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Accurate visualization colorectal cancer by monitoring viscosity variations with a novel mitochondria-targeted fluorescent probe

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Chinese Chemical Letters 2025年第2期36卷 319-322页

作者： Fan Zheng Runsha Xiao Shuai Huang Zhikang Chen Chen Lai Anyao Bi Heying Yao Xueping Feng Zihua Chen Wenbin Zeng Xiangya School of Pharmaceutical Sciences Central South University Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases Central South University Department of General Surgery Xiangya Hospital Central South University Hunan Key Laboratory of Precise Diagnosis and Treatment of Gastrointestinal Tumor Xiangya Hospital Central South University National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Department of Oncology Xiangya Hospital Central South University Department of Otolaryngology-head and Neck Surgery and Institute of Medical Sciences Xiangya Hospital Central South University

Colorectal cancer(CRC) is one of the most prevalent malignant tumors worldwide, exhibiting high morbidity and mortality. Lack of efficient tools for early diagnosis and surgical resection guidance of CRC have been a serious threat to the long-term survival rate of the CRC patients. Recent studies have shown that relative higher viscosity was presented in tumor cells compared to that in normal cells, leading to viscosity as a potential biomarker for CRC. Herein, we reported the development of a series of novel viscosity-sensitive and mitochondria-specific fluorescent probes(HTB, HTI, and HTP) for CRC *** them, HTB showed high sensitivity, minimal background interference, low cytotoxicity, and significant viscous response capability, making it an ideal tool for distinguishing colorectal tumor cells from normal cells. Importantly, we have successfully utilized HTB to visualize in a CRC-cells-derived xenograft(CDX) model, enriching its medical imaging capacity, which laid a foundation for further clinical translational application.

关键词： Bioimaging Cancer diagnosis Colorectal cancer Fluorescent probe Mitochondrial-targeted Viscosity

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Aperiodically semi-intermittent-based fixed-time stabilization and synchronization of delayed discontinuous inertial neural networks

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Science China(Information Sciences) 2025年第1期68卷 238-254页

作者： Guodong ZHANG Jinde CAO School of Mathematics and Statistics South-Central Minzu University School of Mathematics Southeast University

This article concentrates on the fixed-time stabilization(FS) and fixed-time synchronization(FTS) of discontinuous inertial neural networks(DINNs) with distributed delays. Using mathematical induction to a new differential equality, a novel fixed-time stability lemma is constructed. Then, by designing an aperiodically semi-intermittent switching control and combining it with the theory of nonsmooth analysis, some novel criteria on the FS and FTS of DINNs are obtained. Unlike the methods used in most existing studies, the FS and FTS results are structured using the newly proposed fixed-time stability lemma and the nonreduced-order approach, resulting in broader practical applications and strengthening the scientific quality of the derived results. Lastly, numerical simulations and applications proffer the effectiveness of the established FS and FTS criteria.

关键词： inertial neural networks fixed-time synchronization semi-intermittent switching control nonreduced-order approach fixed-time stabilization

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Three-in-one erlotinib-modified NIR photosensitizer for fluorescence imaging and synergistic chemo-photodynamic therapy

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Chinese Chemical Letters 2025年第2期36卷 323-327页

作者： Du Liu Yuyan Li Hankun Zhang Benhua Wang Chaoyi Yao Minhuan Lan Zhanhong Yang Xiangzhi Song College of Chemistry & Chemical Engineering Central South University

Photodynamic therapy(PDT) presents a promising avenue in cancer treatment. Erlotinib, an FDAapproved anticancer drug targeting epidermal growth factor receptor(EGFR), has shown effectiveness in normalizing tumor vasculature across various tumors, thereby promoting tumor oxygenation and facilitating PDT. In this work, erlotinib was conjugated with a near-infrared(NIR) photosensitizer,benzo[a]phenoselenazinium, yielding three EGFR-targeted PDT agents(NBSe-n C-Er). These newly synthesized photosensitizers demonstrate specificity in binding to EGFR, thereby enhancing their accumulation in cancer cells and tumors, and consequently improving the efficiency of both PDT and ***, the NIR fluorescence emitted by the photosensitizer allows for imaging-guided therapy, offering a non-invasive means of monitoring treatment progress. The distinctive properties of the three-inone photosensitizer render it an ideal candidate for precise tumor treatment, overcoming the limitations of conventional therapies.

