while those in the WT mice were secreted out of ameloblasts and distributed evenly in the outer 1/2 of enamel matrix. Surprisingly, the 15 kDa C-terminal fragments of ameloblastin were not detected in the molar lysates of the homozygotes. These results suggest that the phosphorylation of SerSS may be an essential posttranslational modification of ENAm and is required for the interaction with other enamel matrix molecules such as ameloblastin in mediating the structural organization of enamel matrix and protein-mineral interactions during enamel formation.

关键词： ameloblastin enamel enamelin FAm20C phosphorylation phosphoserine

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中美研究生教育模式比较研究

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高等农业教育 2014年第8期 119-124页

作者：常新华 Yadong Qi 张志强王兰珍何艺玲赛江涛北京林业大学 Southern University and A&M College Baton Rouge 70813

中美两国的社会制度、经济制度和教育制度不同,因此研究生教育模式也存在差异,但培养优秀人才作为教育的根本目的却是相同的。以北京林业大学和美国南方大学及Am学院为例,从研究生制度、研究生招学位类型与培养目标、研究生课程设置与... 详细信息

中美两国的社会制度、经济制度和教育制度不同,因此研究生教育模式也存在差异,但培养优秀人才作为教育的根本目的却是相同的。以北京林业大学和美国南方大学及Am学院为例,从研究生制度、研究生招学位类型与培养目标、研究生课程设置与教学方法、研究生培养过程管理与淘汰制等方面对中美研究生教育进行了对比分析,并结合我国研究生教育的实际情况,借鉴美国经验,对我国研究生教育提出了相关改进建议。

关键词：研究生教育模式研究生招生学位类型教学方法淘汰制

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PRELImINARY STUDY ON SKIN CANCER DETECTION IN SENCAR mICE USING mUELLER OPTICAL COHERENCE TOmOGRAPHY

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Journal of Innovative Optical Health Sciences 2009年第3期2卷 289-294页

作者： mILOˇS TODOROVI´C SHULIANG JIAO GEORGE STOICA LIHONG V.WANG Department of Biomedical Engineering Texas A&M University College StationTexas 77843-3120USA Department of Ophthalmology Keck School of Medicine University of Southern CaliforniaLos AngelesCalifornia 90033USA Department of Pathobiology Texas A&M University College StationTexas 77843-5547USA

We report on the use of a fiber-based mueller-matrix optical coherence tomography(OCT)system with continuous source-polarization modulation for in vivo imaging of early stages of skin cancer in SENCAR mice.A homemade hand-held probe with integrated optical scanning and beam delivering optics was coupled in the sample arm.The OCT images show the morphological changes in skin resulting from pre-cancerous papilloma formations that are consistent with histology,thus demonstrating the system’s potential for early skin cancer detection.

关键词： Coherence imaging medical and biological imaging optical coherence tomography birefringence polarization turbid media

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modular next generation fast-neutron detector for portal monitoring

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Nuclear Science and Techniques 2022年第1期33卷 140-148页

作者： E.Aboud S.Ahn G.V.Rogachev V.E.Johnson J.Bishop G.Christian E.Koshchiy C.E.Parker D.P.Scriven Cyclotron Institute Texas A&M UniversityCollege StationTX 77843USA Department of Physics and Astronomy Texas A&M UniversityCollege StationTX 77843USA Department of Statistics Texas A&M UniversityCollege StationTX 77843USA

Nuclear nonproliferation is of critical importance for global security.Dangerous fissile materials including highly enriched uranium and weapons-grade plutonium are especially important to detect.Active interrogation techniques may result in much better sensitivity but are difficult with conventional portal monitors that rely on detecting thermal neutrons.Also,most conventional portal monitoring systems rely on ^(3)He,which has a finite and continually decreasing supply.By designing a highly segmented array of organic scintillators,we posit that we can accurately and quickly identify fissile materials,including weapons-grade plutonium and highly enriched uranium,being smuggled.We propose a new design for a fast-neutron detector that overcomes the limitations of the current generation of portal monitors.mCNP6 simulations have been performed in conjunction with the UmPBT statistical model to determine the sensitivity limitations of the proposed detector.Results suggest that the proposed detector may be 10 times more efficient than current-generation thermal neutron detectors and may be able to positively identify a 81 mg 235U source in as little as 192 seconds utilizing active interrogation techniques.

