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Cancer Drug Resistance 2023年第2期6卷 378-389页

作者： Jiuhui Wang Daotai Nie Department of Medical Microbiology Immunology and Cell BiologySouthern Illinois University School of MedicineSpringfieldIL 62794USA Simmons Cancer Institute Southern Illinois University School of MedicineSpringfieldIL 62794USA

Aim:The nuclear pregnane X receptor(PXR)is a pivotal regulator of steroid and xenobiotics metabolism and plays an important role in shaping tumor cell responses to *** within tumor tissue has multifaceted effects,including multiple drug *** goal of this study was to determine whether PXR contributes to hypoxia-induced drug ***:Metastatic prostate cancer cells were used to study the interaction of PXR and hypoxia-inducible factor-1(HIF-1 in drug resistance associated with *** activities of PXR and HIF-1 were determined by assays for its reporter gene or target gene ***-immunoprecipitation(Co-IP)was used to determine the interaction of PXR and *** or inhibition of PXR or HIF-1 was used to determine their roles in hypoxia-induced ***:PXR was activated by hypoxia,leading to increased expression of multidrug resistance protein 1(MDR1).Inhibition of PXR by pharmacological compounds or depletion by shRNAs reduced the hypoxic induction of MDR1 and sensitized prostate cancer cells to chemotherapy under ***-1 was required for PXR activation under ***-immunoprecipitation results showed that HIF-1 and PXR could physically interact with each other,leading to crosstalk between these two transcription ***:PXR contributes to hypoxia-induced drug resistance in prostate cancer cells through its interaction with HIF-1.

关键词： PXR HIF-1 prostate cancer chemoresistance multidrug resistance MDR1 hypoxia

Mechanistic understanding on oxygen evolution reaction on γ-Fe OOH(010) under alkaline condition based on DFT computational study

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Chinese Journal of Catalysis 2017年第9期38卷 1621-1628页

作者： Miru Tang Qingfeng Ge Department of Chemistry and Biochemistry Southern Illinois University Carbondale IL 62901 USA

An efficient and economical oxygen evolution reaction(OER)catalyst is critical to the widespread application of solar energy to fuel *** many potential OER catalysts,the metal oxyhydroxides,especially FeOOH,show promising OER *** the present work,we performed a DFT+U study of the OER mechanism on theγ‐FeOOH(010)*** particular,we established the chemical potential of the OH?and hole pair and included the OH?anion in the reaction pathway,accounting to the alkaline conditions of anodic OER *** then analyzed the OER pathways on the surface with OH‐,O‐and Fe‐*** the surface with OH‐and O‐terminations,the O2molecule could form from either OH reacting with the surface oxygen species(-OH*and-O*)or the combination of two surface oxygen *** the Fe‐terminated surface,O2can only form by adsorbing OH on the Fe sites *** potential‐limiting step of the oxygen evolution with different surface terminations was determined by following the free‐energy change of the elementary steps along each *** results show that oxygen formation requires recreating the surface Fe sites,and consequently,the condition that favors the partially exposed Fe sites will promote oxygen formation.

关键词： Water splitting Oxygen evolution reaction DFT + U Iron oxyhydroxides

Management of coal processing wastes： studies on an alternate technology for control of sulfate and chloride discharge

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International Journal of Coal Science & Technology 2018年第1期5卷 54-63页

作者： Paul T. Behum Yoginder P. Chugh Liliana Lefticariu Office of Surface Mining and Reclamation Enforcement Alton IL 62002 USA National Academy of Inventors Tampa FL 33612 USA Department of Mining and Mineral Engineering Southern Illinois University Carbondale Carbondale IL 62901 USA Department of Geology Southern Illinois University Carbondale Carbondale IL 62901 USA