关键词： Benzo[a]phenoselenazinium Chemotherapy Fluorescence imaging Photodynamic therapy Photosensitizer

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Different fates of Sb(Ⅲ)and Sb(V)during the formation of jarosite mediated by Acidithiobacillus ferrooxidans

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Journal of Environmental Sciences 2025年第1期147卷 342-358页

作者： Lu Chen Yirong Wang Hongchang Liu Yuhang Zhou Zhenyuan Nie Jinlan Xia Wensheng Shu School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Key Lab of Biometallurgy of Ministry of Education of China Central South UniversityChangsha 410083China School of Life Sciences South China Normal UniversityGuangzhou 510631China

Secondary iron-sulfate minerals such as jarosite,which are easily formed in acid mine drainage,play an important role in controlling metal *** this work,the typical iron-oxidizing bacterium Acidithiobacillus ferrooxidans ATCC 23270 was selected to synthesize jarosite in the presence of antimony ions,during which the solution behavior,synthetic product composition,and bacterial metabolism were *** results show that in the presence of Sb(V),Fe^(2+)was rapidly oxidized to Fe^(3+)by *** and Sb(V)had no obvious effect on the biooxidation of Fe^(2+)under the current experimental *** presence of Sb(Ⅲ)inhibited bacterial growth and Fe^(2+)*** the group with Sb(Ⅲ),products with amorphous phaseswere formed 72 hr later,whichwere mainly ferrous sulfate and pentavalent antimony oxide,and the amorphous precursor was finally transformed into a more stable crystal *** the group with Sb(V),the morphology and structure of jarosite were changed in comparison with those without *** biomineralization process was accompanied by the removal of 94%Sb(V)to form jarosite containing the Fe-Sb-O *** transcriptome analysis shows differential effects of Sb(Ⅲ)and Sb(V)on bacterial *** expression levels of functional genes related to cell components were much more downregulated for the group with Sb(Ⅲ)butmuch more regulated for that with Sb(V).Notably,cytochrome c and nitrogen fixation-relevant genes for the A.f_Fe^(2+)_Sb(Ⅲ)group were enhanced significantly,indicating their role in Sb(Ⅲ)*** study is of great value for the development of antimony pollution control and remediation technology.

关键词： Jarosite Acidithiobacillus ferrooxidans Bacterial iron oxidation Sb(Ⅲ)and Sb(V)transformation Transcriptome analysis

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Leaching of WO_(3)from sulfuric acid converted product of scheelite in NH_(3)·H_(2)O−NH_(4)HCO_(3)solution

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Transactions of Nonferrous Metals Society of China 2025年第1期35卷 326-337页

作者： Lei-ting SHEN Yu LIU Juan-lang GUO Qiu-sheng ZHOU Tian-gui QI Zhi-hong PENG Gui-hua LIU Xiao-bin LI School of Metallurgy and Environment Central South UniversityChangsha 410083China

The leaching of sulfuric acid converted product of scheelite in NH_(3)·H_(2)O−NH_(4)HCO_(3)solution was systemically studied to improve sulfuric acid conversion−ammonium salts leaching technology route for ammonium paratungstate *** results showed that the WO_(3)leaching efficiency was about 99%under optimal conditions of 350 r/min,liquid-to-solid ratio of 3 mL/g,1 mol/L NH_(4)HCO_(3),4 mol/L NH_(3)·H_(2)O,25℃,and 15 *** the leaching,CaSO_(4)almost had no change and was still in a banding or rod-like shape in short leaching time,while conglobate CaCO_(3)was gradually formed on the CaSO_(4)surface.A secondary reaction might occur between CaSO_(4)and WO_(4)^(2−),which could be restrained by a certain amount of CO_(3)^(2−)in the *** was no CaCO_(3)phase determined by XRD in leaching residue of converted product for scheelite concentrate under optimal conditions,which was different from that for synthetic *** leaching process could be explained by neutralization reaction of H_(2)WO_(4)and solid transformation of CaSO_(4)in NH_(3)·H_(2)O−NH_(4)HCO_(3)solution.