关键词： Fast-neutron detection Portal monitoring Nonproliferation

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NADPH oxidase family proteins:signaling dynamics to disease management

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Cellular & molecular Immunology 2022年第6期19卷 660-686页

作者： Rizwana Begum Shilpa Thota Abubakar Abdulkadir Gagandeep Kaur Prathyusha Bagam Sanjay Batra Present address:Department of Environmental medicine University of RochesterSchool of Medicine and DentistryRochesterNY14642USA Laboratory of Pulmonary Immunotoxicology Department of Environmental ToxicologySouthern University and A&M CollegeBaton RougeLA70813USA Present address:Division of Systems Biology National Center for Toxicological ResearchJeffersonAR72079USA

Reactive oxygen species(ROS)are pervasive signaling molecules in biological systems.In humans,a lack of ROS causes chronic and extreme bacterial infections,while uncontrolled release of these factors causes pathologies due to excessive inflammation.Professional phagocytes such as neutrophils(PmNs),eosinophils,monocytes,and macrophages use superoxide-generating NADPH oxidase(NOX)as part of their arsenal of antimicrobial mechanisms to produce high levels of ROS.NOX is a multisubunit enzyme complex composed of five essential subunits,two of which are localized in the membrane,while three are localized in the cytosol.In resting phagocytes,the oxidase complex is unassembled and inactive;however,it becomes activated after cytosolic components translocate to the membrane and are assembled into a functional oxidase.The NOX isoforms play a variety of roles in cellular differentiation,development,proliferation,apoptosis,cytoskeletal control,migration,and contraction.Recent studies have identified NOX as a major contributor to disease pathologies,resulting in a shift in focus on inhibiting the formation of potentially harmful free radicals.Therefore,a better understanding of the molecular mechanisms and the transduction pathways involved in NOX-mediated signaling is essential for the development of new therapeutic agents that minimize the hyperproduction of ROS.The current review provides a thorough overview of the various NOX enzymes and their roles in disease pathophysiology,highlights pharmacological strategies,and discusses the importance of computational modeling for future NOX-related studies.

关键词： NADPH oxidase Reactive oxygen species Inflammation Inhibitors In silico

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Revealing the linguistic and geographical disparities of public awareness to Covid-19 outbreak through social media

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International Journal of Digital Earth 2022年第1期15卷 868-889页

作者： Binbin Lin Lei Zou Nick Duffield Ali mostafavi Heng Cai Bing Zhou Jian Tao mingzheng Yang Debayan mandal Joynal Abedin Department of Geography Texas A&M UniversityCollege StationTXUSA Department of Electrical & Computer Engineering Texas A&M UniversityCollege StationTXUSA Department of Civil & Environmental Engineering Texas A&M UniversityCollege StationTXUSA Department of Visualization Texas A&M UniversityCollege StationTXUSA

The Covid-19 has presented an unprecedented challenge to public health worldwide.However,residents in different countries showed diverse levels of Covid-19 awareness during the outbreak and suffered from uneven health impacts.This study analyzed the global Twitter data from January 1st to June 30th,2020,to answer two research questions.What are the linguistic and geographical disparities of public awareness in the Covid-19 outbreak period reflected on social media?Does significant association exist between the changing Covid-19 awareness and the pandemic outbreak?We established a Twitter data mining framework calculating the Ratio index to quantify and track awareness.The lag correlations between awareness and health impacts were examined at global and country levels.Results show that users presenting the highest Covid-19 awareness were mainly those tweeting in the official languages of India and Bangladesh.Asian countries showed more disparities in awareness than European countries,and awareness in Eastern Europe was higher than in central Europe.Finally,the Ratio index had high correlations with global mortality rate,global case fatality ratio,and country-level mortality rate,with 21-31,35-42,and 13–18 leading days,respectively.This study yields timely insights into social media use in understanding human behaviors for public health research.