Management of coal mining and coal processing wastes, particularly of high sulfur coals, can generate excessive amounts of sulfate （SO4^2-） and chloride （Cl^-） in mine drainage that are known to negatively impact quality of both surface and ground water. The U.S. Environmental Protection Agency provides guidance to states on allowable SO4^2- and Cl^- discharges from mine sites. This research evaluates the hypothesis that co-disposal of CCPW and FCPW with appropriate compaction can result in improved geochemical and geotechnical environments that will minimize acid mine drainage formation and SO4^2- and Cl^- discharges. Addition of ground limestone （ag-lime） to the mix was also evaluated as a drying agent and for improvement in overall geochemistry by buffering higher pH values within the coal waste. These objectives were to develop and implement innovative concepts for engineered co-management of CCPW and FCPW at coal mining sites. The authors performed long-term field column leaching studies to analyze improvement in SO4^2- and Cl^- in water quality. Requirements for stricter standards in some states led to the need for development of potentially improved environmental practices. This paper presents the overall encouraging results of the field kinetic studies.

关键词： Kinetic testing Acid mine drainage Coal chemistry Interior Basin Refuse co-disposal

Bird-plant interactions and vulnerability to biological invasions

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Journal of Plant Ecology 2016年第6期9卷 692-702页

作者： Adam D.Chupp Loretta L.Battaglia Department of Plant Biology Southern Illinois UniversityLife Sciences IIMail Code 6509CarbondaleIL 62901-6509USA

Aims Species interactions regulate the invasiveness of non-native species and as declines of native tree species escalate,exotic tree species that offer supplementary resources to animal seed-dispersers should expand their distributions as they fill ecological *** primary objective was to forecast impacts from an imminent biological invasion(laurel wilt disease)by quantifying resources provided by native(threatened)and exotic fruits(disease-resistant)and associated bird foraging *** In the southeastern USA,we tested for redundancy among the resources provided by native and exotic fruits to overwintering *** between abundant subcanopy species Persea borbonia(native)and Cinnamomum camphora(exotic)were paramount considering the widespread disease-induced decline of ***,and the biological and phylogenetic similarities between these *** two winter survey periods,we quantified fruit removal and documented bird species using motion-activated cameras in the *** and chemical fruit characteristics were also *** Findings Foraging bouts on both *** and *** fruits were documented for four native bird *** was no difference in selectivity between fruit types during Year 1 of our survey,but there was a significant preference for *** fruit in Year 2;the change in preference was correlated with significantly lower temperatures in Year *** the pulp/seed ratio and moisture content differed,the nutritional content of fruit pulp(g/100 g)was similar between fruit *** the apparent redundancy among these native and exotic fruit resources,we forecast increases in the consumption and dispersal of exotic propagules following the widespread laurel wilt disease-induced decline of *** and other native fruit bearing members of *** empirically based prediction is among the first to document exotic forest pathogens as indirect threats to native bird-plant int

关键词： bird frugivory forest pests and pathogens Cinnamomum camphora laurel wilt disease Persea borbonia

A DFT study of CO_2 electrochemical reduction on Pb(211) and Sn(112)

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Science China Chemistry 2015年第4期58卷 607-613页

作者： Chaonan Cui Hua Wang Xinli Zhu Jinyu Han Qingfeng Ge Key Laboratory for Green Chemical Technology School of Chemical Engineering and Technology Tianjin University Collaborative Innovation Center of Chemical Science and Engineering Department of Chemistry and Biochemistry Southern Illinois University

Electrochemical reduction of CO2 has the benefit of turning greenhouse gas emissions into useful resources. We performed a comparative study of the electrochemical reduction of CO2 on stepped Pb(211) and Sn(112) surfaces based on the results of density functional theory slab calculations. We mapped out the potential energy profiles for electrochemical reduction of CO2 to formate and other possible products on both surfaces. Our results show that the first step is the formation of the adsorbed formate(HCOO*) species through an Eley-Rideal mechanism. The formate species can be reduced to HCOO- through a oneelectron reduction in basic solution, which produces formic acid as the predominant product. The respective potentials of forming HCOO* are predicted to be -0.72 and -0.58 V on Pb and Sn. Higher overpotentials make other reaction pathways accessible, leading to different products. On Sn(112), CO and CH4 can be generated at -0.65 V following formate formation. In contrast, the limiting potential to access alternative reaction channels on Pb(211) is -1.33 V, significantly higher than that of Sn.