关键词： tungstic acid calcium sulfate leaching mechanism calcium carbonate ammonium tungstate

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Tumor acidic microenvironment activatable DNA nanostructure for precise cancer cell targeting and inhibition

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Chinese Chemical Letters 2025年第1期36卷 415-419页

作者： Yanfei Liu Yaqin Hu Yifu Tan Qiwen Chen Zhenbao Liu Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Department of Pharmaceutical Engineering College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China Molecular Imaging Research Center of central south university Changsha 410008China

Precise tumor targeting and therapy is a major trend in cancer ***,we designed a tumor acidic microenvironment activatable drug loaded DNA nanostructure,in which,we made a clever use of the sequences of AS1411 and i-motif,which can partially hybridize,and designed a simple while robust DNA D-strand nanostructure,in which,i-motif sequence was designed to regulate the binding ability of the AS1411 aptamer to target *** the normal physiological environment,i-motif inhibits the targeting ability of *** the acidic tumor microenvironment,i-motif forms a quadruplex conformation and dissociates from AS1411,restoring the targeting ability of *** when acidic condition and tumor cell receptor are present,this nanostructure can be internalized by the tumor ***,the structure change of this nanostructure can realize the release of loaded *** drug loaded A-I-Duplex DNA structure showed cancer cell and spheroid targeting and inhibition ability,which is promising in the clinical cancer therapy.

关键词： Aptamer i-motif DNA nanostructure Logic gate Drug delivery system

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Effect of pyrite content on chalcopyrite flotation under different regrinding conditions

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 49-57页

作者： Zejun Wang Qing Shi Guofan Zhang Yuxuan Zhu Binbin Li School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Key Laboratory of Hunan Province for Clean and Efficient Utilization of Strategic Calcium-containing Mineral Resources Central South UniversityChangsha 410083China

This study aimed to investigate the effect of varying pyrite(Py)content on copper(Cu)in the presence of different regrinding conditions,which were altered using different types of grinding media:iron,ceramic balls,and their mixture,followed by flotation in the cleaner *** flotation performance of rough Cu concentrate can be improved by changing the regrinding conditions based on the Py *** electron microscopy,X-ray spectrometry,ethylenediaminetetraacetic acid disodium salt extraction,and X-ray photoelectron spectroscopy studies illustrated that when the Py content was high,the use of iron media in regrinding promoted the generation of hydrophilic Fe OOH on the surface of Py and improved the Cu *** ceramic medium with a low Py content prevented excessive Fe OOH from covering the surface of chalcopyrite(Cpy).Electrochemical studies further showed that the galvanic corrosion current of Cpy-Py increased with the addition of Py and became stronger with the participation of iron media.

关键词： chalcopyrite regrinding media pyrite galvanic corrosion flotation

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Uncovering the oxidation mechanism of sphalerite(ZnS)in the absence and presence of water:A first-principles investigation

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International Journal of Mining Science and Technology 2025年第1期35卷 149-157页

作者： Yuanjia Luo Wei Sun Haisheng Han Jian Peng Feng Jiang School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China

Herein,a first-principles investigation was innovatively conducted to research the surface oxidation of ZnS-like sphalerite in the absence and presence of H_(2)O .The findings showed that single O_(2) was preferred to be dissociated adsorption on sphalerite surface by generating SAO and Zn AO bonds,and the S atom on the surface was the most energy-supported site for O_(2) adsorption,on which a≡Zn-O-S-O-Zn≡structure will be ***,dissociated adsorption of single H_(2)O will not *** was preferred to be adsorbed on the top Zn atom on sphalerite surface in molecular form through Zn-O ***,sphalerite oxidation can occur as if O_(2) was present regardless of the presence of H_(2)O ,and when H_(2)O and O_(2) coexisted,the formation of sulfur oxide(SO_(2) )needed a lower energy barrier and it was easier to form on sphalerite surface than that only O_(2) *** the absence of H_(2)O ,when SO_(2) was generated,further oxidation of which would form neutral zinc *** the presence of H_(2)O ,the formation of SO_(2) on sphalerite surface was easier and the rate of further oxidation to form sulfate was also ***,the occurrence of sphalerite oxidation was accelerated.