关键词： Social media Covid-19 public awareness geographical disparities linguistic disparities

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Hierarchically porous metal–organic frameworks:synthetic strategies and applications

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National Science Review 2020年第11期7卷 1743-1758页

作者： Liang Feng Kun-Yu Wang Xiu-Liang Lv Tian-Hao Yan Hong-Cai Zhou Department of Chemistry Texas A&M UniversityCollege Station Department of materials Science and Engineering Texas A&M UniversityCollege Station

Despite numerous advantages, applications of conventional microporous metal–organic frameworks (mOFs) are hampered by their limited pore sizes, such as in heterogeneous catalysis and guest delivery,which usually involve large molecules. Construction of hierarchically porous mOFs (HP-mOFs) is vital to achieve the controllable augmentation of mOF pore size to mesopores or even macropores, which can enhance the diffusion kinetics of guests and improve the storage capacity. This review article focuses on recent advances in the methodology of HP-mOF synthesis, covering preparation of HP-mOFs with intrinsic hierarchical pores, and modulated, templated and template-free synthetic strategies for HP-mOFs.The key factors which affect the formation of HP-mOF architectures are summarized and discussed,followed by a brief review of their applications in heterogeneous catalysis and guest encapsulation. Overall,this review presents a roadmap that will guide the future design and development of HP-mOF materials with molecular precision and mesoscopic complexity.

关键词： metal–organic frameworks hierarchical design synthesis application

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microencapsulated paraffin as a tribological additive for advanced polymeric coatings

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Friction 2023年第10期11卷 1939-1952页

作者： Reza GHEISARI mariela VAZQUEZ Vasilis TSIGKIS Ali ERDEmIR Karen L.WOOLEY Andreas A.POLYCARPOU J.mike Walker’66 Department of mechanical Engineering Texas A&M UniversityCollege Station 77843USA Department of Chemistry Texas A&M UniversityCollege Station 77843USA Department of materials Science&Engineering Texas A&M UniversityCollege Station 77843USA Department of Chemical Engineering Texas A&M UniversityCollege Station 77843USA

Numerous tribological applications,wherein the use of liquid lubricants is infeasible,require adequate dry lubrication.Despite the use of polymers as an effective solution for dry sliding tribological applications,their poor wear resistance prevents the utilization in harsh industrial environment.Different methods are typically implemented to tackle the poor wear performance of polymers,however sacrificing some of their mechanical/tribological properties.Herein,we discussed the introduction of a novel additive,namely microencapsulated phase change material(mPCm)into an advanced polymeric coating.Specifically,paraffin was encapsulated into melamine-based resin,and the capsules were dispersed in an aromatic thermosetting co-polyester(ATSP)coating.We found that the mPCm-filled composite exhibited a unique tribological behavior,manifested as“zero wear”,and a super-low coefficient of friction(COF)of 0.05.The developed composite outperformed the state-of-the-art polytetrafluoroethylene(PTFE)-filled coatings,under the experimental conditions examined herein.

关键词： microencapsulated phase change material(mPCm) friction reduction additive advanced polymeric coating

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multiple-plateau structure and scaling relation in photoelectron spectra of high-order above-threshold ionization

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Chinese Physics B 2012年第5期21卷 159-166页

作者：吴艳叶会亮张敬涛郭东升 State Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of Sciences Southern University and A&M College LA 70813USA

By developing a full quantum scattering theory of high-order above-threshold ionization,we study the energy spectra and the angular distributions of photoelectrons from atoms with intense laser fields shining on them.We find that real rescattering can occur many times,and even infinite times.The photoelectrons from the rescattering process form a broad plateau in the kinetic-energy spectrum.We further disclose a multiple-plateau structure formed by the high-energy photoelectrons,which absorb many photons during the rescattering process.moreover,we find that both the angular distributions and the kinetic-energy spectra of photoelectrons obey the same scaling law as that for directly emitted photoelectrons.

关键词： photoelectron energy spectrum rescattering process photoelectron angular distribution

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Implications of regional identity for neural stem and progenitor cell transplantation in the injured or diseased nervous system

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Neural Regeneration Research 2024年第4期19卷 715-716页

作者： Prakruthi Amar Kumar Jennifer N.Dulin Department of Biology Texas A&M UniversityCollege Station Texas a&m Institute for Neuroscience Texas A&M UniversityCollege Station

Neural stem and progenitor cell(NSPC)transpla ntation has emerged as a promising therapeutic strategy for replacing lost neuronal populations and repairing damaged neural circuits following nervous system injury and disease.A great deal of experimental work has investigated the biology of NSPC grafting in preclinical animal models;more recently.

关键词： neural system injured

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