关键词： electrochemical reduction reaction mechanism carbon dioxide formate DFT

Semiotic Paradigms of Self and Person:The Perspectives Model of Communicology as the Logic Foundation of Human Science

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Language and Semiotic Studies 2015年第1期1卷 106-129页

作者： Richard Lanigan southern illinois University

Originally proposed by Timothy Leary, the perspective model of interpersonal communication analyzes semiotic comportment at three levels of exchange: Public Communication(Level I) where a person's overt verbal and nonverbal behavior is observed by both the Self and Other in a given situation; Conscious Descriptions(Level II) which are the perceived verbal contents of messages and codes exchanged by the Self and Other; Private Symbolization(Level III) which consists of projective, indirect, imaginative content of the Self and Other as attributed to both the Self and Other. As discussed by Wilden, the French psychoanalyst Jacques Lacan uses the simple terminology of the Real, the Imaginary, and the Symbolic to refer to the respective discourse levels. Subsequent communicologists have adopted the terminology of(1) Direct Perspective,(2) Meta-Perspective, and(3) Meta-Meta-Perspective. The perspectives model thus becomes an applied example of semiotic phenomenological method which progressively moves from(1) Description, to(2) Reduction, and to(3) Interpretation in the analysis and functional specification of human communication. These combinatory eidetic(verbal) and empirical(nonverbal) semiotic codes depict cultural preferences thereby defining the Self in theory and practice.

关键词： communicology person human science semiotic square

大脑血管内胆碱乙酰转移酶免疫反应活性(英文)

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中国药理学与毒理学杂志 1992年第1期6卷 28-35页

作者： Jun-Ge YU Jang-Yen WU Tony J-F LEE Department of Pharmacology Southern Illinois University School of Medicine Springfield Illinois 62794-19230 USADepartment of Pharmacology Southern Illinois University School of Medicine Springfield Illinois 62794-19230 USADepartment of Pharmacology Southern Illinois University School of Medicine Springfield Illinois 62794-19230 USA

本文采用间接免疫荧光染色(双抗体法)和非标记抗体-过氧化物酶-抗过氧化物酶法(PAP法),使用抗纯化胆碱乙酰转移酶(CHAT)抗体,对猫和猪各种体积的脑软膜动静脉,脑实质内微血管以及脉络丛的乙酰胆碱能神经的存在和分布进行了研究。结果表... 详细信息

本文采用间接免疫荧光染色(双抗体法)和非标记抗体-过氧化物酶-抗过氧化物酶法(PAP法),使用抗纯化胆碱乙酰转移酶(CHAT)抗体,对猫和猪各种体积的脑软膜动静脉,脑实质内微血管以及脉络丛的乙酰胆碱能神经的存在和分布进行了研究。结果表明,脑软膜动静脉的ChAT免疫反应性神经主要是成束状的,只有少数是由细小纤维组成,静脉的此类神经供应少于其动脉供应程度,同时,ChAT免疫反应纤维的密度又与血管的体积成比例,在小分枝的动静脉上(外径小于30μm)通常观察不到此类纤维的存在,脉络丛的动静脉有ChAT免疫反应性神经存在,但此类神经在实质内微血管则观察不到,以上结果与以前报告过的颅内和实质外动脉的乙酰胆碱酯酶(AChE)性纤维的密度比同类静脉所存在密度大的结果相符,而ChAT免疫反应纤维分布的方式则与报告过的AChE性纤维的分布方式不同,后者主要是由细小纤维组成,尽管离体的实质内微血管无ChAT免疫反应纤维,但胆碱能神经接近和“突触化”此类微血管的可能性不能排除,脑软膜血管一些内皮细胞胞浆内也有ChAT免疫反应活性存在,因此,本文结果与神经元和血管内皮两者的胆碱能机构在控制脑循环中起着重要作用之假说相一致。

关键词：胆碱乙酰转移酶胆碱能神经支配

Synthesis and crystal structure of (E)-[(2-cyclohexenyl) vinyl]triaryltin

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Chinese Journal of Chemistry 1998年第1期16卷 22-27页

作者：黄葵傅方信潘华德 Department of Chemistry Northeast Normal University Changchun Jilin 130024 China Current address: Department of Chemistry Southern Illinois University at Carbondale IL. USA.