关键词： First-principles Oxidation Sphalerite H_(2)O Lower energy barrier

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Bond length and interface failure mechanism of anchor cable under continuous radial pressure conditions

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International Journal of Mining Science and Technology 2025年第2期35卷 231-247页

作者： Jian Ouyang Xiuzhi Shi Xianyang Qiu Zongguo Zhang Zeyu Li School of Resources and Safety Engineering Central South UniversityChangsha 410083China

The anchoring capacity of the anchor cable is closely related to the bonding length and radial pressure *** field pull-out tests,theoretical analysis,numerical simulation,and industrial tests,this study clarifies the relationship between radial pressure and bonding length for the ultimate pullout force and reveals the microscopic failure process of the resin-rock interface in the anchoring *** results show that the ultimate load increases with the increase of bonding length in three different stages:rapid,slow,and uniform *** new mechanical model developed considering radial pressure describes the inverse relationship between radial pressure and the plastic zone on the bonding section,and quantifies the reinforcing effect of confining pressure on the anchoring *** the pull-out process of the anchor cable,the generation of failure cracks is in the order of orifice,bottom,and middle of the *** pressure can effectively enhance the ultimate pull-out force,alleviate the oscillation increase of pull-out force,and inhibit resin cracking,but will produce an external crushing *** also reveals the synergistic effect between bonding length and radial pressure,and successfully carries out industrial tests of anchor cable support,which ensures the stability of the stope roof and provides an important reference for the design of anchor cable support in deep high-stress mines.

关键词： Radial pressure Anchor cable Bond length Numerical simulation Interface failure Microscopic process

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Comprehensive recovery of rare earth elements and gypsum from phosphogypsum:A wastewater free process combining gravity separation and hydrometallurgy

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Journal of Rare Earths 2025年第2期43卷 362-370,I0005页

作者： Jialin Qing Dapeng Zhao Li Zeng Guiqing Zhang Liang Zhou Jiawei Du Qinggang Li Zuoying Cao Shengxi Wu School of Metallurgy and Environment Central South UniversityChangsha410083China Key Laboratory of Metallurgical Separation Science and Engineering of Non-ferrous Metals Industry Central South UniversityChangsha410083China National Engineering Laboratory for Efficient Utilization of Refractory Non-ferrous Metals Resources Central South UniversityChangsha410083China

Comprehensive utilization of phosphogypsum(PG)has attracted much attention,especially for the recovery of rare earth elements(REEs)and gypsum due to the issues of stockpile,environmental pollution,and waste of associated *** utilization methods suffered the issues of low REEs leaching efficiency,huge amount of CaSO_(4)saturated wastewater and high recovery *** solve these issues,this study investigated the occurrence of REEs in PG and the leaching of *** results show that REEs in PG are in the forms of(1)REEs mineral inclusions,(2)REEs isomorphous substitution of Ca^(2+)in gypsum lattice,(3)dispersed soluble REEs *** leaching results demonstrate that(1)the dissolution of gypsum matrix is the control factor of REEs leaching;(2)H_(2)SO_(4)is a promising leachant considering the recycle of leachate;(3)the gypsum matrix suffers a recrystallization during the acid leaching and releases the soluble REEs from PG to aqueous *** the recovery of the undissolved REEs mineral inclusions,wet sieving concentrated 37.1 wt%of the REEs in a 10.7 wt%mass,increasing REEs content from 309 to 1071 ***,a green process combining gravity separation and hydrometallurgy is *** process owns the merits of wastewater free,considerable REEs recovery(about 10%increase compared with traditional processes),excellent gypsum purification(>95 wt%CaSO_(4)·2H_(2)O,with<0.06 wt%of soluble P_(2)O_(5) and<0.015 wt%of soluble F)and reagent saving(about 2/3less reagent consumption than non-cyclical leaching).

关键词： Phosphogypsum Rare earths Wastewater free Recrystallization reinforcement Gravity separation

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