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Youheng Tang,the pioneering founder of south china Agricultural university

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Protein & Cell 2022年第3期13卷 157-162页

作者： Yuan Chen Alan WAdame Ge-Zhi Chen Yuanyuan Meng south china Agricultural university Guangzhou 510642China Shenzhen Middle School International Department Shenzhen 518001China Beijing Institutes of Life Science Chinese Academy of SciencesBeijing 100101China

Living during the eve of the Qing Dynasty,Youheng Tang(唐有恒)was a pioneer of agricultural education and agronomy research in china.He sought neither money nor vanity,only to fulfill his deep-seated dream to benefit the nation.In addition to being a Chinese agricultural educator,agricultural sciences scholar,and modern agricultural science and education entrepreneur in Guangdong Province,Youheng Tang was also the founder of south china Agricultural university(Fig.1).

关键词： Agricultural education money

仿病毒膜融合型纳米囊泡在体制备CAR-T细胞

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Science Bulletin 2024年第3期69卷 354-366页

作者：赵贵张玥许从飞王均 School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhou 511442China National Engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou 510006China Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of TechnologyGuangzhou 510006China Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education South China University of TechnologyGuangzhou 510006China

Engineered T cells expressing chimeric antigen receptor(CAR)exhibit high response rates in B-cell malignancy treatments and possess therapeutic potentials against various diseases.However,the complicated ex vivo production process of CAR-T cells limits their application.Herein,we use virus-mimetic fusogenic nanovesicles(FuNVs)to produce CAR-T cells in vivo via membrane fusion-mediated CAR protein delivery.Briefly,the FuNVs are modified using T-cell fusogen,adapted from measles virus or reovirus fusogens via displaying anti-CD3 single-chain variable fragment.The FuNVs can efficiently fuse with the T-cell membrane in vivo,thereby delivering the loaded anti-CD19(aCD19)CAR protein onto T-cells to produce aCD19 CAR-T cells.These aCD19 CAR-T cells alone or in combination with anti-OX40 antibodies can treat B-cell lymphoma without inducing cytokine release syndrome.Thus,our strategy provides a novel method for engineering T cells into CAR-T cells in vivo and can further be employed to deliver other therapeutic membrane proteins.

关键词： CAR-T Nanovesicle Fusogen Cancer immunotherapy

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Resisting metal aggregation in pyrolysis of MOFs towards highdensity metal nanocatalysts for efficient hydrazine assisted hydrogen production

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Nano Research 2023年第5期16卷 6067-6075页

作者： Jieting Ding Danyu Guo Anqian Hu Xianfeng Yang Kui Shen Liyu Chen Yingwei Li School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou 510640China Analytical and Testing Centre South China University of TechnologyGuangzhou 510640China South China University of Technology-Zhuhai Institute of Modern Industrial Innovation Zhuhai 519175China

The preparation of supported high-density metal nanoparticles(NPs)is of great importance to boost the performance in heterogeneous catalysis.Thermal transformation of metal-organic frameworks(MOFs)has been demonstrated as a promising route for the synthesis of supported metal NPs with high metal loadings,but it is challenge to achieve uniform metal dispersion.Here we report a strategy of“spatial isolation and dopant anchoring”to resist metal aggregation in the pyrolysis of MOFs through converting a bulk MOF into dual-heteroatom-containing flower-like MOF sheets(B/N-MOF-S).This approach can spatially isolate metal ions and increase the number of anchoring sites,thus efficiently building physical and/or chemical barriers to cooperatively prevent metal NPs from aggregation in the high-temperature transformation process.After thermolysis at 1,000℃,the B/N-MOFS affords B,N co-doped carbon-supported Co NPs(Co/BNC)with uniform dispersion and a high Co loading of 37.3 wt.%,while untreated bulk MOFs yield much larger sizes and uneven distribution of Co NPs.The as-obtained Co/BNC exhibits excellent electrocatalytic activities in both hydrogen evolution and hydrazine oxidation reactions,only a voltage of 0.617 V at a high current density of 100 mA·cm^(−2)is required when applied to a two-electrode overall hydrazine splitting electrolyzer.