(E)-[(2-Cyclohexenyl)vinyl]triaryltin (aryl=phenyl, p-tolyl) were synthesized and characterized by elemental analysis, IR, H-1 NMR spectroscopy. The crystal structure of (E)-[(2-cyclohexenyl)vinyl]triphenyltin was also determined by the X-ray diffraction. Experiments show that this compound has the conjugated system, which makes it have possible bioactivity and antitumor activity.

关键词： organotin compounds crystal structure pi-pi conjugated system

Contagion or Real Linkages? Some Evidence from China's Emerging Parallel Markets

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China & World Economy 2007年第4期15卷 52-65页

作者： Ali M. Kutan Professor of Economics Economics and Finance Department School of BusinessSouthern Illinois University Edwardsville USA.

This paper empirically tests the existence of contagion using data on China ＇ s five parallel markets with different entry barriers for foreign capital. Taking the 1997 stock market crash as our experiment and using data on A, B and H shares, red chips and American depository receipts, the present paper tests whether these China-backed market returns respond differently to foreign shocks during the pre-1997 and post-1997 crash period. Evidence suggests that the contagion effects are stronger in markets with fewer entry barriers. An important implication of our findings is that countries vulnerable to contagion could be justified to impose some limits on capital flows.

关键词： American depository receipt capital control China contagion stock market

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猫大脑动脉的胆碱能性血管收缩(英文)

中国药理学与毒理学杂志 1992年第1期6卷 19-27页

作者： Matthew D LINNIK Tony J-F LEE Department of Pharmacology Southern Illinois University School of Medicine Springfield Illinois 62794 9230 USADepartment of Pharmacology Southern Illinois University School of Medicine Springfield Illinois 62794 9230 USA

本文对猫脑动脉的胆碱能神经冲动传递的离体研究结果进行如下两方面的探讨:1)在乙酰胆碱亚舒张浓度下的反应;2)在阿托品敏感性神经源性血管舒张的可能性上的争议. 观察结果表明,55％的脑动脉血管条对0.1～3nmol·L^(-1)浓度的乙酰胆碱(A... 详细信息

本文对猫脑动脉的胆碱能神经冲动传递的离体研究结果进行如下两方面的探讨:1)在乙酰胆碱亚舒张浓度下的反应;2)在阿托品敏感性神经源性血管舒张的可能性上的争议. 观察结果表明,55％的脑动脉血管条对0.1～3nmol·L^(-1)浓度的乙酰胆碱(ACh)产生了收缩反应,高于上述浓度的乙酰胆碱引起了血管内皮依赖性的舒张反应.进一步提高乙酰胆碱浓度则导致直接的血管平滑肌的收缩反应,0.1～3 nmol·L^(-1)亚舒张浓度乙酰胆碱引起的血管收缩反应以及高于此浓度乙酰胆碱所致的血管内皮依赖性舒张反应仅发生干预先已收缩而有张力的脑血管,亚舒张浓度乙酰胆碱(0.1～3nmol·L^(-1))所致的收缩反应并不依赖于血管内皮的存在,在Krebs溶液4℃条件下保存5d的同样脑血管对亚舒张浓度乙酰胆碱(0.1～3nmol·L^(-1))所致的收缩反应频率下降至13％,但血管内皮依赖性舒张反应或直接的血管平滑肌收缩反应在如此条件下保存的脑血管上依然完好. 以上结果与乙酰胆碱作为脑血管神经末梢递质导致神经源性血管舒张的假说是不相符合的。

关键词：脑动脉毒蕈碱能受体拮抗剂