关键词： electrocatalysis metal-organic frameworks metal nanoparticles overall hydrazine splitting thermal transformation

Distributionally Robust Optimal Dispatch of Offshore Wind Farm Cluster Connected by VSC-MTDC Considering Wind Speed Correlation

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CSEE Journal of Power and Energy Systems 2023年第3期9卷 1021-1035页

作者： Xiangyong Feng Shunjiang Lin Wanbin Liu Weikun Liang Mingbo Liu School of Electric Power Engineering South China University of TechnologyGuangzhou 510640China Guangdong Key Laboratory of Clean Energy technology South China University of TechnologyGuangzhou 511458China

Multi-terminal voltage source converter-based highvoltage direct current(VSC-MTDC)transmission technology has become an important mode for connecting adjacent offshore wind farms(OWFs)to power systems.Optimal dispatch of an OWF cluster connected by the VSC-MTDC can improve economic operation under the uncertainty of wind speeds.A two-stage distributionally robust optimal dispatch(DROD)model for the OWF cluster connected by VSC-MTDC is established.The first stage in this model optimizes the unit commitment of wind turbines to minimize mechanical loss cost of units under the worst joint probability distribution(JPD)of wind speeds,while the second stage searches for the worst JPD of wind speeds in the ambiguity set(AS)and optimizes active power output of wind turbines to minimize the penalty cost of the generation deviation and active power loss cost of the system.Based on the Kullback–Leibler(KL)divergence distance,a data-driven AS is constructed to describe the uncertainty of wind speed,considering the correlation between wind speeds of adjacent OWFs in the cluster by their joint PD.The original solution of the two-stage DROD model is transformed into the alternating iterative solution of the master problem and the sub-problem by the column-and-constraint generation(C&CG)algorithm,and the master problem is decomposed into a mixedinteger linear programming and a continuous second-order cone programming by the generalized Benders decomposition method to improve calculation efficiency.Finally,case studies on an actual OWF cluster with three OWFs demonstrate the correctness and efficiency of the proposed model and algorithm.

关键词： C&CG algorithm distributionally robust optimization generalized Benders decomposition offshore wind farm wind speed correlation

Scale adaptive fitness evaluation‐based particle swarm optimisation for hyperparameter and architecture optimisation in neural networks and deep learning

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CAAI Transactions on Intelligence technology 2023年第3期8卷 849-862页

作者： Ye‐Qun Wang Jian‐Yu Li Chun‐Hua Chen Jun Zhang Zhi‐Hui Zhan School of Computer Science and Engineering South China University of TechnologyGuangzhouChina School of Software Engineering South China University of TechnologyGuangzhouChina Hanyang university AnsanSouth Korea

Research into automatically searching for an optimal neural network(NN)by optimi-sation algorithms is a significant research topic in deep learning and artificial intelligence.However,this is still challenging due to two issues:Both the hyperparameter and ar-chitecture should be optimised and the optimisation process is computationally expen-sive.To tackle these two issues,this paper focusses on solving the hyperparameter and architecture optimization problem for the NN and proposes a novel light‐weight scale‐adaptive fitness evaluation‐based particle swarm optimisation(SAFE‐PSO)approach.Firstly,the SAFE‐PSO algorithm considers the hyperparameters and architectures together in the optimisation problem and therefore can find their optimal combination for the globally best NN.Secondly,the computational cost can be reduced by using multi‐scale accuracy evaluation methods to evaluate candidates.Thirdly,a stagnation‐based switch strategy is proposed to adaptively switch different evaluation methods to better balance the search performance and computational cost.The SAFE‐PSO algorithm is tested on two widely used datasets:The 10‐category(i.e.,CIFAR10)and the 100−cate-gory(i.e.,CIFAR100).The experimental results show that SAFE‐PSO is very effective and efficient,which can not only find a promising NN automatically but also find a better NN than compared algorithms at the same computational cost.

关键词： deep learning evolutionary computation hyperparameter and architecture optimisation neural networks particle swarm optimisation scale‐adaptive fitness evaluation

A polymeric co-assembly of subunit vaccine with polyoxometalates induces enhanced immune responses

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Nano Research 2022年第5期15卷 4175-4180页

作者： Xinpei Li Xiaofeng He Dongrong He Yuan Liu Kun Chen Panchao Yin south china Advanced Institute for Soft Matter Science and technology School of Molecular Science and EngineeringSouth China University of TechnologyGuangzhou 510640China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhou 510640China

Long-lasting protective immune responses are expected following vaccination.However,most vaccines alone are inability to evoke an efficient protection.The combinatory administration of adjuvants with vaccines is critical for generating the enhanced immune responses.Herein,with biocompatible poly(4-vinylpyridine)(P4VP)as template,2.5 nm iron/molybdenum oxide cluster,{Mo_(72)Fe_(30)},is applied as an adjuvant to co-assemble with antigens of Mycobacterium bovis via hydrogen bonding at molecular scale.Molecular scale integration of the antigens and{Mo_(72)Fe_(30)}and their full exposure to body fluid media contribute to the augmentation of both humoral and cellular immune responses of the vaccines after inoculation in mice.Anti-inflammatory factor IL-10 gradually increases after 2 weeks followed by a final back to normal level by the 5th week.The balance between proinflammatory cytokines and anti-inflammatory factors suggests that immune system can be activated in the early stage of infection by the antigens carried by the supra-particles and secrete acute inflammatory factors for host defense and anti-inflammatory factors for immune protection.

关键词： co-assembly immune response metal oxide cluster supramolecular interaction vaccine adjuvant

Evaluation and optimization of a hybrid wave energy converter using excited motion response in two degrees of freedom

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Journal of Hydrodynamics 2023年第1期35卷 145-154页

作者： Bin-zhen Zhou Yu Wang Jian-jian Hu Peng Jin Lei Wang School of Civil Engineering and Transportation South China University of TechnologyGuangzhou510641China School of Marine Science and Engineering South China University of TechnologyGuangzhou511442China

As waves in china seas are not high,a wave energy converter consisting of a coaxial annular buoy and a cylindrical buoy that extracts wave energy using two generators through the relative heave motion between the buoys and the pitch motion of the cylinder could be a more efficient choice.A dynamic model considering constraints and assuming linear power take-off is established to evaluate the power performance of the device.The influences of two key factors,the diameter of the annular buoy and the power take-off stiffness of the pitching generator,and their couplings on the power performance are analyzed.The power of the pitching generator accounts for a major proportion of the total power.An increase in the annular buoy diameter increases the power of the heaving generator while greatly decreases the power of the pitching generator.An increase in the power take-off stiffness of the pitching generator greatly decreases its power while has little influence on the power of the heaving generator.These two factors also influence the peak period of the total power.Based on the findings and practical limitations,an optimization strategy is proposed.Further,the device is optimized based on a real wave environment in Shandong Province,china.

关键词： Wave energy converter(WEC) two degrees of freedom(DOF) parametric study power optimization real wave environment

Mucosal vaccine delivery:A focus on the breakthrough of specific barriers

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Acta Pharmaceutica Sinica B 2022年第9期12卷 3456-3474页

作者： Mengwen Huang Miaomiao Zhang Hongbin Zhu Xiaojiao Du Jun Wang School of Medicine South China University of TechnologyGuangzhou 510006China School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhou 511442China National Engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou 510006China Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of TechnologyGuangzhou 510006China Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education South China University of TechnologyGuangzhou 510006China

Mucosal vaccines can effectively induce an immune response at the mucosal site and form the first line of defense against microbial invasion.The induced mucosal immunity includes the proliferation of effector T cells and the production of IgG and IgA antibodies,thereby effectively blocking microbial infection and transmis sion.However,after a long period of development,the transformation of mucosal vaccines into clinical use is still relatively slow.To date,fewer than ten mucosal vaccines have been approved.Only seven mucosal vaccines against coronavirus disease 2019(COVID-19) are under investigation in clinical trials.A representative vaccine is the adenovirus type-5 vectored COVID-19 vaccine(Ad5-nCoV) developed by Chen and coworkers,which is currently in phase Ⅲ clinical trials.The reason for the limited progress of mucosal vaccines may be the complicated mucosal barriers.Therefore,this review summarizes the characteristics of mucosal barriers and highlights strategies to overcome these barriers for effective mucosal vaccine delivery.

关键词： Mucosal vaccine Mucosal barrier Mucosal immune response Vaccine delivery Nanocarriers

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Suppression of partially irreversible phase transition in O′3-Na_(3)Ni_(2)SbO_(6)cathode for sodium-ion batteries by interlayered structural modulation

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Journal of Energy Chemistry 2022年第10期31卷 436-444,I0011页

作者： Jingjie Feng Jiajie Li Ni Wen Siyuan Chen Jian Wu Qinghua Fan Youzhong Dong Quan Kuang Yanming Zhao School of Physics South China University of TechnologyGuangzhou 510640GuangdongChina south china Institute of Collaborative Innovation South China University of TechnologyDongguan 523808GuangdongChina Guandong Provincial Key Laboratory of Advanced Energy Storage Materials South China University of TechnologyGuangzhou 510640GuangdongChina

As a promising cathode material for sodium ion batteries,honeycomb-ordered layered Na_(3)Ni_(2)Sb O_(6)still suffers from rapid capacity fading because of partially irreversible phase transition.Herein,a substitution of Na+by Rb+with a larger ionic radius in honeycomb layered Na_(3)-xRbxNi_(2)Sb O_(6)is proposed to modulate the interlayer structure.The results unveil that biphasic transition reversibility of the intermediate P′3phase is substantially enhanced,and the structure evolution behavior during the charge/discharge process changes due to the structural modulation,which contributes to a suppression of the unfavorable O_(1)phase and an alleviation of the lattice distortion.Moreover,Rb substituted samples exhibited an improved Na+(de)intercalation thermodynamics and kinetics.Attributed to the modifications,the sample with optimized Rb content delivers superior cycle stability and rate capacity,demonstrating a feasible strategy for suppressing irreversible phase transition and developing high-performance honeycomb layered materials for sodium ion batteries.

关键词： Sodium-ion batteries High-voltage electrochemistry Honeycomb-ordered materials Rb doping Structural modulation

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